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| 1 | 在初治和经治丙型肝炎病毒基因1b型慢性感染的非肝硬化亚洲成年患者中评价奥比帕利联合达塞布韦治疗的有效性和安全性:随机、双盲、安慰剂对照研究显示文摘目的 评估奥比帕利(奥比他韦/帕立瑞韦/利托那韦,OBV/PTV/r)25/150/100mg,1次/d,联合达塞布韦250mg,2次/d,在丙型肝炎病毒基因1b型感染的初治和经治非肝硬化中国成年患者中的有效性和安全性.方法 采用随机、双盲、安慰剂对照、多中心Ⅲ期临床试验,在中国大陆、韩国、中国台湾地区进行.纳入基因1b型初治和普通干扰素/聚乙二醇干扰素α联合利巴韦林经治非肝硬化患者,随机分为2组,分别接受OBV/PTV/r联合达塞布韦方案立即治疗12周(A组),或接受安慰剂治疗12周后再继续接受OBV/PTV/r联合达塞布韦方案治疗12周(B组).评估患者停药12周获得的持续病毒学应答(SVR12)及停药24周获得的持续病毒学应答(SVR24)率,及双盲阶段和开放标签阶段治疗后的不良事件和实验室异常发生率. 结果 共纳入410例中国大陆患者资料,按1∶1比例随机分至A组和B组(每组205例).A组(205例)中初治患者的SVR12及SVR24率均为99% (95%CI:94.8% ~ 99.8%),经治患者的SVR12及SVR24率均为100% (95% CI:96.3%~ 100%),不同基线特征对SVR12及SVR24率没有影响.发生的大多数不良事件为轻度,治疗期间≥3级实验室异常少见,主要包括丙氨酸氨基转移酶升高(双盲阶段A组2例)、天冬氨酸氨基转移酶升高(双盲阶段A组3例)和总胆红素升高(开放标签阶段B组1例),通常无症状,用药中断或停药后可恢复.仅有1例因不良事件停药(B组,开放标签阶段). 结论 疗程为12周的OBV/PTV/r联合达塞布韦方案治疗中国基因1b型初治和经治非肝硬化慢性丙型肝炎患者可获得99%~ 100%的SVR12及SVR24率,且耐受性和安全性良好. | 魏来 成军 Luo Yan 李军 段钟平 侯金林 贾继东 张明香 黄燕 谢青 王贵强 杨东亮 赵伟 赵彩彦 唐红 蔺淑梅 龚国忠 牛俊奇 高志良 Sarah Kopecky-Bromberg Linch Fredrick Niloufar Mobashery Wang Ye 王介非 | 2018 | 中华肝脏病杂志2018，26，5： | 18 |
| 2 | 在初治和经治丙型肝炎病毒基因1b型慢性感染的代偿期肝硬化亚洲成年患者中评价奥比帕利和达塞布韦联合利巴韦林治疗的有效性和安全性显示文摘目的 评估奥比帕利(奥比他韦/帕立瑞韦/利托那韦)25/150/100mg,1次/d和达塞布韦(DSV) 250 mg,2次/d联合利巴韦林在丙型肝炎病毒基因1b型感染的代偿期肝硬化中国大陆成年患者中的有效性和安全性. 方法 采用开放标签、多中心Ⅲ期临床试验,在中国大陆、中国台湾地区和韩国开展,纳入初治和经治基因1b型丙型肝炎病毒感染的代偿期肝硬化(Metavir 评分纤维化分期=F4)成年患者,接受奥比他韦/帕立瑞韦/利托那韦和达塞布韦联合利巴韦林治疗12周.评估患者停药12周获得的持续病毒学应答(SVR)及24周获得的SVR率,并在接受至少1次研究药物的患者中评估有效性和安全性. 结果 共纳入63例中国大陆患者,其中62例(98.4%)患者基线Child-Pugh评分为5分.患者总体SVR12率及SVR24率为100% (95% CI:94.3% ~ 100.0%).发生的大多数不良事件为轻度.常见(发生率≥10%)所有级别不良事件和实验室异常包括总胆红素升高(36.5%)、乏力(19.0%)、非结合胆红素升高(19.0%)、结合胆红素升高(17.5%)和贫血(14.3%).3例(4.8%)患者发生≥3级不良事件,均被研究者判定为与研究药物无关.无患者出现导致提前停药的不良事件. 结论 丙型肝炎病毒基因1b型感染的代偿期肝硬化中国大陆患者接受奥比他韦/帕立瑞韦/利托那韦和达塞布韦联合利巴韦林治疗12周,停药12周和24周的SVR均为100%.耐受性及安全性良好,大多数不良事件为轻度. | 魏来 王贵强 Sarah Kopecky-Bromberg 成军 诩青 汪茂荣 许敏 段钟平 侯金林 张明香 张跃新 唐红 赵伟 蔺淑梅 贾战生 牛俊奇 高志良 袁宏 林明华 周新民 Luo Yan Linda Fredrick Niloufar Mobashery Wang Ye 贾继东 | 2018 | 中华肝脏病杂志2018，26，5： | 17 |
| 3 | Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease显示文摘There is currently no treatment for effectively slowing the progression of Alzheimer's disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer's disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 m L/kg saline. Behavioral test(the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease. | Matin Ramezani Niloufar Darbandi Fariba Khodagholi Azam Hashemi | 2016 | Neural Regeneration Research2016，11，12： | 6 |
| 4 | Experimental investigation of cluster properties in dense gas-solid fluidized beds of different diameters显示文摘The local solid flow structure of a bubbling fluidized bed of sand particles was investigated in three different columns to characterize the properties of clusters.The experiments were performed using a reflective optical fiber probe.The variations in size,velocity,and void fraction of the clusters due to changes in the superficial gas velocity,particle size,and radial positions were studied.The results indicate that the velocity of the clusters remained unchanged while their size increased as the column diameter increased.In addition,the radial profile of the clusters' velocity did not depend on the radial position.The results indicate that larger particles form larger clusters,which move slower. | Niloufar Firuzian Rahmat Sotudeh-Gharebagh Navid Mostoufi | 2014 | Particuology2014，12，5： | 3 |
| 5 | High Refractive Index Ti3O5 Films for Dielectric Metasurfaces显示文摘Ti_3 O_5 films are deposited with the help of an electron beam evaporator for their applications in metasurfaces.The film of subwavelength(632 nm) thickness is deposited on a silicon substrate and annealed at 400°C. The ellipsometr.y result shows a high refractive index above 2.5 with the minimum absorption coefficient in the visible region, which is necessary for high efficiency of transparent metasurfaces. Atomic force microscopy analysis is employed to measure the roughness of the as-deposited films. It is seen from micrographs that the deposited films are very smooth with the minimum roughness to prevent scattering and absorption losses for metasurface devices. The absence of grains and cracks can be seen by scanning electron microscope analysis, which is favorable for electron beam lithography. Fourier transform infrared spectroscopy reveals the transmission and reflection obtained from the film deposited on glass substrates. The as-deposited film shows high transmission above 60%,whieh is in good agreement with metasurfaces. | Sohail Abdul Jalil Mahreen Akram Gwanho Yoon Ayesha Khalid Dasol Lee Niloufar Raeis-Hosseini Sunae So Inki Kim Qazi Salman Ahmed Junsuk Rho Muhammad Qasim Mehmoo | 2017 | Chinese Physics Letters2017，34，8： | 2 |
| 6 | HPLC方法测定肉桂和桂枝中七种苯丙素类成分的含量(英文)显示文摘建立了同时测定桂枝和肉桂中7种苯丙素类成分(2-羟基肉桂醛,香豆素,肉桂醇,肉桂酸,2-甲氧基肉桂酸,肉桂醛,2-甲氧基肉桂醛)含量的HPLC方法。采用该方法对48批中国肉桂和桂枝(27批肉桂和21批桂枝)商品药材中7种成分的含量进行测定并比较。结果表明,7种苯丙素类成分在肉桂中的总含量为17.5-61.6 mg/g,在桂枝中的总含量为9.91-23.4 mg/g;其中2-甲氧基肉桂酸在肉桂中的含量在检测限以下,而在桂枝中的含量在0-0.119 mg/g之间。肉桂和桂枝药材中(肉桂醇+肉桂酸)/肉桂醛的含量比值(R_(346))范围分别是0.0121-0.0467和0.0598-0.182,该比值可用以区分肉桂(<0.05)和桂枝(>0.05)。7种成分在沸水中的煎出率不同,肉桂醛煎出率最低(<3%),肉桂酸煎出率最大(约60%)。 | 袁鹏飞 马雅静 苏丹 尚明英 徐风 刘广学 Niloufar Iranmanesh 李兰芳 姜廷良 蔡少青 | 2015 | Journal of Chinese Pharmaceutical Sciences2015，24，9： | 2 |
| 7 | A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment显示文摘 | Eric Lawitz Maribel Rodriguez-Torres Albrecht Stoehr Edward J. Gane Lawrence Serfaty Sanhita Bhanja Richard J. Barnard Di An Jacqueline Gress Peggy Hwang Niloufar Mobashery | 2013 | Journal of Hepatology2013，，1： | 1 |
| 8 | Role of tau phosphorylation by glycogen synthase kinase-3βin the regulation of organelle transport显示文摘 | Yoshitaka T Niloufar H Yunn-Chyn T | 2004 | J Cell Sci2004，117，： | 1 |
| 9 | Macro- and microvascular disease in systemic sclerosis显示文摘 | Niloufar Kavian Frédéric Batteux | 2015 | Vascular Pharmacology2015，，： | 1 |
| 10 | Protection of neuron-like PCI2 cells against H2O2-induced neurotoxicity by oxazine derivative: role of transcription factors, NF-kB and Nff2显示文摘 | Niloufar Ansari Mohsen Amini Fariba Khodagholi | 2010 | Alzheimer''s and Dementia2010，6，4： | 1 |
| 11 | Fabrication of an electro- chemical sensor based on the eleetrodeposition of Pt nano- particles on multiwalled carbon nanotubes film for voltam- metric determination of ceftriaxone in the presence of lido- caine, assisted by factorial-based response-surface methodo- logy 显示文摘 | Saeed S Niloufar H Zahra K | 2014 | Solid State Electrochem2014，18，： | 1 |
| 12 | Combination of Vaniprevir With Peginterferon and Ribavirin Significantly Increases the Rate of SVR in Treatment-Experienced Patients With Chronic HCV Genotype 1 Infection and Cirrhosis显示文摘 | Maribel Rodriguez–Torres Albrecht Stoehr Edward J. Gane Lawrence Serfaty Eric Lawitz Amy Zhou Michael Bourque Sanhita Bhanja Julie Strizki Richard J.O. Barnard Peggy M.T. Hwang Mark J. DiNubile Niloufar Mobashery | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 13 | ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats显示文摘 | Ghorbangol Ashabi Mahmoudreza Ramin Pegah Azizi Zahra Taslimi Shabnam Zeighamy Alamdary Abbas Haghparast Niloufar Ansari Fereshteh Motamedi Fariba Khodagholi | 2012 | Behavioural Brain Research2012，，： | 1 |
| 14 | Thermo economic evaluation of oxy fuel combustion cycle in Kazeroon power plant considering enhanced oil recovery revenues显示文摘Oxy fuel combustion and conventional cycle(currently working cycle) in Kazeroon plant are modeled using commercial thermodynamic modeling software. Economic evaluation of the two models regarding the resources of transport and injection of carbon dioxide into oil fields at Gachsaran for enhanced oil recovery in the various oil price indices is conducted and indices net present value(NPV) and internal rate of return on investment(IRR) are calculated. The results of the two models reveal that gross efficiency of the oxy fuel cycle is more than reference cycle(62% compared to 49.03%), but the net efficiency is less(41.85% compared to 47.92%) because of the high-energy consumption of the components, particularly air separation unit(ASU) in the oxy fuel cycle. In this model, pure carbon dioxide with pressure of 20×105 Pa and purity of 96.84% was captured. NOX emissions also decrease by 4289.7 tons per year due to separation of nitrogen in ASU. In this model, none of the components of oxy fuel cycle is a major engineering challenge. With increasing oil price, economic justification of oxy fuel combustion model increases. With the price of oil at $ 80 per barrel in mind and $ 31 per ton fines for emissions of carbon dioxide in the atmosphere, IRR is the same for both models. | Ehsan Torabnejad Ramin Haghighi-Khoshkhoo Niloufar Sarabchi | 2014 | Journal of Central South University2014，21，3： | 1 |
| 15 | Investigation of corrosion performance of epoxy coating containing polyaniline nanoparticles显示文摘 | Niloufar B P Mahmood P Iman D | 2012 | Iranian Polymer Journal2012，21，11： | 1 |
| 16 | Rofecoxib inhibits cyclooxygenase-2 expression and reduces cell proliferation in Barrett's esophagus显示文摘 | Baljeet SK Niloufar K Mohamed I | 2002 | Gastroenterology2002，123，： | 1 |
| 17 | Supravalvular arrhythmia:identifying and ablating the substrate 显示文摘 | Niloufar T Samuel JA | 2009 | Circ Arrhythm Electrophysiol2009，2，： | 1 |
| 18 | Attenuation of NF-k B and activation of Nrf 2 signaling by 1,2,4-triazine derivatives,protects neuron-like PC12 cells against apoptosis显示文摘 | Solaleh KT Niloufar A Mohse A | 2010 | Apoptosis2010，15，： | 1 |
| 19 | Diffusion of MRI and CT contrast agents in articular cartilage under static compression 显示文摘 | YOUSEF Shafieyan NILOUFAR Khosravi MOHAM- MAD Moeini | 2014 | Biophysical Journal2014，107，2： | 1 |
| 20 | Land-use change and carbon stocks: A case study, Noor County, Iran显示文摘Land-use changes and land cover strongly influence carbon stock and distribution within ecosystems. Changing the land-use from natural forest to other land-uses has been more rapid in the past few decades than at any time in Iran's history. In this study, we investigated the effects of changing the land-use from natural forest to other land-uses on carbon stocks in northern Iran. We selected five sites for this study: (Ⅰ) a natural forest, (Ⅱ) an agricultural field and (Ⅲ) plantations of three different species (Alnus subcordata .L, Acer velutinum .Boiss and Cupressus sempervirens). We examined the effects of land-use changes on: (Ⅰ) soil carbon stock (0-50 cm depth), (Ⅱ) biomass and carbon content of grassy vegetation and litter and (Ⅲ) aboveand below-ground biomass C in trees. Soil C stock was higher under A. velutinum and C. sempervirens whereas it was lower under A. subcordata and agricultural sites. Biomass and C content of grassy vegetation were significantly higher at A. velutinum and C. sempervirens plantations. However, litter biomass and C content were significantly higher at the natural forest site. Natural forest had the highest amount of C content in aboveand below-ground biomass. Total ecosystem C stocks declined following land-use changes. | Niloufar Haghdoost Moslem Akbarinia Seyed Mohsen Hosseini | 2013 | Journal of Forestry Research2013，24，3： | 1 |
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