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| 1 | A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum显示文摘In filamentous fungi,nitrogen metabolism is repressed by GATA-type zinc finger transcription factors.Nitrogen metabolite repression has been found to affect antibiotic production,but the mechanism is still poorly understood.AcareB,encoding a homologue of fungal GATA-type regulatory protein,was cloned from Acremonium chrysogenum.Gene disruption and genetic complementation demonstrated that AcareB plays a key role in utilization of ammonium,glutamine and urea.In addition,significant reduction of cephalosporin production in the AcareB disruption mutant indicated that AcareB is important for cephalosporin production.In consistence with it,the transcriptional level of cephalosporin biosynthetic genes was significantly decreased in the AcareB disruption mutant.Electrophoretic mobility shift assay showed that AcAREB directly bound to the intergenic regions of pcbAB-pcbC,cefD1-cefD2 and cefEF-cefG.Sequence analysis showed that all the AcAREB binding sites contained the consensus GATA elements.AcareB is negatively autoregulated during cephalosporin production.Moreover,another GATA zinc-finger protein encoded by AcareA positively regulates the transcription of AcareB.However,AcareB does not regulate the transcription of AcareA.These results indicated that AcAREB plays an important role in both regulation of nitrogen metabolism and cephalosporin production in A.chrysogenum. | Feifei Guan Yuanyuan Pan Jinyang Li Gang Liu | 2017 | Science China(Life Sciences)2017，60，9： | 8 |
| 2 | Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance显示文摘Background:Non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)mutations or anaplastic lymphoma kinase(ALK)fusions show dramatic responses to specific tyrosine kinase inhibitors(TKIs);however,after 10-12 months,secondary mutations arise that confer resistance.We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two patients with NSCLC to investigate the mechanisms of resistance against the ALK-and EGFR-targeted TKIs crizotinib and osimertinib,respectively.Methods:Genotypes of patient biopsies and xenograft tumors were determined by whole exome sequencing(WES),and patients and xenograft-bearing mice received targeted treatment(crizotinib or osimertinib)accordingly.Xenograft mice were also treated for prolonged periods to identify whether the development of drug resistance and/or treatment responses were associated with tumor size.Finally,the pathology of patients biopsies and xenograft tumors were compared histologically.Results:The histological characteristics and chemotherapy responses of xenograft tumors were similar to the actual patients.WES showed that the genotypes of the xenograft and patient tumors were similar(an echinoderm microtu-bule-associated protein-like 4-ALK(EML4-ALK)gene fusion(patient/xenograft:CTC15035EML4-ALK)and EGFR L858R and T790M mutations(patient/xenograft:CTC15063EGFR L858R,T790M)).After continuous crizotinib or osimertinib treatment,WES data suggested that acquired ALK E1210K mutation conferred crizotinib resistance in the CTC15035EML4-ALK xenograft,while decreased frequencies of EGFR L858R and T790M mutations plus the appearance of v-RAF murine sarcoma viral oncogene homolog B(BRAF)G7V mutations and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha(PIK3C2A)A86fs frame shift mutations led to osimertinib resistance in the CTC15063EGFR L858R,T790M xenografts.Conclusions:We successfully developed a new method of generating drug resistance xenograft models from liquid biopsies using microfluidic technology,which might be a useful tool to investigate the mechanisms of drug resist-ance in NSCLC. | Yunhua Xu Feifei Zhang Xiaoqing Pan Guan Wang Lei Zhu Jie Zhang Danyi Wen Shun Lu | 2018 | Cancer Communications2018，38，1： | 7 |
| 3 | Programmable soft bending actuators with auxetic metamaterials显示文摘Soft robotics has been receiving increasing attention due to its flexibility and adaptability offered by embodied intelligence. A soft robot may undergo complex motions including stretching,contraction,bending,twisting,and their intricate combinations.Among these basic motions,bending plays a central role when a robot accomplishes tasks such as locomotion,grasping and manipulation. Although a rich repertoire of bending mechanisms has been reported,a systematic and rational design framework is still lack. In this paper,we provide a novel design strategy for soft bending actuators which allows integral modeling and design optimization. Nowadays,metamaterials are emerging as a new tool for soft robots,by encoding the desired complex motions directly within the material architectures,leading to conformable monolithic systems. We combine pneumatic actuators and flexible metamaterials to provide an alternative solution to soft bending actuators,with advantages of compact design,large bending motion,and convenient fabrication. A regular pneumatic chamber is embedded inside auxetic and non-auxetic metamaterials,and bending is generated when inflated. We carry out dimensionless analysis to identify the key design variables. To provide insight into design optimization,we develop a computation framework by modeling metamaterial structures with beam elements and the inner chamber with shell elements as an integral part,allowing efficient simulation of the coupled system. We systematically investigate how the bending angle varies with the key design variables and find the optimal design parameters.The experimental results are well in line with the simulation,and a remarkable bending motion of 0.43°/mm is achieved. | PAN Qi CHEN ShiTong CHEN FeiFei ZHU XiangYang | 2020 | Science China(Technological Sciences)2020，63，12： | 5 |
| 4 | Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation显示文摘Numerous valuable studies on electron dynamics have focussed on the extraordinary properties of molybdenum disulfide(MoS_(2));however,most of them were confined to the level below the damage threshold.Here the electron dynamics of MoS_(2) under intense ultrafast laser irradiation was investigated by experiments and simulations.Two kinds of ablation mechanisms were revealed,which led to two distinct types of electron dynamics and final ablation morphology.At a higher fluence,the emergence of superheated liquid induced a dramatic change in the transient reflectivity and micro-honeycomb structures.At a lower fluence,the material was just removed by sublimation,and the ablation structure was relatively flat.X-ray photoelectron spectroscopic(XPS)measurements demonstrated that thermal decomposition only occurred at the higher fluence.Furthermore,a theoretical model was developed to deeply reveal the ultrafast dynamics of MoS_(2) ablation.The simulation results were in good agreement with the temporal and spatial reflectivity distribution obtained from the experiment.The electron and lattice temperature evolution was also obtained to prove the ablation mechanism.Our results revealed ultrafast dynamics of MoS_(2) above the damage threshold and are helpful for understanding the interaction mechanism between MoS_(2) and intense ultrafast lasers,as well as for MoS_(2) processing applications. | Changji Pan Lan Jiang Jingya Sun Qingsong Wang Feifei Wang Kai Wang Yongfeng Lu Yeliang Wang Liangti Qu Tianhong Cui | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 5 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 6 | A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres显示文摘The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively. | Mingzhu Ye Hongliang Duan Lixia Yao Yicheng Fang Xiaoyu Zhang Ling Dong Feifei Yang Xinggang Yang Weisan Pan | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
| 7 | Novel rat model of multiple mitochondrial dysfunction syndromes(MMDS)complicated with cardiomyopathy显示文摘Background:Multiple mitochondrial dysfunction syndromes(MMDS)presents as complex mitochondrial damage,thus impairing a variety of metabolic pathways.Heart dysplasia has been reported in MMDS patients;however,the specific clinical symptoms and pathogenesis remain unclear.More urgently,there is a lack of an animal model to aid research.Therefore,we selected a reported MMDS causal gene,Isca1,and established an animal model of MMDS complicated with cardiac dysplasia.Methods:The myocardium-specific Isca1 knockout heterozygote(Isca1 HET)rat was obtained by crossing the Isca1 conditional knockout(Isca1 cKO)rat with theαmyosin heavy chain Cre(α-MHC-Cre)rat.Cardiac development characteristics were determined by ECG,blood pressure measurement,echocardiography and histopatho-logical analysis.The responsiveness to pathological stimuli were observed through adriamycin treatment.Mitochondria and metabolism disorder were determined by activity analysis of mitochondrial respiratory chain complex and ATP production in myocardium.Results:ISCA1 expression in myocardium exhibited a semizygous effect.Isca1 HET rats exhibited dilated cardiomyopathy characteristics,including thin-walled ventri-cles,larger chambers,cardiac dysfunction and myocardium fibrosis.Downregulated ISCA1 led to deteriorating cardiac pathological processes at the global and organiza-tional levels.Meanwhile,HET rats exhibited typical MMDS characteristics,including damaged mitochondrial morphology and enzyme activity for mitochondrial respira-tory chain complexesⅠ,ⅡandⅣ,and impaired ATP production.Conclusion:We have established a rat model of MMDS complicated with cardiomyopathy,it can also be used as model of myocardial energy metabolism dysfunction and mitochondrial cardiomyopathy.This model can be applied to the study of the mechanism of energy metabolism in cardiovascular diseases,as well as research and development of drugs. | Yahao Ling Jiaxin Ma Xiaolong Qi Xu Zhang Qi Kong Feifei Guan Wei Dong Wei Chen Shan Gao Xiang Gao Shuo Pan Yuanwu Ma Dan Lu Lianfeng Zhang | 2021 | Animal Models and Experimental Medicine2021，4，4： | 2 |
| 8 | Data-Driven Discovery in Mineralogy: Recent Advances in Data Resources, Analysis, and Visualization显示文摘Large and growing data resources on the diversity, distribution, and properties of minerals are ushering in a new era of data-driven discovery in mineralogy. The most comprehensive international mineral database is the IMA database, which includes information on more than 5400 approved mineral species and their properties, and the mindat.org data source, which contains more than 1 million species/locality data on minerals found at more than 300 000 localities. Analysis and visualization of these data with diverse techniques—including chord diagrams, cluster diagrams, Klee diagrams, skyline diagrams, and varied methods of network analysis—are leading to a greater understanding of the co-evolving geosphere and biosphere. New data-driven approaches include mineral evolution, mineral ecology, and mineral network analysis—methods that collectively consider the distribution and diversity of minerals through space and time. These strategies are fostering a deeper understanding of mineral co-occurrences and, for the first time, facilitating predictions of mineral species that occur on Earth but have yet to be discovered and described. | Robert M. Hazen Robert T. Downs Ahmed Eleish Peter Fox Olivier C. Gagné Joshua J. Golden Edward S. Grew Daniel R. Hummer Grethe Hystad Sergey V. Krivovichev Congrui Li Chao Liu Xiaogang Ma Shaunna M. Morrison Feifei Pan Alexander J. Pires Anirudh Prabhu Jolyon Ralph Simone E. Runyon Hao Zhong | 2019 | Engineering2019，5，3： | 2 |
| 9 | Structure-Mediated Excitation of Air Plasma and Silicon Plasma Expansion in Femtosecond Laser Pulses Ablation显示文摘Femtosecond laser-induced surface structures upon multiple pulses irradiation are strongly correlated with the pulse number,which in turn signifcantly afects successive laser-material interactions.By recording the dynamics of femtosecond laser ablation of silicon using time-resolved shadowgraphy,here we present direct visualization of the excitation of air plasma induced by the refected laser during the second pulse irradiation.Te interaction of the air plasma and silicon plasma is found to enhance the shockwave expansion induced by silicon ablation in the longitudinal direction,showing anisotropic expansion dynamics in diferent directions.We further demonstrate the vanishing of air plasma as the pulse number increases because of the generation of a rough surface without light focusing ability.In the scenario,the interaction of air plasma and silicon plasma disappears;the expansion of the silicon plasma and shockwave restores its original characteristic that is dominated by the laser-material coupling.Te results show that the excitation of air plasma and the laser-material coupling involved in laser-induced plasma and shockwave expansion are structure mediated and dependent on the pulse number,which is of fundamental importance for deep insight into the nature of laser-material interactions during multiple pulses ablation. | Qingsong Wang Lan Jiang Jingya Sun Changji Pan Weina Han Guoyan Wang Feifei Wang Kaihu Zhang Ming Li Yongfeng Lu | 2018 | Research2018，，1： | 2 |
| 10 | Adjacent segment disease after anterior cervical decompression and fusion: analysis of risk factors on X-ray and magnetic resonance imaging显示文摘 | Zhao Yanbin Sun Yu Zhou Feifei Wang Shaobo Zhang Fengshan Pan Shengfa | 2014 | Chinese Medical Journal2014，，22： | 2 |
| 11 | Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women显示文摘 | Rong Yang Xiaojing Ma Xiaoping Pan Feifei Wang Yuqi Luo Chengchen Gu Yuqian Bao Weiping Jia | 2013 | Menopause: The Journal of The North American Menopause Society2013，，5： | 1 |
| 12 | Synthesis of towerlike ZnO structures and visible photoluminescence origins of varied-shaped ZnO nanostructures显示文摘 | Wang Feifei Cao Li Pan Anlian | 2007 | J Phys Chem C2007，111，21： | 1 |
| 13 | Profiles of and correlation between objective and subjective outcome assessments following open-door laminoplasty for cervical spondylotic myelopathy显示文摘 | Zhou Feifei Zhang Yilong Sun Yu Zhang Fengshan Pan Shengfa Diao Yinze Chen Xin Zhao Yanbin | 2014 | Chinese Medical Journal2014，，14： | 1 |
| 14 | Characteristics of Liver Functions in Patients With COVID-19 and Construction of a Prognostic Evaluation Decision Model Based on Liver Functions显示文摘A number of studies have suggested that coronavirus disease 2019(COVID-19)can cause liver damage.However,clinical features and outcome of COVID-19 in patients with liver injury remain to be further investigated.In this study,the clinical data of 265 COVID-19 patients admitted to seven tertiary hospitals were collected.Based on a threshold for transaminase or total bilirubin levels at two times the normal upper limit,patients were divided into mild or moderate/severe liver injury groups.Among the 265 patients,183 patients showed liver injury within 48 hours of admission.Aspartate aminotransferase levels were predominantly elevated in the liver injury group,but albumin levels were reduced.Moreover,fibrinogen and D-dimer were significantly increased.Furthermore,68%of the patients with moderate/severe liver injury had one or more underlying diseases.Almost half of these patients developed acute respiratory distress syndrome(44%)and secondary infections(46%).These patients showed increased interleukin-6 and interleukin-10 levels and a decrease in PaO2 and the oxygenation index.In addition,levels of alanine aminotransferase,aspartate aminotransferase,and albumin were correlated with the oxygenation index,D-dimer and lymphocyte counts.Furthermore,a novel prognostic assessment model based on liver function was established,which accuracy reached 88%and was able to accurately assess the prognosis of COVID-19 patients. | Tongtong Pan Dazhi Chen Chenwei Pan Yi Kang Junping Liu Feifei Su Liang Hong Huili Li Hui Zhao Zhuo Lin Xiaodong Wang Hongwei Lin Qianjing Du Chao Cai Yongping Chen | 2020 | Infectious Microbes & Diseases2020，2，4： | 1 |
| 15 | On the relationship be- tween mean and variance of soil moisture fields 显示文摘 | Pan Feifei Peters-Lidard C D | 2008 | Journal of the American Water Resources Association2008，44，1： | 1 |
| 16 | Superimposed training for channel estimation of OFDM modulated amplify-and-forward relay networks显示文摘This paper is concerned with the problem of channel estimation for amplify-and-forward(AF)cooperative relay networks with orthogonal frequency division multiplexing(OFDM)modulation.The algorithm is based on both the least square(LS)and minimum mean square error(MMSE)technique with a superimposed training strategy.Specifcally,both the source and relay superimpose their own training signal onto data stream prior to transmission so as to estimate the separate channel state information of the source to relay link and the relay to destination link.We also present the performance analysis and derive the approximated closed-form expressions for the MSE of separate channel estimation of source to relay link and the relay to destination link,respectively,from which we compute the optimal training signal as well as the relay power-amplifcation factor.To further improve the performance of channel estimation,we adopt a weighted average process to enhance the estimation performance over multiple OFDM blocks,from which we compute the optimal tracking factor.Simulation results are provided to corroborate the proposed scheme. | ZHANG Han PAN DaRu CUI HaiXia GAO FeiFei | 2013 | Science China(Information Sciences)2013，56，10： | 0 |
| 17 | Ferroelectricity coexisted with p-orbital ferromagnetism and metallicity in two-dimensional metal oxynitrides显示文摘Two-dimensional (2D) multiferroics have attracted increasing interests in basic science and technological fields in recent years.However,most reported 2D magnetic ferroelectrics are based on the d-electron magnetism,which makes them rather rare due to the empirical d^(0) rule and limits their applications for low magnetic phase transition temperature.In this work,we demonstrate that the ferroelectricity can coexist with the p-electron-induced ferromagnetism without the limitation of d^(0) rule and metallicity in a family of stable 2D MXene-analogous oxynitrides,X_(2)NO_(2) (X = In,Tl).Remarkably,the itinerant character of p electrons can lead to the strong ferromagnetic metallic states.Furthermore,a possible magnetoelectric effect is manifested in a Tl_(2)NO_(2)/WTe_(2) heterostructure through the interface engineering.Our findings provide an alternative possible route toward 2D multiferroics and enrich the concept of ferroelectric metals. | Haoqiang Ai Feifei Li Haoyun Bai Dong Liu Kin Ho Lo Shengyuan AYang Yoshiyuki Kawazoe Hui Pan | 2022 | npj Computational Materials2022，，1： | 0 |
| 18 | Effects of Temperature, pH, Ammonia Nitrogen Content and Salinity on Coral (Acropora millepora & Palythoa sp. ) Bleaching显示文摘This study was conducted to investigate the effects of temperature,pH,ammonia nitrogen content and salinity on the bleaching of Acropora millepora and Palythoa sp. This study included two experiments: Experiment 1 was designed to test the effects of different gradients of temperature,pH,ammonia nitrogen content and salinity at a time point( 6 h) on Palythoa sp. breeding; and Experiment 2 tested the effects of different levels of temperature,pH,ammonia nitrogen content and salinity at three time points( 24,48 and 72 h) on A. millepora bleaching. Before the experiments,A. millepora and Palythoa sp. were washed with filtered seawater( 0. 45 μm microporous membrane filtration) and then reared in interior seawater aquarium cylinder. The experiments were carried out when the coral tentacles extended and the growth condition were good. The results showed that under high temperature( 32-40 ℃),both A. millepora and Palythoa sp. showed drastic reactions in the course of time,reflecting considerably significant stress responses. The number of releasing zooxanthellae increased with increase or decreaseof the pH value( pH 0,4,6,10,12) over time. Meanwhile,a relatively thick layer of mucus was found on the upper zone of the seawater and the corals started to bleach. As the concentration of ammonia nitrogen( NH_4^+,0 mmol/L) increased in the course of time,the number of zooxanthellae floating on A. millepora and Palythoa sp. had the tendency to rise. When the salinity level were at 15‰ and 40‰ for A. millepora and below 34‰ for Palythoa sp.,a considerable number of zooxanthellae floated out and had rising trend in their number over time at 24-72 h and 6 h,respectively. In this occasion,the corals stopped growing and started to bleach. In conclusion,it revealed that temperature,pH,ammonia nitrogen content and salinity are the potential impact factors on coral breeding. It is suggested that,as temperature,pH value and salinity decrease or increase,as well as ammonia nitrogen content rises,the quantity of phycobiont would be raised,and the bleaching would be more severe. | Yan CHEN Jun MA Hai HUANG Pan CHEN Feifei CHAO Wenxiang LUO | 2017 | Agricultural Biotechnology2017，6，6： | 0 |
| 19 | Magnesium incorporation activates perovskite cobaltites toward efficient and stable electrocatalytic oxygen evolution显示文摘Cobalt-rich perovskite oxides play a paramount role in catalyzing oxygen evolution reaction(OER)on account of their acceptable intrinsic activity but are still challenging due to the high costs and undesired stability.In response to the defects,herein,the Mg-incorporated perovskite cobaltite SrCo_(0.6)Fe_(0.3M)g_(0.1)O_(3-δ)(SCFM-0.1)is proposed as a novel earth-abundant and durable OER electrocatalyst.A well-consolidated cubic-symmetry structure and more active oxygen intermediates are enabled upon Mg substitution.Hence,the optimized SCFM-0.1 perovskite oxide achieves prominent OER electrocatalytic performance,that is,a low overpotential of only 320 mV at 10 mA cm^(-2),a small Tafel slope of 65 mV dec^(-1),as well as an outstanding durability within 20 h,substantially outperforming that of the pristine SrCo_(0.7)Fe_(0.3)O_(3-δ)and benchmark Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)and IrO_(2) catalysts.The strong pHdependent behavior associated with lattice oxygen activation mechanism for SCFM-0.1 catalyst is also confirmed.This work paves a unique avenue to develop cost-effective and robust perovskite cobaltites for efficient OER electrocatalysis. | Siyu Pan Zilin Ma Wenying Yang Biaokui Dongyang Huizhi Yang Shimin Lai Feifei Dong Xixian Yang Zhan Lin | 2023 | Materials Reports(Energy)2023，3，3： | 0 |
| 20 | Discussion on the Mechanism of Action of High-frequency Drugs for Treating Heart Failure Based on Network Pharmacology显示文摘Objective:To explore the target and mechanism of Astragalus membranaceus,poria,salvia miltiorrhiza and semen leiocarpa in the treatment of heart failure by network pharmacology.Methods:The active components of traditional Chinese medicine and the target of heart failure were screened by multi-platform,and the standard gene was transformed by Uniprot.CytoCasp 3.6.1 was used to draw the network diagram of traditional Chinese medicine・component-target.Go and KEGG analysis were performed by Metascape.Results:A total of 36 predictive target sites of Radix Astragalus,Fuling poria,Salvia miltiorrhiza and Draba nemorosa were screened for treatment of heart failure,mainly involving nerve and factor pathways:ADRB2,ADRA1B and AChE.Cancer pathway:TP53,TNF;Pathways of inflammation:IL1B,PTSG2,PTSG1;Sex hormone pathway:ESRI,AR,PGR;Others:SCN5A,HIF1A,etc.The results of GO and KEGG enrichment suggested that the treatment of heart failure with the top four drugs involved cancer pathway,calcium signaling pathway,HIF-1 signaling pathway,and involved in blood circulation,cell proliferation and other processes.Conclusion:This study combines the pharmacological studies of Chinese medicine and western medicine to reveal the mechanism of multi-target and multi-channel regulation of body balance in Chinese medicine treatment. | Feifei Lei Mingjun Zhao Haifang Wang Chao Pan Xiaoya Shi | 2021 | Journal of Clinical and Nursing Research2021，5，3： | 0 |
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