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| 1 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 2 | Living With Prostate Cancer:Patients' and Spouses' Psychosocial Status and Quality of Life显示文摘 | Laurel L N Darlene W M James E M | 2007 | American Society of Clinical Oncology2007，25，： | 1 |
| 3 | The efficacy of thyroidectomy for Graves' disease a meta-analysis 显示文摘 | Tapash K Charle C Darlene M | 2002 | J Surg Res2002，90，2： | 1 |
| 4 | The changing spectrum of fungal keratitis in South Florida显示文摘 | Robert H Darlene M Eduardo CA | 1994 | Ophthalmology1994，101，： | 1 |
| 5 | The efficacy of thyroideetomy for Graves' disease:a meta-analysis显示文摘 | Tapash K Charle C Darlene M | 2002 | J Surg Res2002，90，2： | 1 |
| 6 | Determination of Formatdehyde in Air bu Chemisorption on Glass Filters Impregnated with 2,4-Dinitrophenylhydrazine Using Gas Chromatography with Therionmic Specific Detection显示文摘 | Darlene M Persson P Skarping G | 1992 | J Chromatogr1992，626，： | 1 |
| 7 | The efficacy of thyroideetomy for Graves' disease:a meta-analysis显示文摘 | Tapash K Charle C Darlene M | | 0，，02： | 1 |
| 8 | Ethnic Variation in Adiponectin and Leptin Levels and Their Association With Adiposity and Insulin Resistance显示文摘 | Mente Andrew Razak Fahad Blankenberg Stefan Vuksan Vlad Davis A Darlene Miller Ruby Teo Koon Gerstein Hertzel Sharma Arya M Yusuf Saum Anand Sonia S | 2010 | Diabetes Care2010，，7： | 1 |
| 9 | Quality of life of women with recurrent breast cancer and their family members显示文摘 | LAUREL L N DARLENE M TRACE K | 2002 | J Clin Oncol2002，20，19： | 1 |
| 10 | 90Y-Ibritumomab Tiuxetan in the Treatment of Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma显示文摘 | DARLENE M FINK-BENNET T KATHY T | 2003 | J Nucl Med Tech2003，31，2： | 1 |
| 11 | reative approaches for reducing burnout in medical personnel 显示文摘 | Brooks Darlene M Bradt Joke Eyre Lillian Hunt Andrea Dileo Chery | 2010 | The Arts in Psychotherapy2010，，3： | 1 |
| 12 | Joining pipe with the hybrid laser-GMAW process:weld test results and cost analysis显示文摘 | EDWARD W R MICHAEL J S DARLENE A M | 2006 | Welding Journal2006，85，6： | 1 |
| 13 | Quality of life of women with recurrent breast cancer and their family mem-bers 显示文摘 | Laurel LN Darlene M Trace K | 2002 | J Clin Oncol2002，20，19： | 1 |
| 14 | Postsurgical pain syndromes: Chronic pain after hysterectomy and cesarean sec- tion显示文摘 | Darlene C Recker D O Patricia M | 2011 | Reg Anesth Pain Med2011，15，3： | 1 |
| 15 | Interventions (Solutions) Usage and Expertise in Performance Technology Practice: An Empirical Investigation显示文摘 | Darlene M Van Tiem | 2004 | Performance Improvement Quarterly2004，17，3： | 1 |
| 16 | Effects of a family in-tervention on the quality of life of women with recurrent breast cancer and their family earegivers显示文摘 | Laurel N Trace K Darlene M | 2005 | Psycho- Oncol- ogy2005，14，6： | 1 |
| 17 | Analysis of 12 variants in the development of gastric and colorectal cancers显示文摘AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS v.20.RESULTS After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other combinations.CONCLUSION These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population. | Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos | 2017 | World Journal of Gastroenterology2017，23，48： | 0 |
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