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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | Small bowel tumors detected and missed during capsule endoscopy: Single center experience显示文摘AIM:To characterize small bowel(SB)tumors detected by capsule endoscopy(CE),and identify missed tumors.METHODS:The study included 145 consecutive patients in whom 150 CEs were performed.Following CE,the medical records of the study population were reviewed.Results of double-or single-balloon enteroscopy performed after CE and the results of surgery in all patients operated on were retrieved.The patients were contacted through telephone interviews or postal mail.In addition,the national cancer registry and the polish clinical gastrointestinal stromal tumor(GIST)Registry were searched to identify missed neoplasms.RESULTS:Indications for CE included overt and occult obscure gastrointestinal bleeding(n=81,53.7%),anemia(n=19,12.7%),malabsorption(n=18,12%),abnormal CB follow through(n=9,6%),abdominal pain(n=7,5%),celiac disease(n=5,3%),neuroendocrine tumor(n=3,2%),Crohn’s disease(n=2,<2%),Peutz-Jeghers syndrome(n=2,<2%),other polyposes(n=2,<2%),and diarrhea(n=2,<2%).The capsule reached the colon in 115(76.6%)examinations.In 150 investigations,CE identified 15SB tumors(10%),14 of which were operated on or treated endoscopically.Malignancies included metastatic melanoma(n=1),adenocarcinoma(n=2),and GIST(n=3).Benign neoplasms included dysplastic Peutz-Jeghers polyps(n=4).Non-neoplastic masses included venous malformation(n=1),inflammatory tumors(n=2),and a mass of unknown histology(n=1).During the follow-up period,three additional SB tumors were found(2 GISTs and one mesenteric tumor of undefined nature).The National Cancer Registry and Polish Clinical GIST Registry revealed no additional SB neoplasms in the post-examination period(follow-up:range 4.2-102.5 mo,median 39 mo).The sensitivity of CE for tumor detection was 83.3%,and the negative predictive value was 97.6%.The specificity and positive predictive value were both 100%.CONCLUSION:Neoplasms may be missed by CE,especially in the proximal SB.In overt obscure gastrointestinal bleeding,complementary endoscopic and/or radiologic diagnostic tests are indicated. | Edyta S Zagorowicz Anna M Pietrzak Ewa Wronska Jacek Pachlewski Piotr Rutkowski Ewa Kraszewska Jaroslaw Regula | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 3 | Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens显示文摘 | Lisa MW Jacek S Michard MR | 2013 | Proc Natl Acad Sci USA2013，110，19： | 1 |
| 4 | Effect of chromium nitride coating on the corrosion and wear resistance of stainless steel显示文摘 | Khanna A S | 2000 | Applied Surface Science2000，156，： | 1 |
| 5 | Influence of superplasticizers on rheological behaviour of fresh cement mortars显示文摘 | Jacek G Janusz S | 2004 | Cement and Concrete Research2004，，34： | 1 |
| 6 | Serum visfatin concentration is elevated in pregnant women irrespectively of the presence of gestational diabetes显示文摘 | Jacek S Mariusz K Beata T | 2009 | Ginekol Pol2009，80，1： | 1 |
| 7 | Economics of exhaust air heat recovery systems for mine ventilation显示文摘 | Hugo D S Kostas F Jacek P | 2012 | Reclamation and Environment2012，26，3： | 1 |
| 8 | Inducible cAMP early repressor,an endogenous antagonist of cAMP responsive element-binding protein,evokes neuronal apoptosis in vitro显示文摘 | Jacek J Barbara M Amelia S | 2003 | J Neurosei2003，23，11： | 1 |
| 9 | Spine stability: The six blind men and the elephan显示文摘 | N PETER REEVES KUMPATI S NARENDRA JACEK CHOLEWICKI | 2007 | Clin Biomechanics2007，22，： | 1 |
| 10 | An experimental and theoretical study of the self-assembly of gold nanoparticles at the surface of functionalized multiwalled carbone nanotubes显示文摘 | Toby S Jacek S Donald F | 2005 | J Phys Chem B2005，109，16： | 1 |
| 11 | Polymorphism of the renalase gene in end-stage renal disease patients affected by hypertension 显示文摘 | Anna S Andrzej S Jacek F | 2011 | Nephrol Dial Transplant2011，26，5： | 1 |
| 12 | Application of particle image velocimetry (PIV) for deformation measurement during granular silo flow 显示文摘 | Cezary S Maciej N Jacek T | 2007 | Powder Technology2007，173，1： | 1 |
| 13 | Multi-criteria Group Decision Making Under Uncertainty with Application to Air Traffic Safety显示文摘 | Jacek S | 2014 | Expert Systems with Applications2014，41，16： | 1 |
| 14 | CDM based modeling of damage and fracture mechanisms in concrete under tension and compression显示文摘 | HALINA K C JACEK J S | 2004 | Engineering Fracture Mechanics2004，71，4： | 1 |
| 15 | IL-18 ac- celerates atherosclerosis accom partied by elevation of IFN-7 and CXCL1 6 expression independently of T cells 显示文摘 | CHARLOTYA T ANNA S JACEK J | 2010 | Arterioscler Thromb Vasf Biol2010，25，3： | 1 |
| 16 | Estimating Uncertainty in Analytical Procedures Based on Chromatographic Techniques 显示文摘 | Piotr K Jacek N S | 2010 | Journal of Chromatography A2010，1217，： | 1 |
| 17 | Application of Particle Image Velocimetry (PIV) for Deformation Measurement During Granular Silo Flow 显示文摘 | Cezary S Maciej N Jacek T | 2007 | Powder Technology2007，173，： | 1 |
| 18 | Sinonasal coma involving the cavernous sinus 显示文摘 | JACEK S MARTIN B MARK T S | 2005 | J Otolaryngol2005，34，4： | 1 |
| 19 | Current developments in microvolt T-wave alternans 显示文摘 | BEATA S AGATA M L JACEK K | 2006 | Indian Pacing and Elcctrophysiology Journal2006，6，4： | 1 |
| 20 | CDM based modeling of damage and fracture mechanisms in concrete under tension and compression 显示文摘 | HALINA K C JACEK J S | 2004 | Engineering Fracture Mechanics2004，71，1： | 1 |
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