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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 3 | Inverse gas chromatographic study of activated carbons: The effect of controlled oxidation on microstructure and surface chemical functionality显示文摘 | Jacek Jagiello Teresa J Bandosz James A Schwarz | 1992 | J Coll Interf Sci1992，151，2： | 1 |
| 4 | Groundwater-surface water interaction under scenarios of climate change using a high-resolution transient groundwater model显示文摘 | Jacek Scibek Diana M Allen Alex J Cannon Paul H Whitfield | 2006 | Journal of Hydrology2006，，8： | 1 |
| 5 | Heat and mass transfer during microwave-convective drying显示文摘 | Stefan J Kowalski G M Jacek B | 2010 | American Institute of Chemical Engineers2010，56，： | 1 |
| 6 | Krill for human consumption:nutritional value and potential health benefits显示文摘 | Janet C Jacek J Chen Y | | 0，，02： | 1 |
| 7 | Inducible cAMP early repressor,an endogenous antagonist of cAMP responsive element-binding protein,evokes neuronal apoptosis in vitro显示文摘 | Jacek J Barbara M Amelia S | 2003 | J Neurosei2003，23，11： | 1 |
| 8 | CDM based modeling of damage and fracture mechanisms in concrete under tension and compression显示文摘 | HALINA K C JACEK J S | 2004 | Engineering Fracture Mechanics2004，71，4： | 1 |
| 9 | IL-18 ac- celerates atherosclerosis accom partied by elevation of IFN-7 and CXCL1 6 expression independently of T cells 显示文摘 | CHARLOTYA T ANNA S JACEK J | 2010 | Arterioscler Thromb Vasf Biol2010，25，3： | 1 |
| 10 | Ligand liposomes and BNCT显示文摘 | Carlsson J Erika B K Jacek C | 2003 | Journal of Neuro-Oncology2003，62，12： | 1 |
| 11 | Krill for human consumption: Nutritional value and potential health benefits显示文摘 | Janet C T Jacek J Yi C C | 2007 | Nutrition Reviews2007，65，2： | 1 |
| 12 | Fish protein isolate: Development of functional foods with nutraceutical ingredients 显示文摘 | Reza T Kristen E M Jacek J | 2014 | Journal of Functional Foods2014，18，： | 1 |
| 13 | CDM based modeling of damage and fracture mechanisms in concrete under tension and compression 显示文摘 | HALINA K C JACEK J S | 2004 | Engineering Fracture Mechanics2004，71，1： | 1 |
| 14 | Gas sorption properties of microporous metal organic frameworks显示文摘 | Lee J Y Li J Jacek J | 2005 | Solid State Chemistry2005，178，： | 1 |
| 15 | The effect of anabolic steroids and corticosteroids on healing of muscle contusion injury显示文摘 | John MB Peter J Jacek C | 1999 | Am J Sports Med1999，27，1： | 1 |
| 16 | Characterization of the cysJIH regions of Salmonella typhimurium and Escherichia coli B 显示文摘 | Jacek O Wu J Y David C R | 1989 | J Bio Chem1989，264，15： | 1 |
| 17 | A modified genetic algorithm for optimal control problems显示文摘 | CEZARY Z J JACEK B K | 1992 | Computers Math Applic1992，23，2： | 1 |
| 18 | Stock index futures arbitrage in emerging markets: Polish evidence显示文摘 | J?drzej Bia?kowski Jacek Jakubowski | 2006 | International Review of Financial Analysis2006，，2： | 1 |
| 19 | Shape optimization of coils andcooling ducts in dry-type transformers using computationfluid dynamics and genetic algorithm显示文摘 | JACEK S ANDRZEJ J N | 2011 | IEEE Transactionson Magnetics2011，47，6： | 1 |
| 20 | The diversity of soil mites(Acari:Mesostigmata)in yellow ant(Lasius flavus)nests along a gradient of land use显示文摘 | Jacek K Dariusz J G | 2013 | Biologia2013，68，： | 1 |
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