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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Behavioral profile of a heter-ozygous mutant mouse model for EGF-like domain neuregulin-1显示文摘 | Duffy L Cappas E Scimone A | 2008 | Behav Neurosci2008，122，4： | 1 |
| 3 | Abnormal keratinization of the inner root sheath and cuticles of hair follicles in the scalp with'loose anagen syndrome'显示文摘 | Uno H Cappas A Dong S | 1989 | J Invest Dermatol1989，92，4： | 1 |
| 4 | Treatment of acute silicoproteinosis by whole-lung lavage显示文摘 | Stafford M Cappa A Weyant M | 2013 | Semin Cardiothorac Vase Anesth2013，17，2： | 1 |
| 5 | Identification of seven novel mutations in A BCD1 by a DHPLC-based assay in Italian patients with X-linked adrenoleukodystrophy 显示文摘 | Montagna G Di Biase A Cappa M | 2005 | Hum Mutat2005，25，2： | 1 |
| 6 | The effect of topical tretinoin on the facial pigmented macula of the macaque显示文摘 | Cappas A Dong S | 1991 | J Invest Dermatol1991，96，： | 1 |
| 7 | The Effect of So- cial Content on Deductive Reasoning: An fMRI S tudy显示文摘 | Canessa N Gorini A Cappa SF | 2005 | Human Brain Mapping2005，26，1： | 1 |
| 8 | Identification of seven novel mutations in ABCD1 by a DHPLC-based assay in Italian patients with X-linked adrenoleukodystrophy显示文摘 | Montagna G di Biase A Cappa M | 2005 | Hum Mutat2005，25，2： | 1 |
| 9 | A Novel Methodology for the Experimental of Pulmonary Ventilator Performance Drift显示文摘 | Branca F P Cappa P Sciuto S A | 1997 | Journal of Clinical Engineering1997，5，： | 1 |
| 10 | Somesthetic-visual matching disorders in right and left hemisphere-damaged patients显示文摘 | Bottini G Cappa S F Vignolo L A | 1991 | Cortex1991，27，2： | 1 |
| 11 | Terlipressin infusion induces ischemia of breast skin in a cirrothic patient with hepatorenal syndrome 显示文摘 | Di Micoli A Bracci E Cappa FM | 2008 | Dig Liver Dis2008，40，4： | 1 |
| 12 | The effect of an acute ener- gy deficit on the hormone profile of dominant follicles in dairy cows 显示文摘 | COMIN A GERIN D CAPPA A | 2002 | Theriogenology2002，58，： | 1 |
| 13 | Unilateral spatial neglect in degenerative brain pathology显示文摘 | Silveri MC Ciccarelli N Cappa A | 2011 | Neuropsychology2011，25，5： | 1 |
| 14 | Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence显示文摘 | V Garibotto B Borroni E Kalbe K Herholz E Salmon V Holtoff S Sorbi S F. Cappa A Padovani F Fazio D Perani | 2008 | Neurology2008，，： | 1 |
| 15 | The effect of an acute energy deficit on the hormone profile of dominanffollicles in dairy cows 显示文摘 | COMIN A GER/N D CAPPA A | 2002 | Theriogenology2002，58，5： | 1 |
| 16 | The effect of an acute energy deficit on the hormone profile of dominant follicles in dairy cows显示文摘 | Comin A Gerin D Cappa A | 2002 | Theriogenology2002，，58： | 1 |
| 17 | Relationship between oxidation level and optical properties of secondary organic aerosol显示文摘 | LAMBE A T CAPPA C D MASSOLI P | 2013 | Environmental Science &Teehnology2013，47，12： | 1 |
| 18 | Impact of brown and clear carbon on light absorption enhancement, single scatter albedo and absorption wavelength dependence of black carbon显示文摘 | Lack D A Cappa C D | 2010 | Atmospheric Chemistry and Physics2010，10，9： | 1 |
| 19 | Action and object processing in aphasia:From nouns and verbs to the effect of manipulability显示文摘 | Arévalo A Perani D Cappa SF | 2007 | Brain Lang2007，100，： | 1 |
| 20 | Kinetic ^12O effects in the hydrologic cycle: Indirect evidence and implications 显示文摘 | Angert A Cappa C D DePaolo D | 2004 | Geochimica et Cosmochimica Acta2004，68，17： | 1 |
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