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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Dual Principles in Frame Theory显示文摘 | CASAZZA P G KUTYNIOK G LAMMER M C | 2004 | J Fourier Anal Appl2004，10，： | 1 |
| 3 | Initial validation of a numeric zero to ten scale to measure children's state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 4 | Initial validation of anu- meric zero to ten scale to measure children' s state anxiety 显示文摘 | Crandall M Lammers C Senders C | 2007 | AnesthAnal2007，105，5： | 1 |
| 5 | Duality princi- ples in frame theory显示文摘 | Casazza P G Kutyniok G Lammers M C | 2004 | J Fourier Anal Appl2004，10，4： | 1 |
| 6 | Family risk factors associated with adolescent pregnancy:Study of a group of adolescent girls and their family in Ecuador显示文摘 | Guijarro S Naranjo J Padilla M Gutierez R Lammers C Blum R.W | | 0，，： | 1 |
| 7 | Electrodeposition of mixed chromium metal-carbide-oxide coatings from a trivalent chromium-formate electrolyte without a buffering agent显示文摘 | WIJENBERG J H O J STEEGH M AAENTS M P LAMMERS K R MOL J M C | 2015 | Electrochimica Acta2015，173，： | 1 |
| 8 | Orofacial clefts parental cigarette smoking and transforming growth factor-alpha gene variants显示文摘 | Shaw G M Wasserman C R Lammer E J | 1996 | Am J Hum Genet1996，58，3： | 1 |
| 9 | Initial validation of a numeric zero to ten scale to measure Children' s state Anxiety 显示文摘 | Crandall M Lammers C Senders CW | 2007 | Anesth Analg2007，105，5： | 1 |
| 10 | Initial validation of a numeric zero to ten scale to measure children’s state anxiety显示文摘 | Crandall M Lammers C Sender C | 2007 | Anesth Analg2007，24，19： | 1 |
| 11 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Crandall M Lammers C Senders C | 2007 | Anesth Analg2007，105，5： | 1 |
| 12 | Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression显示文摘 | Taher M M Lammering G Hershey C | 2003 | Mol Cell Biochem2003，254，12： | 1 |
| 13 | Hilbert C * -modules 显示文摘 | COCO M LAMMERS M C | 2001 | Gabor systems and the Zak algebra2001，145，569： | 1 |
| 14 | Geomorphometric attributes of the global system of rivers at 30- minute spatial resolution 显示文摘 | Vorosmarty C J Fekete B M Meybeck M Lammers R B | 2000 | Jounal of Hydrology2000，237，： | 1 |
| 15 | The tomato carotenoid cleavage dioxygenase8 (SlCCD8) regulates rhizosphere signaling,plant architecture and affects reproductive development through strigolactone biosynthesis显示文摘 | Kohlen W Charnikhova T Lammers M Pollina T Toth P Haider I Pozo M J de Maagd R A Ruyter-Spira C Bouwmeester H J | 2012 | The New Phytologist2012，196，2： | 1 |
| 16 | Duality principles in frame theory 显示文摘 | Casazza P G Kutyniok G Lammers M C | 2004 | J Fourier Anal Appl2004，10，4： | 1 |
| 17 | Superparamagnetic i ron oxide nanoparticles encapsulated in biodegradable thermosen sitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery显示文摘 | Talelli M Rijcken C J Lammers T | 2009 | Langmuir2009，25，4： | 1 |
| 18 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | CRANDALL M LAMMERS C SENDERS C | 2007 | Anesth Analg2007，105，5： | 1 |
| 19 | Initial validation of a numeric zero to ten scale to measure children's state anxiety显示文摘 | Crandall M Lammers C Senders C | | 0，，19： | 1 |
| 20 | Contrast -enhanced magnetic resonance angiography in the evaluation of peripheral bypass grafts显示文摘 | Loewe C Cejna M Lammer J | 2000 | European Radiology2000，10，： | 1 |
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