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| 1 | A Survey on Terahertz Communications显示文摘With the exponential growth of the data traffic in wireless communication systems, terahertz(THz) frequency band is envisioned as a promising candidate to support ultra-broadband for future beyond fifth generation(5G), bridging the gap between millimeter wave(mmWave) and optical frequency ranges. The purpose of this paper is to provide a comprehensive literature review on the development towards THz communications and presents some key technologies faced in THz wireless communication systems. Firstly, despite the substantial hardware problems that have to be developed in terms of the THz solid state superheterodyne receiver, high speed THz modulators and THz antennas, the practical THz channel model and the efficient THz beamforming are also described to compensate for the severe path attenuation. Moreover, two different kinds of lab-level THz communication systems are introduced minutely, named a solid state THz communication system and a spatial direct modulation THz communication system, respectively. The solid state THz system converts intermediate frequency(IF) modulated signal to THz frequency while the direct modulation THz system allows the high power THz sources to input for approving the relatively long distance communications. Finally, we discuss several potential application scenarios as well as some vital technical challenges that will be encountered in the future THz communications. | Zhi Chen Xinying Ma Bo Zhang Yaxin Zhang Zhongqian Niu Ningyuan Kuang Wenjie Chen Lingxiang Li Shaoqian Li | 2019 | China Communications2019，16，2： | 43 |
| 2 | Reliable and Energy-Aware Job Offloading at Terahertz Frequencies for Mobile Edge Computing显示文摘In this paper,we co-design the transmission power and the offloading strategy for job offloading to a mobile edge computing(MEC)server at Terahertz(THz)frequencies.The goal is to minimize the communication energy consumption while providing ultra-reliable low end-to-end latency(URLLC)services.To that end,we first establish a novel reliability framework,where the end-to-end(E2E)delay equals a weighted sum of the local computing delay,the communication delay and the edge computing delay,and the reliability is defined as the probability that the E2E delay remains below a certain pre-defined threshold.This reliability gives a full view of the statistics of the E2E delay,thus constituting advancement over prior works that have considered only average delays.Based on this framework,we establish the communication energy consumption minimization problem under URLLC constraints.This optimization problem is non-convex.To handle that issue,we first consider the special single-user case,where we derive the optimal solution by analyzing the structure of the optimization problem.Further,based on the analytical result for the single-user case,we decouple the optimization problem for multi-user scenarios into several sub-optimization problems and propose a sub-optimal algorithm to solve it.Numerical results verify the performance of the proposed algorithm. | Sha Xie Haoran Li Lingxiang Li Zhi Chen Shaoqian Li | 2020 | China Communications2020，17，12： | 2 |
| 3 | Use of donor-specific red blood cell transfusions for patients undergoing liver transplantation during the COVID-19 pandemic显示文摘Background:Increased risks have been found for patients undergoing liver transplantation due to the blood supply shortage following the ongoing coronavirus disease 2019(COVID-19)pandemic.Hence,exploring a method to alleviate this dilemma is urgent.This phase I,nonrandomized,prospective trial aimed to evaluate the safety and feasibility of using donor-specific red blood cell transfusion(DRBCT)as an urgent measurement to alleviate the blood supply shortage in deceased donor liver transplantation(DDLT).Methods:The outcomes of 26 patients who received DRBCT and 37 patients in the control group who only received 3rd party packed red blood cells(pRBCs)transfusion between May 2020 and January 2021 were compared.Results:Patients receiving DRBCT did not develop transfusion-related complications,and the incidence of postoperative infection was similar to that in the control group(23.1%vs.18.9%,P=0.688).Because the patients received the red blood cells from organ donors,the median volume of intraoperative allogeneic red blood cell transfusion from blood bank was 4.0 U(IQR 1.1-8.0 U)in the DRBCT group,which is significantly lower than that(7.5 U,IQR 4.0-10.0 U)in the control group(P=0.018).The peak aspartate aminotransferase(AST)level was significantly lower in the DRBCT group than in the control group(P=0.008)and so were the AST levels in the first two days after the operation(P=0.006 and P=0.033).Conclusions:DRBCT is a safe and effective procedure to lower the need for blood supply and is associated with a reduction in AST levels after transplantation.DRBCT is beneficial to patients receiving life-saving transplantation without sufficient blood supply during the COVID-19 pandemic. | Tao Lv Xi Xu Jiulin Song Yifei Tan Li Jiang Jian Yang Diao He Lingxiang Kong Weiyi Zhang Panyu Chen Qiwen Xiang Tao Zhu Hong Wu Tianfu Wen Jiayin Yang | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 2 |
| 4 | A set of miRNAs from Brassica napus in response to sulphate deficiency and cadmium stress显示文摘 | Si QiHuang An LingXiang Li LingChe SongChen HuiLi Jian BoSong Zhi MinYang | 2010 | Plant Biotechnology Journal2010，，8： | 1 |
| 5 | MicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma显示文摘 | Lingxiang Yu Jiabin Zhang Xiaodong Guo Zhiwei Li Peirui Zhang | 2014 | Cancer Epidemiology2014，，： | 1 |
| 6 | Optics‑guided Robotic System for Dental Implant Surgery显示文摘At present,dental implant surgery mainly relies on the clinical experience of the doctor and the assistance of preoperative medical imaging.However,there are some problems in dental implant surgery,such as narrow space,sight obstruction,inaccurate positioning,and high requirements of doctors’proficiency.Therefore,a dental implant robot system(DIRS)guided by optical navigation is developed in this study,with an x-shaped tool and an irregular pentagonal tracer are designed for spatial registration and needle tip positioning strategy respectively.The coordinate system of each unit in DIRS is unified through system calibration,spatial registration,and needle tip positioning strategy.Then the surgical path is planned on the computed tomography(CT)images in the navigation software before operation.The automatic positioning method and the auxiliary positioning method can be used in the operation to achieve accurate positioning and assist doctors to complete the operation.The errors of spatial registration,needle tip positioning strategy,and the overall accuracy of the system were evaluated respectively,and the results showed that they all met the needs of clinical surgery.This study preliminarily verified the feasibility of the precise positioning method for dental surgery robots and provided certain ideas for subsequent related research. | Biao Yan Wenlong Zhang Lijing Cai Lingxiang Zheng Kaiyang Bao Yuming Rao Lin Yang Weitao Ye Peifeng Guan Wei Yang Jiang Li Rongqian Yang | 2022 | Chinese Journal of Mechanical Engineering2022，35，3： | 1 |
| 7 | Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS显示文摘The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is lacking.To address this gap,we conducted a study aiming to investigate this association and identify relevant biomarkers.We analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune microenvironment.Additionally,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)populations.We employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune cells.Our findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal tissues.Moreover,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA replication.In conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets. | Sumeng Wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu Lingxiang Liu | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 8 | Recent progress in high-entropy metallic glasses显示文摘High-entropy metallic glass(HEMG)is a new type of metallic material with high-entropy alloy-like com-position and amorphous structure,which render HEMGs unusual glass formation behaviors and unique properties.In recent years,fast research progress has been witnessed on the HEMGs,and thus a sys-tematic review is required.In this review,we first introduce the concept of the HEMGs and summarize the developed HEMGs.Then,the glass-forming ability of the HEMGs is discussed,and the general rules are proposed.Focusing on the thermal stability of HEMGs,the effect of entropy on the energy states of HEMGs and the crystallization behavior of HEMGs are discussed.Finally,the mechanical,magnetic,cat-alytic and other properties of HEMGs are presented,and the advantages and disadvantages of HEMGs are shown.This review can function as a quick guideline for overviewing the HEMG field. | Hengwei Luan Keran Li Lingxiang Shi Wei Zhao Hengtong Bu Pan Gong Ke-Fu Yao | 2023 | Journal of Materials Science & Technology2023，，30： | 0 |
| 9 | The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression显示文摘Dear Editor,SARS-CoV-2 is the etiological cause of COVID-19.RIG-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral pathway.IFN deficiency2,3 was identified to be a significant risk factor of severe COVID-19,highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19. | Weifeng Liang Ming Gu Lingxiang Zhu Ziqi Yan Dominik Schenten Shelby Herrick Hongmin Li Subodh Kumar Samrat Jiapeng Zhu Yin Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 10 | MET fusions and splicing variants convergently defne a subgroup of glioma sensitive to MET inhibitors显示文摘Purpose:Our previous study has shown that PTPRZ1-MET(ZM)fusion is a viable target for MET inhibitors in gliomas.However,the diversity and prevalence of somatic MET alterations in difuse gliomas are still elusive and need to be extensively characterized for identifying novel therapeutic targets.Methods:Totally,1,350 glioma patients and 31 patient-derived cells were collected from the Chinese Glioma Genome Atlas(CGGA)and published data.All kinds of MET fusions and/or splicing variants(MET F/SVs)were identifed by bioinformatical methods.Single-cell RNA sequencing(scRNA-seq)were used for validation.In vitro experiments of drug resistance were conducted for the possibility of MET-targeted treatment.Results:MET F/SVs but not genomic amplifcation,were highly enriched in the secondary glioblastomas(sGBM)and marked worse prognosis.Further molecular and scRNA-seq analysis revealed that MET F/SVs were induced in the course of glioma evolution and highly associated with MET overexpression.Subsequent in vitro and the clinical study showed that cells and patients harboring MET F/SVs have better response to MET inhibitors.Conclusion:Our fndings expanded the percentage of gliomas with abnormal MET alterations and suggested that a subgroup of gliomas harboring MET F/SVs may beneft from MET-targeted therapy. | Ke-Nan Zhang Zheng Zhao Jing Chen Zhaoshi Bao Rui-Chao Chai Zhiyan Sun Lingxiang Wu Zhiliang Wang Hanjie Liu Quanhua Mu Huimin Hu Fan Zeng Zheng Wang Guanzhang Li Yuanhao Chang Qiangwei Wang Fan Wu Ying Zhang Yuqing Liu Chunjie Jiang Ulf Dietrich Kahlert Do-Hyun Nam Wei Zhang Chunsheng Kang Jiguang Wang Rongjie Tao Qianghu Wang Tao Jiang | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 11 | Predicting Illness Severity and Short-Term Outcomes of COVID-19:A Retrospective Cohort Study in China显示文摘Introduction COVID-19,caused by SARS-CoV-2,is a highly contagious disease.1 By April 8,2020,more than 1,350,000 patients were diagnosed with COVID-19 globally,with more than 79,000 deaths worldwide attributable to the disease.2 Recent clinical data reported that mild and critical patients manifested different symptoms.Most of the mild patients with COVID-19 had symptoms such as fever,cough,and mild pneumonia,whereas the critical cases presented dyspnea,respiratory failure,sepsis,organ dysfunction,and even eventual death. | Chuming Chen Haihui Wang Zhichao Liang Ling Peng Fang Zhao Liuqing Yang Mengli Cao Weibo Wu Xiao Jiang Peiyan Zhang Yinfeng Li Li Chen Shiyan Feng Jianming Li Lingxiang Meng Huishan Wu Fuxiang Wang Quanying Liu Yingxia Liu | 2020 | The Innovation2020，1，1： | 0 |
| 12 | Identification and Control of HLB Disease in Citrus grandis显示文摘HLB disease has been endangering citrus production,and it is an important task in Citrus grandis production to identify and control HLB disease. Diaphorina citri and Trioza erytreae are the main vectors for the spreading of HLB disease. Scientific and proper release of predatory natural enemies such as ladybugs,combined with chemical control can effectively control psyllid. For suspected HLB disease strains,a simple ' HLB disease detection reagent' can be used for detection. This method is simple,cheap and accurate,and it is an economical and feasible identification method for ordinary growers. | Derong YANG Zhiwei ZENG Long ZHOU Jinping LI Chen XU Lingxiang ZHOU Fang WANG | 2019 | Asian Agricultural Research2019，11，3： | 0 |
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