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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | A Regional Ocean Reanalysis System for Coastal Waters of China and Adjacent Seas显示文摘A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China ocean reanalysis).The regional ocean model used is based on the Princeton Ocean Model with a generalized coordinate system(POMgcs).The model is parallelized by NMDIS with the addition of the wave breaking and tidal mixing processes into model parameterizations.Data assimilation is a sequential three-dimensional variational(3D-Var) scheme implemented within a multigrid framework.Observations include satellite remote sensing sea surface temperature(SST),altimetry sea level anomaly(SLA),and temperature/salinity profiles.The reanalysis fields of sea surface height,temperature,salinity,and currents begin with January 1986 and are currently updated every year. Error statistics and error distributions of temperature,salinity and currents are presented as a primary evaluation of the reanalysis fields using sea level data from tidal gauges,temperature profiles,as well as the trajectories of Argo floats.Some case studies offer the opportunity to verify the evolution of certain local circulations.These evaluations show that the reanalysis data produced provide a good representation of the ocean processes and phenomena in the coastal waters of China and adjacent seas. | Guijun Han Wei Li Xuefeng Zhang Dong Li Zhongjie He Xidong Wang Xinrong Wu Ting Yu Jirui Ma | 2011 | Advances in Atmospheric Sciences2011，28，3： | 27 |
| 4 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 5 | A general end-to-end diagnosis framework for manufacturing systems显示文摘The manufacturing sector is envisioned to be heavily influenced by artificial-intelligence-based technologies with the extraordinary increases in computational power and data volumes. A central challenge in the manufacturing sector lies in the requirement of a general framework to ensure satisfied diagnosis and monitoring performances in different manufacturing applications. Here, we propose a general data-driven,end-to-end framework for the monitoring of manufacturing systems. This framework, derived from deep-learning techniques, evaluates fused sensory measurements to detect and even predict faults and wearing conditions. This work exploits the predictive power of deep learning to automatically extract hidden degradation features from noisy, time-course data. We have experimented the proposed framework on 10 representative data sets drawn from a wide variety of manufacturing applications. Results reveal that the framework performs well in examined benchmark applications and can be applied in diverse contexts,indicating its potential use as a critical cornerstone in smart manufacturing. | Ye Yuan Guijun Ma Cheng Cheng Beitong Zhou Huan Zhao Hai-Tao Zhang Han Ding | 2020 | National Science Review2020，7，2： | 18 |
| 6 | Weak minimum aberration and maximum number of clear two-factor interactions in 2_(IV)^(m-p)designs显示文摘 | YANG Guijun,LIU Minqian & ZHANG Runchu Department of Statistics, Tianjin University of Finance and Economics, Tianjin 300222, China Department of Statistics, School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300071, China | 2005 | Science China Mathematics2005，48，11： | 12 |
| 7 | K-quasi-additive fuzzy integrals of set-valued mappings显示文摘我们首先由介绍引入的操作符定义伪增加和伪增加操作,然后,在 K 伪添加剂模糊措施空格,我们建立 K-quasi-additive 模糊积分一通常可测量的珍视集合的印射。使用不可分的转变定理,关于这种珍视集合的印射的 K-quasi-additive 模糊积分的一些基本性质被学习。最后,这种模糊积分的概括单调集中定理被获得。 | WANG Guijun LI Xiaoping | 2006 | Progress in Natural Science:Materials International2006，16，2： | 10 |
| 8 | The Effects of Biochar on Germination and Growth of Wheat in Different Saline-alkali Soil显示文摘Saline alkali soil can cause physiological drought on crops,so only some salinity tolerant crops can grow in saline alkali soil.Biochar can increase the utilize efficiency of nutrient and the water retention of the soil,and affect the growth of the plant.In this research,four different proportion of biochar was added in five different levels of saline-alkali soil for pot culture experiment.The pH of the soil increases as the proportion of biochar increase in same saline-alkali level soil,while the EC decrease as the proportion of biochar increase.The germination rate of wheat seeds varies as the different of soil's saline-alkali level.Notable among these results is the germination of wheat seeds in the serious saline-alkali soil without biochar added is 0,while in 45%biochar added in serious saline-alkali soil,the germination rate get to as high as 48.9%.Also,biochar improve the growth of wheat seedling,while for mild saline alkali soil and normal soil.Biochar had no obvious effect on the growth of wheat seedling. | Guijun WANG Zhenwen XU | 2013 | Asian Agricultural Research2013，5，11： | 7 |
| 9 | Additive manufacturing of steel–copper functionally graded material with ultrahigh bonding strength显示文摘Additive manufacturing enables processing of functionally graded materials(FGMs)with flexible spatial design and high bonding strength.A steel-copper FGM with high interfacial strength was developed using laser powder bed fusion(LPBF).The effect of laser process parameters on interfacial defects was evaluated by X-ray tomography,which indicates a low porosity level of 0.042%therein.Gradient/fine dendritic grains in the interface are incited by high cooling rates,which facilitates interface strengthening.Multiple mechanical tests evaluate the bonding reliability of interface;and the fatigue tests further substantiate the ultrahigh bonding strength in FGMs,which is superior to traditional manufacturing methods.Mechanisms of the high interfacial bond strength were also discussed. | Chaolin Tan Youxiang Chew Guijun Bi Di Wang Wenyou Ma Yongqiang Yang Kesong Zhou | 2021 | Journal of Materials Science & Technology2021，，13： | 7 |
| 10 | Effect of Saline-alkali Stress on Seed Germination and Seedling Growth of Oat显示文摘Neutral black soil was mixed with strong saline-alkali soil in different weight ratios,then physiological indexes during seed germination and seedling growth in soil of different ratios and the corresponding leaching liquor treatments were observed to explore effect of saline-alkali stress on oat seed germination and seedling growth,and analyze tolerance of oat to saline-alkali soil.The results showed that germination ability of oat seeds reduced with the increasing salinealkali stress,salt injury index increased and seedling growth was inhibited.Effect of different saline-alkali stresses on germination ability of oat seeds showed difference,and effect of leaching liquor treatment on oat seed germination was stronger than that of soil treatment. | Wang Guijun Wang Lei Meng Xuan Xu Zhenwen | 2015 | Plant Diseases and Pests2015，6，2： | 6 |
| 11 | Models for estimating the leaf NDVI of japonica rice on a canopy scale by combining canopy NDVI and multisource environmental data in Northeast China显示文摘Remote sensing of rice traits has advanced significantly with regard to the capacity to retrieve useful plant biochemical,physiological and structural quantities across spatial scales.The rice leaf NDVI(normalized difference vegetation index)has been developed and applied in monitoring rice growth,yield prediction and disease status to guide agricultural management practices.This study combined rice canopy NDVI and environmental data to estimate rice leaf NDVI.The test site was a japonica rice experiment located in the eastern city of Shenyang,Liaoning Province,China.This paper describes(1)the use of multiple linear regression to establish four periods of rice leaf NDVI models with good accuracy(R2=0.782–0.903),and(2)how the key point of the rice growth period based on these models was determined.The techniques for modeling leaf NDVI at the point of remote canopy sensing were also presented.The results indicate that the rice leaf NDVI has a high correlation with the canopy NDVI and multisource environmental data.This research can provide an efficient method to detect rice leaf growth at the canopy scale in the future. | Yu Fenghua Xu Tongyu Cao Yingli Yang Guijun Du Wen Wang Shu | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 6 |
| 12 | SMART/ASTC dynamic soft reduction technology and its application on the bloom continuous caster at Pangang显示文摘The SMART/ASTC dynamic soft reduction technology of VAI and its application on the 6-strand bloom continuous casterat Pangang, China are presented. The operation results show that soft reduction technology is effective to improve the inner quality ofcontinuously cast blooms. At Pangang, both the central porosity and the central segregation ratings are no more than 1.0, the centralshrinkage cavity rating is no more than 0.5, and the central segregation index of carbon is no more than 1.05. Rails made from theblooms have excellent quality and are used for high-speed tracks. | Guijun Li Kaijian Zhang Chuanfi Han Yong Chen Guoyan Zhao Kaike Cai | 2006 | Journal of University of Science and Technology Beijing2006，13，2： | 6 |
| 13 | 气候变化下旱区农业生态系统的可持续性显示文摘农业生产是将自然资源不断转化为农产品的过程。简单的说就是将阳光、空气、水和土壤等无机资源转化为可以供人类消费的有机产物。农业生态系统必须对全球气候变化、市场竞争、自然环境的恶化、经济等政策法规和人民的需求等因素做出灵活的应对策略,同时还要保证自然生态系统的稳定性。在发展中国家, | 李凤民 Kadambot H. M Siddique Neil C Turner 欧阳志云 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 5 |
| 14 | Direct synthesis of L10-FePt nanopartides from single-source bimetallic complex and their electrocatalytic applications in oxygen reduction and hydrogen evolution reactions显示文摘L10-FePt nan oparticles(NPs)with high chemical ordering represent effective electrocatalysts to reduce the cost and enhance theircatalytic performanee in fuel cells.A molecular strategy of preparing highly ordered FePt NPs was used by direct pyrolysis of a Fe,Pt-containing bimetallic complex.The resultant L10-FePt NPs had very high crystallinity as reflected by the obvious diffractionpatterns,clear lattice fringes and characteristic X-ray diffraction peaks,etc.Besides,the strong ferromagnetism with room temperaturecoercivity of 27 kOe further confirmed the face-centered tetrag on al(fet)phase in good agreement with the ordered nano structures.TheFePt NPs can be used as electrocatalysts to catalyze oxygen reduction reaction(ORR)in an O2·saturated 0.1 M HClO4 solution andhydrogen evolution reaction(HER)in the 0.5 M H2SO4 electrolyte with much better performance than commercial Pt/C,and showedquite high stability after 10,000 cycles.The strategy utilizing orga no metallic precursors to prepare metal alloy NPs was dem on strated tobe a reliable approach for improving the catalytic efficiency in fuel cells. | Zhengong Meng Fei Xiao Zhuoxun Wei Xuyun Guo Ye Zhu Yurong Liu Guijun Li Zhen-Qiang Yu Minhua Shao Wai-Yeung Wong | 2019 | Nano Research2019，12，12： | 5 |
| 15 | Predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome显示文摘AIM To analyze predictors of healthcare-seeking behavior among Chinese patients with irritable bowel syndrome(IBS) and their satisfaction with medical care.METHODS Participating patients met IBS Rome Ⅲ criteria(excluding those with organic diseases) and were enrolled in an IBS database in a tertiary university hospital. Participants completed IBS questionnaires in face-to-face interviews. The questionnaires covered intestinal and extra-intestinal symptoms, medical consultations, colonoscopy,medications, and self-reported response to medications during the whole disease course and in the past year. Univariate associations and multivariate logistic regression were used to identify predictors for frequent healthcareseeking behavior(≥ 3 times/year), frequent colonoscopies(≥ 2 times/year), long-term medications, and poor satisfaction with medical care.RESULTS In total, 516 patients(293 males, 223 females) were included. Participants' average age was 43.2 ± 11.8 years. Before study enrollment, 55.2% had received medical consultations for IBS symptoms. Ordinary abdominal pain/discomfort(non-defecation) was an independent predictor for healthcare-seeking behavior(OR = 2.07, 95%CI: 1.31-3.27). Frequent colonoscopies were reported by 14.7% of patients(3.1 ± 1.4 times per year). Sensation of incomplete evacuation was an independent predictor for frequent colonoscopies(OR = 2.76, 95%CI: 1.35-5.67). During the whole disease course, 89% of patients took medications for IBS symptoms, and 14.7% reported they were satisfied with medical care. Patients with anxiety were more likely to report dissatisfaction with medical care(OR = 2.08, 95%CI: 1.20-3.59). In the past year, patients with severe(OR = 1.74, 95%CI: 1.06-2.82) and persistent(OR = 1.66, 95%CI: 1.01-2.72) IBS symptoms sought medical care more frequently.CONCLUSION Chinese patients with IBS present high rates of frequent healthcare-seeking behavior, colonoscopies, and medications, and low satisfaction with medical care. Intestinal symptoms are major predictors for healthcare-seeking behavior. | Wenjuan Fan Dong Xu Min Chang Liming Zhu Guijun Fei Xiaoqing Li Xiucai Fang | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 16 | Monitoring Maize Lodging Grades via Unmanned Aerial Vehicle Multispectral Image显示文摘Lodging is one of the main factors affecting the quality and yield of crops.Timely and accurate determination of crop lodging grade is of great significance for the quantitative and objective evaluation of yield losses.The purpose of this study was to analyze the monitoring ability of a multispectral image obtained by an unmanned aerial vehicle(UAV)for determination of the maize lodging grade.A multispectral Parrot Sequoia camera is specially designed for agricultural applications and provides new information that is useful in agricultural decision-making.Indeed,a near-infrared image which cannot be seen with the naked eye can be used to make a highly precise diagnosis of the vegetation condition.The images obtained constitute a highly effective tool for analyzing plant health.Maize samples with different lodging grades were obtained by visual interpretation,and the spectral reflectance,texture feature parameters,and vegetation indices of the training samples were extracted.Different feature transformations were performed,texture features and vegetation indices were combined,and various feature images were classified by maximum likelihood classification(MLC)to extract four lodging grades.Classification accuracy was evaluated using a confusion matrix based on the verification samples,and the features suitable for monitoring the maize lodging grade were screened.The results showed that compared with a multispectral image,the principal components,texture features,and combination of texture features and vegetation indices were improved by varying degrees.The overall accuracy of the combination of texture features and vegetation indices is 86.61%,and the Kappa coefficient is 0.8327,which is higher than that of other features.Therefore,the classification result based on the feature combinations of the UAV multispectral image is useful for monitoring of maize lodging grades. | Qian Sun Lin Sun Meiyan Shu Xiaohe Gu Guijun Yang Longfei Zhou | 2019 | Plant Phenomics2019，1，1： | 5 |
| 17 | Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development显示文摘Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4(TLR4) plays an essential part.With their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains inadequate.Herewith,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide(LPS)-induced rat preeclampsia model,through targeting the TLR4/NF-κB pathway.The results showed that pravastatin reduced the blood pressure [maximum decline on gestational day(GD) 12,(101.33±2.49) mmHg vs.(118.3±1.37) mmHg,P<0.05] and urine protein level [maximum decline on GD9,(3,726.23± 1,572.86) μg vs.(1,991.03 ±609.37)μg,P< 0.05],which were elevated following LPS administration.Pravastatin also significantly reduced the rate of fetal growth restriction in LPS-treated rats(34.10% vs.8.99%,P<0.05).Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin treatment.These effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in serum.Additionally,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of pravastatin.These results provide supportive evidence for use of pravastatin in preventing preeclampsia. | Muyi Yang Zhenyu Diao Zhiyin Wang Guijun Yan Guangfeng Zhao Mingming Zheng Anyi Dai Yimin Dai Yali Hu | 2018 | The Journal of Biomedical Research2018，32，4： | 5 |
| 18 | Loss of gonadal soma derived factor damaging the pituitary-gonadal axis in medaka显示文摘Medaka sex is determined by dmy/dmrt1b Y,the doublesex and mab-3 domain gene on the Y chromosome[1,2].Most recent studies have revealed a germ cell-intrinsic cue for the sperm-egg fate decision present in medaka,leading to spermatogenesis occurrence in a female gonadal environment without the presence of dmy[3].Targeted disruption of dmy,or sex related genes,such | Kaiqing Sun Lidong Fan Chuanyun Wang Xiaoyu Yang Shuangguang Zhu Xi Zhang Xiaowu Chen Yunhan Hong Guijun Guan | 2017 | Science Bulletin2017，62，3： | 4 |
| 19 | A theoretical study of the multigrid three-dimensional variational data assimilation scheme using a simple bilinear interpolation algorithm显示文摘In order to solve the so-called 'bull-eye' problem caused by using a simple bilinear interpolation as an observational mapping operator in the cost function in the multigrid three-dimensional variational(3DVAR) data assimilation scheme,a smoothing term,equivalent to a penalty term,is introduced into the cost function to serve as a means of troubleshooting.A theoretical analysis is first performed to figure out what on earth results in the issue of 'bull-eye',and then the meaning of such smoothing term is elucidated and the uniqueness of solution of the multigrid 3DVAR with the smoothing term added is discussed through the theoretical deduction for one-dimensional(1D) case,and two idealized data assimilation experiments(one-and two-dimensional(2D) cases).By exploring the relationship between the smoothing term and the recursive filter theoretically and practically,it is revealed why satisfied analysis results can be achieved by using such proposed solution for the issue of the multigrid 3DVAR. | LI Wei XIE Yuanfu HAN Guijun | 2013 | Acta Oceanologica Sinica2013，32，3： | 4 |
| 20 | 第二届生态系统评估与管理(EAM)国际会议综述显示文摘自2005年联合国《千年生态系统评估》发布以来,旱区农业生态系统评估与管理研究越来越受到世界各国的广泛关注和重视。综述了2010年7月19日至25日在兰州大学举行的第二届生态系统评估与管理(Ecosystem assessment and management,EAM)国际会议28场特邀专家报告,围绕'气候变化与旱区农业生态系统管理'主题,分别从生态系统时空格局、全球变化生态学、植物逆境适应机制、植物与土壤关系和生态系统管理五个方面进行总结,旨在探讨全球气候变化条件下如何提高干旱与半干旱脆弱农业生态系统生产力和可持续性发展的创新理论研究。对生态系统评估与管理的未来发展趋势和目标进行了探讨,并对该会议将来的举办和组织形式提出了建议。 | 李朴芳 赵旭喆 程正国 Kadambot H. M Siddique Neil C Turner 李凤民 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 3 |
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