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| 1 | Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury显示文摘Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of c-aminobutyric acid A receptors(GABA_ARs), which play a vital role in pain modulation in the lateral thalamus, a main gate where somatosensory information enters the cerebral cortex. Using high-performance liquid chromatography/tandem mass spectrometry,we found increased levels of neurosteroids(pregnenolone,progesterone, deoxycorticosterone, allopregnanolone, and tetrahydrodeoxycorticosterone) in the chronic stage of neuropathic pain(28 days after spared nerve injury) in rats.The expression of the translocator protein TSPO, the upstream steroidogenesis rate-limiting enzyme, increased at the same time. In vivo stereotaxic microinjection of neurosteroids or the TSPO activator AC-5216 into the lateral thalamus(AP-3.0 mm, ML ±3.0 mm, DV 6.0 mm)alleviated the mechanical allodynia in neuropathic pain,while the TSPO inhibitor PK 11195 exacerbated it. The analgesic effects of AC-5216 and neurosteroids were significantly attenuated by the GABA_AR antagonist bicuculline. These results suggested that elevated neurosteroids in the lateral thalamus play a protective role in the chronic stage of neuropathic pain. | Meng Zhang Jia Liu Meng-Meng Zhou Honghai Wu Yanning Hou Yun-Feng Li Yuxin Yin Lemin Zheng Feng-Yu Liu Ming Yi You Wan | 2016 | Neuroscience Bulletin2016，32，4： | 6 |
| 2 | Vacuum ultraviolet photovoltaic arrays显示文摘As one of the ideal tools for monitoring the formation and evolution of solar storms, the vacuum ultraviolet(VUV) detector should have both a fast temporal response and an array structure that enables image formation.Here, by combining a nontraditional graphene processing technique with traditional metal organic chemical vapor deposition epitaxy technology, we created hybrid heterostructure(HH) arrays of p-Gr/AlN/p-Si with VUV photovoltaic response capability and silicon integration potential. The HH arrays not only exhibit ultrafast temporal response(rise time of only 120 ns) and an extremely high I_(on)∕I_(off) ratio of 10~7, but also achieve the imaging demonstration of a VUV pattern for the first time. The HH technique provides a possible new path for the development of VUV imaging devices. | WEI ZHENG RICHENG LIN LEMIN JIA FENG HUANG | 2019 | Photonics Research2019，7，1： | 3 |
| 3 | 8-nm narrowband photodetection in diamonds显示文摘Spectrally-selective photodetection plays a crucial role in various applications,including target imaging and environmental monitoring.Traditional deep-ultraviolet(DUV)narrowband photodetection systems consist of broadband photodetectors and filters,which complicates the architecture and constrains imaging quality.Here,we introduce an electronic-grade diamond single-crystal photodetector exhibiting an exceptionally narrow spectral response in the DUV range with a full width at half maximum of 8 nm.By examining diamond photodetectors with varying dislocation densities,we propose that mitigating the defect-induced trapping effect to achieve charge collection narrowing,assisted by free exciton radiative recombination,is an effective strategy for narrowband photodetection.The superior performance of this device is evidenced through the imaging of DUV light sources,showcasing its capability to differentiate between distinct light sources and monitor human-safe sterilization systems.Our findings underscore the promising potential applications of electronicgrade diamond in narrowband photodetection and offer a valuable technique for identifying electronic-grade diamond. | Lemin Jia Lu Cheng Wei Zheng | 2023 | Opto-Electronic Science2023，2，7： | 0 |
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