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3篇 您的检索式：作者名="Marc Jacobsen"

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		题名	作者	年代	出处	被引量
	1	Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients显示文摘T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease progression.Pro-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell function.Constitutive STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune diseases.We characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for M.tuberculosis-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 expression.Lentiviral modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after M.tuberculosis-specific stimulation compared to healthy contacts.In addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy contacts.Notably,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in T-cells.Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.SOCS3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 phosphorylation.SOCS3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 phosphorylation.We conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients.	Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch Marc Jacobsen	2019	Cellular & Molecular Immunology2019，16，3：	15
	2	Chemical vapor deposition of pyrolytic carbon on carbon nanotubes显示文摘	Hatem Allouche Marc Monthioux Ronald L Jacobsen	2003	Carbon2003，，15：	1
	3	Aberrant cytokine milieu and signaling affect immune cell phenotypes and functions in tuberculosis pathology:What can we learn from this phenomenon for application to inflammatory syndromes?显示文摘Our previous study published in Cellular&Molecular Immunology(Harling et al.1)described aberrant immunological features in the pathogenesis of tuberculosis.Overall,we provided evidence supporting an impact chain regarding aberrant high interleukin(IL)-6 and IL-10 cytokine expression and respective receptor signaling affecting T-cell functions in acute tuberculosis.Constitutive STAT3 phosphorylation,high expression of its key regulator suppressor of cytokine signaling(SOCS)3 and spontaneous IL-6/IL-10 secretion characterized CD4^(+)T cells from tuberculosis patients.	Ernest Adankwah Julia Seyfarth Richard Phillips Marc Jacobsen	2021	Cellular & Molecular Immunology2021，18，8：	0

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