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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Effects of leflunomide on glomerulonephritis induced by antibasement membrane antibody in rats显示文摘 | Ogawa T Inazu M Gotoh K | | 0，，： | 1 |
| 3 | Hypolipidemic effect ofPleurotus eryngii extract in fat-loaded mice 显示文摘 | MIZUTANI T INATOMI S INAZU A | 2010 | J Nutr Sci Vitaminol2010，56，1： | 1 |
| 4 | Development of high efficiency 255- 355 nm A1GaN-based light-emitting diodes 显示文摘 | Pernot C Fukahori S Inazu T | 2011 | Phys Status Solidi A2011，208，： | 1 |
| 5 | Chemo-enzymatic synthesis of the glycosylated α-mating factor of Saccharomyces cerevisiae and analysis of its biological activity显示文摘 | Saskiawan I Mizuno M Inazu T | 2002 | Arch Biochem Biophys2002，406，： | 1 |
| 6 | Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol显示文摘 | Inazu A Jiang XC Haraki T | 1994 | J Clin Invest1994，94，5： | 1 |
| 7 | A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels,including those with plasma cholesteryl ester transfer protein deficiency显示文摘 | Moriyama Y Okamura T Inazu A | 1998 | Prev Med1998，27，51： | 1 |
| 8 | Functional expression of the norepinephrine transporter in cultured rat astrocytes显示文摘 | Inazu M Takeda H Matsumiya T | 2003 | J Neurochem2003，84，： | 1 |
| 9 | Dichlorodifluoromethane decomposition to CO2 with simultaneous halogen fixation by calcium oxide based materials 显示文摘 | Tamai T Inazu K Aika K | 2006 | Environ Sci Technol2006，40，4： | 1 |
| 10 | Effect of air velocity on fresh Japanese noodle (udon) drying 显示文摘 | Inazu T Iwasaki K Furuta T | 2003 | Lebensmittel-Wissenschaft und Technologie2003，36，2： | 1 |
| 11 | Electronic and structural promotion of barium hexaaluminate as a ruthenium catalyst support for ammonia synthesis 显示文摘 | You Z X Inazu K Baba T | 2007 | Journal of Catalysis2007，251，： | 1 |
| 12 | Characteristics of methoxycarbonylation of aromatic diamine with dimethyl carbonate to dicarbamate using a zinc acetate catalyst 显示文摘 | Baba T Kobayashi A Kawanami Y Inazu K Ishikawa A Echizerm T Murai K Aso S Inomata M | 2005 | Green Chemistry2005，7，3： | 1 |
| 13 | NMR spectroscopicdetection of interactions between a HIV protein sequence and a highlyanti-HIV active curdlan sulfate显示文摘 | JEON K J KATSURAYA K INAZU T | 2000 | Journal of the American ChemicalSociety2000，122，12： | 1 |
| 14 | Long-term treatment with Pitavastatin (NK-104),a new HMG-CoA reductase inhibitor,of patients with heterozygous familial hypercholesterolemia显示文摘 | Noji Y Higashikata T Inazu A | 2002 | Atherosclerosis2002，163，1： | 1 |
| 15 | Long- term treatment with pitavastatin( NK- 104), a new HMG- CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia显示文摘 | Noji Y Higashikata T Inazu A | 2002 | Atherosclerosis2002，163，1： | 1 |
| 16 | Effect of temperature andrelative humidity on drying kinetics of fresh Japanese noodle ( ud-on) 显示文摘 | INAZU T IWASAKI K FURUTA T | 2002 | LWT-Food Science and Technology2002，35，8： | 1 |
| 17 | Rapid detection and prevalence of cholesteryl ester transfer protein deficiency caused by an intron 14 splicing defect in hyperalphalipoproteinemia 显示文摘 | Inazu A Koizumi J Haraki T | 1993 | Hum Genet1993，91，： | 1 |
| 18 | Amphiregulin is a potent mitogen for the vascular smooth muscle cell line,A7r5显示文摘 | Kato M Inazu T Kawai Y | 2003 | Biochem Biophys Res Commun2003，301，4： | 1 |
| 19 | Angew Chem Int Ed Engl显示文摘 | Miyahara Y Abe K Inazu T | 2002 | 41:3 0202002，41，： | 1 |
| 20 | Molecular and functional characterization of an Na + -independent choline transporter in rat astrocytes 显示文摘 | INAZU M TAKEDA H MATSUMIYA T | 2005 | J Neurochem2005，94，5： | 1 |
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