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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Eosinophilic esophagitis: Current concepts in diagnosis and treatment显示文摘Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology(genetic and environmental)that affects both pediatric and adult patients.Its symptoms,which include heartburn,regurgitation,and esophageal stenosis(with dysphagia being more frequent in eosinophilic esophagitis in young adults and children),are similar to those of gastroesophageal reflux disease,causing delays in diagnosis and treatment.Although endoscopic findings such as furrows,esophageal mucosa trachealization,and whitish exudates may suggest its presence,this diagnosis should be confirmed histologically based on the presence of more than 15 eosinophils per high-power field and the exclusion of other causes of eosinophilia(parasitic infections,hypereosinophilic syndrome,inflammatory bowel disease,among others)for which treatment could be initiated.Currently,the 3“D”s(“Drugs,Diet,and Dilation”)are considered the fundamental components of treatment.The first 2 components,which involve the use of proton pump inhibitors,corticosteroids,immunosuppressants and empirical diets or guided food elimination based on allergy tests,are more useful in the initial phases,whereas endoscopic dilation is reserved for esophageal strictures.Herein,the most important aspects of eosinophilic esophagitis pathophysiology will be reviewed,in addition to evidence for the various treatments. | Andrés Gómez-Aldana Mario Jaramillo-Santos Andrés Delgado Carlos Jaramillo Adán Lúquez-Mindiola | 2019 | World Journal of Gastroenterology2019，25，32： | 2 |
| 3 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 4 | Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor显示文摘 | Abad Catalina Delgado Mario | 2002 | Proc Natl Acad Sci USA2002，99，2： | 1 |
| 5 | Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit chemokine production in activated microglia显示文摘 | Delgado Mario Jonakait G Miller Ganea Doina | 2002 | Glia2002，39，2： | 1 |
| 6 | Therapeutic Action of Ghrelin in a Mouse Model of Colitis显示文摘 | Elena Gonzalez–Rey Alejo Chorny Mario Delgado | 2006 | Gastroenterology2006，，6： | 1 |
| 7 | Enhancement of student learning through the use of a hinting computer e-learning system and comparison with human teachers显示文摘 | Munoz-Merino Pedro J Kloos Carlos Delgado Munoz-Organero Mario | 2011 | IEEE Transactions on Education2011，54，1： | 1 |
| 8 | Phospholipid oxidation, non-enzymatic browning development and volatile compounds generation in model systems containing liposomes from porcine Longissimus dorsi and selected amino acids显示文摘 | Sonia Ventanas Mario Estévez Carmen L. Delgado Jorge Ruiz | 2007 | European Food Research and Technology2007，，5： | 1 |
| 9 | Vasoactive intestinal peptide inhibits IL-8 produc, tion in human monocytes 显示文摘 | Mario Delgado Doina Ganea | 2003 | Biochemical and Biophysical Re-search Communications2003，301，： | 1 |
| 10 | Anti-inflammatory neuropeptides: A new class of endogenous V 显示文摘 | Mario Delgado Doina Ganea | 2008 | Brain Behavior and Immunity2008，22，： | 1 |
| 11 | The significance of vascoactive intestinal peptide in immunomodulation显示文摘 | Mario Delgado David Pozo Doina Ganea | 2004 | Pharmacol Rev2004，56，： | 1 |
| 12 | Urocortin and Adrenomedullin Prevent Lethal Endotoxemia by Down-Regulating the Inflammatory Response显示文摘 | Elena Gonzalez-Rey Alejo Chorny Nieves Varela Gema Robledo Mario Delgado | 2006 | The American Journal of Pathology2006，，6： | 1 |
| 13 | Modeling considerations in seismic assessment of RC bridges using state-of-practice structural analysis software tools显示文摘多次,向结构的地震安全的一般社会的增加的了解因此导致了更限制的表演要求到使用结构的分析的新、更精确的方法的需要。在这些之中,永远,非线性的静态的过程正在变得设计的多数的比较喜欢的选择编码,作为完成为结构的地震设计和评价的非线性的时间历史分析的一种选择。许多可得到的软件工具应该因此被评估并且很好理解,容易并且很熟由专业人员采用了以便是。此处介绍的学习打算由在桥结构的非线性的分析关于通常采用的结构的分析软件工具的使用提供进一步的卓见贡献这需要。在不同非线性的建模假设之间的比较被介绍,和有真实试验性的结果的比较。而且,其他的适应闲差事过程被建议并且适用于一座案例研究桥,基于一个通用塑料绞链模型。采用的结构的分析程序证明了精确,产出可靠估计,两个以本地塑料依赖行为和全球结构的行为。 | Ricardo MONTEIRO Miguel ARAUJO Raimundo DELGADO Mario o MARQUES | 2018 | Frontiers of Structural and Civil Engineering2018，12，1： | 0 |
| 14 | Experimental Investigation of Solid Fuel Combustion Process in a Hybrid Porous Reactor显示文摘 | Vojislav Jovicic Nataliia Fedorova Ana Zbogar-Rasic Mario Toledo Torres Antonio Delgado | 2017 | Journal of Energy and Power Engineering2017，11，9： | 0 |
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