|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients. | Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | Effect of harmless acute pancreatitis score, red cell distribution width and neutrophil/lymphocyte ratio on the mortality of patients with nontraumatic acute pancreatitis at the emergency department显示文摘BACKGROUND: Harmless acute pancreatitis score(HAPS), neutrophile/lymphocyte ratio and red blood cell distribution width(RDW) are used to determine the early prognosis of patients diagnosed with nontraumatic acute pancreatitis in the emergency department(ED).METHODS: Patients diagnosed with acute pancreatitis(K 85.9) in the ED according to the ICD10 coding during one year were included in the study. Patients with chronic pancreatitis and those who had missing data in their files were excluded from the study. Patients who did not have computed tomography(CT) in the ED were not included in the study.RESULTS: Ultimately, 322 patients were included in the study. The median age of the patients was 53.1(IQR=36–64). Of the patients, 68.1%(n=226) had etiological causes of the biliary tract. The mortality rate of these patients within the first 48 hours was 4.3%(n=14). In the logistic regression analysis performed by using Balthazar classification, HAPS score, RDW, neutrophile/lymphocyte ratio, age, diabetes mellitus and systolic blood pressure, the only independent variable in determining mortality was assigned as Balthazar classification(OR: 15; 95% CI: 3.5 to 64.4).CONCLUSIONS: HAPS, neutrophile/lymphocyte ratio and RDW were not effective in determining the mortality of nontraumatic acute pancreatitis cases within the first 48 hours. The only independent variable for determining the mortality was Balthazar classifi cation. | Bedia Gülen Ertan Sonmez Serpil Yaylaci Mustafa Serinken Cenker Eken Ali Dur Figen Tunali Turkdogan ?zgür S?güt | 2015 | World Journal of Emergency Medicine2015，6，1： | 13 |
| 3 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 4 | Extended release lipophilic indomethacin microspheres:formulation factors and mathematical equations fitted drug release rates显示文摘 | KARASULU E YESIM KARASULU H ERTAN G | 2003 | Eur J Pharm Sci2003，19，23： | 1 |
| 5 | Metabolic and demographic characteristics of children with urolithiasis in western Turkey 显示文摘 | Ertan P Tekin G Oger N | 2011 | Urol Res2011，39，2： | 1 |
| 6 | Magnetic resonance imaging and diffusion-weighted imaging of normal-appearing white matter in children and young adults with tuberous sclerosis complex 显示文摘 | Arulrajah S Ertan G Jordan L | 2009 | Neuroradiology2009，51，11： | 1 |
| 7 | The effects of citric acid ( antioxidant ) and benzoic acid ( antimi- crobial agent) on the mouse liver: Biochemical and histopathologieal study 显示文摘 | Aktae T Kaboglu A Ertan F Ekinci F Huseyinova G | 2003 | Biologia-Section Cellular and Molecular Biology2003，58，3： | 1 |
| 8 | Different geometric shaped hydrogel theophylline tablets: statistical approach for estimating drug release显示文摘 | Karasulu HY Ertan G | 2002 | Farmaco2002，57，11： | 1 |
| 9 | Reliability and validity of the GeriatricDepression Scale in depression in Parkinson’s disease 显示文摘 | Ertan FS Ertan T Kiziltan G | 2005 | J NeurolNeurosurg Psychiatry2005，76，10： | 1 |
| 10 | Modeling of theophylline release from different geometrical erodible tablets显示文摘 | Karasulu HY Ertan G Ktlse T | 2002 | Eur JPharm Biopharm2002，49，2： | 1 |
| 11 | Modeling of theophylline release from different geometrical erodible tablets显示文摘 | Karasulu HY Ertan G Kose T | 2002 | Eur Pharm Biopharm2002，49，： | 1 |
| 12 | The preparation and evaluation of sustained release suppositories containing ketoprofen and Enduagit RL 100 by using factorial design显示文摘 | OZGUNEY S OZCAN ERTAN G | 2007 | Phar Deve Tech2007，12，1： | 1 |
| 13 | Modeling of theoghylline release form different geometrical erodible tablets 显示文摘 | Karasulu HY Ertan G Kose Y | 2000 | Eur J Pharm Biopharm2000，349，2： | 1 |
| 14 | Neuroprotective effects of infliximab in experimental spinal cord injury显示文摘 | G?khan Kurt Ertan Ergün Berker Cemil Alp ?zgün B?rcek Pelin B?rcek ?zlem Gülbahar Necdet ?eviker | 2009 | Surgical Neurology2009，，3： | 1 |
| 15 | Release and diffusional modeling of metronidazole lipid matrices 显示文摘 | Ozyazici M Gokce E H Ertan G | 2006 | Eur J Pharm Biopharm2006，63，3： | 1 |
| 16 | Vertical placement of aphakic Artisan intraocular lens in a patient with traumatic localized aniridia显示文摘 | Kamburoglu G Bahadir M Ertan A | 2006 | J Cataract Refract Surg2006，32，9： | 1 |
| 17 | Parkinsonism caused by cavernoma located in basal ganglion显示文摘 | Ertan S Benbir G Tanriverdi T | 2005 | Parkinsonism Relat Disord2005，11，： | 1 |
| 18 | Dural plasmaeytoma mimicking meningioma in a patient with multiple myeloma显示文摘 | Sahin F Saydam G Ertan Y | 2006 | J Clin Neurosci2006，13，2： | 1 |
| 19 | Pediatric littoral cell angioma of the spleen: muhimodality imaging including diffusion-weighted imaging显示文摘 | Ertan G Tekes A Mitchell S | 2009 | Pediatr Radial2009，39，10： | 1 |
| 20 | Pediatric littoral cell an- gioma of the spleen: muhimodality imaging including diffusion- weighted imaging显示文摘 | Ertan G Tekes A Mitchell S | 2009 | Pediatr Radiol2009，39，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员