|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling显示文摘Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases.Therefore,understanding how different receptors on T cells impact functional outcomes is crucial.The influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains controversial.Here we examined global transcriptomic changes in human T cells induced by B7-H7.Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation.The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production.Interestingly,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation.This inhibitory activity was comparable to that observed with PD-L1.Finally,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break signal.Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling. | Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher ERudd Roland Kolbeck | 2021 | Cellular & Molecular Immunology2021，18，6： | 9 |
| 2 | Nano-Structured Carbide-Derived Carbon Films and Their Tribology显示文摘Carbide-derived carbon (CDC) is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the re- arrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tri- bological performance. CDC coatings are distinguished by their low friction coefficients and high wear resis- tance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail. | Michael McNallan Daniel Ersoy Ranyi Zhu Allen Lee Christopher White Sascha Welz Yury Gogotsi Ali Erdemir Andriy Kovalchenko | 2005 | Tsinghua Science and Technology2005，10，6： | 6 |
| 3 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 4 | Controls on methane production in a tidal freshwater estuary and a peatland: methane production via acetate fermentation and CO2 reduction显示文摘 | G. Brooks Avery Robert D. Shannon Jeffrey R. White Christopher S. Martens Marc J. Alperin | 2003 | Biogeochemistry2003，，1： | 2 |
| 5 | 2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (Updating the 2005 Guideline)显示文摘 | Thom W. Rooke Alan T. Hirsch Sanjay Misra Anton N. Sidawy Joshua A. Beckman Laura K. Findeiss Jafar Golzarian Heather L. Gornik Jonathan L. Halperin Michael R. Jaff Gregory L. Moneta Jeffrey W. Olin James C. Stanley Christopher J. White John V. White R. E | 2011 | Journal of the American College of Cardiology2011，，： | 2 |
| 6 | MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review <ce:link locator='eulogo1'/>显示文摘 | James W.F. Catto Antonio Alcaraz Anders S. Bjartell Ralph De Vere White Christopher P. Evans Susanne Fussel Freddie C. Hamdy Olli Kallioniemi Lourdes Mengual Thorsten Schlomm Tapio Visakorpi | 2011 | European Urology2011，，5： | 2 |
| 7 | Reporting standards for endovascular aortic aneurysm repair显示文摘 | Elliot L. Chaikof Jan D. Blankensteijn Peter L. Harris Geoffrey H. White Christopher K. Zarins Victor M. Bernhard Jon S. Matsumura James May Frank J. Veith Mark F. Fillinger Robert B. Rutherford K.Craig Kent | 2002 | Journal of Vascular Surgery2002，，： | 2 |
| 8 | ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance显示文摘 | W. Gregory Hundley David A. Bluemke J. Paul Finn Scott D. Flamm Mark A. Fogel Matthias G. Friedrich Vincent B. Ho Michael Jerosch-Herold Christopher M. Kramer Warren J. Manning Manesh Patel Gerald M. Pohost Arthur E. Stillman Richard D. White Pamela K. Wo | 2010 | Journal of the American College of Cardiology2010，，23： | 1 |
| 9 | Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction显示文摘 | HARVEY D. WHITE ROBIN M. NORRIS MICHAEL A. BROWN PETER W. T. BRANDT RALPH M. L. WHITLOCK CHRISTOPHER J. WILD | 1987 | Circulation1987，，1： | 1 |
| 10 | Haemodynamically unstable pelvic fractures显示文摘 | Christopher E. White Joseph R. Hsu John B. Holcomb | 2008 | Injury2008，，10： | 1 |
| 11 | Three-dimensional geological modelling and multivariate statistical analysis of water chemistry data to analyse and vis- ualise aquifer structure and groundwater composition in the Wairau Plain, Marlborough District, New Zealand显示文摘 | Matthias Raiber Paul A White Christopher J Daughney | 2012 | Journal of Hydrology2012，，： | 1 |
| 12 | Absolute Calibration in Bass Strait, Australia: TOPEX, Jason-1 and OSTM/Jason-2显示文摘 | Christopher Watson Neil White John Church Reed Burgette Paul Tregoning Richard Coleman | 2011 | Marine Geodesy . 2011 (3-4)2011，，3： | 1 |
| 13 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 14 | Comparison of primary immune responses to SRBC and KLH in rodents 显示文摘 | WHITE K L CHRISTOPHER J SHETH M | 2007 | J Immunotoxicol2007，4，： | 1 |
| 15 | ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents显示文摘 | W. Gregory. Hundley David A. Bluemke J. Paul Finn Scott D. Flamm Mark A. Fogel Matthias G. Friedrich Vincent B. Ho Michael Jerosch-Herold Christopher M. Kramer Warren J. Manning Manesh Patel Gerald M. Pohost Arthur E. Stillman Richard D. White Pamela K. W | 2010 | Circulation2010，，22： | 1 |
| 16 | Pivotal results of the Medtronic Vascular Talent Thoracic Stent Graft System: The VALOR Trial显示文摘 | Ronald M. Fairman Frank Criado Mark Farber Christopher Kwolek Manish Mehta Rodney White Anthony Lee J. Michael Tuchek | 2008 | Journal of Vascular Surgery2008，，3： | 1 |
| 17 | Persistence of urothelial carcinoma of the bladder risk among former smokers: Results from a contemporary, prospective cohort study显示文摘 | Christopher J. Welty Jonathan L. Wright James M. Hotaling Parveen Bhatti Michael P. Porter Emily White | 2012 | Urologic Oncology: Seminars and Original Investigations2012，，： | 1 |
| 18 | Endovascular Stenting for Vertebral Artery Stenosis显示文摘 | J. Stephen Jenkins Samir N. Patel Christopher J. White Tyrone J. Collins John P. Reilly Paul W. McMullan Mark A. Grise Arthur G. Grant Stephen R. Ramee | 2010 | Journal of the American College of Cardiology2010，，6： | 1 |
| 19 | Reperfusion strategies for acute myocardial infarction in the elderly显示文摘 | Rajendra H. Mehta Christopher B. Granger Karen P. Alexander Eduardo Bossone Harvey D. White Michael H. Sketch | 2005 | Journal of the American College of Cardiology2005，，4： | 1 |
| 20 | Contact allergy to common ingredients in hair dyes显示文摘 | Heidi S?sted Thomas Rustemeyer Margarida Gon?alo Magnus Bruze An Goossens Ana M. Giménez‐Arnau Christophe J. Le Coz Ian R. White Thomas L. Diepgen Klaus E. Andersen Tove Agner Howard Maibach Torkil Menné Jeanne D. Johansen | 2013 | Contact Dermatitis2013，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员