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| 1 | Cigarette smoking, dietary habits and genetic polymorphisms in GSTT1, GSTM1 and CYP1A1 metabolic genes: A case-control study in oncohematological diseases显示文摘AIM To analyze the association between oncohematological diseases and GSTT1 /GSTM1 /CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control study.METHODS This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. Deletions in GSTT1 and GSTM1 (null genotypes) were addressed by PCR. CYP1A1 MspI polymorphism was detected by PCR-RFLP. Odds ratio(OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological disease.RESULTS Women showed lower risk of disease compared to men(OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education(> 12 years) were significantly associated with an increased risk, compared to complete primary school or less(OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease(OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk(OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 and CYP1A1 polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found. CONCLUSION We reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer. | María Belén Cerliani Walter Pavicic Juan Antonio Gili Graciela Klein Silvia Saba Silvina Richard | 2016 | World Journal of Clinical Oncology2016，7，5： | 1 |
| 2 | Targeting galectin-1 overcomes breast Cancer-Associated immunosuppression and pre- vents metastatic disease显示文摘 | Dalotto-Moreno T Croci DO Cerliani JP | 2013 | Cancer Res2013，73，： | 1 |
| 3 | Galectin-1 controls cardiac inflammation and ventrleular remodeling during acute myocardial infaretion显示文摘 | Seropian IM Cerliani JP Toldo S | 2013 | Am J Patbol2013，182，： | 1 |
| 4 | The in vivo apoptotic effect of interferon alfa-2b on rat preneoplastic liver involves Bax protein显示文摘 | De Lujan Alvarez M Cerliani JP Monti J | 2002 | Hepatology2002，35，4： | 1 |
| 5 | Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors显示文摘 | Croci DO Cerliani JP Dalotto-Moreno T | 2014 | Cell2014，156，4： | 1 |
| 6 | Targeting galec- tin-1 overcomes breast cancer-associated prevents metastatic disease显示文摘 | Dalotto-Moreno T Croci D O Cerliani J P | 2013 | Cancer Res2013，73，3： | 1 |
| 7 | Glycosyla- tion-dependent lectin-receptor interactions preserve angio- genesis in anti-VEGF refractory tumors显示文摘 | Croci DO Cerliani JP Dalotto-Moreno T | 2014 | Cell2014，156，4： | 1 |
| 8 | The in vivo apoptotic effect of interferon alfa-2b on rat preneo plastic liver involves Bax protein显示文摘 | De Lujan AlvarezM Cerliani JP Monti J | 2002 | Hepatology2002，35，4： | 1 |
| 9 | Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis:role of the host microenvironment显示文摘 | Montero Girard G Vanzulli SI Cerliani JP | 2007 | Breast Cancer Res2007，9，2： | 1 |
| 10 | Endogenous lectins shape the function of dendritic cells and tailor adaptive immu- nity: mechanisms and biomedical applications显示文摘 | Mascanfroni I D Cerliani J P Dergan-Dylon S | 2011 | International imm- unopharmacology2011，11，7： | 1 |
| 11 | Glycosylation- dependent lectin-receptor interactions preserve angiogenesis in anti-VFGF refractory tumors显示文摘 | Croci DO Cerliani JP Dalotto- Moreno T | 2014 | Cell2014，156，4： | 1 |
| 12 | Carcinoma - associat- ed fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth : A role for the FGF - 2/FG- FR-2 axis 显示文摘 | GiuIianelli S Cerliani JP Lamb CA | 2008 | Int JCancer2008，123，11： | 1 |
| 13 | Interaction between FGFR-2, STATS, and progesterone receptors in breast cancer显示文摘 | Cerliani JP Guillardoy T Giulianelli S | 2011 | Cancer Res2011，71，10： | 1 |
| 14 | Endoge-nous lectins shape the function of dendritic cells and tailoradaptive immunity: Mechanisms and biomedical applications显示文摘 | Mascanfroni ID Cerliani JP Dergan-Dylon S | 2011 | Int Immunopharmacol2011，11，7： | 1 |
| 15 | Targeting galectin-I breast cancer associated immunosuppression and pro- vents metastatic disease 显示文摘 | Dalotto-Moreno T Croci DO Cerliani JP | 2013 | Cancer Rcs2013，73，3： | 1 |
| 16 | Endoge-nous lectins shape the function of dendritic cells and tailor a -daptive immunity:Mechanisms and biomedical applications显示文摘 | Mascanfroni I D Cerliani J P Dergan-Dylon S | 2011 | Int Immunopharmacol2011，11，7： | 1 |
| 17 | When galectins recognize glycans: from biochemistry to physiology and back again 显示文摘 | Di Lella S Sundblad V Cerliani JP | 2011 | Biochemistry2011，50，37： | 1 |
| 18 | Cancer Stem Cell‐Like Phenotype and Survival Are Coordinately Regulated by A kt/ F oxO/ B im Pathway显示文摘 | Ricardo Gargini Juan P. Cerliani Maribel Escoll Inés M. Antón Francisco Wandosell | 2015 | Stem Cells2015，，3： | 1 |
| 19 | Probabilistic tractography re- covers a rostrocaudal trajectory of connectivity variability in the hu- man insular cortex 显示文摘 | Cerliani L Thomas RM Jbabdi S | 2012 | Hum Brain Mapp2012，33，9： | 1 |
| 20 | Associated expressions of FGFR-2 and FGFR-3:from mouse mammary gland physiology to human breast cancer显示文摘 | Cerliani JP Vanzulli SI Pinero CP | | 0，，03： | 1 |
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