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| 1 | Optimal treatment for Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction: A retrospective cohort study with long-term follow-up显示文摘AIM To determine the optimal treatment strategy for Siewert type Ⅱ and?Ⅲ?adenocarcinoma of the esophagogastric junction.METHODS We retrospectively reviewed the medical records of 83 patients with Siewert type?Ⅱ?and?Ⅲ?adenocarcinoma of the esophagogastric junction and calculated both an index of estimated benefit from lymph node dissection for each lymph node(LN) station and a lymph node ratio(LNR: ratio of number of positive lymph nodes to the total number of dissected lymph nodes). We used Cox proportional hazard models to clarify independent poor prognostic factors. The median duration of observation was 73 mo.RESULTS Indices of estimated benefit from LN dissection were as follows, in descending order: lymph nodes(LN) along the lesser curvature, 26.5; right paracardial LN, 22.8; left paracardial LN, 11.6; LN along the left gastric artery, 10.6. The 5-year overall survival(OS) rate was 58%. Cox regression analysis revealed that vigorous venous invasion(v2, v3)(HR = 5.99; 95%CI: 1.71-24.90) and LNR of > 0.16(HR = 4.29, 95%CI: 1.79-10.89) were independent poor prognostic factors for OS.CONCLUSION LN along the lesser curvature, right and left paracardial LN, and LN along the left gastric artery should be dissected in patients with Siewert type?Ⅱ?or?Ⅲ?adenoca rcinoma of the esophagogastric junction. Patients with vigorous venous invasion and LNR of > 0.16 should be treated with aggressive adjuvant chemotherapy to improve survival outcomes. | Kei Hosoda Keishi Yamashita Hiromitsu Moriya Hiroaki Mieno Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，15： | 19 |
| 2 | Trend in gastric cancer:35 years of surgical experience in Japan显示文摘AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring surgery.RESULTS:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed pe-riod.Interestingly,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to decrease.The incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic surveillance.As a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly improved.CONCLUSION:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention. | Keishi Yamashita Shinichi Sakuramoto Masayuki Nemoto Tomotaka Shibata Hiroaki Mieno Natsuya Katada Shiroh Kikuchi Masahiko Watanabe | 2011 | World Journal of Gastroenterology2011，17，29： | 11 |
| 3 | Macroscopic appearance of TypeⅣand giant Type Ⅲ is a high risk for a poor prognosis in pathological stage Ⅱ/Ⅲ advanced gastric cancer with postoperative adjuvant chemotherapy显示文摘AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer. | Keishi Yamashita Akira Ema Kei Hosoda Hiroaki Mieno Hiromitsu Moriya Natsuya Katada Masahiko Watanabe | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 2 |
| 4 | Preparation of cubic boron nitride films by radio frequency bias sputtering 显示文摘 | Mieno M Yoshida T | 1992 | Sur Coat tech1992，52，： | 2 |
| 5 | Oxidative stress and atrial fibrillation after cardiac surgery:a case-control study显示文摘 | Ramlawi B Otu H Mieno S | | 0，，： | 1 |
| 6 | The max-min Delphi Method and Fuzzy Dslphi Method Via Fuzzy Integration显示文摘 | Ishikawa A Amagasa M Shiga T Tomizawa G Tatsuta R Mieno H | 1993 | Fuzzy Sets and Systems1993，，5： | 1 |
| 7 | The max-rain Delphi method and fuzzy Delphi method via fuzzy integration显示文摘 | Ishikawa A Amagasa M Shiga T Tomizawa G Tatsuta R Mieno H | 1993 | Fuzzy Sets and Systems1993，55，： | 1 |
| 8 | C-reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery显示文摘 | Ramlawi B Rudolph JL Mieno S | 2006 | Surgery2006，140，2： | 1 |
| 9 | C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery显示文摘 | RAMLAWI B RUDOLPHJ L MIENO S | 2006 | Surgery2006，140，2： | 1 |
| 10 | Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts 显示文摘 | Okawa H Horimoto H Mieno S | 2003 | Mol Cell Biochem2003，248，12： | 1 |
| 11 | Serologic markers of brain injury and cognitive function after eardiopulmonary bypass显示文摘 | Ramlawi B Rudolph JL Mieno S | 2006 | Ann Surg2006，244，4： | 1 |
| 12 | Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia:role of endostatin and oxidative stress显示文摘 | Nakai Y Mieno S | 2006 | Ann Thorac Surg2006，81，： | 1 |
| 13 | Mitochondrial ATP-sensitive potassi- um channel plays a dominant role in ischemic preconditioning of rabbit heart 显示文摘 | Nakai Y Horimoto H Mieno S | 2001 | Eur Surg Res2001，33，： | 1 |
| 14 | Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension 显示文摘 | Kanki - Horimoto S Horimoto H Mieno S | 2006 | Circulation2006，114，1： | 1 |
| 15 | Functional,cellular,and nlolecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes 显示文摘 | Boodhwani M Sodha NR Mieno S | 2007 | Circulation2007，1，11： | 1 |
| 16 | Characteridtics andfunction of cryopreserved bone marrow-derived endothelial progeni-tor cells显示文摘 | Mieno S Clements RT Boodhwani M | 2008 | Ann Thorac Surg2008，85，4： | 1 |
| 17 | Implantation of Mesenchymal Stem Ceils Overexpressing Endothelial Nitric Oxide Synthase Improves Right Ventricular Impairments Caused by Pulmonary Hypertension显示文摘 | Kanki HS Horimoto H Mieno S | 2006 | Circ2006，，： | 1 |
| 18 | C-Reactive protein and inflammatory response associated to neurocognitive decline following cardiac surgery显示文摘 | Basel Ramlawi James L. Rudolph Shigetoshi Mieno Jun Feng Munir Boodhwani Kamal Khabbaz Sue E. Levkoff Edward R. Marcantonio Cesario Bianchi Frank W. Sellke | 2006 | Surgery2006，，2： | 1 |
| 19 | Oxidative stress and atrial fi?brillation after cardiac surgery: a case - control study显示文摘 | Ramlawi B Otu H Mieno S | 2007 | Ann Thorac Surg2007，84，4： | 1 |
| 20 | Ftmctional, cellu- lar, and molecular characterization of the angiogenic re- sponse to chronic myocardial ischemia in diabetes 显示文摘 | Boodhwani M Sodha NR Mieno S | 2007 | Cir- culation2007，116，11： | 1 |
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