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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications显示文摘 | Ji Yong Ahn Hwoon-Yong Jung Kee Don Choi Ji Young Choi Mi-Young Kim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Ho June Song Gin Hyug Lee Jin-Ho Kim Young Soo Park | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 3 | EMR versus gastrectomy for intramucosal gastric cancer: comparison of long-term outcomes显示文摘 | Kwi-Sook Choi Hwoon-Yong Jung Kee Don Choi Gin Hyug Lee Ho June Song Do Hoon Kim Jeong Hoon Lee Mi-Young Kim Byung Sik Kim Sung Tae Oh Jeong Hwan Yook Se Jin Jang Sung-Cheol Yun Seon Ok Kim Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 2 |
| 4 | Endoscopic submucosal dissection as alternative to surgery for complicated gastric heterotopic pancreas显示文摘BACKGROUND Gastric heterotopic pancreas(GHP)is generally asymptomatic and rarely features complications such as pancreatitis,pseudocysts,gastric outlet obstruction,bleeding,obstructive jaundice,or intussusception.However,the treatment of complicated GHP is challenging and often requires surgical resection.AIM To investigate the clinical outcomes of endoscopic submucosal dissection(ESD)as alternative to surgical resection for complicated GHP.METHODS This is a single-center,retrospective study.Between January 2013 and December 2017,a total of 5 patients underwent ESD for complicated GHP at Asan Medical Center.Patients who were diagnosed with complicated GHP were treated conservatively as with general practice for acute pancreatitis.After conservative management for resolving the acute phase of pancreatitis,ESD was performed as definitive treatment for complicated GHP.ESD was performed using the conventional method under conscious sedation.The clinical features of patients and tumors,procedure-related characteristics,and long-term outcomes were investigated.RESULTS The age of the 5 patients ranged from 28-43 years.Two of the patients were males.All lesions were located in the greater curvature of the antrum.On endoscopic ultrasonography during the pain episode,all lesions were located across the muscularis mucosa,submucosa,and proper muscle layers.The median lesion size was 20[interquartile range(IQR),18-35]during the pain episode at the time of the diagnosis of complicated GHP,and 15 mm(IQR,9-33)at the time of ESD after conservative treatment.The procedure time ranged from 15-120 min.There were no procedure-related adverse events such as perforation or bleeding.The length of hospital stay after the procedure ranged from 2-4 d.All patients were symptom free during the median follow-up period of 46.0 mo(IQR,39-60).CONCLUSION ESD appears to be a feasible and effective treatment option for complicated GHP based on the favorable clinical outcomes. | Jin Hee Noh Do Hoon Kim So-Woon Kim Young Soo Park Hee Kyong Na Ji Yong Ahn Kee Wook Jung Jeong Hoon Lee Kee Don Choi Ho June Song Gin Hyug Lee Hwoon-Yong Jung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 5 | Feasibility of endoscopic resection in superficial esophageal squamous carcinoma显示文摘 | Ji Young Choi Young Soo Park Hwoon-Yong Jung Ji Yong Ahn Mi-Young Kim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Kyung-Ja Cho Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 6 | Incorporation of cholesterol into the cell membrance of Lactobacillus acidophilus ATCC43121 显示文摘 | DON DO KIM SH GILLILAND SE | 1997 | J Dairy Sci1997，80，： | 1 |
| 7 | Immunoglobulin G4–related inflammatory pseudotumor of the stomach显示文摘 | Do Hoon Kim Jihoon Kim Do Hyun Park Jeong Hoon Lee Kee Don Choi Gin Hyug Lee Hwoon-Yong Jung Jin-Ho Kim | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 8 | Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications显示文摘 | Ji Yong Ahn Hwoon-Yong Jung Kee Don Choi Ji Young Choi Mi-Young Kim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Ho June Song Gin Hyug Lee Jin-Ho Kim Young Soo Park | 2011 | Gastrointestinal Endoscopy2011，，3： | 1 |
| 9 | Seroconversion Rates of Helicobacter pylori Infection in Korean Adults显示文摘 | Ji Hoon Jung Kee Don Choi Seungbong Han Hwoon‐Yong Jung Mi Young Do Hye‐Sook Chang Jae‐Won Choe Gin Hyug Lee Ho June Song Do Hoon Kim Kwi‐Sook Choi Jeong Hoon Lee Ji Yong Ahn Mi‐Young Kim Suh Eun Bae Jin‐Ho Kim | 2013 | Helicobacter2013，，4： | 1 |
| 10 | Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients显示文摘 | Sollip Kim Jun-Won Chung Tae-Dong Jeong Young-Soo Park Jeong Hoon Lee Ji Yong Ahn Do Hoon Kim Kee Don Choi Woochang Lee Ho June Song Gin Hyug Lee Sail Chun Hwoon-Yong Jung Won-Ki Min Jin-Ho Kim | 2013 | Familial Cancer2013，，3： | 1 |
| 11 | Procedure time of endoscopic submucosal dissection according to the size and location of early gastric cancers: analysis of 916 dissections performed by 4 experts显示文摘 | Ji Yong Ahn Kee Don Choi Ji Young Choi Mi-Young Kim Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 12 | Clinical outcomes of endoscopic and surgical management for postoperative upper gastrointestinal leakage显示文摘 | Seohyun Lee Ji Yong Ahn Hwoon-Yong Jung Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Jin-Ho Kim Beom Su Kim Jeong Hwan Yook Sung Tae Oh Byung Sik Kim Seungbong Han | 2013 | Surgical Endoscopy2013，，11： | 1 |
| 13 | Optimal Biopsy Site for H elicobacter pylori Detection during Endoscopic Mucosectomy in Patients with Extensive Gastric Atrophy显示文摘 | Jeong Hoon Lee Young Soo Park Kwi‐Sook Choi Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Se Jin Jang Hwoon‐Yong Jung Jin‐Ho Kim | 2012 | Helicobacter2012，，6： | 1 |
| 14 | A nationwide seroepidemiology of hepatitis C virus infection in South Korea显示文摘 | Do Young Kim In Hee Kim Sook‐Hyang Jeong Yong Kyun Cho Joon Hyoek Lee Young‐Joo Jin Don Lee Dong Jin Suh Kwang‐Hyub Han Neung Hwa Park Ha Yan Kang Young Kul Jung Young Seok Kim Kyung‐Ah Kim Youn Jae Lee Byung Seok Lee Hyung Joon Yim Heon Ju Lee Soon Koo B | 2013 | Liver Int2013，，4： | 1 |
| 15 | Immunoglobulin G4–related inflammatory pseudotumor of the stomach显示文摘 | Do Hoon Kim Jihoon Kim Do Hyun Park Jeong Hoon Lee Kee Don Choi Gin Hyug Lee Hwoon-Yong Jung Jin-Ho Kim | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 16 | Clinical impact of EUS-guided Trucut biopsy results on decision making for patients with gastric subepithelial tumors ≥2 cm in diameter显示文摘 | Jeong Hoon Lee Kee Don Choi Mi-Young Kim Kwi-Sook Choi Do Hoon Kim Young Soo Park Kab Choong Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Jeong Hwan Yook Byung Sik Kim Yoon-Koo Kang Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 17 | Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection显示文摘BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current criteria.AIM To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for ESD.METHODS We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in Korea.To identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:4.We reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of LNM.Univariate and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for ESD.Of the 1240 cases,14(1.1%)cases had LNM.Among the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of LNM.Moreover,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for UDEGC.Histological evaluation could provide useful clues for reducing the risk of LNM. | Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob Lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn Jeong Hoon Lee Kee Wook Jung Do Hoon Kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung | 2022 | World Journal of Gastroenterology2022，28，15： | 0 |
| 18 | 破裂和未破裂颅内动脉瘤栓塞治疗实践标准显示文摘弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤,但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步,新器材的研发使得以前因血管解剖结构复杂而无法填塞的动脉瘤也得以治疗,从而扩大了血管内治疗的适应证。而且,血管内弹簧圈栓塞已成为当前动脉瘤血管内治疗的主流方法;医学文献证明,在特定患者人群中,弹簧圈栓塞的转归优于外科手术夹闭。最近的一份美国心脏协会(AmericanHeartAssociation,AHA)科学声明指出,对于适合治疗的脑动脉瘤,不论是血管内栓塞还是显微外科手术夹闭,均为破裂动脉瘤I级推荐治疗方法和未破裂动脉瘤的11a级推荐治疗方法。在这两组患者中,治疗利大于弊。一个在血管显微神经外科、神经重症监护和介入神经外科方面有着丰富经验的多学科团队最有利于对颅内动脉瘤的处理实施最佳的技术。神经血管联合写作组此前已发表过一份联合声明,提出了有关脑血管介入治疗的培训和认证的推荐意见。 | Athos Patsalides Ketan R Bulsara Daniel P Hsu Todd Abruzzo Sandm Narayanan Mahesh V Jayaraman Gary Duckwiler Richard Paul Klucznik Michael Kelly Joshua A Hirsch Don Heck Jeffery Stmshine Don Frei Michael J Alexander Huy M Do Philip M Meyers 邱忠明(译) 张君(译) 徐格林(译) | 2013 | 国际脑血管病杂志2013，21，6： | 0 |
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