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| 1 | Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury显示文摘Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of c-aminobutyric acid A receptors(GABA_ARs), which play a vital role in pain modulation in the lateral thalamus, a main gate where somatosensory information enters the cerebral cortex. Using high-performance liquid chromatography/tandem mass spectrometry,we found increased levels of neurosteroids(pregnenolone,progesterone, deoxycorticosterone, allopregnanolone, and tetrahydrodeoxycorticosterone) in the chronic stage of neuropathic pain(28 days after spared nerve injury) in rats.The expression of the translocator protein TSPO, the upstream steroidogenesis rate-limiting enzyme, increased at the same time. In vivo stereotaxic microinjection of neurosteroids or the TSPO activator AC-5216 into the lateral thalamus(AP-3.0 mm, ML ±3.0 mm, DV 6.0 mm)alleviated the mechanical allodynia in neuropathic pain,while the TSPO inhibitor PK 11195 exacerbated it. The analgesic effects of AC-5216 and neurosteroids were significantly attenuated by the GABA_AR antagonist bicuculline. These results suggested that elevated neurosteroids in the lateral thalamus play a protective role in the chronic stage of neuropathic pain. | Meng Zhang Jia Liu Meng-Meng Zhou Honghai Wu Yanning Hou Yun-Feng Li Yuxin Yin Lemin Zheng Feng-Yu Liu Ming Yi You Wan | 2016 | Neuroscience Bulletin2016，32，4： | 6 |
| 2 | Vacuum ultraviolet photovoltaic arrays显示文摘As one of the ideal tools for monitoring the formation and evolution of solar storms, the vacuum ultraviolet(VUV) detector should have both a fast temporal response and an array structure that enables image formation.Here, by combining a nontraditional graphene processing technique with traditional metal organic chemical vapor deposition epitaxy technology, we created hybrid heterostructure(HH) arrays of p-Gr/AlN/p-Si with VUV photovoltaic response capability and silicon integration potential. The HH arrays not only exhibit ultrafast temporal response(rise time of only 120 ns) and an extremely high I_(on)∕I_(off) ratio of 10~7, but also achieve the imaging demonstration of a VUV pattern for the first time. The HH technique provides a possible new path for the development of VUV imaging devices. | WEI ZHENG RICHENG LIN LEMIN JIA FENG HUANG | 2019 | Photonics Research2019，7，1： | 3 |
| 3 | A NEW DIGITAL MODULATION RECOGNITION METHOD USING FEATURES EXTRACTED FROM GAR MODEL PARAMETERS显示文摘Based on the features extracted from generalized autoregressive (GAR) model parameters of the received waveform, and the use of multilayer perceptron(MLP) neural network classifier, a new digital modulation recognition method is proposed in this paper. Because of the better noise suppression ability of the GAR model and the powerful pattern classification capacity of the MLP neural network classifier, the new method can significantly improve the recognition performance in lower SNR with better robustness. To assess the performance of the new method, computer simulations are also performed. | Lu Mingquan Xiao Xianci Li Lemin (University of Electronic Science and Technology of China, Chengdu 610054) | 1999 | Journal of Electronics(China)1999，16，3： | 3 |
| 4 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 5 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 6 | Biotinylated dextran amine anterograde tracing of the canine corticospinal tract显示文摘In this study, biotinylated dextran amine (BDA) was microinjected into the left cortical motor area of the canine brain. Fluorescence microscopy results showed that a large amount of BDA-labeled pyramidal cells were visible in the left cortical motor area after injection. In the left medulla oblongata, the BDA-labeled corticospinal tract was evenly distributed, with green fluorescence that had a clear boundary with the surrounding tissue. The BDA-positive corticospinal tract entered into the right lateral funiculus of the spinal cord and descended into the posterior part of the right lateral funiculus, close to the posterior horn, from cervical to sacral segments. There was a small amount of green fluorescence in the sacral segment. The distribution of BDA labeling in the canine central nervous system was consistent with the course of the corticospinal tract. Fluorescence labeling for BDA gradually diminished with time after injection. Our findings indicate that the BDA anterograde tracing technique can be used to visualize the localization and trajectory of the corticospinal tract in the canine central nervous system. | Xiao Han Guangming Lv Huiqun Wu Dafeng Ji Zhou Sun Yaofu Li Lemin Tang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 7 | Traffic-Aware VDC Embedding in Data Center: A Case Study of FatTree显示文摘Virtualization is a common technology for resource sharing in data center.To make efficient use of data center resources,the key challenge is to map customer demands(modeled as virtual data center,VDC) to the physical data center effectively.In this paper,we focus on this problem.Distinct with previous works,our study of VDC embedding problem is under the assumption that switch resource is the bottleneck of data center networks(DCNs).To this end,we not only propose relative cost to evaluate embedding strategy,decouple embedding problem into VM placement with marginal resource assignment and virtual link mapping with decided source-destination based on the property of fat-tree,but also design the traffic aware embedding algorithm(TAE) and first fit virtual link mapping(FFLM) to map virtual data center requests to a physical data center.Simulation results show that TAE+FFLM could increase acceptance rate and reduce network cost(about 49%in the case) at the same time.The traffic aware embedding algorithm reduces the load of core-link traffic and brings the optimization opportunity for data center network energy conservation. | LUO Shouxi YU Hongfang LI Lemin LIAO Dan SUN Gang | 2014 | China Communications2014，11，7： | 2 |
| 8 | Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients显示文摘Voxel-based morphometry can be used to quantitatively compare structural differences and functional changes of gray matter in subjects.In the present study,we compared gray matter images of 32 patients with Parkinson's disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores.Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls.In particular,the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced,but mean scores of non-motor symptoms significantly increased,in patients with Parkinson's disease.In addition,gray matter volume was significantly diminished in Parkinson's disease patients compared with normal controls,including bilateral temporal lobe,bilateral occipital lobe,bilateral parietal lobe,bilateral frontal lobe,bilateral insular lobe,bilateral parahippocampal gyrus,bilateral amygdale,right uncus,and right posterior lobe of the cerebellum.These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease,and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson's disease. | Jianguo Xia Juan Wang Weizhong Tian Hongbin Ding Qilin Wei Huanxin Huang Jun Wang Jinli Zhao Hongmei Gu Lemin Tang | 2013 | Neural Regeneration Research2013，8，27： | 1 |
| 9 | Pervasive QpS routing in next gener- ation networks 显示文摘 | Wang Yu Li Lemin Xu Du | 2008 | Computer Communications2008，，： | 1 |
| 10 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 11 | Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function显示文摘 | Dao-Quan Peng Gregory Brubaker Zhiping Wu Lemin Zheng Belinda Willard Michael Kinter Stanley L. Hazen Jonathan D. Smith | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，11： | 1 |
| 12 | A Distributed Flow Rate Control Algorithm for Networked Agent System with Multiple Coding Rates to Optimize Multimedia Data Transmission 显示文摘 | ZENG Shuai LI Lemin LIAO Dan | 2013 | Mathematical Problems in Engineering2013，，2013： | 1 |
| 13 | Estimation of air quality degradation due to Saharan dust at Nouakchott,Mauritania,from horizontal visibility data显示文摘 | Ozer P Laghdaf M Lemine S | 2007 | Water Air & Soil Pollution2007，178，1234： | 1 |
| 14 | Supporting IP on the ATM networks: An overview显示文摘 | Ke Huang Lemin Li | 1998 | Computer Communications1998，21，2： | 1 |
| 15 | Improving Thermal and Flame Retardant Properties of Epoxy Resin with Organic NiFe-Layered Double Hydroxide-Carbon Nanotubes Hybrids显示文摘在环氧基树脂树脂(EP ) 改进碳 nanotubes (CNT ) 和分层的双氢氧化物(LDH ) 的火焰 retardancy 的分散,器官的镍铁分层的双氢氧化物(ONiFe-LDH-CNTs ) 混血儿通过一起沉淀被装配。这些混血儿进一步被用作增强 filler in EP。与 ONiFe-LDH 和 CNT 的不同比率包含 ONiFe-LDH-CNTs 的 4 wt% 的 EP/ONiFe-LDH-CNTs nanocomposites 被治好的超声的分散和节目温度准备。获得的混血儿的结构和形态学被不同技术描绘。在 EP 矩阵的 nanofillers 的分散被传播电子显微镜学(TEM ) 观察。结果揭示了 exfoliated 的共存并且设置在聚合物矩阵的 ONiFe-LDH- CNT。有 EP 矩阵的上述 nanofillers 的强壮的联合提供了一有效热并且为 nanocomposites 的火焰 retardant 改进。它证明 EP/ONiFe-LDH-CNTs nanocomposites 与 EP 相比展出了优异火焰 retardant 和热性质。如此的改进热性质能被归因于更好同类的分散,更强壮的界面的相互作用, ONiFe-LDH 的优秀 charring 表演和在 ONiFe-LDH 和 CNT 之间的 synergistic 效果。 | Qinghong Kong Ting Wu Yingqi Tang Lemin Xiong Hong Liu Junhao Zhang Ruihua Guo Feng Zhang | 2017 | Chinese Journal of Chemistry2017，35，12： | 1 |
| 16 | The Beijing four-component density functional program package (BDF) and its application to EuO, EuS, YbO and YbS显示文摘 | Wenjian Liu Gongyi Hong Dadi Dai Lemin Li Michael Dolg | 1997 | Theoretical Chemistry Accounts1997，，2： | 1 |
| 17 | Limit Cycles in a General Kolmogorov Model显示文摘 | Xuncheng Huang Lemin Zhu | 2005 | Nonlinear Analysis:TMA2005，60，： | 1 |
| 18 | T cell-mediated immune deficiency or compromise in patients with CTEPH显示文摘 | Haoming S Lemin W Zhu G | 2011 | Am J Respir Crit Care Med2011，183，3： | 1 |
| 19 | Sol-Gel Synthesis of 8 nm Magnetite (Fea O~ ) Nanoparticles and Their Magnetic Properties 显示文摘 | Lemine O M Omri K Zhang B | 2012 | Superlattices and Microstructures2012，52，4： | 1 |
| 20 | The Beijing four-component density functional program package (BDF) and its application to EuO, EuS, YbO and YbS显示文摘 | Wenjian Liu Gongyi Hong Dadi Dai Lemin Li Michael Dolg | 1997 | Theoretical Chemistry Accounts1997，，2： | 1 |
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