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| 1 | Mesenchymal stem cell-mediated cancer therapy: A dualtargeted strategy of personalized medicine显示文摘Cancer remains one of the leading causes of mortal-ity and morbidity throughout the world. To a signifi-cant extent, current conventional cancer therapies are symptomatic and passive in nature. The major obstacle to the development of effective cancer therapy is be-lieved to be the absence of suffi cient specifi city. Since the discovery of the tumor-oriented homing capacity of mesenchymal stem cells (MSCs), the application of specific anticancer gene-engineered MSCs has held great potential for cancer therapies. The dual-targeted strategy is based on MSCs’ capacity of tumor-directed migration and incorporation and in situ expression of tumor-specifi c anticancer genes. With the aim of trans-lating bench work into meaningful clinical applications, we describe the tumor tropism of MSCs and their use as therapeutic vehicles, the dual-targeted anticancer potential of engineered MSCs and a putative personal-ized strategy with anticancer gene-engineered MSCs. | Garth L Warnock | 2011 | World Journal of Stem Cells2011，3，11： | 7 |
| 2 | Organic/inorganic hybrid network materials by the sol-gel approach 显示文摘 | WEN Jianye WILKES Garth L | 1996 | Chem Mater1996，，8： | 2 |
| 3 | Dynamic sonification as a free music improvisation tool for physically disabled adults显示文摘 | Alan L Garth P | 2011 | Music and Medicine2011，1，3： | 1 |
| 4 | Solid state structure- property behavior of semicrystallinepoly(ether-block-amide) PEBAw ther- moplastic elastomers显示文摘 | Jignesh P Sheth Jiannong Xu Garth L Wilkes | 2003 | Polymer2003，44，： | 1 |
| 5 | Health-Related Quality of Life in Men after Treatment of Localized Prostate Cancer with External Beam Radiotherapy Combined with( 192 )Brachy Therapy: A Prospective Study of 93 Cases Using the EORTC Questionnaires QLQ-C30 and QLQ-PR25 显示文摘 | Wangren T Brandberg YH Garth L | 2004 | Int J Radiat Oncol Biol Phys2004，60，1： | 1 |
| 6 | Creep behavior of high density polyethylene films having well-defined morpholohies of stacked lamellae with and without an observable row-nucle-ated fibril structure 显示文摘 | Hongyi Zhou Garth L Wilkes | 1998 | Polymer1998，39，16： | 1 |
| 7 | A Delay/Doppler-mapping receiver system for GPS-reflection remote sensing显示文摘 | Stephen T L Peter K Garth F | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，5： | 1 |
| 8 | Monte Carlo Analysis of Dose Profiles Near Photon Irradiated Material Interfaces显示文摘 | Garth J C Chadsey W L | | IEEE Transactions on Nuclear Science0，22，6： | 1 |
| 9 | High antifreeze protein levels in wolffish (Anarhichas lupus) make them an ideal candidate for culture in cold, potentially ice laden waters显示文摘 | Marive D Nathalie R L Garth L F | 2007 | Aquaculture2007，272，： | 1 |
| 10 | Quantized CMA equalization for shaped signal constellations显示文摘 | ATHURALIYA S A GARTH L M | 2004 | IEEE Signal Processing Letters2004，11，2： | 1 |
| 11 | Physical aging studies of semicrystalline poly(ethylene terephthalate)显示文摘 | MARTIN R TANT GARTH L Wilkes | 1981 | J Appl polym Sci1981，26，9： | 1 |
| 12 | Role of chain symmetry and hydrogen bonding in segmented copolymers with monodisperse hard segments 显示文摘 | Jignesh P S Derek B K Garth L W | 2005 | Polymer2005，46，18： | 1 |
| 13 | Hybrid Materials Incorporating Polymeric/Oligomeric Species with Inorganic Glasses by a Sol-gel Press 显示文摘 | HUANG Hao-hsin BRUCE Orler GARTH L etc | 1985 | Polymer Bulletin1985，14，2： | 1 |
| 14 | Creep behavior of high density polyethylene films having well-defined morphologies of stacked lamellae with and without an observable row-nucleated fibril structure显示文摘 | Hong-yi Zhou Garth L Wilkes | 1998 | Polymer1998，39，16： | 1 |
| 15 | Joint density for eigenvalues of two correlated complex Wishart matrices: characterization of MIMO systems 显示文摘 | Kuo Ping Heng Smith P J Garth L M | 2007 | IEEE Transac- tions on Wireless Communications2007，6，11： | 1 |
| 16 | Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function 显示文摘 | Garth L N | 2007 | Journal of Cellular Biochemistry2007，100，6： | 1 |
| 17 | B7-H4 as a protective shield for pancreatic islet beta cells显示文摘Auto- and alloreactive T cells are major culprits that damage β-cells in type 1 diabetes(T1D) and islet transplantation. Current immunosuppressive drugs can alleviate immune-mediated attacks on islets. T cell co-stimulation blockade has shown great promise in autoimmunity and transplantation as it solely targets activated T cells, and therefore avoids toxicity of current immunosuppressive drugs. An attractive approach is offered by the newly-identified negative T cell cosignaling molecule B7-H4 which is expressed in normal human islets, and its expression co-localizes with insulin. A concomitant decrease in B7-H4/insulin colocalization is observed in human type 1 diabetic islets. B7-H4 may play protective roles in the pancreatic islets, preserving their function and survival. In this review we outline the protective effect of B7-H4 in the contexts of T1 D, islet cell transplantation, and potentially type 2 diabetes. Current evidence offers encouraging data regarding the role of B7-H4 in reversal of autoimmune diabetes and donor-specific islet allograft tolerance. Additionally, unique expression of B7-H4 may serve as a potential biomarker for the development of T1 D. Futurestudies should continue to focus on the islet-specific effects of B7-H4 with emphasis on mechanistic pathways in order to promote B7-H4 as a potential therapy and cure for T1 D. | Annika C Sun Dawei Ou Dan S Luciani Garth L Warnock | 2014 | World Journal of Diabetes2014，5，6： | 1 |
| 18 | The fluid mosaic model of the structure of cell membranes 显示文摘 | Singer S J Garth L N | 1972 | Science New Series1972，175，4023： | 1 |
| 19 | Medical and developmental outcome at 1 year for children conceived by intra- cytoplasmic sperm injection 显示文摘 | Jennifer R Bowen Frances L Gibson Garth I Leslie | 1998 | The Lancet1998，351，9115： | 1 |
| 20 | Non-isothermal crystallization kinetics of poly(p-phenylene sulphide)显示文摘 | Leonardo C L6pez Garth L Wilkes | 1989 | Polymer1989，30，5： | 1 |
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