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| 1 | The greater seedling high-light tolerance of Quercus robur over Fagus sylvatica is linked to a greater physiological plasticity显示文摘 | Fernando Valladares José Chico Ismael Aranda Luis Balaguer Pierre Dizengremel Esteban Manrique Erwin Dreyer | 2002 | Trees2002，，6： | 1 |
| 2 | Elderly patients with advanced colorectal cancer derive similar benefit without excessive toxicity after first-line chemotherapy with oxaliplatin-based combinations: Comparative outcomes from the 03-TTD-01 phase III study显示文摘 | Javier Sastre Enrique Aranda Bartomeu Massutí Jose Tabernero Manuel Chaves Albert Abad Alfredo Carrato Juan José Reina Bernardo Queralt Auxiliadora Gómez-Espa?a Encarnación González-Flores Fernando Rivera Ferrán Losa Teresa García Pedro Sanchez-Rovira Inm | 2008 | Critical Reviews in Oncology and Hematology2008，，2： | 1 |
| 3 | Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain显示文摘 | Núria Aranda Fernando E. Viteri Carme Montserrat Victoria Arija | 2010 | Annals of Hematology2010，，8： | 1 |
| 4 | Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis显示文摘Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors.Available evidence supports CD6,a lymphocyte surface receptor mostly expressed by T cells,as a putative target in autoimmunity.Accordingly,a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders,including psoriasis.Here,we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology.First,an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice,as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines,namely,interleukin-17A.Thus,isolated CD4+CD62L+T cells from CD6-deficient mice displayed decreased in vitro T-helper type 17 polarization.Second,a statistically significant association between CD6 single-nucleotide polymorphisms(rs17824933,rs11230563 and rs12360861)and more severe forms of psoriasis was demonstrated in a cohort of 304 patients at three public hospitals from the metropolitan area of Barcelona.Taken together,these results provide new supportive evidence of the contribution of the CD6 lymphocyte receptor in psoriasis at both experimental and clinical levels. | Marta Consuegra-Fernández Marc Julià Mario Martínez-Florensa Fernando Aranda Cristina Català Noelia Armiger-Borràs María-Teresa Arias Francisca Santiago Antonio Guilabert Anna Esteve Carlos Muñoz Carlos Ferrándiz José-Manuel Carrascosa Edurne Pedrosa Jorge Romaní MercèAlsina José-Manuel Mascaró-Galy Francisco Lozano | 2018 | Cellular & Molecular Immunology2018，15，10： | 1 |
| 5 | Gut microbiota metabolites for sweetening type I diabetes显示文摘Type 1 diabetes(T1D),also referred to as insulin-dependent diabetes mellitus,is a debilitating disease that follows the destruction of pancreatic insulin-producingβcells by autologous T-cells.T1D primarily affects children and has a strong genetic component,with>50 susceptibility loci identified,including HLA-DQβchains.1 However,the striking differences between European regions with similar genetic backgrounds and a sharp rise in T1D incidence in developed countries over the last several decades suggest that environmental factor(s)also play a relevant etiopathogenic role.2 Given the accumulating evidence linking the gut microbiota to protection against metabolic diseases,3 Mariño et al.4 recently tested the hypothesis that short-chain fatty acids(SCFAs),which are the end products of fermentation of dietary fibers by anaerobic intestinal microbiota,can protect genetically susceptible mice from developing T1D.Interestingly,the authors found that diets enriched in acetate or butyrate(two of the main SCFAs)can protect animals from developing diabetes through different and complementary cellular mechanisms.Such findings significantly enhance our understanding of the role of diet and gut microbiota in the development of autoimmune diseases and indicate that the use of medicinal foods may be a cost-effective treatment against T1D and other autoimmune diseases with a cellular component.Given that current anti-T1D approaches(which focus on prevention or modulation of the adaptive specific immune response against autoantigens)have been generally disappointing,5 such a new and refreshing strategy has attracted a great deal of attention(reviewed in Ref.2). | Thamer Aljutaily Marta Consuegra-Fernández Fernando Aranda Francisco Lozano Eduardo Huarte | 2018 | Cellular & Molecular Immunology2018，15，2： | 0 |
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