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| 1 | A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice显示文摘The Wnt signaling pathway plays key roles in differentiation and development and alterations in this signaling pathway are causally associated with numerous human diseases.While several laboratories were examining roles for Wnt signaling in skeletal development during the 1990s,interest in the pathway rose exponentially when three key papers were published in 2001-2002.One report found that loss of the Wnt co-receptor,Low-density lipoprotein related protein-5(LRP5),was the underlying genetic cause of the syndrome Osteoporosis pseudoglioma(OPPG).OPPG is characterized by early-onset osteoporosis causing increased susceptibility to debilitating fractures.Shortly thereafter,two groups reported that individuals carrying a specific point mutation in LRP5(G171V)develop high-bone mass.Subsequent to this,the causative mechanisms for these observations heightened the need to understand the mechanisms by which Wnt signaling controlled bone development and homeostasis and encouraged significant investment from biotechnology and pharmaceutical companies to develop methods to activate Wnt signaling to increase bone mass to treat osteoporosis and other bone disease.In this review,we will briefly summarize the cellular mechanisms underlying Wnt signaling and discuss the observations related to OPPG and the high-bone mass disorders that heightened the appreciation of the role of Wnt signaling in normal bone development and homeostasis.We will then present a comprehensive overview of the core components of the pathway with an emphasis on the phenotypes associated with mice carrying genetically engineered mutations in these genes and clinical observations that further link alterations in the pathway to changes in human bone. | Kevin A.Maupin Casey J.Droscha Bart O.Williams | 2013 | Bone Research2013，1，1： | 18 |
| 2 | 6 Risks Your BYOD Policy Must Address显示文摘 | Casey Kevin | 2012 | EN2012，，： | 1 |
| 3 | Social Capital and E- conomic Performance in the American States 显示文摘 | Terrence Casey and Kevin Christ | 2005 | Social Science Quarterly2005，，86： | 1 |
| 4 | Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy显示文摘 | Barry J. Maron Paolo Spirito Michael J. Ackerman Susan A. Casey Christopher Semsarian N.A. Mark Estes Kevin M. Shannon Euan A. Ashley Sharlene M. Day Giuseppe Pacileo Francesco Formisano Emmanuela Devoto Aristidis Anastasakis J. Martijn Bos Anna Woo Camil | 2013 | Journal of the American College of Cardiology2013，，14： | 1 |
| 5 | Systems biology via redescription and ontologies(I):finding phase changes with applications to malaria temporal data显示文摘 | Kleinberg Samantha Casey Kevin Mishra Bud | 2008 | Systems and Synthetic Biology2008，1，4： | 1 |
| 6 | Epidemiology of Hypertrophic Cardiomyopathy–Related Death: Revisited in a Large Non–Referral-Based Patient Population显示文摘 | Barry J. Maron Iacopo Olivotto Paolo Spirito Susan A. Casey Pietro Bellone Thomas E. Gohman Kevin J. Graham David A. Burton Franco Cecchi | 2000 | Circulation: Journal of the American Heart Association2000，，8： | 1 |
| 7 | Alternate dispute resolution and patent law 显示文摘 | KEVIN R CASEY | 1993 | The Federal Circuit Bar Journal1993，3，1： | 1 |
| 8 | Social capital and eco nomic performance in the American states显示文摘 | Terence Casey and Kevin Christ | 2005 | Social Science Quarterly2005，86，： | 1 |
| 9 | Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers显示文摘 | Meredith Yeager Nianqing Xiao Richard B. Hayes Pascal Bouffard Brian Desany Laura Burdett Nick Orr Casey Matthews Liqun Qi Andrew Crenshaw Zdenek Markovic Karin M. Fredrikson Kevin B. Jacobs Laufey Amundadottir Thomas P. Jarvie David J. Hunter Robert Hoov | 2009 | Human Genetics2009，，2： | 1 |
| 10 | Implementing a surgical checklist: More than checking a box显示文摘 | Shauna M. Levy Casey E. Senter Russell B. Hawkins Jane Y. Zhao Kaitlin Doody Lillian S. Kao Kevin P. Lally KuoJen Tsao | 2012 | Surgery2012，，： | 1 |
| 11 | Hidden blood loss during posterior spine fusion surgery显示文摘 | Yossi Smorgick Kevin C Baker Casey C Bachison | | 0，，08： | 1 |
| 12 | Outcomes after Long-Term Follow-Up of Combat-Related Extremity Injuries in a Multidisciplinary Limb Salvage Clinic显示文摘 | Kevin Casey Pamela Demers Sophia Deben Meghann E. Nelles Jeffrey S. Weiss | 2015 | Annals of Vascular Surgery2015，，3： | 1 |
| 13 | Flap Coverage Outcomes following Vascular Injury and Repair: Chronicling a Decade of Severe War-Related Extremity Trauma显示文摘 | Kevin Casey Jennifer Sabino Elliot Jessie Barry D. Martin Ian Valerio | 2015 | Plastic and Reconstructive Surgery2015，，1： | 1 |
| 14 | Series of Noncontrast Time-of-Flight Magnetic Resonance Angiographies to Identify Problems with Arteriovenous Fistula Maturation显示文摘 | Aaron J. Gonzalez Kevin M. Casey Benjamin J. Drinkwine Jeffrey S. Weiss | 2015 | Annals of Vascular Surgery2015，，： | 1 |
| 15 | Social capital and economic performance in the American states显示文摘 | Terrence Casey and Kevin Christ | 2005 | Social Science Quarterly2005，86，： | 1 |
| 16 | 台北艺术中心显示文摘正近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2000席的大型演艺厅和一个1500席的中型剧院,再加上一个黑盒子剧场。标志性的外形,饰以典型19世纪做法的保守内部剧场布局,以及见证社会阶级观念的包厢。纵然剧院最基本的构造元素如舞台、镜框式剧场和观众席等已有三千多年的历史,但我们仍不应以此为借口,让现代剧场建筑的创新发展停滞不前。 | Yannis Chan Hin-Yeung Cheung Jim Dodson Inge Goudsmit Alasdair Graham Vincent Kersten Chiaju Lin Vivien Liu Kai Sun Luk Kevin Mak Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz Frans Parthesius Iwan Baan | 2012 | 建筑技艺2012，，4： | 0 |
| 17 | 公共云安全:4个误区和现实显示文摘当新兴科技出现时,总是会有一些炒作,将会出现各种各样的术语、误解和神话。云计算在其炒作周期中有一个很好的运行过程,IT方面没有什么重大转变是一个主要原因。当然,云计算现仵已经历了过度炒作期,并且成为市场主流。但这并不意味着云计算的发展已经成熟,尤其是当涉及公共云安全性时。现在是重新澄清关于公共云安全的一些重大误解的时候了,其中一些涉及私有云或混合云环境。 | Kevin Casey | 2018 | 电脑知识与技术(经验技巧)2018，0，5： | 0 |
| 18 | The use of feed-grade amino acids in lactating sow diets显示文摘Background: The use of feed grade amino acids can reduce the cost of lactation feed. With changing genetics,increasing feed costs, and higher number of pigs weaned with heavier wean weights further evaluation of higher inclusion levels of feed-grade amino acid in lactation diets than previously published is warranted. Two experiments(Exp.) were conducted to determine the optimal inclusion level of L-lysine HCl to be included in swine lactation diets while digestible lysine levels remain constant across dietary treatments and allowing feed grade amino acids to be added to the diet to maintain dietary ratios relative to lysine to maximize litter growth rate and sow reproductive performance. Furthermore, the studies were to evaluate minimal amino acid ratios relative to lysine that allows for optimal litter growth rate and sow reproductive performance.Results: Exp. 1: Increasing L-lysine HCl resulted in similar gilt feed intake, litter, and reproductive performance.Average litter gain from birth to weaning was 2.51, 2.49, 2.59, 2.43, and 2.65 kg/d when gilts were fed 0.00, 0.075,0.150, 0.225, and 0.30% L-lysine HCl, respectively. Exp. 2: The average litter gain from birth to weaning was 2.68,2.73, 2.67, 2.70, and 2.64 kg/d(P < 0.70) when sows were fed 0.1, 0.2, 0.3, 0.4, and 0.4% L-lysine HCl plus valine,respectively. No other differences among dietary treatments were observed.Conclusions: Collectively, these studies demonstrate corn-soybean meal based lactation diets formulated with a constant SID lysine content for all parities containing up to 0.40% L-lysine HCl with only supplemental feed grade threonine and a methionine source have no detrimental effect on litter growth rate and subsequent total born. | Laura Greiner Pairat Srichana James L.Usry Casey Neill Gary L.Allee Joseph Connor Kevin J.Touchette Christopher D.Knight | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 0 |
| 19 | 中小企业远程IT协助方略显示文摘您所在的企业是否会因为团队的扩展而难以管理诸多个人电脑和移动设备?不妨参考以下的建议。 | Kevin Casey 星竹(编译) | 2011 | 中国建设信息2011，，18： | 0 |
| 20 | 台北艺术中心显示文摘为什么过去百年间最令人兴奋的剧场盛事总是发生在正规场所之外?建筑如何才能超越自身卑微的命运,摆脱那种限制各种可能的宿命?
近年来,世界各地的演艺中心数目渐增,但不知何故,这些演艺中心似乎达成一种共识,呈现出雷同的空间组合:一座约2 000席的大型演艺厅和一个1 500席的中型剧院,再加上一个黑盒子剧场。 | Yannis Chan Hin-Yeung Cheung Inge Goudsmit Vincent Kersten Chiaju Lin Kevin Mak Jim Dodson Alasdair Graham Vivien Liu Kai Sun Luk Slobodan Radoman Roberto Requejo Saul Smeding Elaine Tsui Viviano Villarreal Casey Wang Leonie Wenz | 2014 | 城市环境设计2014，，6： | 0 |
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