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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn's disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway显示文摘 | Ouburg S Mallant-Hent R Crusius JB | 2005 | Gut2005，54，3： | 1 |
| 3 | Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women显示文摘 | den Hartog JE Ouburg S Land JA | 2006 | BMC Infect Dis2006，6，： | 1 |
| 4 | The CD14 functional gene polymorphism 260 CT is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology显示文摘 | Ouburg S Spaargaren J den Hartog JE | 2005 | BMC Infect Dis2005，5，： | 1 |
| 5 | Chlamydia trachomatis:identification of susceptibility markers for ocular and sexually transmitted infection by immunogenelics显示文摘 | Morré SA Karimi O Ouburg S | 2009 | FEMS Immunol Med Microbiol2009，55，2： | 1 |
| 6 | 2015 European guide- line on the management of Chlamydia trachomatis infections 显示文摘 | Lanjouw E Ouburg S de Vries HJ | 2016 | Int J STD AIDS2016，27，5： | 1 |
| 7 | Background review for the ' 2015 European guideline on the management of Chlamydia trachomatis infections' 显示文摘 | Lanjouw E Ouburg S de Vries HJ | 2015 | Int J STD AIDS2015，，26： | 1 |
| 8 | Background re-view for the '2015 European guideline on the manage-ment of Chlamydia trachomatis infections'显示文摘 | Lanjouw E Ouburg S de Vries HJ | 2016 | Int J STDAIDS2016，27，5： | 1 |
| 9 | Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women? 显示文摘 | Hartog JE Ouburg S Land JA | 2006 | BMC Infect Dis2006，6，122： | 1 |
| 10 | TLR9 KO mice,haplotypes and CPG indices in Chlamydia trachomatis infection显示文摘 | Ouburg S Lyons JM Land JA | 2009 | Drugs Today (Barc)2009，45，： | 1 |
| 11 | Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection 显示文摘 | Jiang J Karimi O Ouburg S | 2012 | PLoS one2012，7，47： | 1 |
| 12 | Lymhogranuloma venereum diagnostics: from culture to realtime quadriplex polymerase chain reaction显示文摘 | Morre SA Ouburg S van Agtmael MA | 2008 | Sex Transm Infect2008，84，4： | 1 |
| 13 | The CD14 functional gene polymorphism-260 C> T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology显示文摘 | Ouburg S Spaargaren J den Hartog JE | 2005 | BMC Infect Dis2005，20，5： | 1 |
| 14 | Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion显示文摘 | Barr EL Ouburg S Igietserne JU | 2005 | Microbiol Immunol Infect2005，38，4： | 1 |
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