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| 1 | Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier显示文摘AIM To investigate whether gut microbiota metabolite sodium butyrate(Na B)is an effective substance for attenuating non-alcoholic fatty liver disease(NAFLD)and the internal mechanisms.METHODS Male C57BL/6J mice were divided into three groups,normal control were fed standard chow and model group were fed a high-fat diet(HFD)for 16 wk,the intervention group were fed HFD for 16 wk and treated with Na B for 8 wk.Gut microbiota from each group were detected at baseline and at 16 wk,liver histology were evaluated and gastrointestinal barrier indicator such as zonula occluden-1(ZO-1)were detected by immunohistochemistry and realtime-PCR,further serum or liver endotoxin were determined by ELISA and inflammation-or metabolism-associated genes were quantified by real-time PCR.RESULTS Na B corrected the HFD-induced gut microbiota imbalance in mice,while it considerably elevated the abundances of the beneficial bacteria Christensenellaceae,Blautia and Lactobacil us.These bacteria can produce butyric acid in what seems like a virtuous circle.And butyrate restored HFD induced intestinal mucosa damage,increased the expression of ZO-1 in small intestine,further decreased the levels of gut endotoxin in serum and liver compared with HF group.Endotoxin-associated genes such as TLR4 and Myd88,pro-inflammation genes such as MCP-1,TNF-α,IL-1,IL-2,IL-6 and IFN-γin liver or epididymal fat were obviously downregulated after Na B intervention.Liver inflammation and fat accumulation were ameliorated,the levels of TG and cholesterol in liver were decreased after Na B intervention,NAS score was significantly decreased,metabolic indices such as FBG and HOMA-IR and liver function indicators ALT and AST were improved compared with HF group.CONCLUSION Na B may restore the dysbiosis of gut microbiota to attenuate steatohepatitis,which is suggested to be a potential gut microbiota modulator and therapeutic substance for NAFLD. | Da Zhou Qin Pan Feng-Zhi Xin Rui-Nan Zhang Chong-Xin He Guang-Yu Chen Chang Liu Yuan-Wen Chen Jian-Gao Fan | 2017 | World Journal of Gastroenterology2017，23，1： | 77 |
| 2 | Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: An endoscopist-blinded, prospective, randomized study显示文摘AIM: To assess the efficacy of premedicaton with pronase or N-acetylcysteine (NAC) at 20 min before upper gastrointestinal (UGI) endoscopy and to determine whether pronase or NAC pretreatment influences the reliability of the rapid urease test. METHODS: A total of 146 patients were prospectively and randomly assigned into the study groups according to different premedications before endoscopy. One endoscopist assessed mucosal visibility (MV) with scores ranged from 1 to 4 at four sites in the stomach. The sum of the MV scores from these four locations was defined as the total mucosal visibility (TMV) score. Identification of H pylori was performed using CLO test, histology, and serology. RESULTS: The Group with pronase premedication had a significantly lower TMV score than did the groups with gascon and gascon water (P < 0.001 and P < 0.01, respectively). The group with NAC had a significantly lower TMV score than the group with gascon (P < 0.01) and a trend of a lower MV score than the group with gascon water (P = 0.06). The TMV score did not significantly differ between the group with pronase and the group with NAC (P = 0.39 and P = 0.14, respectively). The sensitivity and specificity of the CLO test were 92.5% and 93.9%, respectively, in groups premedicated with pronase and NAC together.CONCLUSION: Premedication with pronase or NAC at 20 min before UGI endoscopy improves the mucosal visibility of the stomach. Neither pronase nor NAC produces any obvious interference with the CLO test for the identification of H pylori infection. | Chun-Chao Chang Sheng-Hsuan Chen Chih-Ping Lin Ching-Ruey Hsieh Horng-Yuan Lou Fat-Moon Suk Shiann Pan Ming-Shun Wu Jun-Nan Chen Yung-Fa Chen | 2007 | World Journal of Gastroenterology2007，13，3： | 31 |
| 3 | Oxidative Damage to DNA and Its Relationship With Diabetic Complications显示文摘Objective To detect the oxidative DNA damage in diabetic patients and to investigate the relationship of oxidative DNA damage with diabetes and diabetic nephropathy. Methods Single cell gel electrophoresis(SCGE) was used to detect the DNA strand breaks in peripheral blood lymphocytes,and oxidative DNA damage product and serum 8-OHdG were determined by a competitive ELISA in 47 cases,including 25 patients without diabetic complications,22 patients with diabetic nephropathy and 25 normal control subjects. Results Diabetic patients showed greater oxidative damage to DNA. The percentage of comet cells and the length of DNA migration(comet tail length) of peripheral blood lymphocytes were significantly increased in patients with diabetes,and significantly higher in patients with diabetic nephropathy than in diabetic patients without vascular complications(P<0.05). There was a significant increase in serum 8-OHdG in diabetic patients compared with normal subjects(P<0.05). Moreover,serum 8-OHdG was much higher in patients with diabetic nephropathy than in diabetic patients without vascular complications(P<0.05). Conclusion There is severe oxidative DNA damage in diabetic patients. Enhanced oxidative stress may be associated with diabetes,especially in patients with diabetic nephropathy. | HONG-ZHI PAN DONG CHANG LEI-GUANG FENG FENG-JUAN XU HONG-YU KUANG MING-JUN LU | 2007 | Biomedical and Environmental Sciences2007，20，2： | 23 |
| 4 | Developing land use scenario dynamics model by the integration of system dynamics model and cellular automata model显示文摘Modeling land use scenario changes and its potential impacts on the structure and function of the ecosystem in the typical regions are helpful to understanding the interactive mechanism between land use system and ecological system. A Land Use Scenario Dynamics (LUSD) model by the integration of System Dynamics (SD) model and Cellular Automata (CA) model is developed with land use scenario changes in northern China in the next 20 years simulated in this paper. The basic idea of LUSD model is to simulate the land use scenario de-mands by using SD model at first, then allocate the land use scenario patterns at the local scale with the considerations of land use suitability, inheritance ability and neighborhood effect by using CA model to satisfy the balance between land use scenario demands and supply. The application of LUSD model in northern China suggests that the model has the ability to reflect the complex behavior of land use system at different scales to some extent and is a useful tool for assessing the potential impacts of land use system on ecological system. In addition, the simulated results also indicate that obvious land use changes will take place in the farming-pastoral zone of northern China in the next 20 years with cultivated land and urban land being the most active land use types. | HE Chunyang, SHI Peijun, CHEN Jin, Li Xiaobing, PAN Yaozhong, LI Jing, LI Yuechen & LI Jinggang Key Laboratory of Environmental Change and Natural Disaster, Ministry of Education of China, Beijing Normal University College of Resources Science & Technology, Beijing Normal University, Beijing 100875, China | 2005 | Science China Earth Sciences2005，48，11： | 21 |
| 5 | New technological partition for “three zones” spontaneous coal combustion in goaf显示文摘On detailed analysis basis of spontaneous coal combustion for the three zones in mine goaf,we use O2 and CO concentrations to divide the three zones of the coal combustion.Through our experiment,we selected a typical working face and focused on the changes in gas concentrations.In order to overcome establishment limitations of actual layout location and underground conditions in a mine goaf,we based our observations on the three zones,combined them with numerical simulation,described the distribution and the changes in O2 and CO concentrations during the coal spontaneous combustion in the goaf,which provided us with an understanding of the distribution of coal spontaneous combustion in the three zones in the form of maps.Essentially,our study summarizes the changes of O2and CO concentrations in the entire goaf and shows them to be in agreement with our observations at the scene.The study shows that it is feasible to divide the three zones,given our comprehensive targets of O2,CO and our numerical simulation.This method avoids the limitation of dividing the three zones with a single target and the likely errors of observations at the scene.In addition,the method offers a basis for optimizing measures of fre-fghting with important and practical effects. | Pan Rongkun Cheng Yuanping Yu Minggao Lu Chang Yang Ke | 2013 | International Journal of Mining Science and Technology2013，23，4： | 20 |
| 6 | Current medical therapy for ulcerative colitis显示文摘NTRODUCTIONInrecentyears,theadvancesintherapyofulcerativecolitis(UC)havebeencharacterizedmainlybythemoreextensiveuseofimmuno... | XU Chang Tai and PAN Bo Rong | 1999 | World Journal of Gastroenterology1999，5，1： | 16 |
| 7 | Mitochondrial DNA variation analysis suggests extreme low genetic diversity in Guizhou snub-nosed monkeys (Rhinopithecus brelichi)显示文摘Guizhou snub-nosed monkey (Rhinopithecus brelichi) is a unique, endangered primate in China, mainly distributed in Fanjing Mountain National Natural Reserve, Guizhou Province, in an area of 275 km2. Recently, habitat loss and fragmentation have caused population isolation. To assess genetic diversity within this species and its population structure, we sequenced 400 bp of the hypervariable I segment from the mitochondrial DNA control region for 128 individuals. Only one haplotype was identified from these individuals. Compared with other primate species, R. brelichi can be regarded as a species with very low genetic diversity, which further adds to the conservation concern. | PAN HuiJuan SHI FangLei CHANG ZongFei XIANG ZuoFu SUN TingTing LIU ZhiJin LIMing | 2011 | Chinese Science Bulletin2011，56，24： | 15 |
| 8 | Current status of gene therapy in gastroenterology显示文摘CurentstatusofgenetherapyingastroenterologyXUChangTai1andPANBoRong2Subjectheadingsgastroenterology;genetherapy;genetransfer... | XU Chang Tai 1 and PAN Bo Rong 2 | 1998 | World Journal of Gastroenterology1998，4，1： | 15 |
| 9 | Evaluation of Oxidative Stress in Colorectal Cancer Patients显示文摘Objective To evaluate the oxidative stress in patients with colorectal cancer and to investigate the relationship between oxidative stress and colorectal cancer. Methods Seventy-six subjects were divided into two groups (36 colorectal cancer patients as the study group and 40 normal healthy individuals as the control group). Their protein oxidation, DNA damage, lipid peroxidation and antioxidants, vitamin C, vitamin E, glutathione (GSH), and antioxidative enzymes in serum were detected. Results The levels of protein carbonyl and advanced oxidation protein products (AOPP) were significantly higher in the study group than in the control group (P<0.01). Serum 8-OHdG was significantly increased in the study group compared to the control group (P<0.01). However, the mean serum level of MDA and conjugated diene was lower in the study group than in the control group (P<0.01). The activity of antioxidative enzymes was significantly decreased in the study group compared to the control group (P<0.01). Serum vitamins C and E concentrations were significantly reduced in the study group compared to the control group (P<0.01). Conclusion Colorectal cancer is associated with oxidative stress, and assessment of oxidative stress and given antioxidants is important for the treatment and prevention of colorectal cancer. | DONG CHANG FAN WANG YA-SHUANG ZHAO HONG-ZHI PAN | 2008 | Biomedical and Environmental Sciences2008，21，4： | 14 |
| 10 | Trends and challenges of emergency and acute care in Chinese mainland:2005–2017显示文摘BACKGROUND:Emergency medical service system(EMSS)is essential in providing acute care services for health conditions.However,trends of emergency and acute care in China haven’t been studied systematically.METHODS:Relevant literature was carefully reviewed,including original and review articles,letters,government reports,yearbooks,both in Chinese and in English.Data on the number of emergency visits,physicians and beds in emergency departments(EDs),and the workforce of prehospital emergency care were summarized and analyzed from China Health and Family Planning Statistical Yearbooks(2006–2018).RESULTS:Over the past decade,the number of ED visits tripled from 51.9 million to 166.5 million;and utilization of pre-hospital emergency care increased from 3.2 million to 6.8 million.In response to rapid increases in demand,the number of licensed emergency physicians raised from 20,058 to 59,409;the beds’number increased from 10,783 to 42,367.For pre-hospital emergency care,the volume of health workforce increased from 3,687 to 8,671,with a 109%increase in the number of physicians from 1,774 to 3,712.However,overcrowding,the long length of stay in EDs,poor work environment,and work exhaustion were still the critical challenges faced by China’s EMSS.CONCLUSIONS:The number of emergency visits has grown with continual capability enhancement during the past decade.However,overcrowding,the long length of stay in EDs,poor work environment,and work exhaustion still need to be solved by China’s EMSS.These fi ndings and comparison with the USA could offer experiences and lessons to EMSS development worldwide,especially for developing countries. | Chang Pan Jiao-jiao Pang Kai Cheng Feng Xu Yu-guo Chen | 2021 | World Journal of Emergency Medicine2021，12，1： | 14 |
| 11 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 12 | A review of fire-extinguishing agent on suppressing lithium-ion batteries fire显示文摘Safety issue of lithium-ion batteries(LIBs)such as fires and explosions is a significant challenge for their large scale applications.Considering the continuously increased battery energy density and wider large-scale battery pack applications,the possibility of LIBs fire significantly increases.Because of the fast burning and the easy re-ignition characteristics of LIBs,achieving an efficient and prompt LIBs fire suppression is critical for minimizing the fire hazards.Different from conventional fire hazards,the LIBs fire shows complicated and comprehensive characteristics,and an effective and suitable fire-extinguishing agent particularly designed for LIBs is highly desirable.Considerable efforts have been devoted to this topic,to the best of our knowledge,a comprehensive review on this regard is still rare.Moreover,in practice,a guidance for the design and selections of a proper fire-extinguishing agent for LIBs is urgently needed.Herein,the special mechanisms and characteristics for LIBs fire and the corresponding design principles for LIBs fire-extinguishing agent were introduced.It is revealed that a fire-extinguishing agent developed for LIBs fire will most likely need a high heat capacity,high wetting,low viscosity and low electrical conductivity.After a comprehensive comparison of these agents in terms of these performances,water-based fire-extinguishing agents show best.Several typical fire-extinguishing agents such as gaseous agents,dry powders,water-based and aerosol fire-extinguishing agents were then introduced,and their fire extinguishment mechanisms were presented.Finally,their effectiveness in suppressing the fire were summarized.Water-based fire-extinguishing agents possess high cooling capacity and excellent anti-reflash performance for the fire.We believe this review could shed light on developing an efficient fire-extinguishing agent particularly designed for LIBs. | Shuai Yuan Chongye Chang Shuaishuai Yan Pan Zhou Xinming Qian Mengqi Yuan Kai Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 13 |
| 13 | Formation control and collision avoidance for multi-UAV systems based on Voronoi partition显示文摘This paper deals with the formation control problem of multiple unmanned aerial vehicles(UAVs) with collision avoidance. A distributed formation control and collision avoidance method is proposed based on Voronoi partition and conventional artificial potential field. The collision avoidance is achieved by partitioning the whole space into non-overlapping regions based on Voronoi partition theory, which is taken as the task region to confine the movement of each UAV. The general motion control law is designed based on the conventional artificial potential field. As this often leads to local optimum when two UAVs are going to collide with each other and they may stay still where the repulsive force is adversely equivalent to the attractive force. To address this problem,the destination switch scheme is further proposed to let UAVs switch destinations when they reach the local equilibrium. Finally,the effectiveness of proposed formation control algorithm is validated by simulations and experiments. | HU JinWen WANG Man ZHAO ChunHui PAN Quan DU Chang | 2020 | Science China(Technological Sciences)2020，63，1： | 12 |
| 14 | Trends in mortality of emergency departments patients in China显示文摘BACKGROUND: Emergency medical service system (EMSS) in China is becoming more important. However, studies on mortality of emergency departments (EDs) patients in tertiary hospitals and on the trends in mortality of ED patients all over China are stagnant. The objective of this study was to quantify and describe the trends in mortality of ED patients in China. METHODS: Nine tertiary teaching hospitals were selected from tertiary teaching hospitals in different regions. The annual numbers of ED visits and deaths of these hospitals in 2004, 2009 and 2014 were recorded and analyzed. Chi-square test was used to compare the mortality of the EDs’ visits. Moreover, data on the mortality of ED patients in China from 2005 to 2015 were summarized and analyzed from the China Health and Family Planning Statistical Yearbooks (2006–2016). RESULTS: From 2004 to 2014, the overall annual mortalities in EDs increased among the tertiary hospitals (P<0.001). However, the overall annual mortality in EDs all over China decreased from 0.12% in 2005 to 0.08% in 2015. And the mortalities of EDs patients in the eastern, central and western regions of China all decreased. In addition, the average mortality of EDs patients in northern China was obviously higher than that in southern China (P<0.05). CONCLUSION: The ED mortality was increased in tertiary hospitals while decreased all over China during the past decade, which may be partly caused by some critical challenges faced by China’s EMSS, such as overcrowding and long length of stay in EDs of tertiary hospitals. | Chang Pan Xiao-ran Huang Jiao-jiao Pang Kai Cheng Feng Xu Yu-guo Chen | 2019 | World Journal of Emergency Medicine2019，10，3： | 11 |
| 15 | Immunogenicity and safety of a severe acute respiratory syndrome coronavirus 2 inactivated vaccine in healthy adults: randomized, double-blind, and placebo-controlled phase 1 and phase 2 clinical trials显示文摘Background:The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)call for urgent development of effective and safe vaccines.We report the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine,KCONVAC,in healthy adults.Methods:Phase 1 and phase 2 randomized,double-blind,and placebo-controlled trials of KCONVAC were conducted in healthy Chinese adults aged 18 to 59 years.The participants in the phase 1 trial were randomized to receive two doses,one each on Days 0 and 14,of either KCONVAC(5 or 10 mg/dose)or placebo.The participants in the phase 2 trial were randomized to receive either KCONVAC(at 5 or 10 mg/dose)or placebo on Days 0 and 14(0/14 regimen)or Days 0 and 28(0/28 regimen).In the phase 1 trial,the primary safety endpoint was the proportion of participants experiencing adverse reactions/events within 28 days following the administration of each dose.In the phase 2 trial,the primary immunogenicity endpoints were neutralization antibody seroconversion and titer and anti-receptor-binding domain immunoglobulin G seroconversion at 28 days after the second dose.Results:Inthe phase1 trial,60 participantswere enrolled andreceived at least one dose of 5-mgvaccine(n=24),10-mgvaccine(n=24),or placebo(n=12).In the phase 2 trial,500 participantswere enrolled and received at least one dose of 5-mg vaccine(n=100 for 0/14 or 0/28 regimens),10-mg vaccine(n=100 for each regimen),or placebo(n=50 for each regimen).In the phase 1 trial,13(54%),11(46%),and seven(7/12)participants reported at least one adverse event(AE)after receiving 5-,10-mg vaccine,or placebo,respectively.In the phase 2 trial,16(16%),19(19%),and nine(18%)0/14-regimen participants reported at least oneAEafter receiving 5-,10-mg vaccine,or placebo,respectively.Similar AE incidences were observed in the three 0/28-regimen treatment groups.No AEs with an intensity of grade 3+were reported,expect for one vaccine-unrelated seriousAE(foot fracture)reported in the phase 1 trial.KCONVACinduced significant antibody responses;0/28 regimen showed a higher immune responses than that did 0/14 regimen after receiving two vaccine doses.Conclusions:Both doses of KCONVAC are well tolerated and able to induce robust immune responses in healthy adults.These results support testing 5-mg vaccine in the 0/28 regimen in an upcoming phase 3 efficacy trial.Trial Registration:http://gffzz62a03ee25e6f4a77h659wf0fc5ko065un.ffgz.tsg.suse.edu.cn/index.aspx(No.ChiCTR2000038804,http://gffzz62a03ee25e6f4a77h659wf0fc5ko065un.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=62350;No.ChiCTR2000039462,http://gffzz62a03ee25e6f4a77h659wf0fc5ko065un.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=63353). | Hong-Xing Pan Jian-Kai Liu Bao-Ying Huang Gui-Fan Li Xian-Yun Chang Ya-Fei Liu Wen-Ling Wang Kai Chu Jia-Lei Hu Jing-Xin Li Dan-Dan Zhu Jing-Liang Wu Xiao-Yu Xu Li Zhang Meng Wang Wen-Jie Tan Wei-Jin Huang Feng-Cai Zhu | 2021 | Chinese Medical Journal2021，，11： | 11 |
| 16 | Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in Young Female Population: A Single-center Study显示文摘 | Pei-Na Meng Chen Xu Wei You Zhi-Ming Wu Du-Jiang Xie Hang Zhang Chang Pan Fei Ye | 2017 | Chinese Medical Journal2017，，13： | 10 |
| 17 | Neoadjuvant oxaliplatin and capecitabine combined with bevacizumab plus radiotherapy for locally advanced rectal cancer: results of a single-institute phase II study显示文摘Background:Neoadjuvant chemoradiotherapy followed by surgery is recommended as the standard of care for locally advanced rectal cancer,reducing local recurrence but not distant metastasis.Intensified systemic therapy is warranted to reduce the risk of distant metastasis.The present study aimed to evaluate the safety and efficacy of neo-adjuvant oxaliplatin and capecitabine(XELOX)combined with bevacizumab plus radiotherapy for locally advanced rectal cancer.Methods:Patients with stages II to III rectal cancer received one cycle of induction chemotherapy and concurrent chemoradiotherapy with XELOX plus bevacizumab.Surgery was performed 6-8 weeks after completion of radiotherapy,and postoperative chemotherapy with three cycles of XELOX and two cycles of capecitabine were given.The primary endpoints were pathologic complete response(pCR)rate and safety,and the secondary endpoints were 3-year overall survival and progression-free survival.Results:Forty-five patients were enrolled between February 2013 and April 2015.All completed the neoadjuvant therapy.Seven patients(15.6%)refused subsequent surgical therapy for personal reasons,and the other 38 patients received radical resection,with a sphincter preservation rate of 84.2%and a pCR rate of 39.5%.Toxicity was acceptable,with grades 3-4 hematological toxicity and diarrhea observed in six and two patients,respectively.Incidence of anastomotic leak that required surgical intervention was 13.3%.After a median follow-up period of 37 months,five patients developed disease progression and two died of cancer.The 3-year overall survival rate and 3-year progres-sion-free survival rate were 95.3%and 88.6%,respectively.Conclusions:The addition of bevacizumab to neoadjuvant chemoradiotherapy resulted in a satisfying pCR rate and 3-year survival,but also may increase the risk of anastomotic leak,thus this regimen is not suitable to be considered for regular recommendation for locally advanced rectal cancer. | Xin Yu Qiao-xuan Wang Wei-wei Xiao Hui Chang Zhi-fan Zeng Zhen-hai Lu Xiao-jun Wu Gong Chen Zhi-zhong Pan De-sen Wan Pei-rong Ding Yuan-hong Gao | 2018 | Cancer Communications2018，38，1： | 10 |
| 18 | Removal of formaldehyde over Mn_xCe_(1- x)O_2 catalysts: Thermal catalytic oxidation versus ozone catalytic oxidation显示文摘MnxCe1-xO2(x:0.3–0.9)prepared by Pechini method was used as a catalyst for the thermal catalytic oxidation of formaldehyde(HCHO).At x=0.3 and 0.5,most of the manganese was incorporated in the fluorite structure of Ce O2to form a solid solution.The catalytic activity was best at x=0.5,at which the temperature of 100%removal rate is the lowest(270°C).The temperature for 100%removal of HCHO oxidation is reduced by approximately 40°C by loading 5 wt.%Cu Oxinto Mn0.5Ce0.5O2.With ozone catalytic oxidation,HCHO(61 ppm)in gas stream was completely oxidized by adding 506 ppm O3over Mn0.5Ce0.5O2catalyst with a GHSV(gas hourly space velocity)of 10,000 hr-1at 25°C.The effect of the molar ratio of O3to HCHO was also investigated.As O3/HCHO ratio was increased from 3 to 8,the removal efficiency of HCHO was increased from 83.3%to 100%.With O3/HCHO ratio of 8,the mineralization efficiency of HCHO to CO2was 86.1%.At 25°C,the p-type oxide semiconductor(Mn0.5Ce0.5O2)exhibited an excellent ozone decomposition efficiency of 99.2%,which significantly exceeded that of n-type oxide semiconductors such as Ti O2,which had a low ozone decomposition efficiency(9.81%).At a GHSV of 10,000 hr-1,[O3]/[HCHO]=3 and temperature of 25°C,a high HCHO removal efficiency(≥81.2%)was maintained throughout the durability test of 80 hr,indicating the long-term stability of the catalyst for HCHO removal. | Jia Wei Li Kuan Lun Pan Sheng Jen Yu Shaw Yi Yan Moo Been Chang | 2014 | Journal of Environmental Sciences2014，26，12： | 9 |
| 19 | Laparoscopic lateral lymph node dissection in two fascial spaces for locally advanced lower rectal cancer显示文摘BACKGROUND The procedure for lateral lymph node(LLN)dissection(LLND)is complicated and can result in complications.We developed a technique for laparoscopic LLND based on two fascial spaces to simplify the procedure.AIM To clarify the anatomical basis of laparoscopic LLND in two fascial spaces and to evaluate its efficacy and safety in treating locally advanced low rectal cancer(LALRC).METHODS Cadaveric dissection was performed on 24 pelvises,and the fascial composition related to LLND was observed and described.Three dimensional-laparoscopic total mesorectal excision with LLND was performed in 20 patients with LALRC,and their clinical data were analyzed.RESULTS The cadaver study showed that the fascia propria of the rectum,urogenital fascia,vesicohypogastric fascia and parietal fascia lie side by side in a medial-lateral direction constituting the dissection plane for curative rectal cancer surgery,and the last three fasciae formed two spaces(Latzko's pararectal space and paravesical space)which were the surgical area for LLND.Laparoscopic LLND in two fascial spaces was performed successfully in all 20 patients.The median operating time,blood loss and postoperative hospitalization were 178(152-243)min,55(25-150)mL and 10(7-20)d,respectively.The median number of harvested LLNs was 8.6(6-12),and pathologically positive LLN metastasis was confirmed in 7(35.0%)cases.Postoperative complications included lower limb pain in 1 case and lymph leakage in 1 case.CONCLUSION Our preliminary surgical experience suggests that laparoscopic LLND based on fascial spaces is a feasible,effective and safe procedure for treating LALRC. | Hui-Hong Jiang Hai-Long Liu A-Jian Li Wen-Chao Wang Liang Lv Jian Peng Zhi-Hui Pan Yi Chang Mou-Bin Lin | 2021 | World Journal of Gastroenterology2021，27，24： | 8 |
| 20 | Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats显示文摘Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effect. Spinal cord injury was induced by impacting the spinal cord at the thoracic T10 vertebra level. One group of injured rats received deferoxamine, a second injured group received saline, and a third group was sham operated. Both 2 days and 2 weeks after spinal cord injury, total iron ion levels and protein expression levels of the proinflammatory cytokines tumor necrosis factor-α and interleukin-1β and the pro-apoptotic protein caspase-3 in the spinal cords of the injured deferoxamine-treated rats were significantly lower than those in the injured saline-treated group. The percentage of the area positive for glial fibrillary acidic protein immunoreactivity and the number of terminal deoxynucleotidyl transferase d UTP nick end labeling-positive cells were also significantly decreased both 2 days and 2 weeks post injury, while the number of Neu N-positive cells and the percentage of the area positive for the oligodendrocyte marker CNPase were increased in the injured deferoxamine-treated rats. At 14–56 days post injury, hind limb motor function in the deferoxamine-treated rats was superior to that in the saline-treated rats. These results suggest that deferoxamine decreases total iron ion, tumor necrosis factor-α, interleukin-1β, and caspase-3 expression levels after spinal cord injury and inhibits apoptosis and glial scar formation to promote motor function recovery. | Jian Hao Bo Li Hui-quan Duan Chen-xi Zhao Yan Zhang Chao Sun Bin Pan Chang Liu Xiao-hong Kong Xue Yao Shi-qing Feng | 2017 | Neural Regeneration Research2017，12，6： | 8 |
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