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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Efficient Conditional Privacy-Preserving and Authentication Scheme for Secure Service Provision in VANET显示文摘Vehicle Ad hoc NETworks(VANET) can enhance traffic safety and improve traffic efficiency through cooperative communication among vehicles, roadside infrastructure, and traffic management centers. To guarantee secure service provision in VANET, message authentication is important. Moreover, a vehicle user's private information can also be leaked during service provision. A protection mechanism is needed to prevent such leakage. Therefore, we propose a conditional privacy-preserving and authentication scheme for secure service provision in VANETs. The proposed scheme not only satisfies the security requirements of VANETs, but also optimizes the calculation process of signature generation and verification. We carry out a detailed comparative analysis. The result shows that the proposed scheme is more efficient than existing schemes in terms of communication overhead and computational cost. Therefore, our scheme is suitable for secure service provision in VANETs. | Hong Zhong Jingyu Wen Jie Cui Shun Zhang | 2016 | Tsinghua Science and Technology2016，21，6： | 7 |
| 3 | Enhanced production of seed oil with improved fatty acid composition by overexpressing NAD^(+)-dependent glycerol-3-phosphate dehydrogenase in soybean显示文摘There is growing interest in expanding the production of soybean oils(mainly triacylglycerol, or TAG) to meet rising feed demand and address global energy concerns. We report that a plastidlocalized glycerol-3-phosphate dehydrogenase(GPDH), encoded by GmGPDHp1 gene, catalyzes the formation of glycerol-3-phosphate(G3 P), an obligate substrate required for TAG biosynthesis.Overexpression of GmGPDHp1 increases soybean seed oil content with high levels of unsaturated fatty acids(FAs), especially oleic acid(C18:1), without detectably affecting growth or seed protein content or seed weight. Based on the lipidomic analyses, we found that the increase in G3 P content led to an elevated diacylglycerol(DAG) pool, in which the Kennedy pathwayderived DAG was mostly increased, followed by PC-derived DAG, thereby promoting the synthesis of TAG containing relatively high proportion of C18:1. The increased G3 P levels induced several transcriptional alterations of genes involved in the glycerolipid pathways. In particular, genes encoding the enzymes responsible for de novo glycerolipid synthesis were largely upregulated in the transgenic lines, in-line with the identified biochemical phenotype. These results reveal a key role for GmGPDHp1-mediated G3 P metabolism in enhancing TAG synthesis and demonstrate a strategy to modify the FA compositions of soybean oils for improved nutrition and biofuel. | Ying Zhao Pan Cao Yifan Cui Dongxu Liu Jiapeng Li Yabin Zhao Siqi Yang Bo Zhang Runnan Zhou Minghao Sun Xuetian Guo Mingliang Yang Dawei Xin Zhanguo Zhang Xin Li Chen Lv Chunyan Liu Zhaoming Qi Jingyu Xu Xiaoxia Wu Qingshan Chen | 2021 | Journal of Integrative Plant Biology2021，63，6： | 4 |
| 4 | PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation显示文摘PIP5k1βis crucial to the generation of phosphotidylinosotol(4,5)P2.PIP5k1βparticipates in numerous cellular activities,such as B cell and platelet activation,cell phagocytosis and endocytosis,cell apoptosis,and cytoskeletal organization.In the present work,we aimed to examine the function of PIP5k1βin osteoclastogenesis and osteogenesis to provide promising strategies for osteoporosis prevention and treatment.We discovered that PIP5k1β deletion in mice resulted in obvious bone loss and that PIP5k1β was highly expressed during both osteoclast and osteoblast differentiation.Deletion of the gene was found to enhance the proliferation and migration of bone marrow-derived macrophage-like cells to promote osteoclast differentiation.PIP5k1β-/-osteoclasts exhibited normal cytoskeleton architecture but stronger resorption activity.PIP5kip deficiency also promoted activation of mitogen-activated kinase and Akt signaling,enhanced TRAF6 and c-Fos expression,facilitated the expression and nuclear translocation of NFATC1,and upregulated Grb2 expression,thereby accelerating osteoclast differentiation and function.Finally,PIP5k1β enhanced osteoblast differentiation by upregulating master gene expression through triggering smad1/5/8 signaling.Therefore,PIP5k1βmodulates bone homeostasis and remodeling. | Xiaoying Zhao Penglei Cui Guoli Hu Chuandong Wang Lei Jiang Jingyu Zhao Jiake Xu Xiaoling Zhang | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 5 | A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis显示文摘The complex pathogenesis of osteoporosis includes excessive bone resorption,insufficient bone formation and inadequate vascularization,a combination which is difficult to completely address with conventional therapies.Engineered exosomes carrying curative molecules show promise as alternative osteoporosis therapies,but depend on specifically-functionalized vesicles and appropriate engineering strategies.Here,we developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells(MSCs)derived from human induced pluripotent stem cells(iPSCs).The engineered exosomes BT-Exo-siShn3,took advantage of the intrinsic anti-osteoporosis function of these special MSC-derived exosomes and collaborated with the loaded siRNA of the Shn3 gene to enhance the therapeutic effects.Modification of a bone-targeting peptide endowed the BT-Exo-siShn3 an ability to deliver siRNA to osteoblasts specifically.Silencing of the osteoblastic Shn3 gene enhanced osteogenic differentiation,decreased autologous RANKL expression and thereby inhibited osteoclast formation.Furthermore,Shn3 gene silencing increased production of SLIT3 and consequently facilitated vascularization,especially formation of type H vessels.Our study demonstrated that BT-Exo-siShn3 could serve as a promising therapy to kill three birds with one stone and implement comprehensive anti-osteoporosis effects. | Yongzhi Cui Yuanyuan Guo Li Kong Jingyu Shi Ping Liu Rui Li Yongtao Geng Weihang Gao Zhiping Zhang Dehao Fu | 2022 | Bioactive Materials2022，7，4： | 3 |
| 6 | Visible-light-promoted sulfonylmethylation of imidazopyridines显示文摘The visible light promoted C-H sulfonylmethylation of imidazopyridines with easily accessible bromomethyl sulfones under mild reaction conditions was described.This protocol provides an effective and practical access to sulfonylmethylated imidazopyridines with good functional group tolerance.The desired products were provided in moderate to excellent yields for 50 examples at room temperature.The method could also be an attractive strategy to install a methyl group on imidazopyridines. | Xia Mi Yuanfang Kong Jingyu Zhang Chao Pi Xiuling Cui | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 7 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 8 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 9 | Enhanced electrochemical properties of PEO-based composite polymer electrolyte with shape-selective molecular sieves显示文摘 | XI Jingyu QIU Xinping CUI Mengzhong | 2006 | Journal of Power Sources2006，156，2： | 1 |
| 10 | MATLAB Simulation of Curve Fitting Based Onleast-square 显示文摘 | Chen Lanfeng Yang Jingyu Cui Song | 2014 | Journal of Shenyang Normal University:Natural Science Edition2014，32，1： | 1 |
| 11 | Cerebral paragonimiasis: A retrospective analysis of 89 cases显示文摘 | Jingyu Chen Zhi Chen Jiangkai Lin Gang Zhu Hui Meng Gaoyu Cui Nan Wu Rong Hu Jiexiang Pan Yongjie Zou Hua Feng | 2012 | Clinical Neurology and Neurosurgery2012，，： | 1 |
| 12 | CsTRM5 regulates fruit shape via mediating cell division direction and cell expansion in cucumber显示文摘Fruit shape and size are important appearance and yield traits in cucumber,but the underlying genes and their regulatory mechanisms remain poorly understood.Here we identified a mutant with spherical fruits from an Ethyl Methane Sulfonate(EMS)-mutagenized library,named the qiu mutant.Compared with the cylindrical fruit shape in 32X(wild type),the fruit shape in qiu was round due to reduced fruit length and increased fruit diameter.MutMap analysis narrowed the candidate gene in the 6.47 MB range on Chr2,harboring the FS2.1 locus reported previously.A single-nucleotide polymorphism(SNP)(11359603)causing a truncated protein of CsaV3_2G013800,the homolog of tomato fruit shape gene SlTRM5,may underlie the fruit shape variation in the qiu mutant.Knockout of CsTRM5 by the CRISPR-Cas9 system confirmed that CsaV3_2G013800/CsTRM5 was the causal gene responsible for qiu.Sectioning analysis showed that the spherical fruit in qiu resulted mainly from increased and reduced cell division along the transverse and longitudinal directions,respectively.Meanwhile,the repressed cell expansion contributed to the decreased fruit length in qiu.Transcriptome profiling showed that the expression levels of cell-wall-related genes and abscisic acid(ABA)pathway genes were significantly upregulated in qiu.Hormone measurements indicated that ABA content was greatly increased in the qiu mutant.Exogenous ABA application reduced fruit elongation by inhibiting cell expansion in cucumber.Taken together,these data suggest that CsTRM5 regulates fruit shape by affecting cell division direction and cell expansion,and that ABA participates in the CsTRM5-mediated cell expansion during fruit elongation in cucumber. | Yang Xie Xiaofeng Liu Chengzhen Sun Xiaofei Song Xiaoli Li Haonan Cui Jingyu Guo Liu Liu Ao Ying Zeqin Zhang Xueyun Zhu Liying Yan Xiaolan Zhang | 2023 | Horticulture Research2023，10，3： | 1 |
| 13 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 14 | A review of SAGD technology development and its possible application potential on thin-layer super-heavy oil reservoirs显示文摘Super-heavy oil is a significant unconventional energy source,and more than 30 years of research have shown that steam-assisted gravity drainage(SAGD)technology is suitable for thick super-heavy oil reservoirs.Recently,more and more thin-layer super-heavy oil reservoirs have been discovered in China,while their deep buried depth and serous heterogeneity make the existing SAGD technology difficult to apply,so it is urgent to improve the existing SAGD technology for the thin-layer super-heavy oil.To this end,this paper focuses on the enlightenment of field application in SAGD technology.Firstly,based on typical SAGD field projects,the development history of SAGD technology in the world was reviewed,and the influence of reservoir physical properties on the application of SAGD technology in thin-layer superheavy oil reservoirs was analyzed.Secondly,the well pattern,wellbore structure,pre-heating,artificial lift,and monitor technique of SAGD were detailed described,and their adjustment direction was expounded for the development of thin-layer super-heavy oil reservoirs.Lastly,the gas-and solventassistant SAGD were comprehensively evaluated,and their application potential in thin-layer superheavy oil reservoirs was studied.The research results can provide theoretical guidance for the application of SAGD technology in thin-layer super-heavy oil reservoirs. | Guodong Cui Ting Liu Jingyu Xie Guanghui Rong Lihong Yang | 2022 | Geoscience Frontiers2022，13，4： | 0 |
| 15 | Lactate regulates major zygotic genome activation by H3K18 lactylation in mammals显示文摘Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos in vivo and in vitro.However,its role in preimplantation development is unclear.Here,we report that lactate is highly enriched in the nuclei of early embryos when major zygotic genome activation(ZGA)occurs in humans and mice.The inhibition of its production and uptake results in developmental arrest at the 2-cell stage,major ZGA failure,and loss of lactate-derived H3K18lac,which could be rescued by the addition of Lac-CoA and recapitulated by overexpression of H3K18R mutation.By profiling the landscape of H3K18lac during mouse preimplantation development,we show that H3K18lac is enriched on the promoter regions of most major ZGA genes and correlates with their expressions.In humans,H3K18lac is also enriched in ZGA markers and temporally concomitant with their expressions.Taken together,we profile the landscapes of H3K18lac in mouse and human preimplantation embryos,and demonstrate the important role for H3K18lac in major ZGA,showing that a conserved metabolic mechanism underlies preimplantation development of mammalian embryos. | Jingyu Li Weibo Hou Qi Zhao Wei Han Hongdi Cui Songling Xiao Ling Zhu Jiadan Qu Xiaoyu Liu Weitao Cong Jingling Shen Yuzheng Zhao Shaorong Gao Guoning Huang Qingran Kong | 2024 | National Science Review2024，11，2： | 0 |
| 16 | Enhancing the cycling stability of Na-ion batteries by bonding MoS2 on assembled carbon-based materials显示文摘Room temperature Na-ion batteries(SIBs) show great potential for use as renewable energy storage systems.However, the large-scale application of SIBs has been hindered by the lack of an ideal SIBs anode material. We synthesized MoS2 on carbonized graphene-chitosan(G-C) using the hydrothermal method. The strong interaction between the MoS2 and the G-C greatly improved the electron transport rate and maintained the structural stability of the electrode, which lead to both an excellent rate capability and long cycle stability. The G-C monolith was proven to enhance the electrical conductivity of the composites and served as a matrix for uniformly dispersing active MoS2 nanosheets(NSs), as well as being a buffer material to adapt to changes in volume during the cycle.Serving as an anode material for SIBs, the MoS2-G-C electrode showed good cycling stability(527.3mAh g-1 at100 m A g-1 after 200 cycles), excellent rate capability, and a long cycle life(439.1 m Ah g-1 at 1 A g-1 after 200 cycles). | Pin Song Jun Di Lixing Kang Manzhang Xu Bijun Tang Jun Xiong Jiewu Cui Qingsheng Zeng Jiadong Zhou Yongmin He Qundong Fu Juan Peng Shasha Guo Bo Lin Jingyu Zhang Peng Meng Zheng Liu | 2019 | Nano Materials Science2019，1，4： | 0 |
| 17 | Experimental Investigations on Fiber Motion within Rotor Spinning Unit显示文摘An experimental platform is constructed to photograph fibers' motion within rotor spinning unit, which is mainly composed of a transparent rotor and a transport channel based on the similarity theory. The fibers will stretch and gather into a fiber bundle in the transport channel. The velocity of fibers is increasing along the inlet to the outlet of the transport channel, and the fibers' maximum velocity appears at the outlet of transport channel. The straightness of the fiber bundle is related to the convergence degree of the transport channel, and the greater the convergence degree is, the straighter the fiber bundle stretches. The results will provide a useful insight to the yarn-forming mechanism of rotor spinning. | JIN Yuzhen LI Xiangdong JIANG Shunwei CUI Jingyu ZHU Zuchao | 2017 | Journal of Thermal Science2017，26，4： | 0 |
| 18 | Graphene-incorporated hyaluronic acid-based hydrogel as a controlled Senexin A delivery system显示文摘Perivascular delivery of therapeutic agents against established aetiologies for occlusive vascular remodelling has great therapeutic potential for vein graft failure.However,none of the perivascular drug delivery systems tested experimentally have been translated into clinical practice.In this study,we established a novel strategy to locally and sustainably deliver the cyclin-dependent kinase 8/19 inhibitor Senexin A(SenA),an emerging drug candidate to treat occlusive vascular disease,using graphene oxide-hybridised hyaluronic acid-based hydrogels.We demonstrated an approach to accommodate SenA in hyaluronic acid-based hydrogels through utilising graphene oxide nanosheets allowing for non-covalent interaction with SenA.The resulting hydrogels produced sustained delivery of SenA over 21 days with tunable release kinetics.In vitro assays also demonstrated that the hydrogels were biocompatible.This novel graphene oxide-incorporated hyaluronic acid hydrogel offers an optimistic outlook as a perivascular drug delivery system for treating occlusive vascular diseases,such as vein graft failure. | Panita Maturavongsadit Weiwei Wu Jingyu Fan Igor B.Roninson Taixing Cui Qian Wang | 2022 | Biomaterials Translational2022，3，2： | 0 |
| 19 | Improving fatigue strength of bainite/martensite dual-phase steels in very high cycle fatigue regime by refining microstructures显示文摘Very high cycle fatigue behaviors of two bainite/martensite dual-phase steels were investigated.One of the steels was cyclic rapid heat treated and its microstructures were refined. Fatigue strength of the steel is 225 MPa higher than that without refining.Observation of fracture surfaces show that the fatigue cracks initiate at bainites for non-refined steel and at non-metallic inclusions for the refined steel.The size of inclusions is much smaller than that of bainites which results in the improvement of fatigue strength. | Yangbo Liu Shouxin Li Zhengou Yang Jingyu Cui Jialin Gu Bingzhe Bai | 2012 | Theoretical & Applied Mechanics Letters2012，2，3： | 0 |
| 20 | Oxygen-assisted direct growth of large-domain and high-quality graphene on glass targeting advanced optical filter applications显示文摘Growing high quality graphene films directly on glass by chemical vapor deposition(CVD)meets a growing demand for constructing high-performance electronic and optoelectronic devices.However,the graphene synthesized by prevailing methodologies is normally of polycrystalline nature with high nucleation density and limited domain size,which significantly handicaps its overall properties and device performances.Herein,we report an oxygen-assisted CVD strategy to allow the direct synthesis of 6-inch-scale graphene glass harvesting markedly increased graphene domain size(from 0.2 to 1.8μm).Significantly,as-produced graphene glass attains record high electrical conductivity(realizing a sheet resistance of 900Ω·sq^(-1)at a visible-light transmittance of 92%)amongst the state-of-the-art counterparts,readily serving as transparent electrodes for fabricating high-performance optical filter devices.This work might open a new avenue for the scalable production and application of emerging graphene glass materials with high quality and low cost. | Bingzhi Liu Huihui Wang Wei Gu Le Zhou Zhaolong Chen Yufeng Nie Congwei Tan Haina Ci Nan Wei Lingzhi Cui Xuan Gao Jingyu Sun Yanfeng Zhang Zhongfan Liu | 2021 | Nano Research2021，14，1： | 0 |
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