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| 1 | Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease(CHD),abnormalities of cardiac function and structure(e.g.,left ventricular dysfunction and hypertrophy,and heart failure),valvular heart disease(e.g.,aortic valve sclerosis)and arrhythmias(e.g.,atrial fibrillation).Experimental evidence suggests that NAFLD itself,especially in its more severe forms,exacerbates systemic/hepatic insulin resistance,causes atherogenic dyslipidemia,and releases a variety of pro-inflammatory,pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications.Collectively,these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications.The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular,cardiac and arrhythmic complications,to briefly examine the putative biological mechanisms underlying this association,and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications. | Stefano Ballestri Amedeo Lonardo Stefano Bonapace Christopher D Byrne Paola Loria Giovanni Targher | 2014 | World Journal of Gastroenterology2014，20，7： | 55 |
| 2 | Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications显示文摘 | Giovanni Targher Christopher D. Byrne | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，2： | 5 |
| 3 | Non-invasive fibrosis assessment in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is estimated to affect approximately 25%of the adult population worldwide.[1]NAFLD encompasses a histopathological spectrum of progressive pathologic conditions ranging from non-alcoholic fatty liver(NAFL)to steatohepatitis(NASH)and cirrhosis. | Rafael S.Rios Kenneth I Zheng Giovanni Targher Christopher D.Byrne Ming-Hua Zheng | 2020 | Chinese Medical Journal2020，，22： | 4 |
| 4 | Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients显示文摘 | Lippi Giuseppe Targher Giovanni Montagnana Martina Salvagno Gian Luca Zoppini Giacomo Guidi Gian Cesare | 2009 | Archives of Pathology & Laboratory Medicine2009，，4： | 4 |
| 5 | Fatty liver is associated with an increased risk of diabetes and cardiovascular disease- Evidence from three different disease models: NAFLD, HCV and HIV显示文摘Fatty liver, which frequently coexists with necroinflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease(NAFLD) and chronic infections due to either hepatitis C virus(HCV) or human immunodeficiency virus(HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease(CVD) and type 2 diabetes(T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2 D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2 D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2 D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies. | Amedeo Lonardo Stefano Ballestri Giovanni Guaraldi Fabio Nascimbeni Dante Romagnoli Stefano Zona Giovanni Targher | 2016 | World Journal of Gastroenterology2016，22，44： | 4 |
| 6 | Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey显示文摘 | Jeffrey C. Sirota Kim McFann Giovanni Targher Richard J. Johnson Michel Chonchol Diana I. Jalal | 2012 | Metabolism2012，，： | 3 |
| 7 | NAFLD: A multisystem disease显示文摘 | Christopher D. Byrne Giovanni Targher | 2015 | Journal of Hepatology2015，，1： | 2 |
| 8 | Diagnosis and Management of Nonalcoholic Fatty Liver Disease and Its Hemostatic/Thrombotic and Vascular Complications显示文摘 | Giovanni Targher Christopher Byrne | 2013 | Semin Thromb Hemost2013，，02： | 2 |
| 9 | Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes显示文摘 | Giuseppe Lippi Luca Filippozzi Martina Montagnana Gian Luca Salvagno Massimo Franchini Gian Cesare Guidi Giovanni Targher | 2009 | Clinical Chemistry and Laboratory Medicine2009，，3： | 2 |
| 10 | Associations between serum 25-hydroxyvitamin D 3 concentrations and liver histology in patients with non-alcoholic fatty liver disease显示文摘 | Giovanni Targher Lorenzo Bertolini Luca Scala Massimo Cigolini Luciano Zenari Giancarlo Falezza Guido Arcaro | 2006 | Nutrition Metabolism and Cardiovascular Diseases2006，，7： | 2 |
| 11 | Black esophagus syndrome associated with diabetic ketoacidosis显示文摘Acute esophageal necrosis,also known as 'black esophagus syndrome',is a rare acute esophageal disease that is often associated with vomiting and upper gastrointestinal haemorrhage.At present,little is known regarding the pathogenesis of this disease.We present the case of a 50-year-old white male patient with diabetic ketoacidosis suffering from acute esophageal necrosis with nausea and vomiting but without any clinical signs of upper gastrointestinal bleeding. | Riccardo Rigolon Irene Fossà Luca Rodella Giovanni Targher | 2016 | World Journal of Clinical Cases2016，4，2： | 2 |
| 12 | Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD显示文摘 | Amedeo Lonardo Silvia Sookoian Michel Chonchol Paola Loria Giovanni Targher | 2013 | Current Pharmaceutical Design2013，，29： | 2 |
| 13 | The effect of iron depletion on chronic hepatitis C virus infection显示文摘 | Massimo Franchini Giovanni Targher Franco Capra Martina Montagnana Giuseppe Lippi | 2008 | Hepatology International2008，，3： | 1 |
| 14 | Glycated hemoglobin ( HbAlc ) : old dogmas,a new perpective显示文摘 | Giuseppe Lippi Giovanni Targher | 2010 | Clin Lab Med2010，48，5： | 1 |
| 15 | A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease:a derivation and independent validation study显示文摘Background:Currently,there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy.T2-weighted images(T2WI)are routinely obtained from liver magnetic resonance imaging(MRI)scan sequences.We aimed to establish a radiomics signature based on T2WI(T2-RS)for assessment of hepatic inflammation in people with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 203 individuals with biopsy-confirmed NAFLD from two independent Chinese cohorts with liver MRI examination were enrolled in this study.The hepatic inflammatory activity score(IAS)was calculated by the unweighted sum of the histologic scores for lobular inflammation and ballooning.One thousand and thirty-two radiomics features were extracted from the localized region of interest(ROI)in the right liver lobe of T2WI and,subsequently,selected by minimum redundancy maximum relevance and least absolute shrinkage and selection operator(LASSO)methods.The T2-RS was calculated by adding the selected features weighted by their coefficients.Results:Eighteen radiomics features from Laplacian of Gaussian,wavelet,and original images were selected for establishing T2-RS.The T2-RS value differed significantly between groups with increasing grades of hepatic inflammation(P<0.01).The T2-RS yielded an area under the receiver operating characteristic(ROC)curve(AUROC)of 0.80[95%confidence interval(CI):0.71-0.89]for predicting hepatic inflammation in the training cohort with excellent calibration.The AUROCs of T2-RS in the internal cohort and external validation cohorts were 0.77(0.61-0.93)and 0.75(0.63-0.84),respectively.Conclusions:The T2-RS derived from radiomics analysis of T2WI shows promising utility for predicting hepatic inflammation in individuals with NAFLD. | Zhong-Wei Chen Huan-Ming Xiao Xinjian Ye Kun Liu Rafael S.Rios Kenneth I.Zheng Yi Jin Giovanni Targher Christopher D.Byrne Junping Shi Zhihan Yan Xiao-Ling Chi Ming-Hua Zheng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 1 |
| 16 | Relation Between Red Blood Cell Distribution Width and Inflammatory Biomarkers in a Large Cohort of Unselected Outpatients显示文摘 | Lippi Giuseppe Targher Giovanni Montagnana Martina Salvagno Gian Luca Zoppini Giacomo Guidi Gian Cesare | 2009 | Archives of Pathology & Laboratory Medicine2009，，4： | 1 |
| 17 | Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases显示文摘 | Massimo Franchini Martina Montagnana Giovanni Targher | | 0，，08： | 1 |
| 18 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 19 | The paradoxical relationship between serum uric acid and cardiovascular disease显示文摘 | Giuseppe Lippi Martina Montagnana Massimo Franchini Emmanuel J. Favaloro Giovanni Targher | 2008 | Clinica Chimica Acta2008，，1： | 1 |
| 20 | Pathogenesis, clinical and laboratory aspects of thrombosis in cancer显示文摘 | Massimo Franchini Martina Montagnana Giovanni Targher Franco Manzato Giuseppe Lippi | 2007 | Journal of Thrombosis and Thrombolysis2007，，1： | 1 |
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