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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | 纳米晶铁钴基软磁材料的研究显示文摘铁钴基纳米晶软磁性材料具有高居里温度的非晶纳米晶两相结构,通过两相结构的匹配完成纳米晶粒间的磁矩交换耦合,使得材料在高温环境下具备优异的软磁性能。通过采用 VSM、TEM、XRD 等技术对材料软磁性能、组织结构以及软磁性能的热稳定性的研究与分析,优化了 FeCoHfBCu 合金成分。试验表明(Fe0.6Co0.4)86Hf7B6Cu1合金在500~600 ℃的工作温度区间范围内具备最佳的饱和磁化强度和较低矫顽力,并且 550 ℃条件下具有优异的软磁性能热稳定性。该材料是高温软磁应用领域的重要候选材料。 | Tadeusz Kulik(波) 梁秀兵 Jaro■saw Ferenc(波) 徐滨士 | 2004 | 中国表面工程2004，17，5： | 10 |
| 4 | Prediction on grinding force during grinding powder metallurgy nickel-based superalloy FGH96 with electroplated CBN abrasive wheel显示文摘In this article,a grinding force model,which is on the basis of cutting process of single abrasive grains combined with the method of theoretical derivation and empirical formula by analyzing the formation mechanism of grinding force,was established.Three key factors have been taken into accounts in this model,such as the contact friction force between abrasive grains and materials,the plastic deformation of material in the process of abrasive plowing,and the shear strain effect of material during the process of cutting chips formation.The model was finally validated by the orthogonal grinding experiment of powder metallurgy nickel-based superalloy FGH96 by using the electroplated CBN abrasive wheel.Grinding force values of prediction and experiment were in good consistency.The errors of tangential grinding force and normal grinding force were 9.8%and 13.6%,respectively.The contributions of sliding force,plowing force and chip formation force were also analyzed.In addition,the tangential forces of sliding,plowing and chip formation are 14%,19%and 11%of the normal forces on average,respectively.The pro-posed grinding forcemodel is not only in favor of optimizing the grinding parameters and improving grinding efficiency,but also contributes to study some other grinding subjects(e.g.abrasive wheel wear,grinding heat,residual stress). | Benkai LI Chenwei DAI Wenfeng DING Changyong YANG Changhe LI Olga KULIK Vyacheslav SHUMYACHER | 2021 | Chinese Journal of Aeronautics2021，34，8： | 10 |
| 5 | Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production显示文摘The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action,high potency and reduced toxicity compared to today's standard drugs.However,production of brasilicardin has been hampered since the producer strain Nocardia terpenica IFM0406 synthesizes brasilicardin in only low amounts and is a biosafety level 2 organism.Previously,we were able to heterologously express the brasilicardin gene cluster in the nocardioform actinomycete Amycolatopsis japonicum.Four brasilicardin congeners,intermediates of the BraA biosynthesis,were produced.Since chemical synthesis of the brasilicardin core structure has remained elusive we intended to produce high amounts of the brasilicardin backbone for semi synthesis and derivatization.Therefore,we used a metabolic engineering approach to increase heterologous production of brasilicardin in A.japonicum.Simultaneous heterologous expression of genes encoding the MVA pathway and expression of diterpenoid specific prenyltransferases were used to increase the provision of the isoprenoid precursor isopentenyl diphosphate(IPP)and to channel the precursor into the direction of diterpenoid biosynthesis.Both approaches contributed to an elevated heterologous production of the brasilicardin backbone,which can now be used as a starting point for semi synthesis of new brasilicardin congeners with better properties. | Paul N.Schwarz Luisa Roller Andreas Kulik Wolfgang Wohlleben Evi Stegmann | 2018 | Synthetic and Systems Biotechnology2018，3，1： | 3 |
| 6 | Isolation and characterization of bioactive fungi from shark Carcharodon carcharias' gill with biopharmaceutical prospects显示文摘Until recently,little was known about the fungi found in shark gills and their biomedicinal potential. In this article,we described the isolation,bioactivity,diversity,and secondary metabolites of bioactive fungi from the gill of a shark(Carcharodon carcharias). A total of 115 isolates were obtained and grown in 12 culture media. Fifty-eight of these isolates demonstrated significant activity in four antimicrobial,pesticidal,and cytotoxic bioassay models. Four randomly selected bioactive isolates inhibited human cancer cell proliferation during re-screening. These active isolates were segregated into 6 genera using the internal transcribed spacer-large subunit(ITS-LSU) rDNA-sequence BLAST comparison. Four genera,Penicillium,Aspergillus,Mucor,and Chaetomium were the dominant taxa. A phylogenic tree illustrated their intergenera and intragenera genetic diversity. HPLC-DAD-HRMS analysis and subsequent database searching revealed that nine representative strains produced diverse bioactive compound profiles. These results detail the broad range of bioactive fungi found in a shark's gills,revealing their biopharmaceutical potential. To the best of our knowledge,this is the first study characterizing shark gill fungi and their bioactivity. | 张翼 韩金媛 冯妍 穆军 鲍海燕 Andreas KULIK Stephanie GROND | 2016 | Chinese Journal of Oceanology and Limnology2016，34，1： | 2 |
| 7 | Increased Quality of Life Among Hepatocellular Carcinoma Patients Treated with Radioembolization, Compared with Chemoembolization显示文摘 | Riad Salem Margaret Gilbertsen Zeeshan Butt Khairuddin Memon Michael Vouche Ryan Hickey Talia Baker Michael M. Abecassis Rohi Atassi Ahsun Riaz David Cella James L. Burns Daniel Ganger Al B. Benson Mary F. Mulcahy Laura Kulik Robert Lewandowski | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 8 | A randomized controlled trial of pretransplant antiviral therapy to prevent recurrence of hepatitis C after liver transplantation显示文摘 | Gregory T. Everson Norah A. Terrault Anna S. Lok Del R. Rodrigo Robert S. Brown Sammy Saab Mitchell L. Shiffman Abdullah M.S. Al‐Osaimi Laura M. Kulik Brenda W. Gillespie James E. Everhart | 2013 | Hepatology2013，，5： | 2 |
| 9 | Treatment of Unresectable Primary and Metastatic Liver Cancer with Yttrium-90 Microspheres (TheraSphere?): Assessment of Hepatic Arterial Embolization显示文摘 | Kent Sato Robert J. Lewandowski James T. Bui Reed Omary Russell D. Hunter Laura Kulik Mary Mulcahy David Liu Howard Chrisman Scott Resnick Albert A. Nemcek Robert Vogelzang Riad Salem | 2006 | CardioVascular and Interventional Radiology2006，，4： | 2 |
| 10 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 2 |
| 11 | Radiation Lobectomy: time-dependent analysis of future liver remnant volume in unresectable liver cancer as a bridge to resection显示文摘 | Michael Vouche Robert J. Lewandowski Rohi Atassi Khairuddin Memon Vanessa L. Gates Robert K. Ryu Ron C. Gaba Mary F. Mulcahy Talia Baker Kent Sato Ryan Hickey Daniel Ganger Ahsun Riaz Jonathan Fryer Juan Carlos Caicedo Michael Abecassis Laura Kulik Riad S | 2013 | Journal of Hepatology2013，，： | 2 |
| 12 | Fibrosis, Portal Hypertension, and Hepatic Volume Changes Induced by Intra-arterial Radiotherapy with 90 Yttrium Microspheres显示文摘 | T. F. Jakobs S. Saleem B. Atassi E. Reda R. J. Lewandowski V. Yaghmai F. Miller R. K. Ryu S. Ibrahim K. T. Sato L. M. Kulik M. F. Mulcahy R. Omary R. Murthy M. F. Reiser R. Salem | 2008 | Digestive Diseases and Sciences2008，，9： | 2 |
| 13 | Outcomes of Living and Deceased Donor Liver Transplant Recipients With Hepatocellular Carcinoma: Results of the A2ALL Cohort<sup>?</sup>显示文摘 | L. M. Kulik R. A. Fisher D. R. Rodrigo R. S. Brown Jr. C. E. Freise A. Shaked J. E. Everhart G. T. Everson J. C. Hong P. H. Hayashi C. L. Berg A. S. F. Lok | 2012 | American Journal of Transplantation2012，，11： | 2 |
| 14 | Mapping of liver-enriched transcription factors in the human intestine显示文摘AIM: To investigate the gene expression pattern of hepatocyte nuclear factor 6 (HNF6) and other liverenriched transcription factors in various segments of the human intestine to better understand the differentiation of the gut epithelium. METHODS: Samples of healthy duodenum and jejunum were obtained from patients with pancreatic cancer whereas ileum and colon was obtained from patients undergoing right or left hemicolectomy or (recto)sigmoid or rectal resection. All surgical specimens were subjected to histopathology. Excised tissue was shock-frozen and analyzed for gene expression of liver-enriched transcription factors by semiquantitative reverse transcription polymerase chain and compared to the human colon carcinoma cell line Caco-2. Protein expression of major liver-enriched transcription factors was determined by Western blotting while the DNA binding of HNF6 was investigated by electromobility shift assays. RESULTS: The gene expression patterning of liverenriched transcription factors differed in the various segments of the human intestine with HNF6 gene expression being most abundant in the duodenum (P < 0.05) whereas expression of the zinc finger protein GATA4 and of the HNF6 target gene ALDH3A1 was most abundant in the jejunum (P < 0.05). Likewise, expression of FOXA2 and the splice variants 2 and 4 of HNF4α were most abundantly expressed in the jejunum (P < 0.05). Essentially, expression of transcription factors declined from the duodenum towards the colon with the most abundant expression in the jejunum and less in the ileum. The expression of HNF6 and of genes targeted by this factor, i.e. neurogenin 3 (NGN3) was most abundant in the jejunum followed by the ileum and the colon while DNA binding activity of HNF4α and of NGN3 was conf irmed by electromobility shift assays to an optimized probe. Furthermore, Western blotting provided evidence of the expression of several liver-enriched transcription factors in cultures of colon epithelial cells, albeit at different levels. CONCLUSION: We describe significant local and segmental differences in the expression of liver-enriched transcription factors in the human intestine which impact epithelial cell biology of the gut. | Frank Lehner Ulf Kulik Juergen Klempnauer Juergen Borlak | 2010 | World Journal of Gastroenterology2010，16，31： | 2 |
| 15 | Improved use of the 13C-octanoic acid breath test as intra-individual parameter to study the effect of a prokinetic drug on gastric emptying in preterm infants with oral feeding intolerance显示文摘 | Kulik W van Weissenbruch MM Menelik N | 2001 | J Chromatogr B Biomed Sci Appl2001，750，1： | 1 |
| 16 | Degradation of polycyclic aromatic hydrocarbons by combined chemical preoxidation and bioremediation in creosote contaminated soil显示文摘 | KULIK N GOI A TRAPIDO M TUHKANEN T | 2005 | Journal of Environmental Management2005，，： | 1 |
| 17 | Negotiation-based protocols for disseminating information in wireless sensor networks 显示文摘 | Heinzelman W Kulik J Balakrishnan H | 2002 | Wireless Networks2002，8，： | 1 |
| 18 | Degradation of polycy- clie aromatic hydrocarbons by combined chemical pre - oxidation and bioremediation in creosote contaminated soil 显示文摘 | Kulik N Goi A Trapido M | 2006 | Environmental Management2006，78，4： | 1 |
| 19 | Solid state reactions in Ni-A1-Ti-C system by mechanical alloying显示文摘 | KRVOROUTCHIO K KULIK T MATYJA H | 2000 | Journal of Alloys and Compounds2000，308，： | 1 |
| 20 | Negotiationbased protocols for disseminating information in wireless sensor networks 显示文摘 | KULIK J HEINZELMAN W R BALAKRISHNAN H | 2002 | ACM Wireless Networks2002，8，23： | 1 |
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