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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 13 |
| 3 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 4 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 5 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 6 | Expert consensus on dental caries management显示文摘Dental Caries is a kind of chronic oral disease that greatly threaten human being’s health.Though dentists and researchers struggled for decades to combat this oral disease,the incidence and prevalence of dental caries remain quite high.Therefore,improving the disease management is a key issue for the whole population and life cycle management of dental caries.So clinical difficulty assessment system of caries prevention and management is established based on dental caries diagnosis and classification.Dentists should perform oral examination and establish dental records at each visit.When treatment plan is made on the base of caries risk assessment and carious lesion activity,we need to work out patient-centered and personalized treatment planning to regain oral microecological balance,to control caries progression and to restore the structure and function of the carious teeth.And the follow-up visits are made based on personalized caries management.This expert consensus mainly discusses caries risk assessment,caries treatment difficulty assessment and dental caries treatment plan,which are the most important parts of caries management in the whole life cycle. | Lei Cheng Lu Zhang Lin Yue Junqi Ling Mingwen Fan Deqin Yang Zhengwei Huang Yumei Niu Jianguo Liu Jin Zhao Yanhong Li Bin Guo Zhi Chen Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，2： | 8 |
| 7 | Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice显示文摘 | Jizheng Chen Yang Zhao Chao Zhang Hairong Chen Jin Feng Xiumei Chi Yu Pan Jun Du Min Guo Huang Cao Honghe Chen Zilong Wang Rongjuan Pei Qian Wang Lei Pan Junqi Niu Xinwen Chen Hong Tang | 2014 | Cell Research2014，24，9： | 5 |
| 8 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 9 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 1 |
| 10 | Antiviral Treatment Alters the Frequency of Activating and Inhibitory Receptor-Expressing Natural Killer Cells in Chronic Hepatitis B Virus Infected Patients显示文摘 | Juan Lv Qinglong Jin Haibo Sun Xiumei Chi Xiaoli Hu Hongqing Yan Yu Pan Weihua Xiao Zhigang Tian Jinlin Hou Damo Xu Zhengkun Tu Junqi Niu Alex Kleinjan | 2012 | Mediators of Inflammation2012，，： | 1 |
| 11 | Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT显示文摘 | Fabao Liu Xiaona You Xiumei Chi Tao Wang Lihong Ye Junqi Niu Xiaodong Zhang | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 12 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 1 |
| 13 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 14 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 15 | 14 μm quantum cascade lasers based on diagonal transition and nonresonant extraction显示文摘We report In P-based room-temperature high-average-power quantum cascade lasers emitting at 14 μm. Using a novel active region design, a diagonal bound-to-bound lasing transition is guaranteed by efficient electron injection into the upper laser level and fast nonresonant electron extraction through a miniband from the lower laser level. For a 4 mm long and 40 μm wide double channel ridge waveguide laser with 55 stages of the active region, the threshold current density is only 3.13 k A∕cm^2 at room temperature. At 293 K, the maximum singlefacet peak power and average power are up to 830 m W and 75 m W, respectively. The laser exhibits a characteristic temperature T0 of 395 K over a temperature range from 293 to 353 K. | Shouzhu Niu Junqi Liu Fengmin Cheng Huan Wang Jinchuan Zhang Ning Zhuo Shenqiang Zhai Lijun Wang Shuman Liu Fengqi Liu Zhanguo Wang Xiaohua Wang Zhipeng Wei | 2019 | Photonics Research2019，7，11： | 1 |
| 16 | 2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B显示文摘 | Yun–Fan Liaw Edward Gane Nancy Leung Stefan Zeuzem Yuming Wang Ching Lung Lai E. Jenny Heathcote Michael Manns Natalie Bzowej Junqi Niu Steven–Huy Han Seong Gyu Hwang Yilmaz Cakaloglu Myron J. Tong George Papatheodoridis Yagang Chen Nathaniel A. Brown Efs | 2009 | Gastroenterology2009，，2： | 1 |
| 17 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 18 | Dual-mode distributed feedback quantum cascade laser based on stacked 3D monolithic integration for on-chip multi-channel gas sensing显示文摘To facilitate the development of on-chip integrated mid-infrared multi-channel gas sensing systems,we propose a high-power dual-mode(7.01 and 7.5μm)distributed feedback quantum cascade laser based on stacked 3D monolithic integration.Longitudinal mode control is achieved by preparing longitudinal nested bi-periodic compound one-dimensional Bragg gratings along the direction of the cavity length in the confinement layer.Additionally,transverse coherent coupling ridges perpendicular to the cavity length direction are fabricated in the upper waveguide layer to promote the fundamental transverse mode output when all ridges are in phase.Stable dual-wavelength simultaneous emission with a side-mode suppression ratio of more than 20 dB was achieved by holographic exposure and wet etching.The entire spectral tuning range covers nearly 100 nm through joint tuning of the injection current and heat-sink temperature.High peak power and beam quality are guaranteed by the parallel coherent integration of seven-element ridge arrays.The device operates in a fundamental supermode with a single-lobed far-field pattern,and its peak output power reaches 3.36 W in pulsed mode at 20℃.This dual-mode laser chip has the potential for in-situ on-chip simultaneous detection of CH4and C2H6gases in leak monitoring. | XIYU LU YANJIAO GUAN PENGCHANG YANG SHAN NIU YU MA LIJUN WANG NING ZHUO JINCHUAN ZHANG SHENQIANG ZHAI FENGMIN CHENG SHUMAN LIU FENGQI LIU JUNQI LIU | 2023 | Photonics Research2023，11，12： | 0 |
| 19 | Inhibition of the Neddylation Pathway Suppresses Enterovirus Replication显示文摘Dear Editor,Human enteroviruses(HEVs)comprise polioviruses,coxsackieviruses,echoviruses,rhinoviruses,and the enterovirus subgroups and belong to the genus Enterovirus in the family Picornaviridae(Baggen et al.2018).The HEV genome was thought to contain a single open reading frame(ORF)encoding one polyprotein,which was post-translationally processed into structural capsid proteins(VP1-4)and non-structural accessory proteins(2A,2B,2C,3A,3B,3C,3D)(Baggen et al.2018).Recently,we and others,have identified an additional upstream ORF(Guo et al.2019a;Lulla et al.2019)(ORF2/uORF). | Zhe Zhang Haoran Guo Jing Wang Yan Li Yanhang Gao Quan Liu Junqi Niu Wei Wei | 2021 | Virologica Sinica2021，36，6： | 0 |
| 20 | Thermal-annealing-regulated plasmonic enhanced fluorescence platform enables accurate detection of antigen/antibody against infectious diseases显示文摘Plasmonic enhanced fluorescence(PEF)technology is a powerful strategy to improve the sensitivity of immunofluorescence microarrays(IFMA),however,current approaches to constructing PEF platforms are either expensive/time-consuming or reliant on specialized instruments.Here,we develop a completely alternative approach relying on a two-step protocol that includes the self-assembly of gold nanoparticles(GNPs)at the water–oil interface and subsequent annealing-assisted regulation of gold nanogap.Our optimized thermal-annealing GNPs(TA-GNP)platform generates adequate hot spots,and thus produces high-density electromagnetic coupling,eventually enabling 240-fold fluorescence enhancement of probed dyes in the near-infrared region.For clinical detection of human samples,TA-GNP provides super-high sensitivity and low detection limits for both hepatitis B surface antigen and SARS-CoV-2 binding antibody,coupled with a much-improved detection dynamic range up to six orders of magnitude.With fast detection,high sensitivity,and low detection limit,TA-GNP could not only substantially improve the outcomes of IFMA-based precision medicine but also find applications in fields of proteomic research and clinical pathology. | Ying Yue Jingjie Nan Yuanyuan Che Hongqin Xu Weihong Sun Feiran Zhang Lei Wang Wei Xu Junqi Niu Shoujun Zhu Junhu Zhang Bai Yang | 2023 | Nano Research2023，16，2： | 0 |
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