|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of M2 antibodies in asymptomatic Chinese population显示文摘AIM: To investigate the presence of M2 antibodies specific for pdmary biliary cirrhosis (PBC) in asymptomatic Chinese and identify patients with early PBC.METHODS: Enzyme-linked immunosorbent assay (ElISA)tests for M2 antibodies to recombinant protein were performed in 5 011 subjects (age range, 26-85 years; mean age: 45.81±15.02 years) who took an annual physical examination. M2-positive subjects were further analyzed for immunoglobulin (Ig) classes and subclasses of M2 antibodies.Clinical, biochemical and immunological data were obtained for M2-positive subjects. In addition, ultrasonography (US)or endoscopic retrograde cholangio-pancreatography (ERCP)was performed to exclude any disorders other than PBC.RESULTS: M2 antibodies were detected in 8 (0.16%) of the 5 0LL subjects studied. Of the 8 subjects, 7 were female and 1 was male (age range: 40-74 years). An unexplained increase of serum alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (γ-GT) values, often to striking levels,was detected in 4 M2-positive subjects, 3 of them accorded with the diagnostic criteria recommended by the American Association for the Study of Liver Diseases, even though they had no symptoms of PBC (such as fatigue, pruritus or jaundice).Liver biopsy was performed in two M2-positive subjects and the histology was compatible with PBC in both cases.CONCLUSION: Our data, while not assessing the true prevalence of asymptomatic PBC in the general population,suggest that asymptomatic PBC is much more common in China than has been supposed. | Xiao-HuaJiang Ren-QianZhong Xiao-YunFan YinHu FengAn Jian-WenSun Xian-TaoKong | 2003 | World Journal of Gastroenterology2003，9，9： | 20 |
| 2 | Time-and pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid显示文摘AIM: To investigate Time- and pH-dependent colon-specific drug delivery systems (CDDS) for orally administered diclofenac sodium (DS) and 5-aminosalicylic acid (5-ASA), respectively. METHODS: DS tablets and 5-ASA pellets were coated by ethylcellulose (EC) and methacrylic acid copolymers (Eudragit L100 and $100), respectively. The in vitro release behavior of the DS coated tablets and 5-ASA coated pellets were examined, and then in vivo absorption kinetics of DS coated tablets in dogs were further studied. RESULTS: Release profile of time-dependent DS coated tablets was not influenced by pH of the dissolution medium, but the lag time of DS release was primarily controlled by the thickness of the coating layer. The thicker the coating layer, the longer the lag time of DS release is. On the contrary, in view of the pH-dependent 5-ASA coated pellets, 5-ASA release was significantly governed by pH. Moreover, the 5-ASA release features from the coated pellets depended upon both the combination ratio of the Eudragit~ L100 and S100 pH-sensitive copolymers in the coating formulation and the thickness of the coating layer. The absorption kinetic studies of the DS coated tablets in dogs demonstrated that in vivo lag time of absorption was in a good agreement with in vitro lag time of release. CONCLUSION: Two types of CDDS, prepared herein by means of the regular coating technique, are able to achieve site-specific drug delivery targeting at colon following oral administration, and provide a promising strategy to control drug release targeting the desired lower gastrointestinal region. | GangCheng FengAn Mei-JuanZou JinSun Xiu-HuaHao Yun-XiaHe | 2004 | World Journal of Gastroenterology2004，10，12： | 6 |
| 3 | Mycotoxin fumonisins: Health impacts and biosynthetic mechanism显示文摘Fumonisins 是在农业和食物工业的 mycotoxins 的最重要的组之一。他们被玉米的几普遍真菌的病原体生产。在导出玉米的食物的 Fumonisin 污染并且喂原因在家畜和姿势的几致命的疾病重要癌症风险到人(组 2B 致癌物) 。在最近的年里, fumonisins 在 mycotoxin 研究成为了一个热区域。这评论试图为 fumonisin 生合成和行动的模式在分子的机制的研究加亮进步。在 fumonisins 导致的细胞的效果的分子的基础的当前的理解被讨论。在帐篷离子的专辑被付在涉及 fumonisions 的生合成的单个基因酶的描述介绍进步。 | WANG Qiaomei WANG Jiansheng YU Fengan ZHU Xiangcheng Zaleta-Rivera Kathia DU Liangcheng | 2006 | Progress in Natural Science:Materials International2006，16，1： | 3 |
| 4 | 定位转基因所在的小麦基因组的细胞遗传学方法(英文)显示文摘本文设计了一种利用细胞遗传学原理定位转基因小麦中转基因所在的基因组的系统方法 ,并对该方法的有效性和可靠性进行了验证。该方法利用分别含有AABB、AADD和BBDD基因组的小麦近缘四倍体与待测转基因小麦杂交 ,F1 五倍体与同源非转化品种回交 ,根据回交群体中在抗性基因控制的性状上的分离比例以及各个体的染色体数目分析 ,从而对转基因小麦中转基因所在的基因组进行定位。该方法简单、可靠 ,实用性强 。 | 林毅 Fengan Yu Jonathan Gressel | 2001 | 激光生物学报2001，10，1： | 0 |
| 5 | War Games显示文摘The PLA demonstrates greater transparency and a willingness to learn Between October 29 and November 1, nearly 200 foreign cadets from the University of National Defense, Nanjing Army Command College and the Air Force | LIU FENGAN | 2011 | Beijing Review2011，54，49： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员