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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2显示文摘Renal cell carcinoma(RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with RCC, but responses may be modest or limited due to resistance of the tumor to anticarcinogen. Downregulated expression of organic cation transporter OCT2 is a possible mechanism underlying oxaliplatin resistance in RCC treatment. In this study, we observed that mi R-489-3 p and mi R-630 suppress OCT2 expression by directly binding to the OCT2 30-UTR. Meanwhile, via 786-O-OCT2-mi RNAs stable expression cell models, we found that mi RNAs could repress the classic substrate 1-methyl-4-phenylpyridinium(MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline(ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, mi R-489-3 p and mi R-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray analysis and q PCR validation. The increased binding of c-Myc to the promoter of pri-mi R-630, responsible for the upregulation of mi R-630 in RCC, was further evidenced by chromatin immunoprecipitation and dual-luciferase reporter assay. Overall, this study indicated that mi R-489-3 p and mi R-630 function as oncotherapy-obstructing micro RNAs by directly targeting OCT2 in RCC. | Lu Chen Le Chen Zhiyuan Qin Jinxiu Lei Sheng Ye Kui Zeng Hua Wang Meidan Ying Jianqing Gao Su Zeng Lushan Yu | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 5 |
| 3 | Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug–drug interaction in rats显示文摘 | Liping Ma Lei Zhao Haihong Hu Yahong Qin Yicong Bian Huidi Jiang Hui Zhou Lushan Yu Su Zeng | 2014 | Journal of Ethnopharmacology2014，，3： | 1 |
| 4 | Enhancement of extracellular Cr(Ⅵ) reduction for anammox recovery using hydrazine: performance, pathways, and mechanism显示文摘The hexavalent chromium(Cr(Ⅵ))would frequently impose inhibition to anaerobic ammonium oxidation(anammox)process,hindering the efficiency of nitrogen removal in wastewater treatment.Hydrazine(N2H4),which is an intermediate product of anammox,participates in intracellular metabolism and extracellular Cr(Ⅵ)reduction.However,the roles of N_(2)H_(4)-induced intracellular metabolism and extracellular reduction in nitrogen removal under Cr(Ⅵ)stress remain unclear.The addition of 3.67 mg/L of N2H4 increased the anammox activity by 17%.As an intermediate,N2H4 enhanced anammox metabolism by increasing the heme c content and electron transfer system activity.As a reductant,N_(2)H_(4) accelerated the reduction of c-Cyts-mediated extracellular Cr(Ⅵ)to the less toxic Cr(Ⅲ).Extracellular Cr(Ⅲ)accounts for 74%of the total Cr in a Cr(Ⅵ)-stressed anammox consortia.These findings highlight that N_(2)H_(4)-induced extracellular Cr(Ⅵ)reduction is the dominant mechanism for the survival of anammox consortia.We also found that N_(2)H_(4) increased the production of extracellular polymeric substances to sequester excessive Cr(Ⅵ)and produced Cr(Ⅲ).Taken together,the study findings suggest a potential strategy for enhancing nitrogen removal from ammonium-rich wastewater contaminated with Cr(Ⅵ). | Caiyan Qu Lushan Li Fan Feng Kainian Jiang Xing Wu Muchuan Qin Jia Tang Xi Tang Ruiyang Xiao Di Wu Chongjian Tang | 2023 | Frontiers of Environmental Science & Engineering2023，17，9： | 0 |
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