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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis显示文摘AIM: To report 13 patients with benign esophageal stenosis treated with the biodegradable stent. METHODS: We developed a Ultraflex-type stent by knitting poly-l-lactic acid monofilaments. RESULTS: Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for post- endoscopic mucosal dissection (ESD) stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION: Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis. | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2007 | World Journal of Gastroenterology2007，13，29： | 30 |
| 3 | Novel Biodegradable Stents for Benign Esophageal Strictures Following Endoscopic Submucosal Dissection显示文摘 | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2008 | Digestive Diseases and Sciences2008，，2： | 4 |
| 4 | Dual therapy with zinc acetate and rifaximin prevents from ethanolinduced liver fibrosis by maintaining intestinal barrier integrity显示文摘BACKGROUND Hepatic overload of gut-derived lipopolysaccharide dictates the progression of alcoholic liver disease(ALD)by inducing oxidative stress and activating Kupffer cells and hepatic stellate cells through toll-like receptor 4 signaling.Therefore,targeting the maintenance of intestinal barrier integrity has attracted attention for the treatment of ALD.Zinc acetate and rifaximin,which is a nonabsorbable antibiotic,had been clinically used for patients with cirrhosis,particularly those with hepatic encephalopathy,and had been known to improve intestinal barrier dysfunction.However,only few studies focused on their efficacies in preventing the ALD-related fibrosis development.AIM To investigate the effects of a combined zinc acetate with rifaximin on liver fibrosis in a mouse ALD model.METHODS To induce ALD-related liver fibrosis,female C57BL/6J mice were fed a 2.5%(v/v)ethanol-containing Lieber-DeCarli liquid diet and received intraperitoneal carbon tetrachloride(CCl4)injection twice weekly(1 mL/kg)for 8 wk.Zinc acetate(100 mg/L)and/or rifaximin(100 mg/L)were orally administered during experimental period.Hepatic steatosis,inflammation and fibrosis as well as intestinal barrier function were evaluated by histological and molecular analyses.Moreover,the direct effects of both agents on Caco-2 barrier function were assessed by in vitro assays.RESULTSIn the ethanol plus CCl4-treated mice,combination of zinc acetate and rifaximin attenuated oxidative lipid peroxidation with downregulation of Nox2 and Nox4.This combination significantly inhibited the Kupffer cells expansion and the proinflammatory response with blunted hepatic exposure of lipopolysaccharide and the toll-like receptor 4/nuclear factor kB pathway.Consequently,liver fibrosis and hepatic stellate cells activation were efficiently suppressed with downregulation of Mmp-2,-9,-13,and Timp1.Both agents improved the atrophic changes and permeability in the ileum,with restoration of tight junction proteins(TJPs)by decreasing the expressions of tumor necrosis factorαand myosin light chain kinase.In the in vitro assay,both agents directly reinforced ethanol or lipopolysaccharide-stimulated paracellular permeability and upregulated TJPs in Caco-2 cells.CONCLUSION Dual therapy with zinc acetate and rifaximin may serve as a strategy to prevent ALD-related fibrosis by maintaining intestinal barrier integrity. | Yuki Fujimoto Kosuke Kaji Norihisa Nishimura Masahide Enomoto Koji Murata Soichi Takeda Hiroaki Takaya Hideto Kawaratani Kei Moriya Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji | 2021 | World Journal of Gastroenterology2021，27，48： | 4 |
| 5 | Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma显示文摘AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body. | Kenichi Hakamada Norihisa Kimura Takuya Miura Hajime Morohashi Keinosuke Ishido Masaki Nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 6 | Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study显示文摘 | Norihisa Saeki Hiroe Ono Hiromi Sakamoto Teruhiko Yoshida | 2012 | Cancer Sci2012，，1： | 3 |
| 7 | Systematic review:Eosinophilic esophagitis in Asian countries显示文摘AIM: to investigate the prevalence and the clinical characteristics of Asian patients with eosinophilic esophagitis.METHODS: We conducted a systematic search of the Pub Med and Web of Science databases for original studies, case series, and individual case reports of eosinophilic esophagitis in Asian countries published from January 1980 to January 2015. We found 66 and 80 articles in the Pub Med and Web of Science databases, respectively; 24 duplicate articles were removed. After excluding animal studies, articles not written in English, and meeting abstracts, 25 articles containing 217 patients were selected for analysis.RESULTS: Sample size-weighted mean values were determined for all pooled prevalence data and clinical characteristics. The mean age of the adult patients with eosinophilic esophagitis was approximately 50 years, and 73% of these patients were male. They frequently presented with allergic diseases including bronchial asthma, allergic rhinitis, food allergy, and atopic dermatitis. Bronchial asthma was the most frequent comorbid allergic disease, occurring in 24% of patients with eosinophilic esophagitis. Dysphagia was the primary symptom reported; 44% of the patients complained of dysphagia. Although laboratory blood tests are not adequately sensitive for an accurate diagnosis of eosinophilic esophagitis, endoscopic examinations revealed abnormal findings typical of this disease, including longitudinal furrows and concentric rings, in 82% of the cases. One-third of the cases responded to proton pump inhibitor administration.CONCLUSION: The characteristics of eosinophilicesophagitis in Asian patients were similar to those reported in Western patients, indicating that this disease displays a similar pathogenesis between Western and Asian patients. | Yoshikazu Kinoshita Norihisa Ishimura Naoki Oshima Shunji Ishihara | 2015 | World Journal of Gastroenterology2015，21，27： | 3 |
| 8 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 9 | Superior mesenteric artery syndrome:Diagnosis and management显示文摘Superior mesenteric artery(SMA)syndrome(also known as Wilkie's syndrome,cast syndrome,or aorto-mesenteric compass syndrome)is an obstruction of the duodenum caused by extrinsic compression between the SMA and the aorta.The median age of patients is 23 years old(range 0-91 years old)and predominant in females over males with a ratio of 3:2.The symptoms are variable,consisting of postprandial abdominal pain,nausea and vomiting,early satiety,anorexia,and weight loss and can mimic anorexia nervosa or functional dyspepsia.Because recurrent vomiting leads to aspiration pneumonia or respiratory depression via metabolic alkalosis,early diagnosis is required.The useful diagnostic modalities are computed tomography as a standard tool and ultrasonography,which has advantages in safety and capability of real-time assessments of SMA mobility and duodenum passage.The initial treatment is usually conservative,including postural change,gastroduodenal decompression,and nutrient management(success rates:70%-80%).If conservative therapy fails,surgical treatment(i.e.,laparoscopic duodenojejunostomy)is recommended(success rates:80%-100%). | Akihiko Oka Muyiwa Awoniyi Nobuaki Hasegawa Yuri Yoshida Hiroshi Tobita Norihisa Ishimura Shunji Ishihara | 2023 | World Journal of Clinical Cases2023，11，15： | 2 |
| 10 | Long-term outcomes after a variety of video-assisted thoracoscopic lobectomy approaches for clinical stage IA lung cancer: A multi-institutional study显示文摘 | Norihisa Shigemura Akinori Akashi Soichiro Funaki Tomoyuki Nakagiri Masayoshi Inoue Noriyoshi Sawabata Hiroyuki Shiono Masato Minami Yukiyasu Takeuchi Meinoshin Okumura Yoshiki Sawa | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，3： | 2 |
| 11 | IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a显示文摘 | Mickey C.-T Hu Dung-Fang Lee Weiya Xia Leonard S Golfman Fu Ou-Yang Jer-Yen Yang Yiyu Zou Shilai Bao Norihisa Hanada Hitomi Saso Ryuji Kobayashi Mien-Chie Hung | 2004 | Cell2004，，2： | 2 |
| 12 | Cloning and characterization of a novel chromosomal drug efflux gene in Staphylococcus aureus显示文摘 | KOJI N NORIHISA N KAZUNORI W | 2002 | Biol Pharm Bull2002，25，12： | 1 |
| 13 | Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysacchar ideinduced liver injury in mice and on nitric oxide production in lipopolysaccharide-actirated mouse peritoneal macrophages显示文摘 | Masayuki Y Norihisa N Kiyofumi N | 2006 | Bioorg Anic Med Chem2006，14，： | 1 |
| 14 | Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and star of methicillin-resistant Staphylococcus anreus isolated in Asia during 1998 and 1999显示文摘 | Norihisa N Juniehi S Koji N | 2005 | Journal of Medical Microbiology2005，54，： | 1 |
| 15 | Dynamics of a Microflight MechanismWith MagneticRotational Wings in an Alternating Mag- netic Field 显示文摘 | Norihisa Miki Isao Shimoyama | 2002 | Joumal Of Micro electromechanical Systems2002，1011，5： | 1 |
| 16 | Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma显示文摘 | Tadaaki Arizumi Kazuomi Ueshima Haruhiko Takeda Yukio Osaki Masahiro Takita Tatsuo Inoue Satoshi Kitai Norihisa Yada Satoru Hagiwara Yasunori Minami Toshiharu Sakurai Naoshi Nishida Masatoshi Kudo | 2014 | Journal of Gastroenterology2014，，12： | 1 |
| 17 | Devel- opment of prediction system of environmental burden for ma- chine tool operation(lst report, proposal of calculation method of environmental burden)显示文摘 | NARITA H KAWAMURA H NORIHISA T | 2006 | JSME International Journal Se- ries C-Mechanical Systems Machine Elements And Manufac- turing2006，49，4： | 1 |
| 18 | A Functional Single Nucleotide Polymorphism in Mucin 1 , at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer显示文摘 | Norihisa Saeki Akira Saito Il Ju Choi Keitaro Matsuo Sumiko Ohnami Hirohiko Totsuka Suenori Chiku Aya Kuchiba Yeon–Su Lee Kyong–Ah Yoon Myeong–Cherl Kook Sook Ryun Park Young–Woo Kim Hideo Tanaka Kazuo Tajima Hiroshi Hirose Fumihiko Tanioka Yoshihiro Mats | 2011 | Gastroenterology2011，，3： | 1 |
| 19 | Resveratrol induces apoptosis via ROS-triggered autophagy in human coloncancer cells显示文摘 | Hisanori Miki Norihisa Uehara Ayako Kimura Tomo Sasaki Takashi Yuri Katsuhiko Yoshizawa Airo Tsubura | 2012 | International Journal of Oncology2012，，4： | 1 |
| 20 | Development of NOX removal SCR Catalyst for low SO2 oxidation 显示文摘 | Shigeru Nojima Kozo lida Norihisa Kobayashi | 2001 | Technical Review2001，38，2： | 1 |
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