|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | The need and challenges for development of an Epstein-Barr virus vaccine显示文摘 | Cohen JI Mocarski ES Raab-Traub N | 2013 | Vaccine2013，31，2： | 1 |
| 4 | Roles of ultrasonography and com- puted tomography in the surgical management of cervical lymph node metastases in papillary thyroid carcinoma显示文摘 | Lee DW Ji YB Sung ES | 2013 | Eur J Surg On- col2013，39，2： | 1 |
| 5 | Inflammation and its relationship to insulin resistance ,type 2 diabetes mellitus and endothelial dysfunction显示文摘 | Barzilaym JI Freedlang ES | 2003 | Metab Syndr Relat Disord2003，1，8： | 1 |
| 6 | Roles of ultrasonography and computed tomography in the surgical management of cervical lymph node metastases in papillary thyroid carcinoma 显示文摘 | Lee DW Ji YB Sung ES | 2013 | Euro- pean Journal of Surgical Oncology( EJSO)2013，39，2： | 1 |
| 7 | Characterization and treat- merit of chronic active Epstein -Bar virus disease: a 28 -year ex- perience in the United States显示文摘 | COHEN JI JAFFE ES DALE JK | 2011 | Blood2011，117，22： | 1 |
| 8 | The effect of antiviral therapy on serum cholesterol levels in chronic hepatitis C 显示文摘 | Jang ES Won JE Jung JI | 2011 | Gut Liver2011，5，3： | 1 |
| 9 | Myasthenia gravis crisis 显示文摘 | Bershad EM Feen ES Suarez JI | 2008 | South Med J2008，101，1： | 1 |
| 10 | Vascular complications of hyalu- ronic acid fillers and the role of hyaluronidase in management 显示文摘 | Kim DW Yoon ES Ji YH | 2011 | J Plast Reconstr Aesthet Surg2011，64，12： | 1 |
| 11 | Development of an Evaluation Instrument for Service Quality in Nursing Homes显示文摘 | Lee J Ji ES | 2011 | Journal of Korean Academy of Nursing2011，41，4： | 1 |
| 12 | Vaseular complications of hyalu- renic acid fillers and the role of hyaluronidase in management显示文摘 | Kim DW Yoon ES Ji YH | 2011 | J Plast Reconstr Acsthet Surg2011，64，12： | 1 |
| 13 | Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling显示文摘 | Park ES Kim SY Na JI | 2007 | J Dermatol Sci2007，47，： | 1 |
| 14 | Glutathione prevented dopamine-induced apoptesis of melanocytes and its signaling显示文摘 | Park ES Kim SY Na JI | 2007 | J Dermatol Sci2007，47，2： | 1 |
| 15 | Myasthenia gravis crisis显示文摘 | Berahad EM Feen ES Suarez JI | 2008 | South Med J2008，101，1： | 1 |
| 16 | Development of an evaluation instrument for service quality in nursing homes显示文摘 | Lee J Ji ES | 2011 | J Korean Acad Nurs2011，41，4： | 1 |
| 17 | Chronie intermittent hypoxi a modulates nNOS mRNA and protein expression in the rat hypothal- amus显示文摘 | IHuang JH Tamisier R Ji ES | 2007 | Respir Physiol Neurobio12007，158，1： | 1 |
| 18 | Status epilepticus 显示文摘 | Feen ES Bershad EM Suarez JI | 2008 | South Med J2008，101，4： | 1 |
| 19 | Roles of uhrasonography and computed tomography in the surgical management of cervical lymph nodcmetastases in papillary thyroid carcinoma 显示文摘 | Lee DW Ji YB Sung ES | 2013 | Eur JSurg 0neol2013，39，2： | 1 |
| 20 | Characterization and treatment of chronic active Epstein-Ban virus disease:a 28-year experience in the United States显示文摘 | Cohen JI Jaffe ES Dale JK Pittaluga S Heslop HE Rooney CM | | Blood0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员