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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 2 |
| 4 | Repair of giant paraesophageal hernias routinely produces improvement in respiratory function显示文摘 | Carrott PW Hong Jean Kuppusamy MK | 2012 | Thorac Cardiovasc Surg2012，143，2： | 1 |
| 5 | Energetic quaternary salts containing Bi ( 1, 2, 4-triazoles) 显示文摘 | Xue Hong Twamley Brendan Shreeve Jean' neM | 2005 | Inorganic Chemistry2005，44，20： | 1 |
| 6 | Analyses of gibberellins by capillary electrophoresis–mass spectrometry combined with solid-phase extraction显示文摘 | Liya Ge Clare Yunn Chyn Peh Jean Wan Hong Yong Swee Ngin Tan Lin Hua Eng Shi Ong | 2007 | Journal of Chromatography A2007，，1： | 1 |
| 7 | Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodiaelata Blume by pressurized hot water extraction and microwave-assisted extraction显示文摘 | Chin Chye Teo Swee Ngin Tan Jean Wan Hong Yong | 2008 | Journal of chromatography2008，9，： | 1 |
| 8 | Complex toxic effects of Cd2 +, Zn2 +, and acid rain on growth of kidney bean ( Phaseolus vulgaris L) 显示文摘 | Bo -han Liao Hong - yu Liu Qing - ru Zeng Ping - zhong Yu Anne Probst Jean - Luc Probst | 2005 | Environment International2005，31，： | 1 |
| 9 | Estradiol, Progesterone and Testosterone Exposures Affect the Atrial Natriuretic Peptide Gene Expression in vivo in Rats显示文摘 | Min HONG Qiu YAN Bao TAO Arnold BOERSMA Kia-Ki HAN Marie-Christine VANTYGHEM André RACADOT Jean LEFEBVRE | 2009 | Biological Chemistry Hoppe-Seyler2009，，1： | 1 |
| 10 | Ionic liquids with fluorinecontainingcations显示文摘 | HONG X JEAN' NE M SHREEVE | 2005 | European Journal of Inorganic Chemistry2005，，44： | 1 |
| 11 | Energetic quaternary salts containing Bi(1,2,4-triazoles)显示文摘 | Xue Hong Twamley Brendan Shreeve Jean′ne M | 2005 | Inorganic Chemistry2005，44，20： | 1 |
| 12 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 1 |
| 13 | Evaluation of the Extraction Efficiency of Thermally Labile Bioactive Compounds in Gastrodia Elata Blume by Pressurized Hot Water Extraction and Microwave-assisted Extraction显示文摘 | Chin Chye Teo Swee Ngin Tan Jean Wan Hong Yong | 2008 | J Chromatogr A2008，，1： | 1 |
| 14 | Dietary lutein stimulates immune response in the canine显示文摘 | Hong Wook Kim Boon P Chew Teri S Wong Jean Soon Park Brian B.C Weng Katherine M Byrne Michael G Hayek Gregory A Reinhart | 2000 | Veterinary Immunology and Immunopathology2000，，3： | 1 |
| 15 | Energetic quaternary salts containing bi(1,2,4-triazoles)显示文摘 | Xue Hong Twamley Brendan Shreeve Jean ne M | 2005 | Inorg Chem2005，44，20： | 1 |
| 16 | Review of ion- ic liquids with fluorine-containing anions显示文摘 | Hong Xue Rajendar Verma Jean' ne M Shreeve | 2006 | Jounmal of Chem- istry2006，127，： | 1 |
| 17 | Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response显示文摘RIPK1 is a master regulator of multiple cell death pathways,including apoptosis and necroptosis,and inflammation.Importantly,activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis,in animal models of amyotrophic lateral sclerosis(ALS)and Alzheimer's disease(AD),and in human ALS and AD.Rare human genetic carriers of non-cleavable RIPK1 variants(D324V and D324H)exhibit distinct symptoms of recurrent fevers and increased transcription of proinflammatory cytokines.Multiple RIPK1 inhibitors have been advanced into human clinical trials as new therapeutics for human inflammatory and neurodegenerative diseases,such as ALS and AD.However,it is unclear whether and how RIPK1 kinase activity directly mediates inflammation independent of cell death as the nuclear function of RIPK1 has not yet been explored.Here we show that nuclear RIPK1 is physically associated with the BAF complex.Upon RIPK1 activation,the RIPK1/BAF complex is recruited by specific transcription factors to active enhancers and promoters marked by H3K4me1 and H3K27ac.Activated nuclear RIPK1 mediates the phosphorylation of SMARCC2,a key component of the BAF complex,to promote chromatin remodeling and the transcription of specific proinflammatory genes.Increased nuclear RIPK1 activation and RIPK1/BAF-mediated chromati n-remodeling activity were found in cells expressi ng non-cleavable RIPK1,and in creased enrichment of activated RIPK1 on active enhancers and promoters was found in an animal model and human pathological samples of ALS.Our results suggest that RIPK1 kinase serves as a transcriptional coregulator in nucleus that can transmit extracellular stimuli to the BAF complex to modulate chromatin accessibility and directly regulate the transcription of specific genes involved in mediating inflammatory resp onses. | Wanjin Li Bing Shan Chengyu Zou Huibing Wang Meng-Meng Zhang Hong Zhu Masanori Gomi Naito Daichao Xu Vica Jean Manuel Lauren Mifflin Zhaodong Hou John Ravits Junying Yuan | 2022 | Cell Research2022，32，7： | 1 |
| 18 | Patients with Chronic Visceral Pain Show Sex-Related Alterations in Intrinsic Oscillations of the Resting Brain显示文摘 | Jui-Yang Hong Lisa A. Kilpatrick Jennifer Labus Arpana Gupta Zhiguo Jiang Cody Ashe-McNalley Jean Stains Nuwanthi Heendeniya Bahar Ebrat Suzanne Smith Kirsten Tillisch Bruce Naliboff Emeran A. Mayer | 2013 | Journal of Neuroscience2013，，29： | 1 |
| 19 | Free-volume hole properties of gas-exposed polycarbonate studied by positron annihilation lifetime spectroscopy显示文摘 | Jean Y C Yang H | 1996 | Macromolecules1996，29，24： | 1 |
| 20 | Endothelin- 1 enhances the prolif- eration of normal human melanoeytes in a paradoxical manner from the TNF-x-inhibited condition, but taerolimus promotes exclusively the cellular migration without proliferation : aproposed action mechanism for combination therapy of phototherapy and topical tacrolimusin vitiligo treatment 显示文摘 | Lee KY Jean SY Hong JW | 2013 | J Eur Acad Dermatol Venereol2013，27，5： | 1 |
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