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| 1 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | Antioxidative mechanisms of teacatechins in chicken meet systems 显示文摘 | Tang S Z Kerry J P’Sheeha D | 2002 | Food chemistry2002，16，： | 1 |
| 3 | Detection and quanti- fication of airborne conidia of Fusarium circinatum, the causal agent of pine pitch canker, from two California sites by using a real - time PCR approach combined with a simple spore trapping method 显示文摘 | Wolfgang S Kerry 0 D Matteo G | 2004 | App Envir Micro2004，70，63： | 1 |
| 4 | Detection classification, and tracking of targets 显示文摘 | Li Dan Kerry D Wong Yu Hen Hu | 2002 | IEEE Signal Processing Magazine2002，3，： | 1 |
| 5 | Structure and orientation relation of precipitates formed in Al-Cu-Mg-Ag alloys显示文摘 | Kerry S Soott V D | 1984 | Metals Science1984，18，： | 1 |
| 6 | Antioxidative effect of dietarytea catechins on lipid oxidation of long - term frozen stored chickenmeat显示文摘 | Tang S Z Kerry J P Sheehan D | 2001 | Meat science2001，57，： | 1 |
| 7 | Confocal endomicroscopy显示文摘 | KERRY B D MARCIA I C | 2010 | Techniques in Gastrointestinal Endoscopy2010，12，2： | 1 |
| 8 | Antioxidative effect of added tea catechins on susceptibility of cooked red meat, poultry and fish patties to lipid oxidation 显示文摘 | Tang SZ Kerry JP Sheehan D | 2001 | Food Research International2001，34，8： | 1 |
| 9 | Probes for measuring the thermal conductivity of granular materials显示文摘 | Goldsmith H J Kerrie E D Papazian V | 1981 | J Phys E: Sci Instrum1981，，14： | 1 |
| 10 | Red Light Violation and Crashes at Urban Intersection显示文摘 | Tapan K D Kerrie S Sue D | 2000 | Transportation Research Record2000，，1734： | 1 |
| 11 | The rheological properties of exudates from cured porcine muscle: effects of added carrageenans and whey protein conentrate/carrageenan blends显示文摘 | KERRY J F MORRISSEY P A BUCKLEY D J | 1999 | J Sci Food Agric1999，79，： | 1 |
| 12 | Structure of precipitate in Al-Cu-Mg-Ag alloy显示文摘 | Kerry S Scott V D | 1985 | Archiwum Nauki o Materialach1985，6，2： | 1 |
| 13 | The rheological properties of exudates from cured porcine muscle: effects of added non-meat proteins 显示文摘 | KERRY J F STACK F BUCKLEY D J | 1999 | J Sci Food Agric1999，79，： | 1 |
| 14 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | Scott V D Kerry S Trumper R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 15 | Modelling the influence of inulin as a fat substitute in comminuted meat products on their physico-chemical characteristics and eating quality using a mixture design approach 显示文摘 | Keenan D F Resconi V C Kerry J P | 2014 | Meat Science2014，96，3： | 1 |
| 16 | The rheological properties of exudates from cured porcine muscle: effects of added polysaccharides and whey protein/polysaccharide blends显示文摘 | KERRY J F MORRISSEY P A BUCKLEY D J | 1999 | J Sci Food Agric1999，79，： | 1 |
| 17 | Mucoepidermoid Carcinoma of the Parotid Gland:The Mayo Clinic Experience显示文摘 | Derek Kofi O Boahene Kerry D | 2004 | Arch Otolaryngol Head NeckSurg2004，130，： | 1 |
| 18 | Influence of different gas com~itionsontheshort - termstoragestabilityofmother - packagedretail-ready lamb packs 显示文摘 | Kennedy C Buckley D J Kerry J P | 2005 | Meat Science2005，69，1： | 1 |
| 19 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 20 | Tumors and surgery of the parapharyngeal space显示文摘 | Kerry D Olsen KD | 1994 | Laryngoscope1994，104，： | 1 |
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