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| 1 | GENCODE: The reference human genome annotation for The ENCODE Project显示文摘 | Jennifer Harrow Adam Frankish Jose M. Gonzalez Electra Tapanari Mark Diekhans Felix Kokocinski Bronwen L. Aken Daniel Barrell Amonida Zadissa Stephen Searle If Barnes Alexandra Bignell Veronika Boychenko Toby Hunt Mike Kay Gaurab Mukherjee Jeena Rajan Glo | 2012 | Genome Research2012，，9： | 2 |
| 2 | Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction显示文摘 | Felix M. Gonzalez Sruti Shiva Pamela S. Vincent Lorna A. Ringwood Li-Yueh Hsu Yuen Yi Hon Anthony H. Aletras Richard O. Cannon Mark T. Gladwin Andrew E. Arai | 2008 | Circulation2008，，23： | 2 |
| 3 | Hybrid trans- former model for transient simulation-part I :development and parameters 显示文摘 | MARK B A GONZALEZ F ISHCHENKO D | 2007 | IEEE Trans on Power Delivery2007，22，1： | 1 |
| 4 | IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion显示文摘Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis(RA)patients could reflect activation of innate immune mechanisms.Herein,we show that a TLR7 GU-rich endogenous ligand,miR-Let7b,potentiates synovitis by amplifying RA monocyte and fibroblast(FLS)trafficking.miR-Let7b ligation to TLR7 in macrophages(MΦs)and FLSs expanded the synovial inflammatory response.Moreover,secretion of M1 monokines triggered by miR-Let7b enhanced Th1/Th17 cell differentiation.We showed that IRAK4 inhibitor(i)therapy attenuated RA disease activity by blocking TLR7-induced M1 MΦor FLS activation,as well as monokine-modulated Th1/Th17 cell polarization.IRAK4i therapy also disrupted RA osteoclastogenesis,which was amplified by miR-Let7b ligation to joint myeloid TLR7.Hence,the effectiveness of IRAK4i was compared with that of a TNF inhibitor(i)or anti-IL-6R treatment in collagen-induced arthritis(CIA)and miR-Let7b-mediated arthritis.We found that TNF or IL-6R blocking therapies mitigated CIA by reducing the infiltration of joint F480+iNOS+MΦs,the expression of certain monokines,and Th1 cell differentiation.Unexpectedly,these biologic therapies were unable to alleviate miR-Let7b-induced arthritis.The superior efficacy of IRAK4i over anti-TNF or anti-IL-6R therapy in miR-Let7b-induced arthritis or CIA was due to the ability of IRAK4i therapy to restrain the migration of joint F480+iNOS+MΦs,vimentin+fibroblasts,and CD3+T cells,in addition to negating the expression of a wide range of monokines,including IL-12,MIP2,and IRF5 and Th1/Th17 lymphokines.In conclusion,IRAK4i therapy may provide a promising strategy for RA therapy by disconnecting critical links between inflammatory joint cells. | Sadiq Umar Karol Palasiewicz Katrien Van Raemdonck Michael V.Volin Bianca Romay MAsif Amin Ryan K.Zomorrodi Shiva Arami Mark Gonzalez Vikram Rao Brian Zanotti David A.Fox Nadera Sweiss Shiva Shahrara | 2021 | Cellular & Molecular Immunology2021，18，9： | 1 |
| 5 | Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening显示文摘 | Vani Konda Lusik Cherkezyan Hariharan Subramanian Kirsten Wroblewski Dhwanil Damania Valentin Becker Mariano Gonzalez Ann Koons Michael Goldberg Mark Ferguson Irving Waxman Hermant Roy Vadim Backman | 2013 | Endoscopy2013，，： | 1 |
| 6 | Glioma Recurrence Versus Radiation Necrosis?显示文摘 | Yelda Ozsunar Mark E. Mullins Kenneth Kwong Fred H. Hochberg Christine Ament Pamela W. Schaefer R. Gilberto Gonzalez Michael H. Lev | 2010 | Academic Radiology2010，，3： | 1 |
| 7 | Complete Endoscopic Mucosal Resection Is Effective and Durable Treatment for Barrett’s-Associated Neoplasia显示文摘 | Vani J.A. Konda Mariano Gonzalez Haba Ruiz Ann Koons John Hart Shu–Yuan Xiao Uzma D. Siddiqui Mark K. Ferguson Mitchell Posner Marco G. Patti Irving Waxman | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 8 | Metabolic niche of a prominent sulfate-reducing human gut bacterium显示文摘 | Federico E. Rey Mark D. Gonzalez Jiye Cheng Meng Wu Philip P. Ahern Jeffrey I. Gordon | 2013 | Proceedings of the National Academy of Sciences2013，，33： | 1 |
| 9 | The Behavioral and Immunological Effect of GM-1 Ganglioside on Nerve Root Regeneration Following C5 Nerve Root Avulsion in a Rat Model显示文摘 | Harold Bach Heather Harrison Bassem El Hassan Lawrence Kempton Robert Leven James Kerns Sara Beddow Mark Gonzalez | 2009 | J reconstr Microsurg2009，，02： | 1 |
| 10 | Fetal MRI of clubfoot associated with myelomeningocele显示文摘 | Sabah Servaes Andrea Hernandez Leonardo Gonzalez Teresa Victoria Mark Johnson Diego Jaramillo J. Christopher Edgar Ann Johnson | 2010 | Pediatric Radiology2010，，12： | 1 |
| 11 | Cross-protective vaccine efficacy of the bivalent HPV vaccine against HPV31 is associated with humoral immune responses显示文摘 | Mahboobeh Safaeian Troy J. Kemp David Yuanji Pan Carolina Porras Ana Cecilia Rodriguez Mark Schiffman Bernal Cortes Hormuzd Katki Sholom Wacholder John T. Schiller Paula Gonzalez Kerri Penrose Douglas R. Lowy Wim Quint Leen-Jan van Doorn Rolando Herrero A | 2013 | Human Vaccines & Immunotherapeutics2013，，7： | 1 |
| 12 | 普通金雀花种群在高温下的本土和入侵幼苗抗旱性显示文摘入侵物种的气候生长需求在其本土和非本土环境之间保持一致的假设是评估入侵风险的关键生态学问题。本研究通过生长箱实验,比较水分和温度对普通金雀花幼苗(Ulex europaeus L.)本土种群和入侵种群生长和死亡率的影响。从本土(法国大陆和西班牙)和非本土(新西兰、加那利群岛和留尼旺岛)的5个地区的20个种群中采集了种子样本。幼苗在两种温度处理(环境温度和高温)和两种水处理(灌溉和干旱)中生长超过36天。温度升高被定义为在不同国家的生态位边缘观察到的最高温度。虽然温度升高增加了幼苗的生长,但干旱处理增加了死亡率并限制了幼苗的生长。在高温和干旱条件下,本土种群的死亡率(53%)高于入侵种群(16%)。在这些受限的气候条件下,入侵幼苗的地上和地下发育也好于本土幼苗。虽然表型可塑性在本土种群和入侵种群之间没有差异,但种群之间总干物质生物量的差异可能与起源气候(尤其是降水)的差异有关。评估入侵物种种群之间表型变化的重要性对于确定其气候分布范围的边缘以及对突出应集中管理以限制其传播的区域都至关重要。 | Mathias Christina Céline Gire Mark R.Bakker Alan Leckie Jianming Xue Peter W.Clinton Zaira Negrin-Perez JoséRamon Arevalo Sierra Jean-Christophe Domec Maya Gonzalez | 2023 | Journal of Plant Ecology2023，16，3： | 0 |
| 13 | Diagnostic Yield of Non-Invasive Testing in Patients with Anomalous Aortic Origin of Coronary Arteries:A Multicentric Experience显示文摘Background:Anomalous aortic origin of a coronary artery(AAOCA)is a congenital heart disease with a 0.3%−0.5%prevalence.Diagnosis is challenging due to nonspecific clinical presentation.Risk stratification and treatment are currently based on expert consensus and single-center case series.Methods:Demographical and clinical data of AAOCA patients from 17 tertiary-care centers were analyzed.Diagnostic imaging studies(Bidimensional echocardiography,coronary computed tomography angiography[CCTA]were collected.Clinical correlations with anomalous coronary course and origin were evaluated.Results:Data from 239 patients(42%males,mean age 15 y)affected by AAOCA were collected;154 had AAOCA involving the right coronary artery(AAORCA),62 the left(AAOLCA),23 other anomalies.211(88%)presented with an inter-arterial course.Basal electrocardiogram(ECG)was abnormal in 37(16%).AAOCA was detected by transthoracic echocardiography and CCTA in 53%and 92%of patients,respectively.Half of the patients reported cardiac symptoms(119/239;50%),mostly during exercise in 121/178(68%).An ischemic response was demonstrated in 37/106(35%)and 16/31(52%)of patients undergoing ECG stress test and stress-rest single positron emission cardiac tomography.Compared with AAORCA,patients with AAOLCA presented more frequently with syncope(18%vs.5%,P=0.002),in particular when associated with inter-arterial course(22%vs.5%,P<0.001).Conclusion:Diagnosis of AAOCA is a clinical challenge due to nonspecific clinical presentations and low sensitivity of first-line cardiac screening exams.Syncope seems to be strictly correlated to AAOLCA with inter-arterial course. | Alberto Cipriani Pietro Bernardo Dall’Aglio Laura Mazzotta Domenico Sirico George Sarris Mark Hazekamp Thierry Carrel Alessandro Frigiola Vladimir Sojak Mauro Lo Rito Jurgen Horer Regine Roussin Julie Cleuziou Bart Meyns Jose Fragata Helena Telles Anastasios C.Polimenakos Katrien Francois Altin Veshti Jukka Salminen Alvaro Gonzalez Rocafort Matej Nosal Eleftherios Protopapas Roberto Tumbarello Patrizio Sarto Cinzia Pegoraro Raffaella Motta Giovanni Di Salvo Domenico Corrado Vladimiro LVida Massimo A.Padalino | 2022 | Congenital Heart Disease2022，17，4： | 0 |
| 14 | Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding:A nationwide analysis显示文摘BACKGROUND The optimal timing of esophagogastroduodenoscopy(EGD)and the impact of clinico-demographic factors on hospitalization outcomes in non-variceal upper gastrointestinal bleeding(NVUGIB)remains an area of active research.AIM To identify independent predictors of outcomes in patients with NVUGIB,with a particular focus on EGD timing,anticoagulation(AC)status,and demographic features.METHODS A retrospective analysis of adult patients with NVUGIB from 2009 to 2014 was performed using validated ICD-9 codes from the National Inpatient Sample database.Patients were stratified by EGD timing relative to hospital admission(≤24 h,24-48 h,48-72 h,and>72 h)and then by AC status(yes/no).The primary outcome was all-cause inpatient mortality.Secondary outcomes included healthcare usage.RESULTS Of the 1082516 patients admitted for NVUGIB,553186(51.1%)underwent EGD.The mean time to EGD was 52.8 h.Early(<24 h from admission)EGD was associated with significantly decreased mortality,less frequent intensive care unit admission,shorter length of hospital stays,lower hospital costs,and an increased likelihood of discharge to home(all with P<0.001).AC status was not associated with mortality among patients who underwent early EGD(aOR 0.88,P=0.193).Male sex(OR 1.30)and Hispanic(OR 1.10)or Asian(aOR 1.38)race were also independent predictors of adverse hospitalization outcomes in NVUGIB.CONCLUSION Based on this large,nationwide study,early EGD in NVUGIB is associated with lower mortality and decreased healthcare usage,irrespective of AC status.These findings may help guide clinical management and would benefit from prospective validation. | Simcha Weissman Muhammad Aziz Ayrton I Bangolo Dean Ehrlich Arnold Forlemu Anthony Willie Manesh K Gangwani Danish Waqar Hannah Terefe Amritpal Singh Diego MC Gonzalez Jayadev Sajja Fatma L Emiroglu Nicholas Dinko Ahmed Mohamed Mark A Fallorina David Kosoy Ankita Shenoy Anvit Nanavati Joseph D Feuerstein James H Tabibian | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，4： | 0 |
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