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| 1 | ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease显示文摘AIM: To determine the possible association of the ApoB100 (Xba Ⅰ ), ApoE (Hha Ⅰ ) and CYP7A1 (Bsa Ⅰ ) gene polymorphisms, with the development of cholesterol gallstone disease (GD) in a Mexican population. METHODS: The polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by ethnicity, age and sex: patients with GD (n = 101) and stone-free control subjects (n = 101). RESULTS: Allelic frequencies in patients and controls were: 34.16% vs 41.58% (P = 0.124) for X+of ApoB-100; 4.46% vs 5.94% (P = 0.501) for E2, 85.64% vs 78.22% (P = 0.052) for E3, 9.90% vs 15.84% (P = 0.075) for E4 of ApoE; and 25.74% vs 27.72% (P = 0.653) for C of CYP7A1. Differences in genotypic frequencies between the studied groups were not significant (P < 0.05). CONCLUSION: These results demonstrated that no association exists between the studied polymorphisms and cholelithiasis in this high prevalent population. | Sánchez-Cuén Jaime Aguilar-Medina Maribel Arámbula-Meraz Eliakym Romero-Navarro José Granados Julio Sicairos-Medina Laura Ramos-Payán Rosalío | 2010 | World Journal of Gastroenterology2010，16，37： | 14 |
| 2 | Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target显示文摘ObjectivesIncreased 脂蛋白(a) 浆液集中似乎是一个心血管的风险因素;这没在 extracoronary 动脉粥样硬化复杂并发症被证实。我们因此希望获得更深的卓见 into 在脂蛋白(a) 的血浆集中和类型 2 糖尿病 mellitus 并且到的微脉管、宏脉管的复杂并发症之间的关系在这 association.MethodsThis 识别可能的差别是描述的观察代表性的研究。二 -- 有类型 2 糖尿病 mellitus 的 117 个老病人从内部药 outclinic 被包括。人体测量的数据,分析数据(象高血压的胰岛素保守,基础、饭后的肽 C, glycosylated 血红素,肾的参数,类脂化合物侧面和临床的数据,肥胖,微 -- 并且 macrovascular 复杂并发症是 collected.ResultsPatients 根据类型被组织进化的 2 糖尿病 mellitus 时间。脂蛋白(a) 的吝啬的血浆集中是 22.2 ±17.3 mg/dL (22.1 ±为男性的 15.9 mg/dL,和 22.1 ±为女性的 18.4 mg/dL ) 。有高血压,冠的心疾病,脑血管的事故, microalbuminuria 和 proteinuria 的病人介绍了脂蛋白(a) 的统计上重要的增加的水平。同样,有 hyperlipoprotein (a) 的病人(≥30 mg/dL ) 脲和全部的胆固醇的介绍显著地增加的层次。在 multivariate 回归模型,脂蛋白(a) 的水平断然与冠的心疾病和糖尿病的 nephropathy 被相关(P <0.01 并且 P <0.005,分别地) 脂蛋白(a) 的血浆层次的 .ConclusionsThe 举起与冠的心疾病和 diabe tic nephropathy 的发展被联系。因此,我们认为脂蛋白(a) 的决心可以是在有类型 2 糖尿病 mellitus 的病人的脉管的复杂并发症的一个预示的标记。 | Rocio Toro Eduardo Segura Jesfis Millan Nunez-Cortes Juan Carlos Pedro-Botet Maribel Quezada-Feijoo Alipio Mangas | 2015 | Journal of Geriatric Cardiology2015，12，2： | 10 |
| 3 | Physiological Responses of Contrasting Rice Genotypes to Salt Stress at Reproductive Stage显示文摘Salinity is a major abiotic stress affecting plant growth and productivity. Considerable genetic variation is present in rice in response to salt stress, with higher sensitivity during early seedling and reproductive stage. In this study, physiological changes in leaves and developing panicles of rice genotypes (IR686, Sadri, Rc222, CSR28, IR670 and Pokkali) contrasting in salt tolerance at the reproductive stage were evaluated in greenhouse experiment under salt stress. The results showed that IR670 and the tolerant-check Pokkali maintained lower Na^+/K^+ ratio, less reduction in chlorophyll concentration, lower malondialdehyde (MDA) production, higher concentrations of reduced ascorbate (reduced AsA), higher proline accumulation and lower percentage reduction in pollen viability than the salt-sensitive genotypes under salt stress. The higher concentration of reduced AsA suggests an efficient ROS-scavenging system. Physiological measurements and pollen viability analysis revealed that Sadri (moderately tolerant at the seedling stage) is sensitive to salt stress at the flowering stage. The findings will be useful in breeding salt tolerant varieties at both seedling and reproductive stages by selecting appropriate genotypes and phenotypes. | Maria Elisa B.GERONA Marjorie P. DEOCAMPO James A.EGDANE Abdelbagi M.ISMAIL Maribel L. DIONISIO-SESE | 2019 | Rice science2019，26，4： | 9 |
| 4 | Intravitreal dexamethasone implants for diabetic macular edema显示文摘AIM: To evaluate the safety and efficacy of a dexamethasone(DEX) intravitreal implant for diabetic macular edema(DME).METHODS: Totally 113 eyes of 84 patients were divided in three subgroups: naive patients(n=11), pseudophakic patients(n=72) and phakic patients(n=30). Inclusive criterion comprised adult diabetic patients with central fovea thickening and impaired visual acuity resulting from DME for whom previous standard treatments showed no improvement in both central macular thickness(CMT) and best corrected visual acuity(BCVA) after at least 3 mo of treatment. Outcome data were obtained from patient visits at baseline and at months 1, 3, 5, 9 and 12 after the first DEX implant injection. At each of these visits, patients underwent measurement of BCVA, a complete eye examination and measurement of CMT and macular volume(MV) carried out with optical coherence tomography(OCT) images. RESULTS: Seventy-three eyes(64.5%) received a single implant, 30(26.5%) received two implants and 10(9%) received three implants. At baseline, average in BCVA, CMT and MV were 43.5±20.8, 462.8±145 and 12.6±2.5 respectively. These values improved significantly at 1 mo(BCVA: 47.2±19.5, CMT: 339.6±120, MV: 11.11±1.4) and 3 mo(BCVA: 53.2±18.1, CMT: 353.8±141, MV: 11.3±1.3)(P≤0.05). At 5 mo(BCVA: 50.9±19.8, CMT: 425±150, MV: 12.27±2.3), 9 mo(BCVA: 48.4±17.6, CMT: 445.5±170, MV: 12.5±2.3) and 12 mo(BCVA: 47.7±18.8, CMT: 413.2±149, MV: 12.03±2.5), improvements in the three parameters were no longer statistically significant and decreased progressively but did not reach baseline values. There were no clinical differences between subgroups. Ocular complications were minimal.CONCLUSION: Patients with DEX implants show maximum efficacy at 3 mo which then declined progressively, but is still better than baseline values at the end of follow-up. | Alicia Pareja-Ríos Paloma Ruiz-de la Fuente-Rodríguez Sergio Bonaque-González Maribel López-Gálvez Virginia Lozano-López Pedro Romero-Aroca | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 8 |
| 5 | Polyamines reduces lipid peroxidation induced by different pro-oxidant agents显示文摘 | Nádia Aléssio Velloso Bellé Gerusa Duarte Dalmolin Graciela Fonini Maribel Antonello Rubin Jo?o Batista Teixeira Rocha | 2004 | Brain Research2004，，2： | 3 |
| 6 | World Gastroenterology Organisation Global Guidelines: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis显示文摘 | Douglas R. LaBrecque Zaigham Abbas Frank Anania Peter Ferenci Aamir G. Khan Khean-Lee Goh Saeed S. Hamid Vasily Isakov Maribel Lizarzabal Manuel M. Pe?aranda Juan F.R. Ramos Shiv Sarin Davor Stimac Alan B.R. Thomson Muhammed Umar Justus Krabshuis Anton Le | 2014 | Journal of Clinical Gastroenterology2014，，6： | 3 |
| 7 | Morpho-Physiological Changes in Roots of Rice Seedling upon Submergence显示文摘Submergence is a serious environmental condition that causes large loss in rice production in rain fed lowland and flood affected area. This study evaluated morphological and physiological responses of rice roots to submergence using two tolerant rice genotypes FR13A and Swarna-Sub 1 and two sensitive ones Swarna and IR42. The tolerant genotypes had higher survival rate and less shoot elongation but greater root elongation during submergence than the sensitive ones. After submergence,the tolerant genotypes also had higher root dry weight and more active roots than the sensitive ones.Tolerant genotypes exhibited less root injury, with less malondialdehyde production and slower electrolyte leakage after submergence. Tolerant genotypes also maintained higher concentrations of soluble sugar and starch in roots and shoots and higher chlorophyll retention after submergence than the sensitive ones.Our data showed that root traits such as root activity and root growth are associated with survival rate after submergence. This is probably accomplished through higher energy supply, and membrane integrity is necessary to preserve root function and reduce injury during submergence. These root traits are important for submergence tolerance in rice. | Liem T.BUI Evangelina S.ELLA Maribel L.DIONISIO-SESE Abdelbagi M.ISMAIL | 2019 | Rice science2019，26，3： | 3 |
| 8 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 9 | Eltrombopag Increases Platelet Numbers in Thrombocytopenic Patients With HCV Infection and Cirrhosis, Allowing for Effective Antiviral Therapy显示文摘 | Nezam H. Afdhal Geoffrey M. Dusheiko Edoardo G. Giannini Pei–Jer Chen Kwang–Hyub Han Aftab Mohsin Maribel Rodriguez–Torres Sorin Rugina Igor Bakulin Eric Lawitz Mitchell L. Shiffman Ghias–Un–Nabi Tayyab Fred Poordad Yasser Mostafa Kamel Andres Brainsky Ja | 2014 | Gastroenterology2014，，2： | 2 |
| 10 | Modelling and implementing big data warehouses for decision support显示文摘In the era of Big Data,many NoSQL databases emerged for the storage and later processing of vast volumes of data,using data structures that can follow columnar,key-value,document or graph formats.For analytical contexts,requiring a Big Data Warehouse,Hive is used as the driving force,allowing the analysis of vast amounts of data.Data models in Hive are usually defined taking into consideration the queries that need to be answered.In this work,a set of rules is presented for the transformation of multidimensional data models into Hive tables,making available data at different levels of detail.These several levels are suited for answering different queries,depending on the analytical needs.After the identification of the Hive tables,this paper summarizes a demonstration case in which the implementation of a specific Big Data architecture shows how the evolution from a traditional Data Warehouse to a Big Data Warehouse is possible. | Maribel Yasmina Santos Bruno Martinho Carlos Costa | 2017 | Journal of Management Analytics2017，4，2： | 2 |
| 11 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 12 | Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy显示文摘 | Virginia Hernández-Gea Moira Hilscher Raphael Rozenfeld Maribel P. Lim Natalia Nieto Sabine Werner Lakshmi A. Devi Scott L. Friedman | 2013 | Journal of Hepatology2013，，1： | 2 |
| 13 | The impact of desirability and feasibility on entrepreneurial intentions: A structural equation model显示文摘 | Maribel Guerrero Josep Rialp David Urbano | 2008 | International Entrepreneurship and Management Journal2008，，1： | 2 |
| 14 | High‐Resolution ultrasound of the pudendal nerve: Normal anatomy显示文摘 | Alberto Tagliafico Maribel Miguel Perez Carlo Martinoli | 2012 | Muscle Nerve2012，，： | 2 |
| 15 | Age-related changes in resting-state functional connectivity in older adults显示文摘Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and areas.Frequently,these studies compared young individuals with older subjects,but few studies compared different age groups only in older populations.The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted.Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old.The oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other groups.This occurred possibly because of compensatory mechanism in brain functioning.This study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity characteristics.Approval for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval No.PSI2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively. | Laia Farras-Permanyer Nuria Mancho-Fora Marc Montala-Flaquer David Bartres-Faz Lidia Vaque-Alcazar Maribel Pero-Cebollero Joan Guardia-Olmos | 2019 | Neural Regeneration Research2019，14，9： | 2 |
| 16 | Minimal processing of a Granny Smith apple puree by microwave heating显示文摘 | PIERRE A P ANDREAS L MARIBEL A | 2009 | Innovative Food Science and Emerging Technologies2009，10，4： | 1 |
| 17 | Nutritionally Induced Changes in the Peroxisome Proliferator-Activated Receptor-α Gene Expression in Liver of Suckling Rats Are Dependent on Insulinaemia显示文摘 | Maribel Panadero Hubert Vidal Emilio Herrera Carlos Bocos | 2001 | Archives of Biochemistry and Biophysics2001，，2： | 1 |
| 18 | Cell interactions influence vascular reprogramming by proxl during embryonic development显示文摘 | Harold Kim Maribelle Cruz Annie Bourdeau | 2013 | PLo S One2013，，52： | 1 |
| 19 | Adaptation of Parent-Child Interaction Therapy for Puerto Rican Families : A Preliminary Study显示文摘 | Maribel Matos Rosalie Torres Rocheli Santiago | 2006 | Family Process2006，45，2： | 1 |
| 20 | A phase 2B study of MK-7009 (vaniprevir) in patients with genotype 1 HCV infection who have failed previous pegylated interferon and ribavirin treatment显示文摘 | Eric Lawitz Maribel Rodriguez-Torres Albrecht Stoehr Edward J. Gane Lawrence Serfaty Sanhita Bhanja Richard J. Barnard Di An Jacqueline Gress Peggy Hwang Niloufar Mobashery | 2013 | Journal of Hepatology2013，，1： | 1 |
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