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| 1 | Anti-inflammatory activity of total flavonoids from seeds of Camellia oleifera Abel显示文摘 | Xiaohui Liu Lingyan Jia Ying Gao Bo Li Youying Tu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 7 |
| 2 | Identification of sources,characteristics and photochemical transformations of dissolved organic matter with EEM-PARAFAC in the Wei River of China显示文摘Dissolved organic matter(DOM)in rivers is a critical regulator of the cycling and toxicity of pollutants and the behavior of DOM is a key indicator for the health of the environment.We investigated the sources and characteristics of DOM in surface water and sediment samples of the Wei River,China.Dissolved organic carbon(DOC)concentration and ultraviolet absorbance at 254 nm(UV254)increased in the surface water and were decreased in the sediment downstream,indicating that the source of DOM in the water differed from the sediment.Parallel factor(PARAFAC)analysis of the excitation-emission matrices(EEM)revealed the presence of terrestrial humus-like,microbial humus-like and tryptophan-like proteins in the surface water,whereas the sediment contained UVA humic-like,UVC humic-like and fulvic-like in the sediment.The DOM in the surface water and sediment were mainly derived from microbial metabolic activity and the surrounding soil.Surface water DOM displayed greater photodegradation potential than sediment DOM.PARAFAC analysis indicated that the terrestrial humic-like substance in the water and the fulvic-like component in the sediment decomposed more rapidly.These data describe the characteristics of DOM in the Wei River and are crucial to understanding the fluctuations in environmental patterns. | Yuanyuan Luo Yangyang Zhang Mengfan Lang Xuetao Guo Tianjiao Xia Tiecheng Wang Hanzhong Jia Lingyan Zhu | 2021 | Frontiers of Environmental Science & Engineering2021，15，5： | 2 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Dispersive liquid-liquid microextraction combined with gas chromatography-electron capture detection for the determination of polychlorinated biphenyls in soils 显示文摘 | Jia Hua Lingyan Flab b | 2009 | Analytica Chimica Acta2009，640，2： | 1 |
| 5 | Effect of Pingan Fang, a Traditional Chinese Medicine compound, on behavioral sensitization and conditioned place preference induced by ethanol in mice显示文摘OBJECTIVE:To observe the effect of Pingan Fang(PG)on behavioral sensitization and conditioned place preference(CPP)induced by ethanol in mice,and to determine the intervention mechanism of PG on alcohol addiction.METHODS:A behavioral sensitization mouse model induced by ethanol was established to observe the effect of PG on the development and expression of behavioral sensitization induced by ethanol by recording the spontaneous activity of mice.The resident time of mice in a white box was measured to evaluate the effect of PG on developing CPP induced by ethanol.Concentrations of dopamine(DA),Glutamate(Glu),and?-aminobutyric acid(GABA)in the corresponding mesolimbic region of mice were determined by enzyme-linked immunosorbent assay.RESULTS:Although PG did not alter spontaneous activity in mice,it reduced the growth of spontaneous activity stimulated by ethanol.The residence time in the white box after-ethanol-training of mice in CPP experiments was decreased.CONCLUSION:Our data suggested that PG blocked the development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice.The mechanism might be related to the decreased content of DA and Glu and increased content of GABA in the mesolimbic dopamine system.This suggests that PG might be useful for the prevention and treatment of alcohol addiction. | Jia Lingyan Li Yibei Hu Xiaoyu Lin Wu Wen Dachao Zhong Sen | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 1 |
| 6 | Homogeneous liquid–liquid extraction combined with gas chromatography–electron capture detector for the determination of three pesticide residues in soils显示文摘 | Xuedong Wang Xinna Zhao Xiujuan Liu Yanyan Li Lingyan Fu Jia Hu Changjiang Huang | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 7 | Temperature Effects on Unsaturated Hydraulic Property of Bentonite-Sand Buffer Backfilling Mixtures显示文摘The influence of temperature on the engineered properties of bentonite-sand mixtures (B/S) is of major concern in the design of engineered barriers in underground repositories for high-level radioactive waste disposal. We experimentally studied the influence of temperature on soil unsaturated hydraulic properties related to water holding capacity and permeability of GMZ B/S in China. The vapor equilibrium method and water infiltration apparatus were used to measure the soil water characteristic curve (SWCC) and unsaturated hydraulic conductivity (ku ). The results show that the SWCC under different temperatures from 20 ℃ to 60 ℃ tends to be the same. Temperature influence on unsaturated permeability is more relevant at low suctions, no clear effect is detected below a degree of saturation of 74%, and experimental data show that temperature dependence on unsaturated permeability is small. | 张明 张虎元 ZHOU Lang JIA Lingyan | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，3： | 1 |
| 8 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 9 | Catalytic steam reforming of biomass over Ni-based catalysts: Conversion from poplar leaves to hydrogen-rich syngas显示文摘A series of Ni/SBA-15 catalysts with Ni contents from 5 wt%–20 wt%and CaO-12.5%Ni/SBA-15 catalysts with CaO contents from 1.4 wt%–9.8 wt%have been prepared.The structure of the catalysts was characterized using X-ray diffraction(XRD),N2 adsorption-desorption,transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS).The performance of catalytic steam reforming of the poplar leaves to the hydrogen-rich syngas was tested in a fixed-bed reactor.The results indicate that the 7.0wt%CaO-12.5wt%Ni/SBA-15 catalyst exhibits the best performance for the catalytic steam reforming of poplar leaves to hydrogen-rich syngas.The ratio of H2:CO can reach ca 5:1 in the hydrogen-rich syngas.The yield of H2 can reach 273.30 mL/g(poplar leaves).In the CaO-Ni/SBA-15 catalyst,Ni active component mainly fills the role of catalytic steam reforming of the poplar leaves,and CaO active component mainly plays the role as water-gas shift and CO2 sorbent. | Lingyan Cao Zhigang Jia Shengfu Ji Jinyong Hu | 2011 | Journal of Natural Gas Chemistry2011，20，4： | 1 |
| 10 | Homogeneous liquid–liquid extraction combined with gas chromatography–electron capture detector for the determination of three pesticide residues in soils显示文摘 | Xuedong Wang Xinna Zhao Xiujuan Liu Yanyan Li Lingyan Fu Jia Hu Changjiang Huang | 2008 | Analytica Chimica Acta2008，，1： | 1 |
| 11 | Application of dispersive liquid-liquid microextraetion for the analysis of triazophos and carbaryl pesticides in water and fruit juice samples 显示文摘 | FUA Lingyan LIU Xiujuan HU Jia | 2009 | Analytiea Chimica Aeta2009，632，2： | 1 |
| 12 | Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood显示文摘Aristolochic acids(AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I(AAI) reacts with DNA to form covalent aristolactam(AL)-DNA adducts,leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether AAs exposure was the main cause of liver cancer in the context of HBV infection in China's Mainland. Totally 1256 liver cancer samples were randomly retrieved from 3 medical centers and a refined bioanalytical method was used to detect AAI-DNA adducts. 5.10% of these samples could be identified as AAI positive exposure. Whole genome sequencing suggested 8.41% of 107 liver cancer patients exhibited the dominant AA mutational signature, indicating a relatively low overall AAI exposure rate. In animal models, long-term administration of AAI barely increased liver tumorigenesis in adult mice, opposite from its tumor-inducing role when subjected to infant mice. Furthermore, AAI induced dose-dependent accumulation of AA-DNA adduct in target organs in adult mice, with the most detected in kidney instead of liver. Taken together, our data indicate that AA exposure was not the major threat of liver cancer in adulthood. | Shuzhen Chen Yaping Dong Xinming Qi Qiqi Cao Tao Luo Zhaofang Bai Huisi He Zhecai Fan Lingyan Xu Guozhen Xing Chunyu Wang Zhichao Jin Zhixuan Li Lei Chen Yishan Zhong Jiao Wang Jia Ge Xiaohe Xiao Xiuwu Bian Wen Wen Jin Ren Hongyang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 13 | Application of dispersive liquid-liquid microextraction for the analysis of triazophos and carbaryl pesticides in water and fruit juice samples显示文摘 | FU Lingyan LIU Xiujuan HU Jia | 2009 | Anal China Acta2009，632，2： | 1 |
| 14 | Determination of Two Pesticides in Soils by Dispersive Liquid–Liquid Microextraction Combined with LC-Fluorescence Detection显示文摘 | Lingyan Fu Xiujuan Liu Jia Hu Xinna Zhao Huili Wang Changjiang Huang Xuedong Wang | 2009 | Chromatographia (-)2009，，11： | 1 |
| 15 | Application of dispersive liquid-liquid microextraction for the analysis of tdazophos and carbaryl pesticides in water and fruit juice samples显示文摘 | FU Lingyan LIU Xiujuan HU Jia | 2009 | Analytica Chimica Acta2009，632，2： | 1 |
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