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1Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis显示文摘AIM To investigate the temporal trends in the misdiagnosis rate between Crohn's disease(CD) and intestinal tuberculosis(ITB) in South Korea. METHODS We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB(final CD group) and vice versa(final ITB group). Final diagnostic criteria for ITB and medication for CD before definite diagnosis of TB were also analyzed in final ITB group.RESULTS In total, 2760 patients were managed for CD and 772 patients for ITB between 1996 and 2014. As well, 494 of the 2760 CD patients(17.9%) were initially misdiagnosed as ITB and 83 of the 772 ITB patients(10.8%) as CD. The temporal trend in misdiagnosing CD as ITB showed a decrease(OR = 0.89, 95%CI: 0.87-0.91, P < 0.001), whereas the temporal trend in misdiagnosing ITB as CD showed an increase(OR = 1.06, 95%CI: 1.01-1.11, P = 0.013). Age at diagnosis, presenting symptoms, and proportion of patients with active/past perianal fistula and active/inactive pulmonary tuberculosis(TB) were significantly different between final CD group and final ITB group. Forty patients(48.2%) in final ITB group were diagnosed by favorable response to empirical anti-TB treatment. Seventeen patients(20.5%) in final ITB group had inappropriately received corticosteroids and/or thiopurines due to misdiagnosis as CD. However, there were no mortalities in both groups. CONCLUSION Cases of CD misdiagnosed as ITB have been decreasing, whereas cases of ITB misdiagnosed as CD have been increasing over the past two decades.Hyungil Seo Seohyun Lee Hoonsub So Donghoi Kim Seon-Ok Kim Jae Seung Soh Jung Ho Bae Sun-Ho Lee Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Byong Duk Ye 2017World Journal of Gastroenterology2017,23,34:3
2Ethanol lavage of huge hepatic cysts by using EUS guidance and a percutaneous approach显示文摘Seohyun Lee Dong-Wan Seo Woo Hyun Paik Do Hyun Park Sang Soo Lee Sung Koo Lee Myung-Hwan Kim 2014Gastrointestinal Endoscopy2014,,:1
3ANewSubtype Classification of Ischemic Stroke Based on Treatment and Etiologic Mechanism 显示文摘Sang Won Han SeoHyun Kim JongYun- Lee 2007Eur Neuro12007,57,:1
4Ethanol lavage of huge hepatic cysts by using EUS guidance and a percutaneous approach显示文摘Seohyun Lee Dong-Wan Seo Woo Hyun Paik Do Hyun Park Sang Soo Lee Sung Koo Lee Myung-Hwan Kim 2014Gastrointestinal Endoscopy2014,,:1
5Clinical outcomes of endoscopic and surgical management for postoperative upper gastrointestinal leakage显示文摘Seohyun Lee Ji Yong Ahn Hwoon-Yong Jung Jeong Hoon Lee Kwi-Sook Choi Do Hoon Kim Kee Don Choi Ho June Song Gin Hyug Lee Jin-Ho Kim Beom Su Kim Jeong Hwan Yook Sung Tae Oh Byung Sik Kim Seungbong Han 2013Surgical Endoscopy2013,,11:1
6A New Subtype Classification of Ischemic Stroke Based on Treatment and Etiologic Mechanism显示文摘Sang Won Han SeoHyun Kim Jong Yun Lee 2007Eur Neurol2007,57,:1
7Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials显示文摘Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial resistance.However,the effective minimal antibiotic duration for AOM remains unclear.Moreover,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been assessed.Methods We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October 2021.Network meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 years.For the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day regimens.Compared to amoxicillin,a shorter treatment duration was tolerable with amoxicillin-clavulanate.Conclusions Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 days.Otherwise,5-day regimens would be sufficient for a modest treatment goal.Our findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.Min Seo Kim Jae Han Kim Seohyun Ryu Seung Won Lee Dong Keon Yon Eunyoung Kim Ai Koyanagi Elena Dragioti Jae Il Shin Lee Smith 2024World Journal of Pediatrics2024,20,3:0
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