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| 1 | Importance of bifurcation angle in bifurcation stenting显示文摘Bifurcation coronary lesions are relatively frequent in today's interventional cardiology practice,averaging between 10%-15% of all percutaneous coronary interventions(PCIs).1 Several problems inherent in the treatment of bifurcation lesions are periprocedural side branch(SB)compromise(composite of SB closure or appearance of significant ostial stenosis after main vessel(MV)stenting causing ischemia)frequently related to periprocedural myonecrosis,relatively higher restenosis rates especially in two-stent techniques,and higher rates of stent thrombosis in different time frames.1-4 The lead author and other investigators demonstrated that both periprocedural result and long-term results could be influenced by bifurcation angulations.The purpose of this study is to show why and how bifurcation angulations are important for bifurcation stenting. | Dobrin Vassilev Alexander Alexandrov Dan Le Katrina Nguyen James Nguyen Hung Phan Robert J. Gil | 2012 | Chinese Medical Journal2012，，22： | 7 |
| 2 | Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma显示文摘AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients. | Bing Xia Le Zhang Shan-Qi Guo Xiao-Wu Li Fu-Lian Qu Hai-Feng Zhao Lian-Yu Zhang Bao-Cun Sun James You Yi-Zhuo Zhang | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 3 | Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation显示文摘 | Nhat-Tu Le James P. Corsetti Janet L. Dehoff-Sparks Charles E. Sparks Keigi Fujiwara Jun-ichi Abe Masanori Aikawa | 2012 | <journal-title>International Journal of Inflammation2012，，： | 2 |
| 4 | Phase III randomized comparison of gemcitabine and carboplatin(GC) with mitomycin,ifosfamide and cisplatin (MIP) in advanced non - small cell lung cancer( NSCLC ) 显示文摘 | Rudd RM Gower NH James LE | 2002 | Proc Am Soc Clin Oncol2002，21，： | 1 |
| 5 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 6 | Early compared with late radiotherapy in combined modality treatment for limited disease small-cell lung cancer: a London Lung Cancer Group multicenter randomized clinical trial and meta-analysis显示文摘 | Spiro SG James LE Rudd RM | 2006 | J Clin Oncol2006，24，24： | 1 |
| 7 | Increased YKL-40and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease显示文摘 | James AJ Reinius LE Verhoek M | 2016 | Am J Respir Crit Care Med2016，193，2： | 1 |
| 8 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | JAME C UGO V LE COUEDIC J P | 2005 | Nature2005，434，： | 1 |
| 9 | A unique clonal JAK2 mutation leading to constitutive signalling cau ses polycythaemia vera显示文摘 | James C Ugo V Le Couédic JP | 2005 | Nature2005，434，7037： | 1 |
| 10 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythemia vera显示文摘 | James C Ugo V Le Couedic JP | | 0，，： | 1 |
| 11 | Estimating aboveground biomass using Landsat 7 ETM+ data across a managed landscape in northern Wisconsin, USA显示文摘 | Daolan Zheng John Rademacher Jiquan Chen Thomas Crow Mary Bresee James Le Moine Soung-Ryoul Ryu | 2004 | Remote Sensing of Environment2004，，3： | 1 |
| 12 | A unique clonal JAK2 mutation leading to constitutive signaling causes polycythaemia vera显示文摘 | James C Ugo V Le Couedic JP | 2005 | Nature2005，434，7037： | 1 |
| 13 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | UGO V Le COUEDIC JP | 2005 | Nature2005，434，： | 1 |
| 14 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera 显示文摘 | James C Ugo V Le CJP | 2005 | Nature2005，434，7037： | 1 |
| 15 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera 显示文摘 | James C Ugo V Le Cou6dic JP | 2005 | Nature2005，434，7037： | 1 |
| 16 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | James C Ugo V Le Couedic JP | 2005 | Nature2005，434，7037： | 1 |
| 17 | A unique clonal JAK2 mutati on leading to constitutive signalling causes poly-cythemia vera显示文摘 | James C Ugo V Le Coué dic J P | | 0，，： | 1 |
| 18 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera显示文摘 | James C Ugo V Le Cou6dic JP | 2005 | Nature2005，434，7037： | 1 |
| 19 | A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera 显示文摘 | James C Ugo V Le Couedic JP | 2005 | Nature2005，434，7037： | 1 |
| 20 | N esiritide in con- gestiv e hearlfailure associated with acute coronary syndromes : a pilot study of safety and efficacy 显示文摘 | Wfrank PIV Charles LE James Y | 2004 | J C ardiac Fail2004，10，2： | 1 |
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