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| 1 | Bridging and downstaging treatments for hepatocellular carcinoma in patients on the waiting list for liver transplantation显示文摘Several therapeutic procedures have been proposed as bridging treatments for patients with hepatocellular carcinoma(HCC)awaiting liver transplantation(LT).The most used treatments include transarterial chemoembolization and radiofrequency ablation.Surgical resection has also been successfully used as a bridging procedure,and LT should be considered a rescue treatment in patients with previous HCC resection who experience tumor recurrence or post-treatment severe decompensation of liver function.The aims of bridging treatments include decreasing the waiting list dropout rate before transplantation,reducing HCC recurrence after transplantation,and improving post-transplant overall survival.To date,no data from prospective randomized studies are available;however,for HCC patients listed for LT within the Milan criteria,prolonging the waiting time over 6-12 mo is a risk factor for tumor spread.Bridging treatments are useful in containing tumor progression and decreasing dropout.Furthermore,the response to pre-LT treatments may represent a surrogate marker of tumor biological aggressiveness and could therefore be evaluated to prioritize HCC candidates for LT.Lastly,although a definitive conclusion can not be reached,the experiences reported to date suggest a positive impact of these treatments on both tumor recurrence and post-transplant patient survival.Advanced HCC may be downstaged to achieve and maintain the current conventional criteria for inclusion in the waiting list for LT.Recent studies have demonstrated that successfully downstaged patients can achieve a 5-year survival rate comparable to that of patients meeting the conventional criteria without requiring downstaging. | Maurizio Pompili Giampiero Francica Francesca Romana Ponziani Roberto Iezzi Alfonso Wolfango Avolio | 2013 | World Journal of Gastroenterology2013，19，43： | 24 |
| 2 | Laser ablation for small hepatocellular carcinoma: State of the art and future perspectives显示文摘During the last two decades, various local thermal ablative techniques for the treatment of unresectable hepatocellular carcinoma(HCC) have been developed. According to internationally endorsed guidelines, percutaneous thermal ablation is the mainstay of treatment in patients with small HCC who are not candidates for surgical resection or transplantation. Laser ablation(LA) represents one of currently available loco-ablative techniques. In this article, the general principles, technique, image guidance, and patient selection are reported. Primary effectiveness, long-term outcome, and complications are also discussed. A review of published data suggests that LA is equivalent to the more popular and widespread radiofrequency ablation in both local tumor control and long-term outcome in the percutaneous treatment of early HCC. In addition, the LA technique using multiple thin laser fibres allows improved ablative effectiveness in HCCs greater than 3 cm. Reference centres should be equipped with all the available techniques so as to be able to use the best and the most suitable procedure for each type of lesion for each patient. | Giovan Giuseppe Di Costanzo Giampiero Francica Claudio Maurizio Pacella | 2014 | World Journal of Hepatology2014，6，10： | 14 |
| 3 | Pre-illness changes in dietary habits and diet as a risk factor for inflammatory bowel disease: A case-control study显示文摘AIM: To evaluate whether symptoms of inflammatory bowel disease (IBD), before diagnosis modify dietary habits, and to investigate the pre-illness diet in patients with recent IBD in comparison with an age-matched healthy control group. METHODS: Overall, 83 new cases of IBD (41 ulcerative colitis, 42 Crohn's disease) and 160 healthy controls were studied. Portions per week of 34 foods and beverages before onset of symptoms were recorded using a validated questionnaire. Duration of symptoms before IBD diagnosis, presence of specific symptoms and their impact on subjective changes in usual dietary habits were also recorded. The association between diet and IBD was investigated by multiple logistic regression and dietary patterns were assessed by factor analysis. RESULTS: Changes in dietary habits, due to the presence of symptoms, were reported by 38.6% of patients and were not significantly related to specific symptoms, rather to long duration of symptoms, only in Crohn's disease patients. In IBD patients who did not change dietary habits, moderate and high consumption of margarine (OR = 11.8 and OR = 21.37) was associated with ulcerative colitis, whilst high consumption of red meat (OR = 7.8) and high intake of cheese were associated with Crohn's disease. CONCLUSION: More than one third of IBD patients change dietary habits before diagnosis. Margarine, red meat and cheese increase the risk of ulcerative colitis and Crohn's disease. | Giovanni Maconi Sandro Ardizzone Claudia Cucino Cristina Bezzio Antonio Giampiero Russo Gabriele Bianchi Porro | 2010 | World Journal of Gastroenterology2010，16，34： | 10 |
| 4 | 单个汽球 enteroscopy : 技术方面和临床的应用显示文摘 The small bowel has long been considered a black box for endoscopists because of its long length and the presence of multiple complex loop. Most of the small bowel is inaccessible by traditional endoscopic means. In addition, radiographic studies have significant limitations with regard to diagnostic yield, and surgery is an invasive alternative. This limitation was overcome through the development of balloon enteroscopy that becomes established throughout the world for diagnostic and therapeutic examinations of the small bowel. The single-balloon enteroscope (SBE) system (Olympus, Tokyo, Japan) was introduced into the commercial market in 2007. Several study demonstrated its efficacy and safety. Early reports on the use of singleballoon enteroscopy have suggested a high diagnostic yield and similar therapeutic potential to that of the double-balloon endoscope. SBE is viable technique for in the management of small bowel disease. Technically, it is easy to perform, may be efficient, and in the literature data available, seems to provide high diagnostic and therapeutic yield. | Mauro Manno Carmelo Barbera Helga Bertani Raffaele Manta Vincenzo Giorgio Mirante Emanuele Dabizzi Angelo Caruso Flavia Pigo Giampiero Olivetti Rita Conigliaro | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 8 |
| 5 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 6 | 可靠临床并且在剖腹产附近的腹的墙子宫内膜增生的诊断的 sonographic 调查结果结疤显示文摘 AIM:To highlight sonographic and clinical characteristics of scar endometrioma with special emphasis on size-related features.METHODS:Thirty women(mean age 30.6 years,range 20-42 years)with 33 scar endometriomas(mean diameter 27.1 mm,range 7-60 mm)were consecutively studied by Sonography and Color Doppler examination prior to surgery.Pathological examination was available in all cases.RESULTS:The most frequent(24 of 33 nodules,74%) sonographic B-mode aspect of endometrioma was that of an inhomogenously hypoechoic roundish nodule with fibrotic changes(in the form of hyperechoic spots or strands),a peripheral inflammatory hyperechoic ring,spiculated margins and a single vascular pedicle entering the mass at the periphery.On average,1.6 cesarean sections were recorded per patient(range 1-3).The median interval between the last cesarean section and admission to hospital was 36 mo(range 12-120 mo) and the median duration of symptoms before admission was 25.7 mo(range 0.5-80 mo).13 patients had 13 large endometriomas(≥30 mm)with a mean lesion diameter of 41.3±9.02 mm(range 30-60 mm).Seventeen women had 20 small endometriomas with a mean lesion size of 18.2±5.17 mm(range 7-26 mm).The mean interval between the last cesarean section and admission to hospital(66.0 mo vs 39.6 mo,P<0.01) and the mean duration of symptoms before admission(43.0 mo vs 17.4 mo,P<0.01)were significantly longer in patients with large endometriomas;in addition,a statistically significant higher percentage of patients with large implants had undergone previous inconclusive diagnostic examinations,including either computed tomography/magnetic resonance imaging/fine needle biopsy/laparoscopy(38.4%vs 0%,P<0.05).On sonography,large endometriomas showed frequent cystic portions and fistulous tracts(P<0.02),loss of round/oval shape(P<0.04)along with increased vascularity(P <0.04).CONCLUSION:Endometrioma near cesarean section scar is an often neglected disease,but knowledge of its clinical and sonographic findings may prevent a delay in diagnosis that typically occurs in patients with larger(≥ 3 cm)endometriomas. | Giampiero Francica | 2012 | World Journal of Radiology2012，4，4： | 7 |
| 7 | Intestinal duplication in adulthood: A rare entity, difficult to diagnose显示文摘Duplications of the alimentary tract (ATD) are rare congenital anomalies often found early in life. They may occur anywhere in the intestinal tract but the ileum is the most frequently affected site. Clinical presentation of ATD in adults is variable and because these lesions occur so infrequently they are rarely suspected. In the present report we describe a case of ileal duplication in a 61-year-old patient with Crohn’s disease. Despite various radiological investigations and medical consultations, the diagnosis was only made on the surgical specimen. | Cristina Fiorani Rosa Scaramuzzo Alessandra Lazzaro Livia Biancone Giampiero Palmieri Achille L Gaspari Giuseppe Sica | 2011 | World Journal of Gastrointestinal Surgery2011，3，8： | 6 |
| 8 | Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease显示文摘AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold standard.METHODS:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively enrolled.All patients were under follow-up.The study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed consent.SICUS and CTE were performed ≤ 3 mo before surgery,followed by surgical pathology.The following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel dilation.Comparison between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold standard.RESULTS:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal tube.The analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients enrolled.Differently from CTE,SICUS was feasible in all the 15 patients enrolled.No complications were observed when using SICUS or CTE.Surgical pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 patients.In order to compare findings by using SICUS,CTE,histology and surgery,characteristics of the small bowel lesions observed in CD each patient were blindly reported in the same form by one gastroenterologistsonologist,radiologist,surgeon and anatomopathologist.At surgery,lesions related to CD were detected in the distal ileum in all 13 patients,also visualized by both SICUS and CTE in all 13 patients.Ileal lesions > 10 cm length were detected at surgery in all the 13 CD patients,confirmed by SICUS and CTE in the same 12 out of the 13 patients.When using surgical findings as a gold standard,SICUS and CTE showed the exactly same sensitivity,specificity and accuracy for detecting the presence of small bowel fistulae(accuracy 77% for both) and abscesses(accuracy 85% for both).In the tested CD population,SICUS and CTE were also quite comparable in terms of accuracy for detecting the presence of small bowel strictures(92% vs 100%),small bowel fistulae(77% for both) and small bowel dilation(85% vs 82%).CONCLUSION:In our study population,CTE and the non-invasive and radiation-free SICUS showed a comparable high accuracy for assessing small bowel lesions in CD. | Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 9 | Organelle trafficking, the cytoskeleton, and pollen tube growth显示文摘The pollen tube is fundamental for the reproduction of seed plants. Characteristically, it grows relatively quickly and uni‐directionally('polarized growth') to extend the male gametophyte to reach the female gametophyte. The pollen tube forms a channel through which the sperm cells move so that they can reach their targets in the ovule. To grow quickly and directionally, the pollen tube requires an intense movement of organelles and vesicles that allows the cell's contents to be distributed to sustain the growth rate. While the various organelles distribute more or less uniformly within the pollen tube, Golgi‐released secretory vesicles accumulate massively at the pollen tube apex, that is, the growing region. This intense movement of organelles and vesicles is dependent on the dynamics of the cytoskeleton,which reorganizes differentially in response to external signals and coordinates membrane trafficking with the growth rate of pollen tubes. | Giampiero Cai Luigi Parrotta Mauro Cresti | 2015 | Journal of Integrative Plant Biology2015，57，1： | 4 |
| 10 | Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience显示文摘AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) stones.METHODS: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. The adverse event related to the procedures(ERCP + ES) was only an intra procedural bleeding(6.6%) that occurred after ES and was treated immediately with adrenaline sclerotherapy. No postoperative complications were reported.CONCLUSION: With the current endoscopic techniques, very few patients with choledocholithiasis require surgery. EBD is an eff icacious and safe procedure. | Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 4 |
| 11 | Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition显示文摘We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an SET.This case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis. | Filippo Antonini Liboria Laterza Lorenzo Fuccio Massimo Marcellini Lucia Angelelli Sonia Calcina Corrado Rubini Giampiero Macarri | 2017 | World Journal of Gastrointestinal Oncology2017，9，11： | 3 |
| 12 | Decortication for Chronic Parapneumonic Empyema: Results of a Prospective Study显示文摘 | Giulio Melloni Angelo Carretta Paola Ciriaco Giampiero Negri Carlopietro Voci Giuseppe Augello Piero Zannini | 2004 | World Journal of Surgery2004，，5： | 2 |
| 13 | Hepato-splenic lymphoma:a rare entity mimicking acute hepatitis:A case report显示文摘We reported a case of non-Hodgkin's lymphoma where liver involvement was the predominant clinical manifestation. A 27-year old man presented wiht markedly elevated serum aspartate aminotrasferase, alanine aminotransferase and lactate dehydrogenase, reduced prothrombin activity, thrombocytopenic purpura and hepato-splenomegaly without adenopathy. Viral, toxic,autoimmune and metabolic liver diseases were excluded.Bone marrow biopsy showed an intracapillary infiltration of T-lymphocytes with no evidence of lipid storage disease.Because of a progressive spleen enlargement, splenectomy was performed. Histological examination showed lymphomatous intrasinuses invasion of the spleen.Immunohistochemical investigation revealed the T phenotype of the neoplastic cells: CD45+, CD45RO+,CD3+, CD4-, CD8-, TIA1-. About 50 % of the lymphoid cells expressed CD56 antigen. The diagnosis of hepatosplenic T cell lymphoma was done. The patient was treated with chemotherapy, which induced a complete remission. Eighteen months later, he had a first relapse with increased aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase,thrombocytopenic purpura and blast in the peripheral blood.In spite of autologous bone marrow transplantation, he died twenty months after the diagnosis. Even in the absence of a mass lesion or lymphoadenopathy, hepatosplenic Tcell lymphoma should be considered in the differential diagnosis of a patient whose clinical course is atypical for acute hepatic dysfunction. | Federico Perfetto Roberto Tarquini Francesco Mancuso Simonetta di Lollo Silvia Tozzini Giampiero Bellesi Giacomo Laffi | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 14 | Efficacy of Entecavir With or Without Tenofovir Disoproxil Fumarate for Nucleos(t)ide-Na?ve Patients With Chronic Hepatitis B显示文摘 | Anna S. Lok Huy Trinh Giampiero Carosi Ulus S. Akarca Adrian Gadano Fran?ois Habersetzer William Sievert David Wong Meghan Lovegren David Cohen Cyril Llamoso | 2012 | Gastroenterology2012，，3： | 2 |
| 15 | Human Wharton’s Jelly Mesenchymal Stem Cells Maintain the Expression of Key Immunomodulatory Molecules When Subjected to Osteogenic, Adipogenic and Chondrogenic Differentiation In Vitro: New Perspectives for Cellular Therapy显示文摘 | Giampiero La Rocca Melania Lo Iacono Tiziana Corsello Simona Corrao Felicia Farina Rita Anzalone | 2013 | Current Stem Cell Research & Therapy2013，，： | 1 |
| 16 | Percutaneous Laser Ablation in the Treatment of Hepatocellular Carcinoma with Small Tumors: Analysis of Factors Affecting the Achievement of Tumor Necrosis显示文摘 | Claudio Maurizio Pacella Giancarlo Bizzarri Giampiero Francica Antonio Bianchini Stefano De Nuntis Sara Pacella Anna Crescenzi Silvia Taccogna Giuseppe Forlini Zaccaria Rossi John Osborn Roberto Stasi | 2005 | Journal of Vascular and Interventional Radiology2005，，11： | 1 |
| 17 | Role of CDIA and HSP60 in the antitumoral response of oesophageal cancer 显示文摘 | Simona C Giampiero LR Rita A et ol | 2008 | Oncol Rev2008，1，4： | 1 |
| 18 | Contact allergy in chronic eczematous lip dermatitis 显示文摘 | Donatella Schena Francesca Fantuzzi Giampiero Girolomo- ni | 2008 | European Journal of Dermatology2008，18，6： | 1 |
| 19 | Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure显示文摘 | Dr. Giampiero Rocca Antonino Stefano Ermanno Eleuteri Rita Anzalone Francesca Magno Simona Corrao Tiziana Loria Anna Martorana Claudio Gangi Marilena Colombo Fabrizio Sansone Francesco Patanè Felicia Farina Mauro Rinaldi Francesco Cappello Pantaleo Giannu | 2009 | Basic Research in Cardiology2009，，3： | 1 |
| 20 | Hybrid Aortic Arch Debranching With Staged Endovascular Completion in DeBakey Type I Aortic Dissection显示文摘 | Antonino G.M. Marullo Samuele Bichi Rocco A. Pennetta Gerardo Di Matteo Antonio M. Cricco Luigi Specchia Fausto Castriota Giampiero Esposito | 2010 | The Annals of Thoracic Surgery2010，，6： | 1 |
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