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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi 显示文摘 | Henke JM Bassler BL | 2004 | J Bacteriol2004，186，20： | 1 |
| 3 | Rapid chemotherapyinduced acute endothelial progenitor cell mobilization:implications for antiangiogenic drugs as chemosensitizing agents显示文摘 | Shaked Y Henke E Roodhart JM | | 0，，03： | 1 |
| 4 | Reassessments of ESAs for cancer treatment in the US and Europe显示文摘 | Bennett CL McKoy JM Henke M | 2010 | Oncology (Williston Park)2010，24，3： | 1 |
| 5 | Rapid chemotherapy-induced acute endothelial progenitor cell mobilization:implications for antiangiogenic drugs as chemosensitizing agents显示文摘 | Shaked Y Henke E Roodhart JM | | 0，，03： | 1 |
| 6 | Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents 显示文摘 | Shaked Y Henke E Roodhart JM | 2008 | Cancer Cell2008，14，3： | 1 |
| 7 | Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial显示文摘 | Corine M Koopmans Denise Bijlenga Henk Groen Sylvia MC Vijgen Jan G Aarnoudse Dick J Bekedam Paul P van den Berg Karin de Boer Jan M Burggraaff Kitty WM Bloemenkamp Addy P Drogtrop Arie Franx Christianne JM de Groot Anjoke JM Huisjes Anneke Kwee Aren J va | 2009 | The Lancet2009，，9694： | 1 |
| 8 | Ocular morbidity after radiotherapy of orbital and eonjunctival lymphoma 显示文摘 | Bessell EM Henk JM Whitelocke RAF | 1987 | Eye1987，1，1： | 1 |
| 9 | Bacterial social engagements显示文摘 | Henke JM Bassler BL | 2004 | Trends Cell Biol2004，14，11： | 1 |
| 10 | The effect of midterm peer feedback on student functioning in problem -based tutorials 显示文摘 | Raehelle JA Karnp Diana I-IJM Dolmans Henk JM | 2013 | Adv in Health Sci Educ2013，18，3： | 1 |
| 11 | Quorum sensing regulates type III secretion in Vbrio harveyi and Vibrio parahaemolyticus显示文摘 | Henke JM Bassler BL | 2004 | J Bacteriol2004，186，12： | 1 |
| 12 | Quorum sensing regulates typeⅢsecretionin Vibrioharveyi and Vibrio parabaemolyticus显示文摘 | Henke JM Bassler BL | 2004 | J Bacteriol2004，186，： | 1 |
| 13 | Definitive radiothera-py for extramedullary plasmacytomas of the head and neck显示文摘 | Michalaki VJ Hall J Henk JM | 2003 | Br J Radio2003，76，910： | 1 |
| 14 | Mechanical bowel preparation for elective colorectal surgery: a multicentre randomised trial显示文摘 | Caroline ME Contant Wim CJ Hop Hans Pieter van ’t Sant Henk JM Oostvogel Harm J Smeets Laurents PS Stassen Peter A Neijenhuis Floris J Idenburg Cees M Dijkhuis Piet Heres Willem F van Tets Jos JGM Gerritsen Wibo F Weidema | 2007 | The Lancet . 2007 (9605)2007，，9605： | 1 |
| 15 | Treatment of head and neck cancer with CHART and nimorazole: phase Ⅱ study显示文摘 | Henk JM Bishop K Shepherd SF | 2003 | Radiother Oncol2003，66，1： | 1 |
| 16 | Bacterial social engagements显示文摘 | Henke JM and Bassler BL | 2004 | TRENDS in Cell Biology2004，14，： | 1 |
| 17 | Treatment of head and neck cancer with CHART and nimorazole:phase 11 study 显示文摘 | Henk JM Bishop K Shepherd SF | 2003 | Radiother Oncol2003，66，1： | 1 |
| 18 | Definitive radiotherapy for extramedullary plasmacytomas of the head and neck显示文摘 | Michalaki VJ Hall J Henk JM | 2003 | Br J Radio2003，76，910： | 1 |
| 19 | Glutamine-enriched enteral nutrition decrease infections complications in trauma patients显示文摘 | Boelens PG Houdijk AP Henk JM | 2002 | Am J Clin Nutr2002，76，1： | 1 |
| 20 | Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi显示文摘 | Henke JM Bassler BL | 2004 | Journal of Bacteriology2004，186，20： | 1 |
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