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| 1 | Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid显示文摘AIM: To investigate Time- and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively. METHODS: DS tablets and 5-ASA pellets were coated by ethylcellulose (EC) and methacrylic acid copolymers (Eudragit L100 and $100), respectively. The in vitro release behavior of the DS coated tablets and 5-ASA coated pellets were examined, and then in vivo absorption kinetics of DS coated tablets in dogs were further studied. RESULTS: Release profile of time-dependent DS coated tablets was not influenced by pH of the dissolution medium, but the lag time of DS release was primarily controlled by the thickness of the coating layer. The thicker the coating layer, the longer the lag time of DS release is. On the contrary, in view of the pH-dependent 5-ASA coated pellets, 5-ASA release was significantly governed by pH. Moreover, the 5-ASA release features from the coated pellets depended upon both the combination ratio of the Eudragit~ L100 and S100 pH-sensitive copolymers in the coating formulation and the thickness of the coating layer. The absorption kinetic studies of the DS coated tablets in dogs demonstrated that in vivo lag time of absorption was in a good agreement with in vitro lag time of release. CONCLUSION: Two types of CDDS, prepared herein by means of the regular coating technique, are able to achieve site-specific drug delivery targeting at colon following oral administration, and provide a promising strategy to control drug release targeting the desired lower gastrointestinal region. | GangCheng FengAn Mei-JuanZou JinSun Xiu-HuaHao Yun-XiaHe | 2004 | World Journal of Gastroenterology2004，10，12： | 6 |
| 2 | Thermal Behaviors of Work Roll in Finishing Trains of Hot Rolling显示文摘In order to analyze the thermal field and thermal contour of work roll in finishing trains of hot rolling in rolling process, a quasi two-dimension implicit finite difference model is developed. To improve the calculating speed and precision, some special solutions are introduced, including the development of this model, the simplification of boundary conditions and the computation of heat transfer coefficients. The results show that these solutions of thermal behaviors of work roll are very much efficient and the model can be used as an on-line profile and flatness control model of large industrial mills.. | Anrui He, Jie Zhang, Chen Zhang, Qingdong Zhang, Gangcheng Wei, Siqing Huang Mechanical Engineering School, University of Science and Technology Beijing, Beijing 100083, China Wuhan Iron and Steel Group Corporation, Wuhan 430083, China | 2001 | Journal of University of Science and Technology Beijing2001，8，1： | 2 |
| 3 | Effect of calcium ion and microwave power on structural and quality changes in drying of apple slices显示文摘 | Wu Gangcheng Zhang Min Mujumdar Arum S | 2010 | Drying Technology2010，28，4： | 1 |
| 4 | Sensory-directed flavor analysis of key odorants compounds development of French fries and oils in the break-in,optimum and degrading frying stage显示文摘The flavor is a decisive sensory characteristic that determines the popularity of French fries(FFs).During high-oleic rapeseed oil(RO)frying,the flavor development of FFs showed three noticeable stages including break-in(3.5%-7.5%of total polar compounds(TPC)),optimum(7.5%-22.18%of TPC),and degrading stages(above 22.18%of TPC).Further,in order to distinguish the key aroma compounds in each stage,the FFs prepared in RO at TPC of 3.5%(FF4),14.5%(FF15),and 26.96%(FF27)and their relevant oils(RO4,RO15,RO27)were selected for sensory-directed analysis.The results revealed that the FF4 had low contents of(E,E)-2,4-decadienal(deep-fried odor)which also caused lower sensory score in FF4 sample.The higher contents of(E,E)-2,4-decadienal in FF15 induced its higher deep-fried odor.The FF27 had higher hexanoic acid(sweaty odor),heptanoic acid,nonanoic acid,benzene acetaldehyde(stale odor),and trans-4,5-epoxy-(E)-2-decenal(metallic odor)compared with FF4 and FF15,thus leading to the undesirable flavor of FF27.Moreover,the decrease of 2,5-dimethylpyrazine and 2-ethyl-6-methyl-pyrazine in FF27 induced the lower roasty flavor,which may also lead to the decline of the sensory score.Similarly,the higher contents of(E)-2-undecenal,hexanoic acid,heptanoic acid,and nonanoic acid in RO27 lead to increase its rancid score and thus lower the sensory score. | Lirong Xu Gangcheng Wu Jianhua Huang Hui Zhang Qingzhe Jin Xingguo Wang | 2023 | Food Science and Human Wellness2023，12，1： | 1 |
| 5 | VCR and ASR technology for profile and flatness control in hot strip mills 显示文摘 | Cao Jianguo Wei Gangcheng Zhang Jie | 2008 | Journal of Central South University: Science & Technology of Mining an Metallurgy2008，15，2： | 1 |
| 6 | Evaluation of the burn healing properties of oil extraction from housefly larva in mice显示文摘 | XiFeng GangCheng Shu - yuan Chen etal | 2010 | Journal of Ethnopharmacology2010，130，： | 1 |
| 7 | Research on infiltration clogging effect and its application prospect in anti-seepage project显示文摘Clogging effect,as a new concept in geological engineering,is a phenomenon of permeability decreasing under seeping in reservoir dam foundation of the alluvial and diluvial deposits with deep and thick layer,coarse particle and high permeability in mountains-gully rivers of Tibetan Plateau.A clogging infiltration instrument has been designed successfully and a series of simulation tests have been done.Based on large amounts of data,it is confirmed that the existence of the clogging effect and the law of infiltration clogging is found out.Three indexes are proposed such as 'optimal size of particle','optimal size range of particle' and 'characteristic pore',which are closely related with effect of infiltration clogging.The concept and results can offer a new idea to solve problems on anti-seepage of dam foundation in mountains-gully rivers environment and to study artificial clogging,meanwhile supplement of the concept of seepage deformation. | HUANG Zhiquan WANG Gangcheng ZHANG Guojun | 2009 | Global Geology2009，12，2： | 1 |
| 8 | solidstatecommunieations显示文摘 | Dairingchen Xiulingjiao Gangcheng | 2000 | 113 : 363 - 3662000，113，： | 1 |
| 9 | Effect of calcium ion and microwave power on structural and quality changes in drying of apple slices显示文摘 | WU Gangcheng ZHANG Min MUJUMDAR ARUM S | 2010 | Drying Technology2010，28，4： | 1 |
| 10 | Effect of Deformation between Stands on the Strip Shape in Hot Rolling显示文摘A theoretical model about the secondary deformation is developed by the combination of analytical and experimental approaches. A system simulation based on the model is completed to predict the strip profile after the interstand deformation. On the other hand, comprehensive experiments and quantitative comparisons are made to calibrate the model for a wide variety of products. As a result, the correction of the model has been verified by the actual rolling data from production mill and it is helpful to improve the strip shape control. | Qinghai Wu, Jie Zhang, Changsong Wang, Gangcheng Wei, Ping Song, Changhe Deng ( Mechanical Engineering School, University of Science and Technology Beijing, Beijing 100083, China Wuhan Iron & Steel Corporation) | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，3： | 1 |
| 11 | Effect of calcium ion and microwave power on structural and quality changes in drying of apple slices显示文摘 | WU Gangcheng ZHANG Min MUJUMDAR A S | 2010 | Drying Technology2010，28，4： | 1 |
| 12 | Study on the interaction mechanism of virgin olive oil polyphenols with mucin and α-amylase显示文摘The interaction mechanism of mucin and α-amylase with virgin olive oil (VOO) polyphenols (oleuropein (OL),tyrosol (TY),hydroxytyrosol (HT)) was analyzed by fluorescence,ultraviolet (UV) absorption,attenuated total reflection Fourier transform infrared (ATR-FTIR),circular dichroic (CD) spectroscopy and molecular docking.A total of 17 polyphenols have been identified in the selected VOO,and the TY,HT and OL were the main compounds.The quenching mechanism between mucin/α-amylase and three VOO polyphenols was static,mainly through van der Waals forces and hydrogen bonds.The results of UV absorption,ATR-FTIR,and CD spectroscopy revealed that the conformation of mucin changed after combining with the three polyphenols,while that of the α-amylase changed little.Molecular docking predicted the interaction sites of the three polyphenols with human salivary mucin and α-amylase.The present study could provide the theoretical foundation for further research on the interaction between human salivary protein and phenolic compounds in VOO. | Gangcheng Wu Ruobing Mao Yiren Zhang Ling Zhu Emad Karrar Hui Zhang Qingzhe Jin Xingguo Wang | 2022 | Food Bioscience2022，47，3： | 1 |
| 13 | Engineering geological characteristics of slide zone soil and stability for one landslide in Tibet显示文摘On the basis of geological investigating work and experimental studies on slide zone soil of one landslide in Tibet,the authors analyzed granulometric composition,clay mineral composition and physical and mechanical properties for the soil in the slide zone.The soil samples are gravel containing fine particle.Particles larger than 2 mm occupy the main proportion with the content 51.5%--68.5%.The relative content of clay minerals is low.The clay minerals are illite smectite mixed layer and kaolinite,and their relative contents are 6%--13% and 4%-11%,respectively.The main mineral ingredient is quartz and the relative content is over 30%.Therefore,the soil’s hydrophily is poor.The cohesion and internal friction angle are high,causing preferable physical-mechanical features of slide zone soil.On the basis of the obtained data,the landslide stability is evaluated by means of limit equilibrium method.The safety factors are 3.191 and 1.92 respectively under both natural and normal water level conditions.The study results show that the landslide is stable.It can provide the appropriate basis and reference for landslide stability evaluation and landslide control in Tibet. | XU Xiaohui CHEN Hui'e WANG Gangcheng | 2013 | Global Geology2013，16，3： | 0 |
| 14 | Chinese expert consensus on standardized treatment for presacral cysts显示文摘Presacral cysts are cystic or cyst–solid lesions between the sacrum and rectum,almost involving adjacent pelvic floorstructures including sacrococcygeal fascia,rectum,and anal sphincter.Presacral cysts are usually benign,currently believed to arise from aberrant embryogenesis.Presacral cysts are clinically rare and the true incidence is unknown.Surgical resection remains the major treatment for presacral cysts.Unless the cysts are completely resected,recurrence is unavoidable.Recurrent cysts or hard-to-heal sinuses in the sacrococcyx cause patients extreme pain.However,the current knowledge of presacral cysts is insufficient.They are occasionally confused with other diseases such as ovarian cysts and perianal abscesses.Moreover,lack of the correct surgical concept and skills leads to palliative treatment for complex presacral cysts and serious complications such as impairing the function of the anal sphincter or important blood vessels and nerves.The consensus summarizes the opinions and experiences of multidisciplinary experts in presacral cysts and aims to provide clinicians with a more defined concept of the treatment,standardize the surgical approach,and improve the efficacy of presacral cysts. | Gangcheng Wang Chengli Miao | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 15 | The Network of Protein-protein Interactions in Human Fetal Liver Aged 22 Weeks显示文摘 | GangCHENG Kai-XinZHOU Song-FengWU Chun-JuanDU PingWAN Ting-GuiCHEN Zi-NiuYU Yun-PingZHU Fu-ChuHE | 2004 | Acta Biochimica et Biophysica Sinica2004，36，1： | 0 |
| 16 | A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine显示文摘Cardiac valve replacement is an effective method to treat valvular heart disease.Artificial valves used routinely in clinic still have defects.In our study,we explored a novel method to modify the performance of Decellularized Heart Valve(DHV)scaffold.The decellularized porcine aortic valve was prepared using sequential hydrophile and lipophile solubilization method.The sericin was extracted from silk fibroin-deficient silkworm cocoon by lithium bromide method.First,DHV was immersed in sericin solution to produce the sericin–DHV composite scaffold.Then,we modified the DHV by making a Polydopamine(PDA)coating on the DHV first and then binding the sericin.The physical properties and biological compatibility of our composite scaffold were assessed in vitro and in vivo.Sericin were successfully prepared,combined to DHV and improved its biocompatibility.PDA coating further promoted the combination of sericin on DHV and improved the physical properties of scaffolds.The decay rate of our modified valve scaffold was decreased in vivo and it showed good compatibility with blood.In conclusion,our modification improved the physical properties and biocompatibility of the valve scaffold.The combination of PDA and sericin promoted the recellularization of decellularized valves,showing great potential to be a novel artificial valve. | Peng Bai Gangcheng Kong Weihua Qiao Yu Song Yixuan Wang Jiawei Shi Nan Zhang Chungeng Liu Chong Chu Tixiusi Xiong Ying Zhou Cuifen Lu Lin Wang Nianguo Dong | 2022 | Journal of Bionic Engineering2022，19，4： | 0 |
| 17 | Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine:A Clinical Trial显示文摘Background:Transcatheter closure of patent foramen ovale(PFO)has been widely accepted as a highly effective way to treat high-risk PFO-related diseases.However,traditional non-degradable occluders made of metal alloys will permanently exist in the body,resulting in thrombosis,valve damage,hemolysis,arrhythmia,or other complications.The biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co.,Ltd.,China can be fully absorbed and degrade into nontoxic ingredients,reducing postoperative complications.Objectives:To study the safety and efficacy of biodegradable PFO occluders in treating PFO.Methods:This single-center clinical trial collected 30 patients treated with a biodegradable PFO occluder.The follow-up period lasted 12 months to analyze the echocardiographic characteristics and headache relief through HIT-6 scores.Results:The immediate success rate was 100%,with no intraoperative severe occlusion-related complications.The contrast transcranial Doppler(cTCD)at 12 months showed that all patients’right-to-left shunts(RLS)were grade I or 0 with no serious postoperative complications,indicating the overall success rate was 100%.The biodegradable PFO occluder mostly degraded six months after the occlusion.Conclusion:PFO closure with a Mallow biodegradable occluder is safe and effective and has no severe complications. | Xingbang Li Xuan Zheng Bowen Jin Yunyan Li Yongyu Shao Xiaoxian Deng Dingyang Li Shanshan Li Hongmei Zhou Jie Zhang Xianya Zhang Qunshan Shen Gangcheng Zhang | 2023 | Congenital Heart Disease2023，18，3： | 0 |
| 18 | 微机串口实时通信的实现显示文摘阐述了外部中断在实时通信中的特殊地位以及WINDOWS与DOS在这方面的不同,通过一个典型的范例说明如何利用外部中断实现串口实时通信。 | 康勇 Liu Gangcheng | 2015 | 职大学报2015，，2： | 0 |
| 19 | Research on clogging mechanism of loose foundation显示文摘Combining with the indoor clogging tests of loose foundation in Tibet,the permeability clogging process of loose foundation was simulated based on particle flow method. Under the constant head of 2.2m, numerical micro-simulation was made in three cases,which was not adding any clogging materials,or adding the clogging materials with the diameter between 0.075-0.500 mm and 0.5-1 mm. The dynamic changes of fluid velocity,permeability coefficient,porosity and loss amount were recorded in the numerical simulation. The results have shown that fluid velocity and permeability coefficient decreased rapidly,when adding the clogging materials with the diameter between 0.5 mm and 1.0 mm. With seepage stability,fluid velocity value was very low. By using computer simulation in the two cases,we got that both cases induced clogging effect. Clogging effect was due to one of the interval of particles rather than one size,which could be seen in the phenomenon of the second case. To some extent,numerical method is useful in the study of clogging problems,which gave the same result obtained in laboratory test and simulation test. These data provided basis and reference for further study of clogging problems,and also provided a new method to study the micro-scale permeability clogging mechanism. | WANG Yuanyuan WANG Gangcheng CAO Yu | 2012 | Global Geology2012，15，2： | 0 |
| 20 | A novel advanced glycation endproducts breaker restores cardiovascular dysfunctions in experimental diabetic rats显示文摘AIM The formation of advanced glycation endproducts (AGEs) on connective tissue and matrix components leads to increases in collagen crosslinkingthat contributes to aortic and myocardial stiffness in normal aging and which occurs at an accelerated rate in diabetes. In this study, we examined the effects of a novel AGEs breaker, C36, on cardiovascular dysfunctions in experimental diabetic rats. METHODS and RESULTS Male Wiatar rats were made diabetic by i.p. injection of 70mg/kg streptozotocin. After 12 weeks of diabetes, the animals were randomly divided into 4 groups (n=8-11), | GangCHENG Li-liWANG Hong-yingLIU HaoCUI Ying-linCAO SongLI | 2005 | 中国药理通讯2005，22，2： | 0 |
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