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| 1 | 新版Bethesda指南、微卫星不稳定性检测和免疫组化检查诊断遗传性非息肉性结直肠癌的准确性显示文摘背景:挑选适当个体进行遗传性非息肉性结直肠癌(hereditary nonpolyposis colorectal cancer,HNPCC)基因检测有一定难度。最近,美国国立癌症研究所(National Cancer Institute)在新版Bethesda指南中给出了一套新的推荐方案,以明确哪些HNPCC个体应行微卫星不稳定性检测。 | Virginia Pinol, MD Antoni Castells, MD Montserrat Andreu, MD 许峰(译) 祝学光(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 23 |
| 2 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | 2002 (9325)2002，，9325： | 3 |
| 5 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 6 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet2002，，9325： | 2 |
| 7 | The Long-term Results of a Randomized Clinical Trial of Laparoscopy-assisted Versus Open Surgery for Colon Cancer显示文摘 | Antonio M. Lacy Salvadora Delgado Antoni Castells Hubert A. Prins Vicente Arroyo Ainitze Ibarzabal Josep M. Pique | 2008 | Annals of Surgery2008，，1： | 2 |
| 8 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet2002，，9325： | 2 |
| 9 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 10 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Antonio M Lacy Juan C García-Valdecasas Salvadora Delgado Antoni Castells Pilar Taurá Josep M Piqué Josep Visa | 2002 | The Lancet . 2002 (9325)2002，，： | 1 |
| 11 | RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy显示文摘 | Virginia Alonso-Espinaco Miriam Cuatrecasas Vicente Alonso Pilar Escudero Maribel Marmol Carlos Horndler Javier Ortego Rosa Gallego Jordi Codony-Servat Xabier Garcia-Albeniz Pedro Jares Antoni Castells Juan José Lozano Rafael Rosell Joan Maurel | 2014 | European Journal of Cancer2014，，： | 1 |
| 12 | Percutaneous self-expanding metal stents versus endoscopic polyethylene endoprostheses for treating malignant biliary obstruction: randomized clinical trial 显示文摘 | Virginia Piol Antoni Castells Josep M Bordas | 2002 | Radiology Oct2002，225，： | 1 |
| 13 | Acute phase response in laparoscopic and open colectomy in colon cancer显示文摘 | Salvadora Delgado M.D. Dr. Antonio M. Lacy M.D. Xavier Filella M.D. Antoni Castells M.D. Juan C. García-Valdecasas M.D. Josep M. Pique M.D. Dulce Momblán M.D. Josep Visa M.D | 2001 | Diseases of the Colon & Rectum2001，，5： | 1 |
| 14 | Hepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus–related cirrhosis显示文摘 | Lloren? Caballer??a Albert Parés Antoni Castells Angels Ginés Concepció Bru Joan Rodés | 2001 | The American Journal of Gastroenterology2001，，4： | 1 |
| 15 | Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study显示文摘 | María Dolores Giráldez Juan José Lozano Georgina Ramírez Elizabeth Hijona Luis Bujanda Antoni Castells Meritxell Gironella | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 1 |
| 16 | The Imaging Wind and Rain Airborne Profiler-a Dual Frequency Dual Polarized Conically Scanning Airborne Profiling Radar显示文摘 | Fernandez D E Xuehu Zhang Antoni Castells | 2003 | IGARSS2003，7，： | 1 |
| 17 | Transanal Total Mesorectal Excision in Rectal Cancer: Short-term Outcomes in Comparison With Laparoscopic Surgery显示文摘 | María Fernández-Hevia Salvadora Delgado Antoni Castells Marta Tasende Dulce Momblan Gabriel Díaz del Gobbo Borja DeLacy Jaume Balust Antonio M. Lacy | 2015 | Annals of Surgery2015，，2： | 1 |
| 18 | Endoscopic ultrasound-guided fine needle aspiration: predictive factors of accurate diagnosis and cost-minimization analysis of on-site pathologist显示文摘 | Maria Pellisé Urquiza Glòria Fernández-Esparrach Manel Solé Lluís Colomo Antoni Castells Josep Llach Alfredo Mata Josep M. Bordas Josep M. Piqué àngels Ginès | 2007 | Gastroenterologia y Hepatologia2007，，6： | 1 |
| 19 | Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results From a Genome-Wide Profiling and Validation Study显示文摘 | María Dolores Giráldez Juan José Lozano Georgina Ramírez Elizabeth Hijona Luis Bujanda Antoni Castells Meritxell Gironella | 2013 | Clinical Gastroenterology and Hepatology2013，，6： | 1 |
| 20 | IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn’s Disease Risk in a New Zealand Population显示文摘 | Lynnette R. Ferguson Dug Yeo Han Alan G. Fraser Claudia Huebner Wen Jiun Lam Angharad R. Morgan Antoni Castells | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
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