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| 1 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 2 | Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide显示文摘Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting. | Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie | 2020 | World Journal of Cardiology2020，12，1： | 4 |
| 3 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 4 | Phenotypic and genetic heterogeneity in Dent's disease-the results of an Italian collaborative study显示文摘 | Tosetto E Ghiggeri GM Emma F | 2006 | Nephrol Dial Transplant2006，21，9： | 1 |
| 5 | Sunitinib 显示文摘 | DEEKS E D EMMA D KEATING G M | 2006 | Drugs2006，66，17： | 1 |
| 6 | Phenotypic and molecular characterisation of Brucella isolates from marine mammals显示文摘 | Claire E Dawson Emma J Stubberfield Lorraine L Perrett | 2008 | BMC Microbiology2008，8，： | 1 |
| 7 | Confirmation of the ' long- lived' tetra-nitrogen (N4 ) molecule using neutralization-reion- ization mass spectrometry and ab initio calculations显示文摘 | Emma E Rennie Paul M Mayer | 2004 | The Jour- nal of Chemical Physics2004，120，10： | 1 |
| 8 | C-reactive protein concentra-tion and the vascular benefits of statin therapy:an analysis of 20,536 patients in the Heart Protection Study显示文摘 | Jonathan E Derrick B Emma L | 2011 | LANCET2011，，9764： | 1 |
| 9 | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS显示文摘 | Emma C Juan C E Francisco A T B | 2002 | Journal of Agriculture and Food Chemistry2002，50，： | 1 |
| 10 | Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle显示文摘 | Jooste E Zhang Y EmMa C W | 2005 | Anesthesiology2005，102，： | 1 |
| 11 | Systematic review comparing meropenem with imipenem plus cilastatin in the treatment of severe infections显示文摘 | Steven J Canthy E Emmas C | 2005 | Current medical research and opinion2005，21，5： | 1 |
| 12 | Phenotypic and genetic heterogeneity in Dent's disease-the results of an Italian collab- orative study 显示文摘 | Tosetto E Ghiggeri GM Emma F | 2006 | Nephrol Dial Transplant2006，21，9： | 1 |
| 13 | Renal involvement in mitochondrial cytopathies显示文摘 | Emma F Bertini E Salviati L | | 0，，04： | 1 |
| 14 | Integrated decision support system for urban air quality assessment显示文摘 | Lim Ling Hughes L Susan J Hellawell Emma E | 2005 | Environmental Modelling & Software2005，20，7： | 1 |
| 15 | Sunitinib显示文摘 | DEEKS E D EMMA D KEATING G M | 2006 | Drugs2006，66，17： | 1 |
| 16 | Recovery of meiofauna communities following mudflat disturbance by tramp- ling associated with crab-tiling 显示文摘 | GARETH E L J MARTIN J A EMMA V S | 2007 | Marine Environmental Re- search2007，64，4： | 1 |
| 17 | Electro- chemical detection of aniline: an electrochemically initiated reaction pathway 显示文摘 | Seymour E H Nathan Lawrence S Emma Beckett L | 2002 | Talanta2002，57，： | 1 |
| 18 | End groups in fluoropolymers显示文摘 | Maurizio P Emma B Giuseppe E | 1999 | J Fluorine Chem1999，95，12： | 1 |
| 19 | Melanoma in the gastrointestinal tract显示文摘 | Daniel Blecker Susan Abraham Emma E Furth Michael L Kochman | 1999 | The American Journal of Gastroenterology1999，，12： | 1 |
| 20 | Phenotypic and mo- lecular characterization of Brucella isolates from marine mammals显示文摘 | Claire E D Emma J S Lorraine L P | 2008 | BMC Microbiol2008，，8： | 1 |
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