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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Risk assessment and validation of flood disaster based on fuzzy mathematics显示文摘Floods often take place around rivers and plains,which indicates a higher risk of flooding in these areas.This paper adopts fuzzy comprehensive assessment(FCA),simple fuzzy classification(SFC),and the fuzzy similarity method(FSM) to assess flood disaster risk in Kelantan,Malaysia.Validation data,such as the flooded area,paddy area,urban area,residential area,and refuges,were overlaid to validate and analyze the accuracy of flood disaster risk.The results show that(1) 70-75% of flooded areas lie within the higher and high-est risk zones,which shows an effective assessment accuracy;(2) paddy,built-up,and residential areas concentrated in the higher and highest risk zones are more likely to be destroyed by flood disasters;(3) 200-225 refuges in the higher and highest risk zones account for around 50% of all refuges,which means that more refuges should be built in the higher and highest risk zones to meet the accommodation requirement;(4) three methods proved to be feasible and effective in evaluating flood disaster risk,among which FCA is more suitable for the study area than the two other methods. | Weiguo Jiang Lei Deng Luyao Chen Jianjun Wu Jing Li | 2009 | Progress in Natural Science:Materials International2009，19，10： | 35 |
| 3 | Complication and safety of ultrasound guided percutaneous nephrolithotomy in 8 025 cases in China显示文摘 | Li Jianxing Xiao Bo Hu Weiguo Yang Bo Chen Liang Hu Hao Wang Xiaofeng | 2014 | Chinese Medical Journal2014，，24： | 36 |
| 4 | Mechanical property of artificial methane hydrate under triaxial compression显示文摘Methane production from hydrate reservoir may induce seabed slide and deformation of the hydrate-bearing strata.The research on mechanical properties of methane hydrate is considered to be important for developing an efficient methane exploitation technology.In this paper,a triaxial test system containing a pressure crystal device was developed with the conditions to stabilize the hydrate.A series of triaxial shear tests were carried out on artificial methane hydrate specimen.In addition,mechanical characteristics of methane hydrate were studied with the strain rates of 0.1 and 1.0 mm/min,respectively,under the conditions of different temperatures(T =-5,-10,and-20 ℃) and confining pressures(P = 0,5,10,15,and 20 MPa).The preliminary results show that when the confining pressure was less than 10 MPa,the increase of confining pressure leaded to the enhancement of shear strength.Furthermore,the decreasing temperature and the increasing strain rate both caused the increase in shear strength. | Yongchen Song Feng Yu Yanghui Li Weiguo Liu Jiafei Zhao | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 28 |
| 5 | Late Miocene Red River submarine fan,northwestern South China Sea显示文摘A huge submarine fan is discovered through the research of the seismic and borehole data in the binding site of Yinggehai basin and Qiongdongnan basin in northwestern South China Sea.The fan,mainly formed during Late Miocene (Huangliu period) has an area over 10000 km 2 and maximum thickness of over 2000 m.It is characterized by a wedge-shaped oblique progradation configuration on the dip profile and a hummocky bidirectional progradation configuration on the strike profile.The core and Logging data from the well YC35-1-2 located in the front side of the fan indicate that sandy gravity flow deposits are predominant in lower Huangliu Formation and change to interbeds of sand and mud in upper Huangliu Formation.The fan is interpreted as a sand/mud-rich submarine fan in combination with the bathyal geological background of Huangliu period.A preliminary analysis of provenance indicates that neither the Guiren Uplift in the west nor the Hainan Uplift in the north can serve as the major provenance for the submarine fan.The provenance is considered to be from the Red River,based on the sedimentary facies study of the Huangliu Formation in Yinggehai basin.The fan is thus named as 'Red River submarine fan'.The Red River depositional system consists of the Red River submarine fan,the Red River delta,and associated submarine canyons.The discovery of the Red River submarine fan provides important information for the research of the uplift of Tibetan Plateau and the evolvement of Red River Fault Zone.Furthermore,it also points out a new direction for the deepwater hydrocarbon exploration in the northern South China Sea. | WANG YingMin XU Qiang LI Dong HAN JianHui LU Ming WANG YongFeng LI WeiGuo WANG HaiRong | 2011 | Chinese Science Bulletin2011，56，14： | 28 |
| 6 | Correlation between the coverage percentage of prosthesis and postoperative hidden blood loss in primary total knee arthroplasty显示文摘 | Gao Fuqiang Guo Wanshou Sun Wei Li Zirong Wang Weiguo Wang Bailiang Cheng Liming Kush Nepali | 2014 | Chinese Medical Journal2014，，12： | 18 |
| 7 | The temperature-dependent fracture strength model for ultra-high temperature ceramics显示文摘毁坏材料的全部结构暗示由使用工作或由热转移切断在它的原子之间的所有契约。因为打破契约对任何一个工具冷淡,在热能和紧张精力之间有一种等价。把等价基于这,我们假定包括紧张精力和相应等价物的精力的经常的最大的存储的存在热能。一个温度依赖者破裂力量模型然后被开发为超离频温度陶艺(UHTC ) 。为 UHTC, HfB2, TiC 和 ZrB2 的模型预言,被介绍并且与试验性的结果相比。这些预言被发现与试验性的结果大部分一致。关键词超离频温度陶艺 - 相等的精力 - 批评失败精力 - 力量模型工程被中国(90505015 和 10702035 ) 的国家自然科学基础支持。 | Weiguo Li Fan Yang Daining Fang | 2010 | Acta Mechanica Sinica2010，26，2： | 12 |
| 8 | Orthogonal arrays obtained by generalized difference matrices with g levels显示文摘Nowadays orthogonal arrays play important roles in statistics, computer science, coding theory and cryptography. The usual difference matrices are essential for the construction for many mixed orthogonal arrays. But there are also orthogonal arrays which cannot be obtained by the usual difference matrices, such as mixed orthogonal arrays of run size 60. In order to construct these mixed orthogonal arrays, a class of special so-called generalized difference matrices were discovered by Zhang (1989,1990,1993,2006) from the orthogonal decompositions of projection matrices. In this article, an interesting equivalent relationship between orthogonal arrays and the generalized difference matrices is presented and proved. As an application, a lot of new orthogonal arrays of run size 60 have been constructed. | ZHANG YingShan LI WeiGuo MAO ShiSong ZHENG ZhongGuo | 2011 | Science China Mathematics2011，54，1： | 11 |
| 9 | Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body显示文摘A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of skin.In the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging techniques.Three types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein camera.Several longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by MRI.Among the visualised veins,the partial walls of a few veins were enhanced by Gd-DTPA.The fluorescent images further indicated that STPs likely represent boundless pathways.The findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies. | Hongyi Li Jiabin Tong Weiguo Cao Min Chen Hua Li Hong Dai Liang Xu Xiaoliang Chen | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 10 | Branched tetraether lipids in Chinese soils:Evaluating the fidelity of MBT/CBT proxies as paleoenvironmental proxies显示文摘The ubiquitous occurrence of branched glycerol dialkyl glycerol tetraethers(br GDGTs) in soils has allowed development of new proxies for reconstruction of past climate and environment. The methylation and cyclization degrees of br GDGTs, expressed as MBT and CBT, respectively, are reported to be mainly controlled by mean annual air temperature(MAAT) and soil p H. However, the br GDGT-derived temperatures and soil p H scatter widely when data from different environmental conditions are considered. In this study, we collected over 300 soil samples from China, which are representative of humid(Xishuangbanna, Guangzhou, and Shanghai), semi-arid(Dongying) and semi-arid/arid(Lanzhou, Tibetan Plateau) regions. Collectively we have the most extensive dataset that broadly characterizes the distribution of br GDGTs according to climate zones in China. The overall data demonstrate that the MBT/CBT derived temperatures better match the measured MAATs in humid and non-alkaline regions than those from regions of low MAP(<400 mm/yr) and above neutral soil p H(>7.0–7.5). Similarly, CBT describes soil p H much better in humid and non-alkaline soils than in semi-arid/arid and alkaline soils; the semi-arid/arid and alkaline soils tend to show a positive correlation between soil p H and CBT, which contradicts that in the humid and non-alkaline soils. While soil p H, MAAT and mean annual precipitation(MAP) are dominating factors controlling the br GDGT distribution across all climate zones, conductivity, total organic carbon and total nitrogen, as well as soil water content can also play an important role locally. Removing br GDGT-II resulted in a revised CBT index that provides more accurate estimation of p H, especially in semi-arid/arid and alkaline soils. The overall Chinese dataset demonstrates that continental air temperature derived from br GDGT-proxies can vastly deviate from real measurements and should be used with extreme caution in paleo-climate or-environment studies. | ZHENG FengFeng ZHANG ChuanLun CHEN YuFei LI FuYan MA CenLing PU Yang ZHU YuanQing WANG YongLi LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 11 | Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway显示文摘Lotus seed is well known as traditional food and medicine,but its skin is usually discarded.Recent studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer effects.In the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo.The results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin B4.Although it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factory-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells.Molecular data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional activity.Moreover,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR.These results revealed that lotus seed skin is a promising resource for functional food development. | Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 8 |
| 12 | A SIMPLE METHOD FOR CONSTRUCTING ORTHOGONAL ARRAYS BY THE KRONECKER SUM显示文摘在这篇文章,我们建议一条新一般途径到构造不均匀的直角的数组,也就是 Kronecker 和。自从很多 newmixed 水平,直角的数组能被这个方法获得,有趣。 | Yingshan ZHANG Weiguo LI Shisong MAO Zhongguo ZHENG | 2006 | Journal of Systems Science & Complexity2006，19，2： | 8 |
| 13 | Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input显示文摘Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly. | Qing Du Li Zhou Ping Chen Xiaoming Liu Chun Song Feng Yang Xiaochun Wang Weiguo Liu Xin Sun Junbo Du Jiang Liu Kai Shu Wenyu Yang Taiwen Yong | 2020 | The Crop Journal2020，8，1： | 7 |
| 14 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 15 | Synthesis of Cyclic Carbonate Catalyzed by DBU Derived Basic Ionic Liquids显示文摘 | Wei Li Weiguo Cheng Xia Yang Qian su Lihui Dong Pan Zhang Yunan Yi Bin Li Suojiang Zhang | 2018 | Chinese Journal of Chemistry2018，36，4： | 7 |
| 16 | African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2显示文摘African swine fever virus(ASFV),as a member of the large DNA viruses,may regulate autophagy and apoptosis by inhibiting programmed cell death.However,the function of ASFV proteins has not been fully elucidated,especially the role of autophagy in ASFV infection.One of three Pyrroline-5-carboxylate reductases(PYCR),is primarily involved in conversion of glutamate to proline.Previous studies have shown that depletion of PYCR2 was related to the induction of autophagy.In the present study,we found for the first time that ASFV E199 L protein induced a complete autophagy process in Vero and HEK-293 T cells.Through co-immunoprecipitation coupled with mass spectrometry(Co IP-MS)analysis,we firstly identified that E199 L interact with PYCR2 in vitro.Importantly,our work provides evidence that E199 L down-regulated the expression of PYCR2,resulting in autophagy activation.Overall,our results demonstrate that ASFV E199 L protein induces complete autophagy through interaction with PYCR2 and down-regulate the expression level of PYCR2,which provide a valuable reference for the role of autophagy during ASFV infection and contribute to the functional clues of PYCR2. | Sheng Chen Xinheng Zhang Yu Nie Hongxin Li Weiguo Chen Wencheng Lin Feng Chen Qingmei Xie | 2021 | Virologica Sinica2021，36，2： | 7 |
| 17 | Effect of vegetation type, wetting intensity, and nitrogen supply on external carbon stimulated heterotrophic respiration and microbial biomass carbon in forest soils显示文摘By using packed soil-core incubation experiments,we have studied stimulating effects of addition of external carbon(C)(glucose,6.4 g Cm^(-2))on heterotrophic respiration and microbial biomass C of a mature broadleaf and Korean pine mixed forest(BKPF)and an adjacent white birch forest(WBF)soil under different wetting intensities(55%and 80%WFPS,water-filled pore space)and nitrogen(N)supply(NH_4C1 and KNO_3,4.5 g Nm^(-2))conditions.The results showed that for the control,the cumulative carbon dioxide(CO_2)flux from WBF soil during the 15-day incubation ranged from 5.44 to 5.82 g CO_2-Cm^(-2),which was significantly larger than that from BKPF soil(2.86 to 3.36 g CO_2-Cm^(-2)).With increasing wetting intensity,the cumulative CO_2 flux from the control was decreased for the WBF soil,whereas an increase in the CO_2 flux was observed in the BKPF soil(P<0.05).The addition of NH_4C1 or KNO_3 alone significantly reduced the cumulative CO_2 fluxes by 9.2%-21.6%from the two soils,especially from WBF soil at low wetting intensity.The addition of glucose alone significantly increased soil heterotrophic respiration,microbial biomass C(MBC),and microbial metabolic quotient.The glucose-induced cumulative CO_2 fluxes and soil MBC during the incubation ranged from 8.7 to 11.7 g CO_2-Cm^(-2)and from 7.4 to 23.9 g Cm^(-2),which are larger than the dose of added C.Hence,the addition of external carbon can increase the decomposition of soil native organic C.The glucose-induced average and maximum rates of CO_2 fluxes during the incubation were significantly influenced by wetting intensity(WI)and vegetation type(VT),and by WI×VT,NH_4Cl×VT and WI×VT×NH_4Cl(P<0.05).The addition of NH_4C1,instead of KNO_3 significantly decreased the glucose-induced MBC of WBF soil(P<0.05),whereas adding NH_4C1 and KNO_3 both significantly increased the glucose-induced MBC of BKPF soil at high moisture(P<0.05).According to the differences in soil labile C pools,MBC and CO_2 fluxes in the presence and absence of glucose,it can be concluded that the stimulating effects of glucose on soil heterotrophic respiration and MBC under temperate forests were dependent on vegetation type,soil moisture,and amount and type of the N added. | WU HaoHao XU XingKai DUAN CunTao LI TuanSheng CHENG WeiGuo | 2015 | Science China Earth Sciences2015，58，8： | 6 |
| 18 | A review of the microbiology of the Rehai geothermal field in Tengchong,Yunnan Province,China显示文摘Rehai 地热的领域,在 Tengchong 定位了县在中央西方的云南省,是在中国的最大、最强烈地学习的地热的领域。弹簧的宽物理化学的差异(对 97 | Brian P.Hedlund Jessica K.Cole Amanda J.Williams Weiguo Hou Enmin Zhou Wenjun Li Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 6 |
| 19 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 20 | The fluidity and molding ability of glass-forming Zr-based alloy melt显示文摘The fluidity and filling ability of glass-forming Zr-based alloy melt in copper mould were investigated both theoretically and experimentally. The major factors which affected the flowing behavior of the metallic melt in the mold were determined,which provides the foundation for overcoming the contradiction between the filling and formation of amorphous alloy during the rapid cooling process of the metallic melts. The casting factors to prepare a metallic ring were discussed and selected. As a result,a Zr-based bulk metallic glass ring was prepared successfully. | MA MingZhen ZONG HaiTao WANG HaiYan QI YanPeng LIANG SunXing SONG AiJun ZHANG WeiGuo WANG Qiang ZHANG XinYu JING Qin LI Gong LIU RiPing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 6 |
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