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| 1 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 2 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 5 |
| 3 | Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer显示文摘 | Yoshito Komatsu Takayuki Yoshino Kentaro Yamazaki Satoshi Yuki Nozomu Machida Takahide Sasaki Ichinosuke Hyodo Yutaka Yachi Hiroshi Onuma Atsushi Ohtsu | 2014 | Investigational New Drugs2014，，3： | 2 |
| 4 | Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C)显示文摘 | Shinji Endo Shoji Hirasaki Toshihiko Doi Hisashi Endo Tomohiro Nishina Toshikazu Moriwaki Masahito Nakauchi Toshikazu Masumoto Masahito Tanimizu Ichinosuke Hyodo | 2003 | Journal of Gastroenterology2003，，4： | 1 |
| 5 | Circulating vascular endothelial growth factor (VEGF) is a possible tumor marker for metastasis in human hepatocellular carcinoma显示文摘 | Kenji Jin-no Masahito Tanimizu Ichinosuke Hyodo Yoshiyuki Nishikawa Yasushi Hosokawa Toshihiko Doi Hisashi Endo Tetsuji Yamashita Yoshio Okada | 1998 | Journal of Gastroenterology1998，，3： | 1 |
| 6 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 1 |
| 7 | Circulating vascular endothelial growth factor (VEGF) is a possible tumor marker for metastasis in human hepatocellular carcinoma显示文摘 | Kenji Jin-no Masahito Tanimizu Ichinosuke Hyodo Yoshiyuki Nishikawa Yasushi Hosokawa Toshihiko Doi Hisashi Endo Tetsuji Yamashita Yoshio Okada | 1998 | Journal of Gastroenterology1998，，3： | 1 |
| 8 | Genotype‐directed, dose‐finding study of irinotecan in cancer patients with UGT1A1*28 and/or UGT1A1*6 polymorphisms显示文摘 | Taroh Satoh Takashi Ura Yasuhide Yamada Kentaro Yamazaki Toshimasa Tsujinaka Masaki Munakata Tomohiro Nishina Shu Okamura Taito Esaki Yasutsuna Sasaki Wasaburo Koizumi Yoshihiro Kakeji Naoki Ishizuka Ichinosuke Hyodo Yuh Sakata | 2011 | Cancer Science2011，，10： | 1 |
| 9 | Plasma level of basic fibroblast growth factor increases with progression of chronic liver disease显示文摘 | Kenji Jim-No Masahito Tanimizu Ichinosuke Hyodo Fumihiko Kurimoto Tetuji Yamashita | 1997 | Journal of Gastroenterology1997，，1： | 1 |
| 10 | Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C)显示文摘 | Shinji Endo Shoji Hirasaki Toshihiko Doi Hisashi Endo Tomohiro Nishina Toshikazu Moriwaki Masahito Nakauchi Toshikazu Masumoto Masahito Tanimizu Ichinosuke Hyodo | 2003 | Journal of Gastroenterology2003，，4： | 1 |
| 11 | Circulating vascular endothelial growth factor (VEGF) is a possible tumor marker for metastasis in human hepatocellular carcinoma显示文摘 | Kenji Jin-no Masahito Tanimizu Ichinosuke Hyodo Yoshiyuki Nishikawa Yasushi Hosokawa Toshihiko Doi Hisashi Endo Tetsuji Yamashita Yoshio Okada | 1998 | Journal of Gastroenterology1998，，3： | 1 |
| 12 | Plasma level of basic fibroblast growth factor increases with progression of chronic liver disease显示文摘 | Kenji Jim-No Masahito Tanimizu Ichinosuke Hyodo Fumihiko Kurimoto Tetuji Yamashita | 1997 | Journal of Gastroenterology1997，，1： | 1 |
| 13 | Multiple synchronous early gastric carcinoma with seven lesions显示文摘 | Shoji Hirasaki Toshikazu Moriwaki Ichinosuke Hyodo | 2003 | Journal of Gastroenterology2003，，12： | 1 |
| 14 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 1 |
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