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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 3 | 新兴的微乳技术(英)显示文摘从本世纪40年代初舒尔曼及其助手发现微乳以来,微乳已被广泛地应用于许多领域。微乳具有很高的界面面积,稳定的热力学特性及对难溶液体的强溶解性,所以它被广泛地用在化妆品、制药、润滑剂、食品、农业喷洒、涂料、环境治理、清洗、燃料、化学合成、微孔介质的合成、提高反应的动力学特性、化学分析等诸多领域。讨论了微乳在新兴技术中的应用研究。 | V贺哈布拉 ML弗里 PK坎 SE特鲁斯代尔 DO沙欣 于艳 | 1999 | 日用化学品科学1999，22，1： | 5 |
| 4 | Expanding indication: EUS-guided hepaticoduodenostomy for isolated right intrahepatic duct obstruction (with video)显示文摘 | Se Jeong Park Jun-Ho Choi Do Hyun Park Joon Hyuk Choi Sang Soo Lee Dong-Wan Seo Sung Koo Lee Myung-Hwan Kim | 2013 | Gastrointestinal Endoscopy2013，，2： | 4 |
| 5 | EMR versus gastrectomy for intramucosal gastric cancer: comparison of long-term outcomes显示文摘 | Kwi-Sook Choi Hwoon-Yong Jung Kee Don Choi Gin Hyug Lee Ho June Song Do Hoon Kim Jeong Hoon Lee Mi-Young Kim Byung Sik Kim Sung Tae Oh Jeong Hwan Yook Se Jin Jang Sung-Cheol Yun Seon Ok Kim Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 2 |
| 6 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 7 | Incorporation of cholesterol into the cellular membranes of Lactobacillus acidophilus ATCC 43121 显示文摘 | NOH DO KIM SH GILLILAND SE | 1997 | J Dairy Sci1997，80，12： | 1 |
| 8 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 9 | Rotavirus antigenemia in children is associated with viremia显示文摘 | Blutt SE Matson DO Crawford SE | 2007 | PLoS Med2007，4，4： | 1 |
| 10 | Definitive chemoradiation therapy with capecitabine in locally advanced pancreatic cancer显示文摘 | Hyo Song Kim Seong Yoon Yi Hyun Jung Jun Jeeyun Lee Se Hoon Park Jong Kyun Lee Kyu Taek Lee Kwang Hyuck Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Young Suk Park Ho Yeong Lim Won Ki Kang Hee Chul Park Do Hoon Lim Joon Oh Park | 2010 | Anti-Cancer Drugs2010，，1： | 1 |
| 11 | Rotavirus antigenemia in children is associated with viremia显示文摘 | Blutt SE Matson DO Crawford SE el al | 2007 | J Virol2007，4，4： | 1 |
| 12 | Incorporation of cholesterol into the cellular membranes of Lactobacillus acidophilus ATCC 43121 显示文摘 | NOH DO KIM SH GILLILAND SE | 1997 | J Dairy Sei1997，80，： | 1 |
| 13 | Rcesieracrcuh lating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss显示文摘 | Anumba DO Gelany SE Elliott SL | 2010 | Reprod Biol Endocrinol2010，8，1： | 1 |
| 14 | Incorporation of cholesterol into the cell membrane of Lactobacillus acidophilus ATCC 43121 显示文摘 | Noh DO Kim SH Gilliland SE | 1997 | J Dairy Sci1997，80，12： | 1 |
| 15 | Incorporation of cholesterol into the cell membrance of Lactobacillus acidophilus ATCC43121 显示文摘 | DON DO KIM SH GILLILAND SE | 1997 | J Dairy Sci1997，80，： | 1 |
| 16 | Metallothionein gene expression in human adipose tissue from lean and obese subjects 显示文摘 | Do MS Nam SY Hong SE | 2002 | Horm Metab Res2002，34，6： | 1 |
| 17 | Incorporation of cholesterol into the cellular membrane of Lactobacillus acidophilus ATCC 43121 显示文摘 | Noh DO Kim SH Gilliland SE | 1997 | Dairy Sci1997，80，： | 1 |
| 18 | Incorporation of cholesterol into the cellular membrane of Lactobacillus acidophilus ATCC 43121 显示文摘 | Noh DO Kim SH Gilliland SE | 1997 | J Dairy Sci1997，80，12： | 1 |
| 19 | Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase 显示文摘 | Zharkov DO Rosenquist TA Gerchman SE | 2000 | Journal of Biological Chemistry2000，275，28： | 1 |
| 20 | Creative innovation : possible brain mechanisms 显示文摘 | Heilman KM Nadeau SE Beversdorf DO | 2003 | Neurocase2003，9，5： | 1 |
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