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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies 显示文摘 | Flores-Mateo G Carrillo-Santisteve P Elosua R | 2009 | Am J Epidemiol2009，170，2： | 1 |
| 3 | Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population显示文摘 | G6mez M Vila J Elosua R | 2014 | Atherosclerosis2014，232，1： | 1 |
| 4 | Association of APOE genotype with carotid atherosclerosis in men and women:the Framingham Heart Study显示文摘 | Elosua R Ordovas JM Cupples LA | 2004 | J Lipid Res2004，45，： | 1 |
| 5 | Sport practice and the risk of lone atrial fibrillation:a case-control study显示文摘 | Elosua R Arquer A Mont L | | 0，，： | 1 |
| 6 | Physical activity,height,and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals显示文摘 | Mont L Tamborero D Elosua R | 2008 | Europace2008，10，1： | 1 |
| 7 | Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general popula- tion显示文摘 | Gomez M Vila J Elosua R | 2014 | Atherosclerosis2014，232，1： | 1 |
| 8 | Variables associated with fibrinogen in a population-based study:interation between smoking and age on fibrinogen concentration显示文摘 | Nascetti S Elosua R Pena A | 2001 | Eur J Epidemiol2001，17，： | 1 |
| 9 | Amount and intensity of physical activ- ity, physical fitness, and serum lipids in men显示文摘 | Marrugat J Elosua R Covas MI | 1996 | Am J Epidemlol1996，143，： | 1 |
| 10 | Physical activity,height,and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals显示文摘 | Mont L Tamborero D Elosua R | | 0，，： | 1 |
| 11 | Lone atrial fibrillation and sport practice 显示文摘 | Elosua R Arquer A Mont L | 2002 | Eur Heart J2002，23，： | 1 |
| 12 | Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter显示文摘 | MONT L ELOSUA R BRUGADA J | 2009 | Eu- ropace2009，11，1： | 1 |
| 13 | The relevance of the associa- tion between inflammation and atrial fibrillation显示文摘 | Alegret JM Aragonès G Elosua R | 2013 | Eur J Clin Invest2013，43，4： | 1 |
| 14 | Response of oxidativestress biomarkers to a 16-week aerobic physical activityprogram,and to acute physical activity,in healthy youngmen and women显示文摘 | Elosua R Molina L Fito M | 2003 | Atherosclerosis2003，167，2： | 1 |
| 15 | Cardiovascular risk factors: insights from Framingham Heart Study 显示文摘 | O'Donnell CJ Elosua R | 2008 | Rev Esp Cardiol2008，61，： | 1 |
| 16 | Sport practice and the risk of lone atrial fibrillation:a case-control study显示文摘 | Elosua R Arquer A Mont L | 2006 | Int J Cardiol2006，108，3： | 1 |
| 17 | Relationship of lipid oxi- dation with subclinical atherosclerosis and 10-year coronary events in general population 显示文摘 | Gomez M Vila J Elosua R | 2014 | Atherosclerosis2014，232，1： | 1 |
| 18 | Amount and intensity of physical activity,physical fitness and sermn lipids in men显示文摘 | MARRUGAT J ELOSUA R COVAS M I | 1996 | Am J Epide1996，143，： | 1 |
| 19 | Sudden death显示文摘 | Bayes de Luna A Elosua R | | 0，，： | 1 |
| 20 | Response of oxidative stress biomarkers to a 16 week aerobic physical activity program,and to acute physical activity, in healthy young men and women显示文摘 | ELOSUA R MOLINA L FITO M | 2003 | Atheroselerosis2003，167，2： | 1 |
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