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| 1 | Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock显示文摘Inflammasomes 是触发 caspase-1 的激活和 interleukin-1β 的成熟的多蛋白质建筑群;(IL-1β) ,然而,这些建筑群的规定仍然保持糟糕描绘了。这里,我们显示出那氮的氧化物(没有) 禁止了调停 NLRP3 的 ASC pyroptosome 形成, caspase-1 激活和 IL-1β在从老鼠和人的 myeloid 房间的分泌物。同时,内长不否定地也源于 iNOS (没有 synthase 的可诱导的形式) 调整 NLRP3 inflammasome 激活。iNOS 的弄空响应 LPS 和 ATP 导致了不正常的线粒体的增加的累积,它为增加的 IL-1β 负责;生产和 caspase-1 激活。没有生产的 iNOS 缺乏或药理学抑制在 vivo 提高了 NLRP3 依赖的 cytokine 生产,因此在老鼠从导致 LPS 的败血增加死亡,它被 NLRP3 阻止缺乏。我们的结果因此经由线粒体的稳定作为 NLRP3 inflammasome 的一个批评否定管理者不识别。这研究有重要含意让新策略的设计控制 NLRP3 相关的疾病。 | Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun | 2013 | Cell Research2013，23，2： | 59 |
| 2 | Negative regulation of NLRP3 infl ammasome signaling显示文摘Infl ammasomes are multiprotein complexes that serve as a platform for caspase-1 activation and interleukin-1β(IL-1β)maturation as well as pyroptosis.Though a number of infl ammasomes have been described,the NLRP3 inflammasome is the most extensively studied.NLRP3 inflammasome is triggered by a variety of stimuli,including infection,tissue damage and metabolic dysregulation,and then activated through an integrated cellular signal.Many regulatory mechanisms have been identifi ed to attenuate NLRP3 infl ammasome signaling at multiple steps.Here,we review the developments in the negative regulation of NLRP3 inflammasome that protect host from inflammatory damage. | Shuzhen Chen Bing Sun | 2013 | Protein & Cell2013，4，4： | 23 |
| 3 | Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway显示文摘Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined. HA-mediated cytotoxicity and apoptosis in human lung adenocarcinoma A549 cells were evaluated after photodynamic therapy(PDT). A temporal quantitative proteomics approach by isobaric tag for relative and absolute quantitation(iTRAQ) 2 D liquid chromatography with tandem mass spectrometric(LC–MS/MS) was introduced to help clarify molecular cytotoxic mechanisms and identify candidate targets of HA-induced apoptotic cell death. Specific caspaseinhibitors were used to further elucidate the molecular pathway underlying apoptosis in PDT-treated A549 cells. Finally, down-stream apoptosis-related protein was evaluated. Apoptosis induced by HA was associated with cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation,and mitochondrial disruption, which were preceded by increased intracellular reactive oxygen species(ROS) generations. Further studies showed that PDT treatment with 0.08 mmol/L HA resulted in mitochondrial disruption, pronounced release of cytochrome c, and activation of caspase-3,-9, and-7.Together, HA may be a possible therapeutic agent directed toward mitochondria and a promising photodynamic anticancer candidate for further evaluation. | Shanshan Qi Lingyuan Guo Shuzhen Yan Robert J.Lee Shuqin Yu Shuanglin Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 12 |
| 4 | Synthesis of CNT film on the surface of micro-pyramid array and its intense pulsed emission characteristics显示文摘We developed a new scheme to suppress the electric-field-screening effect in high growth density of a carbon nanotube(CNT) film during its intense pulsed emission.We synthesize the CNT film on a tridimensional surface(t-CNT film).The tridimensional surface includes wet etched silicon pyramids,and the Ni layer is electroless plated thereon.The intense pulsed emission characteristics of the t-CNT and planar-grown CNT(p-CNT) films were measured using a diode structure in single-pulse mode.The even turn-on field decreased from 5.5 V/μm for p-CNTs to 2.8 V/m for t-CNTs,and the peak emission current increased from 232 A for p-CNTs to 324 A for t-CNTs at a peak field intensity ~12.2 V/m.The peak current of the t-CNT film increased by ~39.7% over the p-CNT film.It is clear that the micro-pyramid array can effectively suppress the field screening effect to improve the electron-emission of CNT films. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2012 | Chinese Science Bulletin2012，57，14： | 10 |
| 5 | Incidence of Extended-Spectrum β-Lactamases and Characterization of Integrons in Extended-Spectrum β-Lactamase-producing Klebsiella pneumoniae Isolated in Shantou, China显示文摘这研究涉及生产 Klebsiella pneumoniae 的抗菌素抵抗 ofextended 光谱 beta-lactamase (ESBL ) 的水平,在 Shantou,中国,和它的机制孤立。74 非重复临床 K 孤立。生产在 2 年的一个时期上孤立的 ESBLswere 的 pneumoniae。抗菌素危险性,由 Epsilometer 测试执行了,证明大多数 isolates 是多抵抗的。聚合酶链反应证明在 beta-lactamases 的几种类型之中, SHV 是最流行的, TEM 是第二个大多数流行,并且 CTX-M 是最不流行的。69 孤立为 integrase 基因 IntI1 是积极的,但是没有 IntI2 或 IntI3 基因被发现。班 1 integrons 的可变区域被定序放大并且进一步识别了。13 个不同基因盒子和 11 不同盒子联合被检测。Dfr 和 aadA 盒子是占优势的,盒子 combinationsdfrA12, orfF 和 aadA2 最经常被发现。编码 ESBL 的基因盒子都不是 found.Integrons 是流行的并且起了一个重要作用在多在生产 ESBL K.pneumoniae 的药抵抗。 | Fen YAO Yuanshu QIAN Shuzhen CHEN Peifen WANG Yuanchun HUANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 9 |
| 6 | Improvement in the intense pulsed emission stability of grown CNT films via an electroless plated Ni layer显示文摘Carbon nanotube(CNT)films were grown on silicon wafers with and without a nickel layer(Si-CNT and Ni-CNT)via the pyrolysis of iron phthalocyanine.The nickel layer was prepared using the electroless plating method.To study the emission stability of Si-CNT and Ni-CNT cathodes during intense pulsed emission,emission characteristics were measured repeatedly with a diode structure using a Marx generator as a voltage source.For the peak values of the pulsed voltage,which were in the range between 1.62-1.66 MV(corresponding to electric field intensities between 11.57-11.85 V/μm),the first cycle emission current was 109.4 A for Si-CNT and 180.5 A for Ni-CNT.By comparing the normalized emission currents of the Si-CNT and Ni-CNT cathodes,the improvement in the emission stability can be easily quantified.The number of emission cycles necessary for the peak current to decay from 100%to 50%increased from^3 for Si-CNT to^11 for a Ni-CNT film. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 7 | Thermodynamic Modeling of Fluid-Bearing Natural Gas Inclusions for Geothermometer and Geobarometer of Overpressured Environments in Qiongdongnan Basin, South China Sea显示文摘It is a very difficult problem to directly determine fluid pressure during hydrocarbon migration and accumulation in sedimentary basins. pVt modeling of coupling hydrocarbon fluid inclusion of its coeval aqueous fluid inclusion provides a powerful tool for establishing the relationship of formation pressure evolution with time. Homogenization temperature of fluid inclusion can routinely be measured under microthermometric microscopy. Crushing technique has been employed to obtain the composition of fluid inclusions, and the commercial software VTFLINC easily and rapidly completes the construction of p t phase diagram. The minimum trapping pressure of hydrocarbon fluid inclusion would be then determined in the p t space. In this paper, three samples of YC21 1 1 and YC21 1 4 wells at YC21 1 structural closure, Qiongdongnan basin, South China Sea, were selected for the pVt modeling practice, and the formation pressure coefficient (equals to fluid pressure/hydrostatic pressure) changing trend with time has primarily been established. The modeling results also indicate that the reservoirs of Lingshui and Yacheng formations in YC21 1 structure are within a very high potential system and would have undergone a discharging of thermal fluids through top seal rupture, which depicts that there is a very high risk for natural gas exploration in this area. | Chen Honghan Yao Shuzhen Wang Jiahao Li Chunquan Institute of Resources, China University of Geosciences, Wuhan 430074 | 2002 | Journal of China University of Geosciences2002，13，3： | 7 |
| 8 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 9 | Spatial and temporal variability of heat content above the thermocline in the tropical Pacific Ocean显示文摘Heat content of the upper layer above the 20℃ isotherm in the tropical Pacific Ocean is estimated by using the sea temperature data set with a resolution 2°latitude × 5°longitude (1980~1993) for the water depths (every 10 m) from 0 m to 400 m, and its temporal and spatial variabilities are analyzed. ( 1 ) The temporal variability indicates that the total heat in the upper layer of the equatorial Pacific Ocean is characterized by the interannual variability. The time series of the equatorial heat anomaly 5 months lead that of the El Nino index at the best positive lag correlation between the two, and the former 13 months lag behind the latter at their best negative lag correlation. Therefore the equatorial heat content can be used as a better predictor than the El Nino index for a warm or cold event. In addition, it is also found that less heat anomaly in the equator corresponds to the stronger warm events in the period (1980~1993) and much more heat was accumulated in the 4 years including 1992/1993 ENSO (1989~1993) than the 4 years including 1982/1983 ENSO (1980~1983); (2) The spatial variability indicates that the area with the highest lag correlation among the grids moves in an anti-clockwise circle in the northern tropical Pacific Ocean within 4 years period and in a clockwise circle in the southern tropical Pacific Ocean. This result provides scientific evidence for the quasi - cycle theory of El Nino events. | Pu Shuzhen, Yu Fei, Hu Xiaomin, Chen Xingrong First Institute of Oceanography, State Oceanic Administration, Qingdao 266061,China, | 2003 | Acta Oceanologica Sinica2003，22，2： | 6 |
| 10 | Effects of purified zearalenone on selected immunological and histopathologic measurements of spleen in post-weanling gilts显示文摘The present study was aimed at investigating the adverse effects of dietary zearalenone(ZEA) on the lymphocyte proliferation rate(LPR), interleukin-2(IL-2), mRNA expressions of pro-inflammatory cytokines, and histopathologic changes of spleen in post-weanling gilts. A total of 20 crossbred piglets(Yorkshire × Landrace × Duroc) with an initial BW of 10.36 ± 1.21 kg(21 d of age) were used in the study.Piglets were fed a basal diet with an addition of 0.1.1,2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum.The results showed that LPR and IL-2 production of spleen decreased linearly(P < 0.05) as dietary ZEA increased. Splenic mRNA expressions of interleukin-1β(IL-1β) and interleukin-6(IL-6) were linearly upregulated(P < 0.05) as dietary ZEA increased. On the contrary, linear down-regulation(P<0.05) of mRNA expression of interferon-γ(IFN-γ) was observed as dietary ZEA increased. Swelling splenocyte in1.1 mg/kg ZEA treatments, atrophy of white pulp and swelling of red pulp in 2.0 and 3.2 mg/kg ZEA treatments were observed. The cytoplasmic edema in 1.1 mg/kg ZEA treatments, significant chromatin deformation in 2.0 mg/kg ZEA treatment and phagocytosis in 3.2 mg/kg ZEA treatment were observed.Results suggested that dietary ZEA at 1.1 to 3.2 mg/kg can induce splenic damages and negatively affect immune function of spleen in post-weanling gilts. | Peng Chen Tingjun Liu Shuzhen Jiang Zaibin Yang Libo Huang Faxiao Liu | 2017 | Animal Nutrition2017，，3： | 5 |
| 11 | Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging显示文摘二维(2D ) nanosheets 在 biomedicines 的领域里与大潜力作为 nanomaterial 的一个重要的类出现了,特别地在癌症 theranostics。然而,由于综合的有效方法的缺乏有控制尺寸的一致 2D nanomaterials, 2D nanomaterials 的尺寸依赖者简历行为的系统的评估很少被报导。就我们的知识而言,我们是第一报导对他们的简历行为的 2D nanomaterials 的尺寸的影响的系统的评估。有从 5 ~ 80 nm 的直径的 2D Pd nanosheets 被综合并且在房间和动物模型测试了估计他们基因表示介绍的尺寸依赖者 bioapplication, biodistribution,消除,毒性,和 genomic。我们的结果证明尺寸显著地影响 Pd nanosheets 的生物行为,包括他们的 photothermal 和 photoacoustic 效果, pharmacokinetics,和毒性。比作大尺寸的 Pd nanosheets,更展出的小尺寸的 Pd nanosheets 在 ultralow 之上预付 photoacoustic 成像和 photothermal 效果激光照耀。而且,在 vivo,结果显示 5-nm Pd nanosheets 与更长的血半衰期逃离网状内皮组织的系统并且能被肾的排泄清除,当时有更大的尺寸的 Pd nanosheets 主要在肝和怒气积累。30-nm Pd nanosheets 展出了最高的肿瘤累积。尽管 Pd nanosheets 没在细胞的水平引起任何可估计的毒性,我们在怒气在肝和发炎观察了细微类脂化合物累积。Genomic 基因表达式分析证明 80-nm Pd nanosheets 与更细胞的部件交往了并且在肝影响了更生物的进程,作为与 5-nm Pd nanosheets 相比。我们相信这个工作将作为 nanomedicines 提供珍贵信息和卓见进 2D Pd nanosheets 的临床的申请。 | Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng | 2017 | Nano Research2017，10，4： | 5 |
| 12 | Development of highly glyphosate-tolerant tobacco by coexpression of glyphosate acetyltransferase gat and EPSPS G2-aroA genes显示文摘The widely used herbicide glyphosate targets 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS).Glyphosate acetyltransferase(GAT)effectively detoxifies glyphosate by N-acetylation.With the aim of identifying a new strategy for development of glyphosate-tolerant crops,the plant expression vector pG2-GAT harboring gat and G2-aroA(encoding EPSPS)has been transformed into tobacco(Nicotiana tabacum)to develop novel plants with higher tolerance to glyphosate.Results from Southern and Western blotting analyses indicated that the target genes were integrated into tobacco chromosomes and expressed effectively at the protein level.Glyphosate tolerance was compared among transgenic tobacco plants containing gat,G2-aroA,or both genes.Plants containing both gat and G2-aroA genes were the most glyphosate-tolerant.This study has shown that a combination of different strategies may result in higher tolerance in transgenic crops,providing a new approach for development of glyphosate-tolerant crops. | Baoqing Dun Xujing Wang Wei Lu Ming Chen Wei Zhang Shuzhen Ping Zhixing Wang Baoming Zhang Min Lin | 2014 | The Crop Journal2014，2，Z1： | 4 |
| 13 | Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma显示文摘The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma(HCC) after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1(HMGB1) expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence(85.5% vs. 62.4%, P<0.001). We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients(P<0.001). Notably, expression of HMGB1 was positively correlated with OV6 in density(R2=0.032, P<0.001) and reversely related to HCC outcomes. Abnormal expression of HMGB1 in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone(area under curve(AUC) survival=0.696). Therefore, HMGB1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC. | Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 14 | Marine hydrographic spatial-variability and its cause at the northern margin of the Amery Ice Shelf显示文摘Conductivity,temperature and depth(CTD) data collected along a zonal hydrographic section from the northern margin of the Amery Ice Shelf on 25-27 February 2008 by the 24th Chinese National Antarctic Research Expedition (CHINARE) cruise in the 2007/2008 austral summer are analyzed to study thermohaline structures.Analysis reveals warm subsurface water in a limited area around the east end of the northern margin,where the temperature,salinity and density have east-west gradients in the surface layer of the hydrographic section.The localization of the warm subsurface water and the causes of the CTD gradients in the surface layer are discussed.In addition,the results from these CTD data analyses are compared with those from the 22nd CHINARE cruise in the 2005/2006 austral summer.This comparison revealed that the thermoclines and haloclines had deepened and their strengths weakened in the 2007/2008 austral summer.The difference between the two data sets and the cause for it can be reasonably explained and attributed to the change in ocean-ice-atmosphere interactions at the northern margin of the Amery Ice Shelf. | GE RenFeng DONG ZhaoQian CHEN HongXia LIU Na SHI JiuXing PU ShuZhen | 2011 | Advances in Polar Science2011，22，2： | 3 |
| 15 | Chinese herbal medicine for chronic heart failure:a multicenter,randomized,double-blind,placebo-controlled trial显示文摘Objective:The purpose of this study was to assess the efficacy and safety of Chinese herbal medicine(CHM)in the treatment of chronic heart failure(CHF)patients according to syndrome differentiation.Methods:In this multicenter,randomized,double-blind,placebo-controlled clinical trial,a total of 220 CHF patients were assigned to receive CHM or placebo granules without decoction according to syndrome differentiation in addition to their standard western treatment for 4 weeks.The change in the left ventricular ejection fraction(LVEF)was the primary outcome,and the changes in the TCM syndrome scores(TCM-SS)and New York Heart Association functional classification(NYHA-FC)were the secondary outcomes. | Liangtao Luo Juan Wang Aiqing Han Peng Zhang Shuzhen Guo Chan Chen Xuegong Xu Qian Lin Huihui Zhao Wei Wang | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，2： | 3 |
| 16 | Magnetostratigraphy and provenance of the Qingzhou loess in Shandong province显示文摘Loess deposits with varying thickness are widely distributed on the intermontane valleys and piedmont zones on the northern side of the central Shandong mountainous regions. However, the basal ages and material resources of the loess deposits are not clear. The paper studied the Qingzhou loess profile in Shandong with magnetostratigraphic and optical stimulated luminescence (OSL) methods and further investigated its main provenances with the mineralogical methods. The magnetostratigraphic results showed that the Brunhes/Matuyama (B/M) reversal boundary was not recognized, suggesting a basal age younger than 0.78 Ma. Extrapolations by sedimentation rates, based on the upper part depositional rate from the OSL age, the basal age of the Qingzhou loess is about 0.5 Ma. Until now, older loess deposits have not been reported on the northern side of the central Shandong mountainous regions. The results of the paper indicate that the loess deposits in this area might have strated from the Middle Pleistocene. The basal age of Qingzhou loess is approximately synchronous with the Xiashu loess in the middle-lower reaches of Yangtze River. Major components of clay minerals in the Qingzhou profile are dominated by illite. Other clay mineral compositions are mainly smectite, chlorite and kaolinite, which are similar with the Xifeng loess in the Loess Plateau. However, the contents of smectite and the ratios of illite and kaolinte in the Qingzhou loess samples are higher than those in the Xifeng loess samples of the Loess Plateau, indicating that the loess in the northern side of the central Shandong mountainous regions has different sources from that of the loess deposits in the Loess Plateau. The clay mineral analysis further reinforces the earlier conclu- sion that the marine strata exposed in the Laizhou Bay and the fluvial plain of the lower reaches of Yellow River during the glacier periods are the main material sources for the Qingzhou loess deposits, which is an indicator to the local aridification of the lower reaches of the Yellow River. Loess deposition in the central Shandong mountainous regions started at around 0.5 Ma. The age of Qingzhou loess is approximately synchronous with the ongoing high-latitude cold since the Middle Pleistocene, which indicates that strengthened East Asian winter monsoon was sufficiently energetic to bring substantial quantities of material from the marine strata exposed in the Laizhou Bay and the fluvial plain of the lower reaches of the Yellow River to the central Shandong mountainous regions. The results therefore suggest that both regional geological process and global changes were responsible for the formation of Qingzhou loess since Middle Pleistocene. | ShuZhen PENG LiJun ZHU GuoQiao XIAO YanSong QIAO ZhiDong GAO DongDong CHEN | 2011 | Journal of Arid Land2011，3，3： | 3 |
| 17 | Photoluminescence Properties of Porous Silicon Based on FZ(H) Si Wafer显示文摘The photoluminescence (PL) properties of porous silicon (PS) have been studied based on n-type single- crystal (111) silicon wafers (80-90Ω .cm in the resistivity). The porous silicon layers (PSL) were created by anodizing the wafers with a denuded zone of 20-40 μm formed by neutron transmutation doping (NTD) and thermal treatment at 940℃ for 4 h and then 700℃ for 2 h, two-step heating of the floating-zone silicon (FZ Si) grown in a hydrogen (H2) ambience. By surface modification with stannic chloride or amine immersion and rapid thermal oxidation (RTO), the PL peak position from the PS can be qualitatively controlled factitiously. The as-prepared PS shows an orange-yellow luminescence, while the modified samples emit red, green and blue luminescence. Mechanisms for the different colors of the PL are discussed. Fourier transform infrared (FTIR) is carried out to analyze the differences in the structural configuration of the PS samples. | Yuejiao He, Huaixiang Li, Chenghua Guo, Guirong Liu, Yansheng Chen, Shuzhen Duan (Institute of Semiconductors, Shandong Normal University, Jinan 250014, China Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China) | 2001 | Rare Metals2001，20，1： | 2 |
| 18 | Computer Simulation of Mechanical Properties of Nano-scale Cu/FeS Composite显示文摘The mechanical properties of nano-scale Cu/FeS composite were simulated by molecular dynamics (MD) simulation in this paper. Through the analysis on the stress-strain curves, the results of MD simulation were in good agreement with mechanisms of macroscopic deformation. When the size of particles was smaller than a certain value, the relationship between yield strength and size, which was different from the large size crystals abided by the contrary Hall-Petch relationship. Based on the discussion of nano-scale Cu/FeS composite, some interesting conclusions were obtained. For example, the 'S' type curves were discovered in stress-strain curves and the anisotropy of FeS was very evident when the exposures of reinforcing phase (FeS) were different and so on. The basic theories and calculations of the composite that contains nano-scale particles were discussed. At the same time, a new modeling building method of composites, which was close to actual experiences, were considered in this paper. | Zhenjun Hong Jingchao Chen Jing Feng Yeping Du Jie Yu Lijuan Zhang Shuzhen Wu Futai Xu | 2010 | Journal of Materials Science & Technology2010，26，4： | 2 |
| 19 | IAP's Solar-Powered Unmanned Surface Vehicle Actively Passes through the Center of typhoon Sinlaku(2020)显示文摘The solar-powered marine unmanned surface vehicle(USV) developed by the USV team of the Institute of Atmospheric Physics is a rugged, long-duration, and autonomous navigation vessel designed for the collection of longrange, continuous, real-time, meteorological and oceanographic measurements, especially under extreme sea conditions(sea state 6–7). These solar-powered USVs completed a long-term continuous navigation observation test over 26 days.During this time, they coordinated double-USV observations and actively navigated into the path of Typhoon Sinlaku(2020) before collecting data very close to its center during the 2020 USV South China Sea Typhoon Observation Experiment. Detailed high temporal resolution(1 min) real-time observations collected by the USV on the typhoon were used for operational typhoon forecasting and warning for the first time. As a mobile meteorological and oceanographic observation station capable of reliable, automated deployment, data collection, and transmission, such solar-powered USVs can replace traditional observation platforms to provide valuable real-time data for research, forecasting, and early warnings for potential marine meteorological disasters. | Hongbin CHEN Jun LI Wenying HE Shuqing MA Yingzhi WEI Jidong PAN Yu ZHAO Xuefen ZHANG Shuzhen HU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 20 | Cellular localization of NLRP3 inflammasome显示文摘Infl ammasome is a large protein complex activated upon cellular stress or microbial infection,which triggers maturation of pro-inflammatory cytokines interleukin-1βand interleukin-18 through caspase-1 activation.Nod-like receptor family protein 3(NLRP3)is the most character-ized infl ammasome activated by various stimuli.However,the mechanism of its activation is unclear and its exact cellular localization is still unknown.We examined the potential co-localization of NLRP3 infl ammasome with mi-tochondria and seven other organelles under adenosine triphosphate,nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal micros-copy approach.Our results revealed that the activated endogenous apoptosis-associated speck-like protein containing a CARD(ASC)pyroptosome forms in the cyto-plasm and co-localizes with NLRP3 and caspase-1,but not with any of the organelles screened.This study indicates that the ASC pyroptosome universally localizes within the cytoplasm rather than with any specifi c organelles. | Yan Wang Chen Yang Kairui Mao Shuzhen Chen Guangxun Meng Bing Sun | 2013 | Protein & Cell2013，4，6： | 2 |
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