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| 1 | The design,mechanism and biomedical application of self-healing hydrogels显示文摘Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What's more,the biomedical application of self-healing hydrogels in vivo was discussed. | Qiwen Li Chenlu Liu Junru Wen Yongzhi Wu Yue Shan Jinfeng Liao | 2017 | Chinese Chemical Letters2017，28，9： | 11 |
| 2 | Interactive effects of understory removal and fertilization on soil respiration in subtropical Eucalyptus plantations显示文摘Aims It has been well recognized that understory vegetation plays an important role in driving forest ecosystem processes and functioning.In subtropical plantation forests,understory removal and fertiliza-tion have been widely applied;however,our understanding on how understory removal affects soil respiration and how the process is regulated by fertilization is limited.Here,we conducted an under-story removal experiment combined with fertilization to evaluate the effects of the two forest management practices and their inter-actions on soil respiration in subtropical forest in southern China.Methods The study was conducted in a split-plot design with fertilization as the whole-plot factor,understory removal as the subplot factor and block as the random factor in subtropical Eucalyptus plantations.In total,there were four treatments:control with unfertilized and intact understory(CK),understory removal but without fertilization(UR),with fertilization but without understory removal(FT)and with fertilization+understory removal(FT+UR).Eucalyptus above-and belowground biomass increment,fine root biomass,soil tempera-ture,soil moisture and soil respiration were measured in the present study.understory respiration(Ru)was quantified in different ways:Ru=RCK−Ru or Ru=RFT−R(FT+u);fertilization increased soil respiration(RFI)was also quantified in different ways:RFI=RFT−RCK or RFI=R(FT+u)−Ru.Important Findingsover a 2-year experiment,our data indicate that understory removal significantly decreased soil respiration,while fertilization increased soil respiration.understory removal decreased soil respiration by 28.8%under fertilization,but only 15.2%without fertilization.Fertilization significantly increased soil respiration by 23.6%with the presence of understory vegetation,and only increased by 3.7%when understory was removed,indicating that fertilization increased soil respiration mainly by increasing the contribution of the understory.our study advances our understanding of the interactive effects of understory management and fertilization on soil respiration in subtropical plantations. | Songze Wan Chenlu Zhang Yuanqi Chen Jie Zhao Xiaolin Zhu Jianping Wu Lixia Zhou Yongbiao Lin Zhanfeng Liu Shenglei Fu | 2015 | Journal of Plant Ecology2015，8，3： | 6 |
| 3 | Cytosolic delivery of the immunological adjuvant PolyⅠ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response显示文摘Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy.The precise control of the targeting and release of agents is critical in this methodology.This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy.To obtain a proof-of-concept,a co-delivery system was prepared via a drug-delivering-drug(DDD)strategy for cytosolic co-delivery of Poly I:C,a synthetic ds RNA analog to activate RIG-I signaling,and PTX,a commonly used chemotherapeutics,in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.The co-delivery system with a diameter of 200 nm enables profound immunogenicity of cancer cells,exhibiting increased secretion of cytokines and chemokines,pronounced immune response in vivo,and significant inhibition of tumor growth.Also,we found that intracellularly sustained release of cytotoxic agents could elicit the immunogenicity of cancer cells.Overall,the intracellular asynchronous release of chemotherapeutics and immunomodulators is a promising strategy to promote the immunogenicity of cancer cells and augment the antitumor immune response. | Xiaoqing Du Yuqi Hou Jia Huang Yan Pang Chenlu Ruan Wei Wu Chenjie Xu Hongwei Zhang Lifang Yin Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 4 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 5 | Coupling magnetic particles with flocculants to enhance demulsification and separation of waste cutting emulsion for engineering applications显示文摘Magnetic particles were coupled with a flocculant to enhance the demulsification and separation of waste cutting emulsions.The optimal magnetic particle size and critical magnetic field conditions were investigated to achieve large-scale engineering application of magnetic demulsification separation for waste cutting emulsion treatment.The micro-scale magnetic particles were found to show comparable effects to nano-scale magnetic particles on enhancing the demulsification and separation of cutting emulsions,which are beneficial for broadening the selectivity of low-cost magnetic particles.The critical magnetic separation region was determined to be an area 40 mm from the magnetic field source.Compared to the flocculant demulsification,the magnetic demulsification separation exhibited a significant advantage in accelerating flocs-water separation by decreasing the separation time of flocs from 180-240 min to less than 15 min,compressing the flocs by reducing the floc volume ratio from 60%-90%to lower than 20%,and showing excellent adaptability to the variable properties of waste cutting emulsions.Coupled with the design of the magnetic disk separator,continuous demulsification separation of the waste cutting emulsion was achieved at 1.0 t/hr for at least 10 hr to obtain clear effluent with 81%chemical oxygen demand removal and 89%turbidity reduction.This study demonstrates the feasibility of applying magnetic demulsification separation to large-scale continuous treatment of waste emulsion.Moreover,it addresses the flocs-water separation problems that occur in practical flocculant demulsification engineering applications. | Yongjiao Xiong Baoqiang Wu Xiangfeng Huang Chenlu Li Bin Lu Jia Liu Lijun Lu Shiyang Li Kaiming Peng | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 6 | Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis显示文摘The UFMylation modification is a novel ubiquitin-like conjugation system,consisting of UBA5(E1),UFC1(E2),UFL1(E3),and the conjugating molecule UFM1.Deficiency in this modification leads to embryonic lethality in mice and diseases in humans.However,the function of UFL1 is poorly characterized.Studies on Ufl1 conditional knockout mice have demonstrated that the deletion of Ufl1 in cardiomyocytes and in intestinal epithelial cells causes heart failure and increases susceptibility to experimentally induced colitis,respectively,suggesting an essential role of UFL1 in the maintenance of the homeostasis in these organs.Yet,its physiological function in other tissues and organs remains completely unknown.In this study,we generate the nephron tubules specific Ufl1 knockout mice and find that the absence of Ufl1 in renal tubular results in kidney atrophy and interstitial fibrosis.In addition,Ufl1 deficiency causes the activation of unfolded protein response and cell apoptosis,which may be responsible for the kidney atrophy and interstitial fibrosis.Collectively,our results have demonstrated the crucial role of UFL1 in regulating kidney function and maintenance of endoplasmic reticulum homeostasis,providing another layer of understanding kidney atrophy. | You Zhou Xifu Ye Chenlu Zhang Jiabao Wang Zeyuan Guan Juzhen Yan Lu Xu Ke Wang Di Guan Qian Liang Jian Mao Junzhi Zhou Qian Zhang Xiaoying Wu Miao Wang Yu-Sheng Cong Jiang Liu | 2021 | Journal of Genetics and Genomics2021，48，5： | 1 |
| 7 | LHRH/TAT dual peptides-conjugated polymeric vesicles for PTT enhanced chemotherapy to overcome hepatocellular carcinoma显示文摘Combination therapy such as photothermal therapy(PTT)enhanced chemotherapy is regarded as a promising strategy for cancer treatment.Herein,we developed redox-responsive polymeric vesicles based on the amphiphilic triblock copolymer PCL-ss-PEG-ss-PCL.To avoid the limited therapeutic effect of chemotherapeutic drugs caused by systemic exposures and drug resistance,the redox-sensitive polymeric vesicles were cargoed with two chemotherapeutics:doxorubicin(DOX)and paclitaxel(PTX).Besides,indocyanine green(ICG)was encapsulated,and cell-penetrating peptides and LHRH targeting molecule were modified on the surface of polymeric vesicles.The results indicated that the polymeric vesicles can load different kinds of drugs with high drug loading content,trigger drug release in responsive to the reductive environment,realize high cellular uptake via dual peptides and laser irradiation,and achieve higher cytotoxicity via chemo-photothermal combination therapy.Hence,the redox-responsive LHRH/TAT dual peptides-conjugated PTX/DOX/ICG co-loaded polymeric micelles exhibited great potential in tumor-targeting and chemo-photothermal therapy. | Yu Qin Qing Guo Shengjie Wu Chenlu Huang Zhiming Zhang Li Zhang Linhua Zhang Dunwan Zhu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 8 | Research Trends and Emerging Hotspots of Lung Cancer Surgery during 2012-2021:A 10-Year Bibliometric and Network Analysis显示文摘Background. Lung cancer remains the leading cause of death because of cancer globally in the past years. To inspire researcherswith new targets and path-breaking directions for lung cancer research, this study is aimed at exploring the research trends andemerging hotspots in the lung cancer surgery literature in the recent decade. Methods. This cross-sectional study combinedbibliometric and network analysis techniques to undertake a quantitative analysis of lung cancer surgery literature. Dimensionsdatabase was searched using keywords in a 10-year period (2012-2021). Publications were characterized by publication year,research countries, field citation ratio, cooperation status, research area, and emerging hotspots. Results. Overall, globalscholarly outputs of lung cancer surgery had almost doubled during the recent decade, with China, Japan, and the UnitedStates leading the way, while Denmark and Belgium predominated in terms of scientific influence. Network analysis showedthat international cooperation accounted for a relatively small portion in lung cancer surgery research, and the United States,China, and Europe were the prominent centers of international cooperation network. In the recent decade, research of lungcancer surgery majored in prevention, biomedical imaging, rehabilitation, and genetics, and the emerging research hotspotstransformed into immunotherapy. Research on immunotherapy showed a considerable increase in scientific influence in thelatest year. Conclusions. The study findings are expected to provide researchers and policymakers with interesting insights intothe changing trends of lung cancer surgery research and further generate evidence to support decision-making in improvingprognosis for patients with lung cancer. | Jingyi Wu Chenlu Bao Ganwei Liu Shushi Meng Yunwei Lu Pengfei Li Jian Zhou | 2022 | Health Data Science2022，，1： | 0 |
| 9 | The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population. | Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang | 2023 | Cell Research2023，33，10： | 0 |
| 10 | Spatio-temporal delivery of both intra-and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses显示文摘For cancer immunotherapy,triggering toll-like receptors(TLRs)in dendritic cells(DCs)can potentiate antigen-based immune responses.Nevertheless,to generate robust and long-lived immune responses,a well-designed nanovaccine should consider different locations of TLRs on DCs and co-deliver both antigens and TLR agonist combinations to synergistically induce optimal antitumor immunity.Herein,we fabricated lipid-polymer hybrid nanoparticles(LPNPs)to spatio-temporally deliver model antigen ovalbumin(OVA)on the surface of the lipid layer,TLR4 agonist monophosphoryl lipid A(MPLA)within the lipid layer,and TLR7 agonist imiquimod(IMQ)in the polymer core to synergistically activate DCs by both extra-and intra-cellular TLRs for enhancing adaptive immune responses.LPNPs-based nanovaccines exhibited a narrow size distribution at the mean diameter of 133.23 nm and zeta potential of−2.36 mV,showed a high OVA loading(around 70.83μg/mg)and IMQ encapsulation efficiency(88.04%).Our data revealed that LPNPs-based nanovaccines showed great biocompatibility to immune cells and an excellent ability to enhance antigen internalization,thereby promoting DCs maturation and cytokines production.Compared to Free OVA,OVA-LPNPs promoted antigen uptake,lysosome escape,depot effect and migration to secondary lymphatic organs.In vivo immunization showed that IMQ-MPLA-OVA-LPNPs with dual agonists induced more powerful cellular and humoral immune responses.Moreover,prophylactic vaccination by IMQ-MPLA-OVA-LPNPs effectively suppressed tumor growth and increased survival efficacy.Hence,the nanovaccines we fabricated can effectively co-deliver antigens and different TLR agonists and realize coordinated stimulation of DCs in a spatio-temporal manner for enhanced immune responses,which provides a promising strategy for cancer immunotherapy. | Nannan Wang Yueyue Zuo Shengjie Wu Chenlu Huang Linhua Zhang Dunwan Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
| 11 | Folate-targeted co-delivery polymersomes for efficient photo-chemo-antiangiogenic therapy against breast cancer and in vivo evaluation via OCTA/NIRF dual-modal imaging显示文摘Intelligent nanoplatform that combines multimodal imaging and therapeutic effects holds great promise for precise and efficient cancer therapy.Herein,folate-targeted polymersomes with stimuli-responsiveness were fabricated and evaluated by near-infrared fluorescence(NIRF)and optical coherence tomography angiography(OCTA)dual-imaging for photo-chemo-antiangiogenic therapy against cancer.The folate-targeted polymersomes(FA-MIT-SIPS)not only integrated ammonium bicarbonate(ABC)and mitoxantrone(MIT)into their hydrophilic cavity but also encapsulated indocyanine green(ICG)and sorafenib(SOR)within their hydrophobic layer.NIRF imaging demonstrated that FA-MIT-SIPS effectively accumulated and retained in the tumors.Upon 808 nm laser irradiation,the ICG produced hyperthermia and reactive oxygen species(ROS)for efficient photothermal and photodynamic therapy.In addition,the decomposition of ABC in responsive to acidic tumor environment and ICG-induced hyperthermia accelerated drug release.The released MIT accumulated in nucleus to inhibit DNA synthesis,while the released SOR destructed tumor vascularization.Notably,OCTA imaging was applied to observe the tumor blood flow upon the combination therapy,demonstrating that FA-MIT-SIPS obviously decreased the vessels area density.Moreover,the synergistic photo-chemo-antiangiogenic therapy of FA-MIT-SIPS achieved excellent antitumor effect with 40%of the 4T1 tumor-bearing mice being completely cured without recurrence.The multifunctional polymersomes provide a promising dual-modal imaging-evaluated synergistic strategy for tumor therapy. | Hongjun Wu Chenlu Huang Liwei Wang Qinghua Li Yuejie Li Linhua Zhang Dunwan Zhu | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 12 | The Childlike Interpretation in Elizabeth Bishop’s Poem “First Death in Nova Scotia”显示文摘“Interpretation”is a prominent theme in Elizabeth Bishop’s poem“First Death in Nova Scotia”.It is from a child’s perspective that Bishop obser ves and interprets the death of her cousin.However,during the process of interpretation,the chromographs cause misinterpretation and fail to provide the whole picture.At the same time,there are many literary features such as simile,metaphor,imagery and so on.Bishop also tries t o understand what is happening by means of association,imagination and assumption. | Chenlu Wu | 2020 | 校园英语2020，，22： | 0 |
| 13 | HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation显示文摘Ultra-stable fibrous structure is a hallmark of amyloids.In contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed‘functional amyloids’,contribute to signal transduction as temporal signaling hubs in humans.However,it is unclear how these functional amyloids are effectively disassembled to terminate signal transduction.RHIM motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian cells.Here,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as‘amyloidase’—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and mice.Different from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X_(1))φ(X_(3)).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional monomers.Notably,HSPA8’s amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone system.Using this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis activation.The discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo. | Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun | 2023 | Cell Research2023，33，11： | 0 |
| 14 | Environment and COVID-19 incidence: A critical review显示文摘The coronavirus disease 2019(COVID-19)pandemic is an unprecedented worldwide health crisis.Many previous research studies have found and investigated its links with one or some natural or human environmental factors.However,a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking.This review summarizes the inter-correlation between COVID-19 incidence and environmental factors.Based on keyword searching,we reviewed 100 relevant peer-reviewed articles and other research literature published since January 2020.This review is focused on three main findings.One,we found that individual environmental factors have impacts on COVID-19 incidence,but with spatial heterogeneity and uncertainty.Two,environmental factors exert interactive effects on COVID-19 incidence.In particular,the interactions of natural factors can affect COVID-19 transmission in micro-and macro-ways by impacting SARS-CoV-2 survival,as well as human mobility and behaviors.Three,the impact of COVID-19 incidence on the environment lies in the fact that COVID-19-induced lockdowns caused air quality improvement,wildlife shifts and socio-economic depression.The additional value of this review is that we recommend future research perspectives and adaptation strategies regarding the interactions of the environment and COVID-19.Future research should be extended to cover both the effects of the environment on the COVID-19 pandemic and COVID-19-induced impacts on the environment.Future adaptation strategies should focus on sustainable environmental and public policy responses. | Jiatong Han Jie Yin Xiaoxu Wu Danyang Wang Chenlu Li | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 15 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
| 16 | The C-terminal low-complexity domain involved in liquid-liquid phase separation is required for BRD4 function in vivo显示文摘Dear Editor,Recently,liquid-liquid phase separation(LLPS)attracts great interest for its ability to achieve spatial separation and effective organization of macromolecules(Gomes and Shorter,2018).It is believed to be the driving force to form membraneless organelles and thus plays fundamental roles in a large number of biological processes(Shin and Brangwynne,2017).A list of proteins have been identified that could undergo LLPS in vitro and in vivo(Du and Chen,2018).However,the physiological role of LLPS in animals remains largely unknown. | Chenlu Wang Erhao Zhang Fan Wu Yufeng Sun Yingcheng Wu Baorui Tao Yue Ming Yuanpei Xu Renfang Mao Yihui Fan | 2019 | Journal of Molecular Cell Biology2019，11，9： | 0 |
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